Smiling student class

Students can find information about undergraduate research opportunities currently available at Augusta University. Use the portal below to browse different projects or use the search bar (above the opportunities listed) to look for projects in a specific major or department.

If you are unsure where to begin, please review the First Steps which will help you in your path to success. You are also welcome to schedule an appointment with CURS through Navigate. In addition to the CURS Undergraduate Research Opportunity Portal, students may search the Augusta University Experts Center for terms of interest.

Most all undergraduate research opportunities require initial safety trainings. Please visit the Research Trainings page or ask your mentor for more information. 

For faculty wishing to post a research opportunity, please complete the Undergraduate Research Mentor Registration form. 

Current Projects

Below are ongoing opportunities across the Summerville and Health Science Campuses. Research opportunities are not in any particular order. Projects are vetted on a semesterly basis. Students are encouraged to meet with a CURS advisor for help in approaching a professor for a research opportunity. The portal is updated weekly.

Efficient Epileptic Seizure Prediction Using Artificial Intelligence

Epilepsy is a neurological disorder identified by the frequent occurrence of seizures in which the patient might lose awareness. The seriousness of this condition is centered on the sudden occurrence...

  •   Artificial Intelligence, Machine Learning, Healthcare, Biomedical Engineering
Epilepsy is a neurological disorder identified by the frequent occurrence of seizures in which the patient might lose awareness. The seriousness of this condition is centered on the sudden occurrence of seizure events. Predicting seizures would be a pioneering healthcare solution that would improve the quality of life of epileptic patients. Current machine learning methods have high computational costs and hence high energy consumption which restrict their use in the real-time operation of wearable devices. Spiking neural network (SNN) is an emerging brain-inspired architecture where artificial neurons compute only when separate events are received, leading to an energy-efficient computing method. Current SNN algorithms suffer from some limitations related to input data mapping and the inability to predict new cases with high accuracy. This project aims to develop a novel SNN approach that overcomes these problems to help predict seizures with high accuracy and low power in real-time.
An undergraduate student in the School of Computer and Cyber Sciences with a CGPA not less than 3. Experience in programming, particularly in Python. Excellent verbal and written communication skills. Interested in conducting research in one or more of the following areas: (machine learning - deep learning - spiking neural network - signal processing - Biomedical Engineering)
%Biomedical% %Intelligence, Cyber Security%

Generation of transparent transgenic zebrafish strain to study cardiovascular function in translational cardio-oncology research

Zebrafish is an ideal tool for direct In-vivo observations of developmental processes. To conduct in-vivo whole organism imaging studies, skin transparency is a primary requirement, necessitating the blocking...

  •   Zebrafish, Casper, Transparent, Transgenic, Casper/fli1:EGFP, Cardio-oncology, Vascular system
Zebrafish is an ideal tool for direct In-vivo observations of developmental processes. To conduct in-vivo whole organism imaging studies, skin transparency is a primary requirement, necessitating the blocking of pigmentation. Zebrafish casper mutant maintains skin transparency throughout its life, offering the ideal combination of sensitivity and resolution for in-vivo analyses and imaging. Our Laboratory developing a novel transparent transgenic zebrafish model to address basic cardio-oncology and experimental therapeutics. The fli1 promoter in zebrafish has an enhanced expression reporter gene of green fluorescent protein, GFP. This model will allow for in-vivo examination of the vascular system by using fluorescent and confocal microscopy. In this study, we develop a transparent transgenic strain of Caspe/fli1:EGFP and Casper/myl7/annexin-5:YFP and Casper/fli1:EGFP strain through crossbreeding of proposed lines. This proposed study will aid new dimensions in Cardiooncology research
The Zebrafish lines are available at Dr Rajpurohit Lab. 1- Flourscent and Confocal Imaging Core Facility charges for larve screening $500.00 2-Lab supply (Deep Petri dishes, glass-bottom micro-well Petri dishes (Mat Tek), Pipettes, gloves, etc $300.00 3-Lab chemicals (PTU (Phenyl Thio urea), Clove oil, etc) $200.00 Total request $1000.00
%Cancer% %Cardiology & Vascular Biology%

Predicting Content-Hiding Apps Using Machine Learning

Content-hiding apps (also known as vault apps) are designed to safeguard personal information by concealing it within a seemingly harmless interface, like a calculator. Access to the hidden data Identifying vault apps is significant for several reasons, particularly in the contexts of parental control, cybersecurity, and digital forensics...

  •   machine learning
Content-hiding apps (also known as vault apps) are designed to safeguard personal information by concealing it within a seemingly harmless interface, like a calculator. Access to the hidden data is only granted when a secret password is entered. While these apps can protect privacy, they can also be misused for illicit purposes. Our research aims to employ machine learning techniques to differentiate between vault apps and standard apps. This involves analyzing characteristics from app data on the Aptoide app store, like what the app claims to do, its popularity, and the access it requires to a phone's features. Identifying vault apps is significant for several reasons, particularly in the contexts of parental control, cybersecurity, and digital forensics.
You should be a good programmer. Ideally, you should have some experience programming in Python.
%Intelligence, Cyber Security%

Short-chain fatty acid signaling in retinopathy of prematurity

Retinopathy of prematurity (ROP) is the leading cause of blindness in children. There are limited therapeutic options for this severe ocular pathology. Our overall goal is to identify new and...

  •   Retinopathy
Retinopathy of prematurity (ROP) is the leading cause of blindness in children. There are limited therapeutic options for this severe ocular pathology. Our overall goal is to identify new and more effective therapies for ROP. In particular, we will explore and characterize the potential therapeutic effects of a short-chain fatty acid, butyrate in experimental models of ROP.
Love science, especially biology and chemistry! May have some lab experience and want to do more. Happy to learn new things with technology. Always asking questions and ready to explore!
%Biomedical% %Cell Biology% %Pharmacology%

The role of perivascular adipose tissue in the pathogenesis of lupus-associated vascular disease

Patients with systemic lupus erythematosus (SLE, commonly called lupus), a devastating autoimmune disease that preferentially targets African Americans and women of childbearing age, are at high risk for cardiovascular disease...

  •   Perivascular adipose tissue, lupus, vascular disease
Patients with systemic lupus erythematosus (SLE, commonly called lupus), a devastating autoimmune disease that preferentially targets African Americans and women of childbearing age, are at high risk for cardiovascular disease due to accelerated atherosclerosis. The proposed project will define mechanisms of perivascular adipose tissue (PVAT) in the development of lupus-associated vascular disease. In this project, we will use lupus-prone mice to study the immunological and molecular changes of PVAT. In addition, we will isolate preadipocytes and use 3T3-L1 cell line to study the metabolic characteristics in the context of lupus. Furthermore, we will use a model of combined PVAT transplantation and wire injury to investigate the vascular remodeling in lupus.
None
%Cardiology & Vascular Biology%

Tumor growth modeling in a toxicant-stressed random environment

The consideration of random hypothesis in studying some influencing factors affecting the growth or decline of a tumor is crucial. By analyzing the effects of stress on the volume of...

  •   Tumor density; Chemotherapy, Toxicants; probability distribution; Tumor growth; Stochastic models
The consideration of random hypothesis in studying some influencing factors affecting the growth or decline of a tumor is crucial. By analyzing the effects of stress on the volume of tumor growth in a random environment, we develop stochastic models describing the dynamics of the tumor growth based on random adjustments to the population’s intrinsic growth rate, carrying capacity, and tumor treatments. Apart from the models’ ability to capture fluctuations, the availability of a shape parameter in the models gives it the flexibility to describe a variety of population/tumor data with different shapes. The distribution of the stressed population size is derived and used to calculate the minimum amount of chemotherapy needed to cause shrinkage or eradication of a tumor. This work is applied to analyze tumor growth of breast tumors obtained by orthotopically implanting LM2-4LUC+ cells into the right inguinal mammary fat pads of 6 to 8-week-old female Severe Combined Immuno-Deficient mice.
Knowledge of Probability and Statistics
%Cancer% %Mathematical Biology%

Are Emergency Department (ED) Patients and Visitors Trained in CPR and/or interesting in Learning or Refreshing Hands Only CPR?

The objective of this project is to determine the rate of ED patients and their visitors having ever learned CPR and if ED patients or their visitors are willing to...

  •   Cardiopulmonary resuscitation, CPR education, CPR training, American Heart Association, ACLS
The objective of this project is to determine the rate of ED patients and their visitors having ever learned CPR and if ED patients or their visitors are willing to view a CPR training video during their visits as a refresher or initial training. A secondary objective is to determine if those who watch a short hands only CPR training video are willing to watch a video on how to use an Automatic External Defibrillator (AED). Videos are between 2-3 minutes each fora. total of 5-6 minutes of educational video
30-35 hours of patient data collection in the Emergency Department (ED) at WellStar Augusta University ED during January and February 2024. An additional 2-3 hours of CITI and survey training prior to data collection.
%Cardiology & Vascular Biology% %Nursing% %Primary Care% %Public Health, Health, Well-Being%

Applied Research course: Publishing an Article

After successfully completing an Applied Research course in the French program that focused on reading and analyzing a particularly challenging French text, then critical articles and a book, as well This project would be to research and then write and submit that article. The student will work with the faculty member as they produce a joint article ...

  •   publication, applied research, law, literature, transferable skills
After successfully completing an Applied Research course in the French program that focused on reading and analyzing a particularly challenging French text, then critical articles and a book, as well as doing applied research assignments, all designed to teach applicable skills suitable for a future lawyer, the student and professor have been invited to submit an article for consideration at a peer-reviewed journal. This project would be to research and then write and submit that article. The student will work with the faculty member as they produce a joint article
French 4950: Applied Research (Cours de Recherche appliquée) with Dr. E. Nicole Meyer
%Arts & Humanities% %Literature, Writing% %Political & Judicial%

Exploring Novel Vascular Drug Targets for Alzheimer's Disease and Related Dementias (AD/ADRD)

Recent studies have provided substantial genetic evidence linking soluble epoxide hydrolase (sEH) to AD/ADRD. Our prior research has substantiated that inhibiting sEH effectively alleviates cognitive deficits in rat models...

  •   aging; AD/ADRD; vascular biology; cognition
Recent studies have provided substantial genetic evidence linking soluble epoxide hydrolase (sEH) to AD/ADRD. Our prior research has substantiated that inhibiting sEH effectively alleviates cognitive deficits in rat models of AD/ADRD by improving cerebral hemodynamics. To delve deeper into the underlying mechanisms, we employ a multifaceted approach, harnessing cutting-edge techniques. Furthermore, our lab has identified additional potential treatment targets for AD/ADRD grounded in genetic factors and preliminary investigations of vascular and behavioral aspects, which are currently undergoing detailed mechanism studies.
Positive attitude, team player, able to see the big picture and start from small.
%Aging% %Cardiology & Vascular Biology% %Cell Biology% %Neuroscience, Neurology, Neurosurgery%

Determining the role of interleukin-6 signaling on physical function in mice

In collaboration with Dr. Shruti Sharma in the Center for Biotechnology and Genomic Medicine at MCG, we are looking for a couple motivated undergraduate researchers to work on a project...

  •   inflammation, mice, aging, biology
In collaboration with Dr. Shruti Sharma in the Center for Biotechnology and Genomic Medicine at MCG, we are looking for a couple motivated undergraduate researchers to work on a project measuring physical function in mice. Inflammaging, a chronic low grade inflammatory state that increases with age, has recently be proposed as a driver of negative health outcomes and mortality. Inflammaging is driven by increases in different inflammatory signaling pathways including interleukin-6 (IL-6). In this project, we are using a genetically engineered mouse model with reduced IL-6 signaling. We hypothesize that this mouse will be longer lived and have increased physical function in later ages. Students involved in the project will work directly with the mice to measure physical function as well as other physiological parameters.
No specific pre-reqs. Students need to have an interest in biology and a willingness to work with mice.
%Aging% %Biomedical% %Genetics%

Cyber Security Research Projects in IoT and CPS

...

  •   Cyber Security, Privacy, applied cryptography, IoT, CPS
We have Cybersecurity projects on different Internet of Things (IoT) environments and Cyber-physical systems. These projects include but are not limited to, security and privacy issues in smart grids, smart Healthcare systems, and Vehicular networks. The aim of these projects is to address the privacy and security challenges by employing machine learning/AI models while using lightweight applied cryptography to preserve privacy. Cyber Security, Privacy, applied cryptography, IoT, CPS
Excellent programming skills. ML/AI knowledge is a plus
%Intelligence, Cyber Security%

Affects of marijuana on the brain

Understanding better how marijuana affects the developing brain and the fully developed brain

  •   Marijuana, brain
Understanding better how marijuana affects the developing brain and the fully developed brain
No requirements.
%Addiction & Substance Abuse% %Psychiatry & Psychology%

SECURE-5G: Securing 5G Networks Against Cyber Threats and Data Privacy Leaks in the Era of AI-driven ORAN

ORAN is a new technology being tested for 5G networks in the US. It is open, programmable, and virtualized, making it more flexible and cost-effective for operators. However, its...

  •   5G, Cyber Security, Privacy preservation
ORAN is a new technology being tested for 5G networks in the US. It is open, programmable, and virtualized, making it more flexible and cost-effective for operators. However, its open design and integration of AI also pose a significant security and privacy risk as cybercriminals could exploit vulnerabilities to launch attacks and access confidential information. To mitigate such risks, this Project aims to (1) develop a machine learning (ML)-based ORAN monitoring and threat analysis framework that continuously monitors, analyzes, and mitigates security cyber threats, (2) elucidate the impact of adversarial attacks on the ML-based ORAN applications and propose defense strategies against these attacks, and (3) develop cryptographic-based deception techniques to preserve the privacy of sensitive user/RAN data. The network performance, data privacy and security, and overhead of the proposed tasks will be evaluated using real 5G ORAN datasets.
- Strong programming skills - Machine learning implementation is a plus
%Intelligence, Cyber Security%

Boron nitride quantum dots as nanocarriers and imaging agents for cancer

Boron nitride quantum dots (BNQDs) are novel two dimensional nanomaterials with extraordinary physicochemical properties, biocompatibility and low toxicity. In this project, BNDQs are prepared from bulk hexagonal boron nitrides (hBNs...

  •   Boron nitrides quantum dots, cancer, therapy, imaging
Boron nitride quantum dots (BNQDs) are novel two dimensional nanomaterials with extraordinary physicochemical properties, biocompatibility and low toxicity. In this project, BNDQs are prepared from bulk hexagonal boron nitrides (hBNs) by a method called "liquid-exfoliation", where bulk hBNs are sonicated to reduce their size to observe their fluorescence property. BNDS are have very high surface area with their layered structures and they can adsorb drug molecules. With these unique features, they can be used as nanocarrier to deliver drugs to cancerous cells and imaging agent to monitor their action from their emitted fluorescence.
A solid chemistry and biochemistry background is needed.
%Biomedical% %Chemistry% %Pharmacology%

Differences in Postural Control during the Single-Limb Romanian Deadlift using the Dominant vs Non-Dominant Limb during Weighted and Unweighted Conditions

The single leg Romanian Deadlift (SL-RDL) is a useful exercise in the rehabilitation setting given its ability to simultaneously address balance and strength impairments. Typical rehabilitation programs begin with Students will be performing literature review for manuscript preparation, assisting with data collection, , assisting with data alanysis, and will have the opportunity to publish work...

  •   balance, exercise, force plate, kinesiology
The single leg Romanian Deadlift (SL-RDL) is a useful exercise in the rehabilitation setting given its ability to simultaneously address balance and strength impairments. Typical rehabilitation programs begin with the SL-RDL performed without weight, and then add weight as the patient progresses. Limited research has investigated the differences in postural control (balance) during the exercise on individual’s dominant compared to non-dominant limb. Additionally, little if any research has determined if there are differences in postural control during the SL-RDL with and without weight. Therefore, the purpose of this study is to compare postural control during the SL-RDL on an individual's dominant and non-dominant limb, as well as with and without an external load. Students will be performing literature review for manuscript preparation, assisting with data collection, , assisting with data alanysis, and will have the opportunity to publish work.
Preference will be given to students who have completed kinesiology/biomechanics and/or exercise science courses. Students should know how to use library search engines to search for literature. CITI training is required.
%Kinesiology% %Kinesiology, Physical Therapy%

Pathogenesis and Repair of Developmental Brain Injury

Premature birth is a major public health issue with a growing population of surviving infants. Clinical and laboratory studies demonstrate that environmental factors can benefit recovery from these disabilities, however...

  •   Neuroscience, Neurodevelopment, Brain Injury, White matter, Glia, Myelin, Stem Cells
Premature birth is a major public health issue with a growing population of surviving infants. Clinical and laboratory studies demonstrate that environmental factors can benefit recovery from these disabilities, however specific mechanisms that drive the injury progression and repair are not well understood. Research in the Goldstein lab investigates the pathogenesis and repair mechanisms following developmental brain injury. To do this, we will examine brain tissue from mice housed in a low oxygen environment - a model of premature birth. We also will analyze postmortem human brain samples from babies that were born preterm. These studies will inform the quest to develop improved therapeutic options for babies born prematurely.
A passion for learning and a strong desire to understand how biological systems work are requirements to join the lab. Successful completion of introductory STEM coursework is strongly preferred.
%Biomedical% %Neuroscience, Neurology, Neurosurgery%

Advancing Chemical Separations Simulations: Computational Algorithms and Optimization with Implicit Adsorption Isotherms

The unprecedented growth of biopharmaceuticals in recent years has led to better ways of managing chronic diseases in humans including diabetes, immunodeficiencies, and cancer. As the number of approved drug explicit mathematical relationships. The goals of this project are to develop, validate, analyze, and use computational tools to inform the design of new, rapid membrane chromatography purification processes for biomanufacturing...

  •   Mathematical Modeling, Numerical Simulation Methods, Protein Chromatography, Optimization
The unprecedented growth of biopharmaceuticals in recent years has led to better ways of managing chronic diseases in humans including diabetes, immunodeficiencies, and cancer. As the number of approved drug compounds increases, there is a pressing need for lower cost, faster biomanufacturing operations to make these products available and more affordable for growing patient populations. This research project aims to develop numerical approaches to solve the mathematical descriptions needed to simulate these processes. Mathematical models must incorporate new, more complex ion-exchange relationships that define the solid phase adsorption as an implicit function of the liquid phase adsorption, a significant change from the standard explicit mathematical relationships. The goals of this project are to develop, validate, analyze, and use computational tools to inform the design of new, rapid membrane chromatography purification processes for biomanufacturing environments.
Good knowledge of multi-dimensional calculus, differential equations and linear algebra. Also, must be comfortable programming in at least one language and be willing to learn MATLAB if it is not already known.
%%

Vaccine Hesitancy and Mortality Among Hospitalized COVID-19 Patients

Vaccine hesitancy can pose a significant threat to people and leads to loss of herd immunity and the recurrence of COVID-19. The overall goal of this study was to ...

  •   COVID-19, Vaccination, Mortality, Co-morbidities
Vaccine hesitancy can pose a significant threat to people and leads to loss of herd immunity and the recurrence of COVID-19. The overall goal of this study was to assess the mortality and vaccine hesitancy among hospitalized COVID-19 patients. A retrospective data analysis of COVID-19 patients’ data. A fixed convenience sample of 927 admitted patients aged 18 or above admitted from March 1 to November 30, 2021. Descriptive statistics, bivariate logistic regression, and survival analysis were used.
Basic understanding of scientific research.
%Diversity, Equity, & Inclusion% %Epidemiology% %Public Health, Health, Well-Being% %Social Behavior%

COVID, MENTAL HEALTH, AND SOUL STUDY( CMAS STUDY)

The overall aim of this study is to utilize Church Health Workers (CHWs) to screen for depression among COVID-19 survivors in a Black church and compare the effectiveness of Aim 2: To assess changes in mental health outcomes at 3- and 6-months post-screening among COVID-19 survivors. Aim 3: To identify contextual factors that act as facilitators We hypothesize that Church Health Workers (CHWs) deployed for church-based depression screening can help overcome cognitive barriers and increase treatment engagement among black COVID-19 survivors...

  •   Epidemiology, biostatistics, infectious disease, Depression
The overall aim of this study is to utilize Church Health Workers (CHWs) to screen for depression among COVID-19 survivors in a Black church and compare the effectiveness of Screening, Brief Intervention, and Referral to Treatment (SBIRT; Intervention arm) to individuals as Referral As Usual (RAU; Control arm/Usual Care arm) on treatment engagement for depression. Aim 1: To compare the effect of SBIRT (Intervention arm) among COVID-19 survivors to subjects as Referral As Usual (RAU; Usual Care arm) on treatment engagement Aim 2: To assess changes in mental health outcomes at 3- and 6-months post-screening among COVID-19 survivors. Aim 3: To identify contextual factors that act as facilitators or barriers of depression screening and referral among COVID-19 survivors. We hypothesize that Church Health Workers (CHWs) deployed for church-based depression screening can help overcome cognitive barriers and increase treatment engagement among black COVID-19 survivors.
Basic knowledge of scientific research.
%Epidemiology% %Public Health, Health, Well-Being% %Research Methods% %Social Behavior%

Molecular and genetic analysis of BicD mutations associated with Spinal Muscular Atrophy

Bicaudal-D (BicD) is a cargo adaptor for the Dynein motor. Mutations in BicD in humans is associated with a type of spinal muscular atrophy, a generative neurological disorder. The...

  •   Dynein, Kinesin, motor protein, genetics, developmental biology
Bicaudal-D (BicD) is a cargo adaptor for the Dynein motor. Mutations in BicD in humans is associated with a type of spinal muscular atrophy, a generative neurological disorder. The goal of this project is to use mammalian cells lines and the Drosophila melanogaster model to determine the molecular defects that contribute to the disease pathology.
Some knowledge of general cell biology. Willing to commit about six hours per week to the project.
%Aging% %Cell Biology% %Genetics% %Neuroscience, Neurology, Neurosurgery%

Sex differences in cardiovascular and renal disease

The overall goal of my laboratory is to better understand the molecular mechanisms that regulate blood pressure (BP) and renal health and function in males and females under both physiological...

  •   gender, sex differences, kidney, inflammation
The overall goal of my laboratory is to better understand the molecular mechanisms that regulate blood pressure (BP) and renal health and function in males and females under both physiological and pathophysiological conditions. Ongoing projects are examining the role of immune cells in the development of essential hypertension, and increases in blood pressure on a high fat diet. We are also examining the mechanisms that induce renal injury following ischemia., and the long term impact of this on pregnancy.
decided on a case-by-case basis
%Cardiology & Vascular Biology%

Reimagining Literacy: The Art of Making Zines and Graphic Novels.

Students in ART 4261 will explore storytelling through text and images by creating and designing Graphic Novels and Zines to self-publish and distribute through Printed Matter in NYC. This Students will be encouraged to choose a topic based on personal, contemporary social, or political issues. Students must ask questions that engage their audience by identifying issues that intersect in After completing the small edition Zines and Graphic Novels, students will follow the submission process for Printed Matter in NYC. Printed Matter is one of the largest distributors of self ...

  •   Graphic Novel, Zine
Students in ART 4261 will explore storytelling through text and images by creating and designing Graphic Novels and Zines to self-publish and distribute through Printed Matter in NYC. This project will require learning, researching, and developing creative strategies needed for narrative and concept development specific to Zines and Graphic Novels. Students will be encouraged to choose a topic based on personal, contemporary social, or political issues. Students must ask questions that engage their audience by identifying issues that intersect in areas of common identity and work towards building consensus rather than division. After completing the small edition Zines and Graphic Novels, students will follow the submission process for Printed Matter in NYC. Printed Matter is one of the largest distributors of self-published material in the world. If the student's work is accepted, they are required to have or make a minimum edition of 100 for distribution.
1. Research and Identify the Concept 2. Brainstorm iterations, supporting ideas, questions, and concept. 3. Sequence ideas into storyboard. 4. Create 10 thumbnail sketches for each sequence. 5. Create a “Tight Storyboard” and share it for feedback. 6. Work through each page creating a “Tight Sketch” that is close to finish and can be digitally altered based on feedback 7. Layout, print, and complete pages 8. Bind and curate Zine/Graphic Novel.
%Arts & Humanities%

Insulinotropic drugs in the treatment of retinal degenerative diseases

The goal of this project is to demonstrate the relevance of insulin produced locally in retina to retinal health and function. Our recent published preliminary data confirms the autonomous regulation significance of that insulin production with respect to retinal health and function. Further, we will (2) define key metabolic pathways influenced by retinal insulin or the lack thereof, using unique...

  •   retina insulin retinal degeneration metabolism eye aging diabetes
The goal of this project is to demonstrate the relevance of insulin produced locally in retina to retinal health and function. Our recent published preliminary data confirms the autonomous regulation of insulin in retina. Thus, retinal insulin has its own unique functions that are important to normal retinal metabolism and health. Based on our preliminary findings, we predict endogenous insulin to be an agonist that is secreted steadily to counter the constant metabolic stress that the retina faces. The experimental strategy that we have designed will validate this hypothesis and (1) establish which retinal cell types produce insulin and the significance of that insulin production with respect to retinal health and function. Further, we will (2) define key metabolic pathways influenced by retinal insulin or the lack thereof, using unique genetically engineered conditional knockout mice for key insulin genes, INS1 and INS2.
none
%Aging% %Biomedical%

Tracking UME Telehealth Education from Competency to Patient Outcomes

Our project is focused using tracking medical student progression through a telehealth curriculum and correlate this with pre-defined patient outcomes around the management of chronic hypertension. This approach allows The longitudinal telehealth encounters built into our medical school’s curriculum create a unique opportunity to develop a telehealth curriculum and assessment strategy that benefits the patient as well as...

  •   Telehealth, motivational interview, medicine
Our project is focused using tracking medical student progression through a telehealth curriculum and correlate this with pre-defined patient outcomes around the management of chronic hypertension. This approach allows us to make some direct connections between holistic student assessment and patient outcomes. The longitudinal telehealth encounters built into our medical school’s curriculum create a unique opportunity to develop a telehealth curriculum and assessment strategy that benefits the patient as well as the learner. To continue to support students’ ability to affect patient change in chronic disease care we intend to use Motivational Interviewing (MI) as a way to empower students by giving them a tool to use to impact patient care directly. The MI specific framework is intended to build students skills in the competencies that have the biggest potential to impact patient health as well as help students develop skills that will directly translate from telehealth encounter
Recruiting two to three part-time research assistants. Open to both undergraduate and graduate students. Primary role involves consenting patients, distributing equipment and data collection during telehealth encounters. Minimum of 5 month commitment. Skillset – applicants need to have familiarity with research methodology and be facile with basic mobile application interfaces and using an ipad for recording and uploading interviews. Times:12:30pm to 5:30pm on Tues/Weds/Thurs
%Cardiology & Vascular Biology% %Education% %Epidemiology% %Telehealth%

Impact of cardiovascular risk factor on cognitive decline

The focus of this project is to assess the impact of cardiovascular risk factors such as blood pressure variability, hypertension and heart failure on the early onset of cognitive decline...

  •   brain astrocytes microglia neurovascular
The focus of this project is to assess the impact of cardiovascular risk factors such as blood pressure variability, hypertension and heart failure on the early onset of cognitive decline and dementia. We use an array of methods including behavioral studies, confocal imaging, live in vivo imaging (two photon microscopy) and molecular and cellular approaches. We investigate how different cells of the neurovascular unit (astrocyte, neurons and vascular cells) communicate, and how these processes are affected in diseased conditions contributing to a decline in neuronal function.
Some knowledge of biology is important
%Aging% %Cardiology & Vascular Biology% %Neuroscience, Neurology, Neurosurgery%

Effects of dietary and genetic interventions on lifespan and health in Drosophila melanogaster

Please note Dr. Hoffman is NOT taking on students for Spring 2024 The Hoffman lab is interested in the biology of aging and understanding the genetic, metabolic, and environmental factors...

  •   aging, drosophila, diet, interventions
Please note Dr. Hoffman is NOT taking on students for Spring 2024 The Hoffman lab is interested in the biology of aging and understanding the genetic, metabolic, and environmental factors that influence aging across species. There are multiple projects available undergraduate researchers using the fruit fly as a model for discovering interventions to increase lifespan and improve health. Current ongoing studies in the lab include manipulating the amino acids tryptophan and serine, as well as performing dietary restriction studies. There are also opportunities to study evolution and life history trade-offs (longevity and reproduction) in the fly. Undergraduate researchers have the potential to develop their own intervention experiment or work on any of the projects already started in the lab. Please reach out for more information, as well as a more detailed description of the potential projects.
All that is required is a flexible schedule (ability to commit 5-10 hours a week to the lab), good organizational skills, and an eagerness to learn about aging biology.
%Aging% %Biomedical% %Evolution%

Essential Oils and Pain-Pressure Threshold Feasibility Study

This is a feasibility study - meaning we will use new techniques (also in a new lab space) to ensure everything works as anticipated. If we run into issues, we will...

  •   essential oils, pain-pressure threshold, digital infrared thermal imaging
This is a feasibility study - meaning we will use new techniques (also in a new lab space) to ensure everything works as anticipated. If we run into issues, we will troubleshoot and determine the correct course of action. :) Once we have perfected our methods, we will recruit healthy participants and run our feasibility study. Pain-Pressure Threshold (PPT) is when a non-painful stimulus induces nociception (pain) and is measured by a hand-held algometer. Many essential oils (EOs) have pain-reducing properties, but have not been well-studied. Topically-applied EOs may increase PPT, thus, reducing pain perception. PPT will be measured with control, jojoba, and 16 single diluted EOs in healthy adults using a quasi-experimental, within-subjects design. Additionally, we will use digital infrared thermal imaging (DITI) to ascertain EO absorption spread. Study results will support using PPT in future studies using EOs for chronic pain. Funded: Beta Omicron Chapter, STTI & my start-up funding.
**This faculty member is not taking students Spring 2024** Citi Training, AU Chemical Safety Training, a spirit of inquiry, and the desire to do a good job!
%Neuroscience, Neurology, Neurosurgery% %Nursing% %Pain% %Research Methods%

Metabolic diseases in obesity and lipodystrophy

Obesity and its associated health comorbidities are a worldwide epidemic with serious economic and health burdens on society. Adipose tissue is a vital endocrine organ that plays a crucial role...

  •   obesity, lipodystrophy, metabolism, heart failure, fatty liver diseases
Obesity and its associated health comorbidities are a worldwide epidemic with serious economic and health burdens on society. Adipose tissue is a vital endocrine organ that plays a crucial role in developing obesity and various metabolic disorders. White adipocytes store excess energy in the form of triglycerides for future needs. By contrast, brown and beige (browning-in-white) adipocytes metabolize lipids and glucose to produce heat in a process known as nonshivering thermogenesis, which is crucial in systemic energy homeostasis and thermoregulation. We are interested in identifying important players that are crucial in determining adipocyte fates and functions. We further explore how obesity or lipodystrophy leads to metabolic disorders like diabetes, fatty liver diseases, and heart failure. Please refer to https://www.augusta.edu/mcg/phy/faculty/phys_faculty_chen.php.
Passion for science, motivation to pursue a scientific career, eagerness to learn, teamwork, and good work ethics. Prefer to have taken basic biology classes and have had some training in basic research skills.
%Biomedical% %Cardiology & Vascular Biology% %Endocrinology% %Genetics%

Before Hershey: A History of Mexico’s Gift to the World

This research is to be a chapter in an accepted publication about chocolate. We will be looking through pre-Columbian (before 1519) codices (pictorial accordion-style books) of the ancient...

  •   Commodities, Chocolate, History, Latin America, Globalization
This research is to be a chapter in an accepted publication about chocolate. We will be looking through pre-Columbian (before 1519) codices (pictorial accordion-style books) of the ancient Mesoamerican world (Central and Southern Mexico & Northern Central America), through colonial documents of the Spanish era in New Spain (Mexico, Central America, & US Southwest), and modern publications about the production, sale and consumption of chocolate. Of particular focus is the shift from Aztec and Maya women making chocolate beverages to the monopoly by the Spanish crown over everything chocolate, to the modern era where most people have no idea who grows, dries, grinds, and produces chocolate for everything from desserts, candy, and beverages or how it moved from its Mexican origins around the world. Help Dr. Chiero with the background research and learn about the process of research to writing submission and you will earn mention in the final publication for your effort.
Ability to conduct online research, no fear of reading academic abstracts and articles, attention to detail, good organizational skills, and self-discipline to complete requested tasks and deadlines. Willingness to learn about other cultures and new terminology would be helpful.
%Arts & Humanities% %Culture, Language% %Ecology% %Gender Studies%

Environmental Justice: Central American Climate Wars

This study seeks to uncover the historical antecedents to the modern day climate migrants and migrant caravans out of Central America headed to the United States. We will be looking...

  •   Environmental History, Migration, Latin America, International Business, Deforestation, Climate
This study seeks to uncover the historical antecedents to the modern day climate migrants and migrant caravans out of Central America headed to the United States. We will be looking through historical documents from the colonial era through the 20th century related to mining, hydroelectric dam construction, deforestation, pollution, and the displacement of local populations from ancestral lands. Any publications from the research will credit student assistance.
Good organizational skills, attention to detail, intermediate Spanish language reading ability required.
%Civil Rights% %Culture, Language% %Ecology%

Development of New Drug Candidates for Cancer Treatment using Molecular Hybridization and Rational Drug Design Approach

The development of new drug candidates for cancer treatment is a complex and challenging process. However, recent advances in molecular hybridization (MH) and rational drug design (RDD) approaches have provided...

  •   Drug Discovery; Medicinal Chemistry; Cancer; Natural Product
The development of new drug candidates for cancer treatment is a complex and challenging process. However, recent advances in molecular hybridization (MH) and rational drug design (RDD) approaches have provided new opportunities for the creation of more effective and targeted cancer therapies. By combining different molecular structures and optimizing their properties, scientists can create hybrid molecules with enhanced properties and reduced side effects. This approach allows for the creation of drugs that specifically target cancer cells while leaving healthy cells unharmed. Additionally, the RDD approach involves using computer simulations and molecular modeling to predict the effectiveness of potential drug candidates. Overall, the use of MH and RDD approach offers great promise for the development of new cancer therapies. With continued research and development, these approaches may lead to breakthroughs in the fight against cancer.
Students will need to complete the Initial Chemical and Safety Training
%Cancer% %Cell Biology% %Chemistry% %Research Methods%

Therapeutic potential of using arginase 1 to limit trauma-induced vision loss

Trauma-induced injury of the retina and optic nerve is a major cause of vision loss with few effective therapies. We seek to delineate the molecular mechanisms of the injury...

  •   retinal angiogenesis, diabetic retinopathy, inflammation, ischemia, lipid metabolism
Trauma-induced injury of the retina and optic nerve is a major cause of vision loss with few effective therapies. We seek to delineate the molecular mechanisms of the injury and identify novel strategies to prevent or reverse the damage and preserve vision. We are studying the role of an enzyme called arginase 1 in this process. We have discovered that arginase 1 deletion worsens the damage, whereas treatment with a stable drug form of arginase 1 limits injury and promotes repair by decreasing inflammation and increasing immune cell repair functions. Pharmaceutical forms of this drug are currently under development as cancer therapy. Thus, the treatment is safe for use in patients and can be readily adapted for treating trauma to the retina or optic nerve. Our current studies are expanding this work to further demonstrate its protective effects in models of traumatic optic nerve injury and glaucoma and elucidate the underlying mechanisms.
Basic knowledge of biology and chemistry. Some laboratory experience. Willingness to work with mice. Computer skills. Eagerness to learn.
%Cell Biology% %Neuroscience, Neurology, Neurosurgery%

The effect of Lavandula angustifolia (lavender) essential oil on pain in primary dysmenorrhea: A systematic review

A systematic review was started in 2019 and placed on hold in 2020 due to students graduating. In the fall of 2022, a current CURS student picked up this project...

  •   systematic review, lavender, dysmenorrhea, nursing
A systematic review was started in 2019 and placed on hold in 2020 due to students graduating. In the fall of 2022, a current CURS student picked up this project, and we searched for any relevant publications since 2019. The project is registered in PROSPERO. We have already pared down studies and are preparing to critically appraise those meeting inclusion and exclusion criteria, then, we will synthesize the findings.
**This faculty member is not taking students Spring 2024** patience, attention to detail, and computer access
%Nursing% %Research Methods%

Machine learning applications of quantum magnetism

Machine learning, which is part of artificial intelligence, has become an invaluable tool to manipulate, analyze, predict, and reveal trends and associations hidden within big data. In this project students...

  •   Materials Science, Magnetism, Machine Learning
Machine learning, which is part of artificial intelligence, has become an invaluable tool to manipulate, analyze, predict, and reveal trends and associations hidden within big data. In this project students will explore the cross-cutting applications of materials science, magnetism and machine learning applications to predict material properties.
Introductory calculus based physics, linear algebra, and basic programming familiarity.
%Physics%

Topological properties of photon-mediated interacting fermions in the presence of honeycomb optical lattice

No description available.

  •   Condensed matter physics, cold-atomic physics, topological materials, superconductivity, superfluids
No description available.
Introductory physics, Calculus, differential equations
%Physics%

Transgender Health Studies

Extant research indicates transgender people face numerous forms of minority stress resulting in health disparities which forestalls identity development and may contribute to depression and suicidal thoughts. Under the supervision...

  •   Transgender health; sexual and gender minorities; depression; suicide; mindfulness; identity develop
Extant research indicates transgender people face numerous forms of minority stress resulting in health disparities which forestalls identity development and may contribute to depression and suicidal thoughts. Under the supervision of Dr. Lara Stepleman, Professor of Psychiatry and Health Behavior, undergraduate students are invited to complete an intensive semester spent acquiring hands-on research experience organizing and analyzing previously collected qualitative and quantitative data related to transgender health. Students will also have the opportunity to participate in dissemination efforts of research findings through the preparation and submission of presentation proposals to professional conferences.
CITI Group 6 Social Behavioral Sciences
%Psychiatry & Psychology% %Public Health, Health, Well-Being%

Red blood cell trapping in ischemic acute kidney injury

No description available.

  •   Red blood cells, Kidney, Toxicity, Ischemia, Low blood flow, Shock, Physiology
No description available.
Board of Regents Basic Training Right to Know Board of Regents Hazardous Waste Awareness Training Initial Biosafety and Bloodborne Pathogen Training
%Cell Biology%

Cancer resistance to DNA damage

Our lab's primary focus is understanding cancer resistance to DNA damage-inducing therapeutics like irradiation with the ultimate goal of identifying a noble therapeutic target and developing more effective...

  •   Cancer, DNA damage, DNA damage repair, resistance, treatment, radiation, chemotherapy, glioblastoma
Our lab's primary focus is understanding cancer resistance to DNA damage-inducing therapeutics like irradiation with the ultimate goal of identifying a noble therapeutic target and developing more effective treatment strategies to improve patient survival.
Love biomedical research and motivated to learn. Board of Regents Basic Training Right to Know Board of Regents Hazardous Waste Awareness Training Board of Regents Bloodborne Pathogens Training Initial Biosafety and Bloodborne Pathogen Training NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecule
%Cancer% %Cell Biology%

Physical Activity to Reduce Cardiometabolic Risk in Serious Mental Illness: PARCS Study.

The aim of this project is to trial the protocol of a park-based physical activity (PA) intervention in adults with serious mental illness (SMI) in a community mental health...

  •   Physical activity, serious mental illness, randomized clinical trial
The aim of this project is to trial the protocol of a park-based physical activity (PA) intervention in adults with serious mental illness (SMI) in a community mental health center's peer support program. Outcomes include feasibility (e.g., attendance), acceptability (enjoyment, satisfaction), and changes in physical activity, fitness, and psychological mechanisms. NCT05457179, R34 MH126043
Psychology and/or kinesiology coursework CITI Group 6 Social Behavioral Research and Group 7 Social-behavioral GCP
%Psychiatry & Psychology% %Public Health, Health, Well-Being% %Social Behavior%

Sex differences in high-fat diet-induced hypertension

No description available.

  •   gender, kidney, inflammation, metabolism, mitochondria, salt
No description available.
Board of Regents Basic Training Right to Know Board of Regents Hazardous Waste Awareness Training Board of Regents Bloodborne Pathogens Training Initial Biosafety and Bloodborne Pathogen Training LAS
%%

Intergenerational Cancer Prevention for Latina Mothers

No description available.

  •   Breastfeeding promotion, health behavior, prevention, public health, cancer
No description available.
Ability to read and write in Spanish; language fluency preferred CITI Group 6 Social Behavioral Research
%Cancer%

Does fatigue influence ground reaction forces during landing?

This project is assessing ground reaction forces during landing both before and after a lower body workout. It is long known that landing forces lead to both acute and chronic...

  •   Kinesiology, Biomechanics, Forces, Landing, Exercise, Sport,
This project is assessing ground reaction forces during landing both before and after a lower body workout. It is long known that landing forces lead to both acute and chronic injury in the athletic population, but more information is needed about the influence of external factors on these Landing forces.
No specific qualifications needed, but physics and A&P would be helpful CITI Group 2 Non FDA Regulated Research
%Kinesiology%

Multiple Computer Science Research Projects

We have various projects to work on. It ranges from Blockchain technology to cryptography. All the projects are in the area of computer security and privacy. Our research aims to...

  •   Security, blockchain, applied cryptography
We have various projects to work on. It ranges from Blockchain technology to cryptography. All the projects are in the area of computer security and privacy. Our research aims to implement the ideas that have been shaped using your current skills while learning more about security and privacy.
Excellent programming skill, good mathematics knowledge
%Intelligence, Cyber Security%

What MSTEM (medicine, science, technology, engineering and math) topics do AU undergrads want to learn about?

This is a survey research project that seeks to understand what type of MSTEM topics AU students want to learn about and how it relates their future career plans and...

  •   Survey research; MSTEM education, diversity
This is a survey research project that seeks to understand what type of MSTEM topics AU students want to learn about and how it relates their future career plans and aspirations. For instance, what kind of higher education (e.g., graduate school, medical school, dental school nursing school, etc) do AU undergraduates want to pursue? What type of undergraduate educational experiences (including course work, research experience, mentoring opportunities, networking opportunities, etc) do AU undergrads want to receive? This research project provides an opportunity to learn about state-of-the-art methods of conducting surveys (including in-person and online surveys), and analyzing survey research data.
Citi Group 6 Social Behavioral Research and Group 8 Research Ethics
%Diversity, Equity, & Inclusion% %Education% %Social Behavior%

Brain injury, Alzheimer's disease, neuroprotection

No description available.

No description available.
No requirements.
%Epidemiology% %Anxiety & Stress% %Neuroscience, Neurology, Neurosurgery% %Aging%

Areas of study include: Stress, depression, Alzheimer's disease, neural plasticity, epigenetics

No description available.

No description available.
No requirements.
%Epidemiology% %Anxiety & Stress% %Neuroscience, Neurology, Neurosurgery% %Aging%

Congenital Heart Disease Birth Defect and Cardiac Development

Congenital heart disease (CHD) remains the most common birth defect worldwide, affecting ~ 1% of live births, and arises, at least in part, from defects in cardiovascular development. NEDD8 is a...

Congenital heart disease (CHD) remains the most common birth defect worldwide, affecting ~ 1% of live births, and arises, at least in part, from defects in cardiovascular development. NEDD8 is a novel ubiquitin-like protein that modifies protein targets in a process similar to ubiquitination (termed neddylation), and is mediated by NEDD8-specific E1, E2 and E3 enzymes. Though neddylation participates in diverse cellular processes (cell growth, viability, adipogenesis, etc) and pathophysiological events (tumorigenesis, etc.), the importance of neddylation in cardiovascular development remains unknown. In order to study this, we have developed an NAE1 flox/flox mouse, enabling deletion of the only NEDD8 E1 enzyme, and thus inhibition of neddylation, in various tissues. We have several different Cre strains, including aMHC, SM22a, and Nkx2-5, allowing us to study cardiac-specific deletion of NAE1 during different developmental stages in the heart. Preliminary data has shown that aMHC-Cre driven NAE1 deletion leads to perinatal death and defects in ventricular chamber maturation, with a phenotype resembling left ventricular noncompaction, an increasingly recognized primary cardiomyopathy. We will use the many cellular and molecular biology techniques and biochemical assays at our disposal to 1) identify novel signaling pathways regulated by neddylation during cardiac development, and 2) tease apart the underlying mechanisms behind how these pathways contribute to cardiac disease.
No prior experience necessary. Curiosity, desire to learn, and a good work ethic greatly appreciated. Main student responsibilities would include animal handling, management and maintenance of mouse colonies, genotyping, RNA isolation, biochemical assays, tissue sectioning and staining, etc. Publication is expected.
%Cardiology & Vascular Biology%

General Ecology/Urban Ecology

Recovery of the endangered Shoals Spider Lily; The endangered gopher tortoise and its habitat: tracking, monitoring, and management; Effects of pollution on reproductive physiology of fish

Recovery of the endangered Shoals Spider Lily; The endangered gopher tortoise and its habitat: tracking, monitoring, and management; Effects of pollution on reproductive physiology of fish
No requirements.
%Ecology%

Marine & Freshwater Population/Community Ecology

Description:Oceanic fish diversity among barrier islands along the Georgia-lina coasts; Diel variation in fish communities on a Georgia barrier island; Differences in tidal creek and oceanic fish diversity...

Description:Oceanic fish diversity among barrier islands along the Georgia-lina coasts; Diel variation in fish communities on a Georgia barrier island; Differences in tidal creek and oceanic fish diversity on a Georgia barrier island; Snail densities and movement in tidal salt marshes in South Carolina and Georgia barrier islands; Snail plant preference in tidal salt marshes in South Carolina and Georgia barrier islands; Macroinvertebrate diversity in Butler Creek as an indicator of stream health; Assessing man-made cuts on estuarine systems in Georgia; Biofilm diversity on marine organisms
No requirements.
%Ecology%

Fish & Wildlife Management/Marine & Wildlife Ecology

Fish & Wildlife Management/Marine & Wildlife Ecology

Fish & Wildlife Management/Marine & Wildlife Ecology
Students need ability to work independently, competency with EXCEL, swimming proficiency, capability to pull heavy seine, and people skills.
%Ecology%

MolecularPharmacology

Investigates structure and function of G-protein-coupled receptor (GPCR) signaling complexes. His work uses biophysical methods such as resonance energy transfer and confocal imaging in living cells to investigate...

Investigates structure and function of G-protein-coupled receptor (GPCR) signaling complexes. His work uses biophysical methods such as resonance energy transfer and confocal imaging in living cells to investigate receptor quaternary structure and receptor-G protein coupling. Serves on NIH study sections.
No requirements.
%Pharmacology%

Herpetology/Wetland Ecology

A census of frog populations of aquatic habitats in South Carolina; Aquatic turtle species composition, population evaluation, and environmental toxicology

A census of frog populations of aquatic habitats in South Carolina; Aquatic turtle species composition, population evaluation, and environmental toxicology
No requirements.
%Ecology%

Mechanisms Leading to Hypertension in Obesity

The main goal of the project is to identify the mechanisms leading to hypertension in obesity and to determine whether these mechanisms are sex-specific. Experiments will include characterization of...

The main goal of the project is to identify the mechanisms leading to hypertension in obesity and to determine whether these mechanisms are sex-specific. Experiments will include characterization of the cardiovascular phenotype of mouse models of obesity and collaboration with clinicians working with human patients.
Genuine interest for research, scientific curiosity and strong motivation.
%Chronic Illness% %Cardiology & Vascular Biology%

Molecular Genetics/Genome Stability/Population Genetics

Role of Hob1 protein in DNA repair and genomic stability; Genetic requirements of microsatellite instability during DNA replication; Investigating of the role of unbalanced dNTP pools on DNA mutations and...

Role of Hob1 protein in DNA repair and genomic stability; Genetic requirements of microsatellite instability during DNA replication; Investigating of the role of unbalanced dNTP pools on DNA mutations and DNA stability; Genetic diversity of multiple crab species along the Georgia and South Carolina coast.
Student must have completed BIOL 1108 prior to joining
%Cell Biology% %Genetics%

Cell Physiology/Reproductive Physiology

Effect of endocrine disruptors on mLTC-1 Leydig cells

Effect of endocrine disruptors on mLTC-1 Leydig cells
No requirements.
%Cell Biology% %Endocrinology%

Molecular Microbiology

Nutrient Acquisition by bacteria; E. coli as a Biomarker of Human & Animal Fecal Contamination in Streams & Rivers; Bacterial Physiology and Identification, Antibiotic Resistance

Nutrient Acquisition by bacteria; E. coli as a Biomarker of Human & Animal Fecal Contamination in Streams & Rivers; Bacterial Physiology and Identification, Antibiotic Resistance
No requirements.
%Cell Biology%

Post-Traumatic Stress Disorder research

Uses a multilevel approach to investigate forebrain networks involved in encoding and consolidating of memories for emotional events in models of anxiety and impaired cognitive flexibility with special focus on...

Uses a multilevel approach to investigate forebrain networks involved in encoding and consolidating of memories for emotional events in models of anxiety and impaired cognitive flexibility with special focus on individual differences. The lab has created an animal model of susceptibility for developing Post-Traumatic Stress Disorder. She serves on grant study review sections for NIH, NSF and DOD, and also reviews grants for the VA and the Augusta Biomedical Research Corporation. She is a reviewing editor for Frontiers in Molecular Neuroscience.
No requirements.
%Neuroscience, Neurology, Neurosurgery% %Anxiety & Stress%

Brain Injury research

Focuses on the identification and characterization of molecular targets of brain injury after intracerebral hemorrhage, a fatal stroke subtype employing both genetic and pharmacological approaches. Serves on AHA study section.

Focuses on the identification and characterization of molecular targets of brain injury after intracerebral hemorrhage, a fatal stroke subtype employing both genetic and pharmacological approaches. Serves on AHA study section.
No requirements.
%Neuroscience, Neurology, Neurosurgery%

Aging and Circadian Rhythms in Vascular Disease

Studies the interactions of aging and circadian rhythms in vascular disease. The molecular focus is in identifying the contributions of the transcriptional mechanisms that operate in the inner cell layer...

Studies the interactions of aging and circadian rhythms in vascular disease. The molecular focus is in identifying the contributions of the transcriptional mechanisms that operate in the inner cell layer of the blood vessel called the endothelium. In addition, there are new areas of research that are unfolding in the lab, which seek to query if and what molecularconnections exist between the aging blood vessel and the aging brain, with potential application to Alzheimer's Disease.
No requirements.
%Aging% %Chronic Illness%

Cancer Health Awareness through screeNinG and Education (CHANGE) for Public Housing Resident

This project will deliver a sustainable model of evidence-based cancer awareness through health literacy and education, with an emphasis on prevention, screening, and early detection behaviors and provide access...

This project will deliver a sustainable model of evidence-based cancer awareness through health literacy and education, with an emphasis on prevention, screening, and early detection behaviors and provide access and navigation to high-quality cancer screening and early detection services. We will also develop and implement a cancer cultural competency training for health care providers, in collaboration with the community. Finally, we will conduct a cost-effectiveness analysis of these cancer prevention strategies.
Students will assist with conducting interviews with former patients and housing authority residents about their experiences accessing health care, and what they would like their physicians to know about how they see race affecting their healthcare. They may also participate in cancer education delivery during sessions at the Augusta Housing Authority sites.
%Cancer% %Education%

Neural Development and Regeneration

Our research is centered on identifying genes and genetic processes essential for the generation of neurons during mammalian embryonic development, understanding the the underlying molecular mechanisms, and using these genes...

Our research is centered on identifying genes and genetic processes essential for the generation of neurons during mammalian embryonic development, understanding the the underlying molecular mechanisms, and using these genes and processes for neuroregeneration by promoting the differentiation of neural progenitors into neurons.
Curiosity, good work ethic, and persistence. No prior lab experience needed.
%Neuroscience, Neurology, Neurosurgery% %Genetics%

Engineering cell communication in the fruit fly

In my lab we look at how cells communicate during the development of the fruit fly (Drosophila melanogaster) as it grows from a single cell to a multicellular animal. We...

In my lab we look at how cells communicate during the development of the fruit fly (Drosophila melanogaster) as it grows from a single cell to a multicellular animal. We take a synthetic approach, which means we investigate how cells communicate by designing news forms of communication and testing them to see if they work. The investigation is relevant to the fundamental understanding of how animals, including humans, develop and also has potential applications in regenerative medicine, tissue engineering and anti-cancer therapies. Students build skills related to fly genetics, molecular biology, the presentation of their work to a wider audience and scientific problem solving.
The completion of the Genetics course is preferred.
%Cell Biology%

Vascular Cognitive Impairment

Background and Purpose: Vascular dysfunction and resultant chronic cerebral hypoperfusion leads to vascular cognitive impairment (VCI), the second most common cause of dementia. We reported that Remote Ischemic conditioning (RIC...

Background and Purpose: Vascular dysfunction and resultant chronic cerebral hypoperfusion leads to vascular cognitive impairment (VCI), the second most common cause of dementia. We reported that Remote Ischemic conditioning (RIC)-therapy improves cerebral blood flow (CBF) in both murine stroke and VCI models. RIC is a non-invasive, simple, inexpensive, and safe use of repetitive inflation of a blood pressure (BP) cuff on the arm or leg to protect distant organs such as the brain from ischemic injury. We have some preliminary data after Bilateral Carotid Artery Stenosis (BCAS) in the mouse (model of VCI) that daily remote ischemic postconditioning (RIPostC) using a BP cuff for 2 weeks increases CBF in a sustained manner, improves cognitive performance, and decreases aggregation of amyloid-beta 42 protein (A?42) in the brain. Our central hypothesis is that RIPostC therapy after BCAS improves cognitive function in animal model of vascular cognitive impairment (VCI).
Minimum of 6 months commitment.
%Neuroscience, Neurology, Neurosurgery%

Brain function research

There are a selection of projects available in my laboratory. In my laboratory, we study brain function using a variety of methods, including those of cognitive psychology, brain imaging, and...

There are a selection of projects available in my laboratory. In my laboratory, we study brain function using a variety of methods, including those of cognitive psychology, brain imaging, and computational methods (please see my website, www.hegde.us). I try to do my best to match the project to the aptitudes, interests and the plans of the student. Please consult the aforementioned lab website.
Preferred, but not required: Expertise in computer programming (in any language).
%Neuroscience, Neurology, Neurosurgery%

Analysis of skeletal muscle degeneration

Overview: Our lab studies mechanisms of muscle loss in a variety of settings including aging, disuse (immobilization), and trauma. We utilize mouse models for this work, and have a large...

Overview: Our lab studies mechanisms of muscle loss in a variety of settings including aging, disuse (immobilization), and trauma. We utilize mouse models for this work, and have a large sample of muscle histological sections for analysis. We are interested in identifying new ways to analyze images of these samples, ideally using AI or Machine Learning algorithms. The work will involve capturing microscopic images of these muscle sections and uploading them into image analysis software.
Some knowledge of biology and computers! We can likely find some collaborators in data science or computer science to help with algorithm development.
%Aging%

Concept of Productivity as it has evolved over time

In this research project we are analyzing economic texts from the 19th and 20th centuries. The goal is to understand how the concept of productivity has evolved over time, specifically...

In this research project we are analyzing economic texts from the 19th and 20th centuries. The goal is to understand how the concept of productivity has evolved over time, specifically whose work and what activities get included and excluded from being defined as economically productive. This is central to understand given that productivity is a key metric we use to define the value and worth of people and their activities. The method we will use to understand this is the historical analysis of economic textbooks and canonical economic texts. We have a body of textbooks from 1890-1960 at the moment, but need to extend that sample backwards earlier into the 1800s and expand it outwards to include not just textbooks but canonical economic texts.
No prior experience necessary, but the project requires the ability to read, code, and synthesize often dense written texts. Students will also develop samples of texts from historical sources and archives and locate electronic copies of historical texts.
%Business, Management, Economics%

Cancer of the colorectum

Cancer of the colorectum (CRC) is one of the most common cancers in the world, representing about 8% of allannually reported cancers. Chemoprevention of CRC development is, therefore, a priority...

Cancer of the colorectum (CRC) is one of the most common cancers in the world, representing about 8% of allannually reported cancers. Chemoprevention of CRC development is, therefore, a priority for people at high risk,though no drugs are currently available for this unmet clinical need.This work is aimed at developing PDE5 inhibitors (PDE5i) for colon cancer prevention. Novel PDE5i will showfewer side effects than existing PDE5i by designing their polar structural analogs to affect the gut lining whileminimizing entrance into the bloodstream. Our strategy is to design novel localized PDE5i's that remain in theGI tract to specifically target GI diseases. As proof of principle, we have synthesized and tested 2 novel polaranalogs of sildenafil: malonyl sildenafil and boronyl-sildenafil. Our central hypothesis is to develop and test newgut localized analogs of sildenafil that have been proven to be effective in colon cancer prevention in preclinicalmodels. Our long-term goal is to develop a family of gut-localized, safe, and effective drugs that can be usedfor colon cancer prevention. The objective of this proposal is to develop a library of structurally optimized novelchemical entities and determine their efficacy at inhibiting PDE5i in vitro and in mice. The research approachesused in this project will be implemented in the existing Medicinal Chemistry undergraduate program at AugustaUniversity. This project blends the expertise of medicinal chemistry and biology and their roles in early drugdiscovery. Both the drug design and biological testing reflect the key steps in the pharmaceutical industryworkflow for drug development.
Must have OCHEM 1 completed with B or better
%Cancer%

Role of VEGF-A isoforms in regulating angiogenesis in Peripheral Artery Disease (PAD)

Role of VEGF-A isoforms in regulating angiogenesis in Peripheral Artery Disease (PAD)

Role of VEGF-A isoforms in regulating angiogenesis in Peripheral Artery Disease (PAD)
Good listening skills, follow directions. Pays attention to details in the protocol, good record maintenance.
%Cancer% %Chronic Illness%

Understanding Cancer Metastasis

Understanding cancer metastasis

Understanding cancer metastasis
Interested students will be part of the ongoing project in the Korkaya lab after extensive training by the PI and postdoc/graduate students. Persistent students based on their contribution may eventually be listed as co-authors in posters in various meetings and in publications.
%Cancer%

Research collaboration with Georgia State Univ. on Teen Sexual Assault prevention and substance abuse prevention project.

The Alcohol and Sexual Assault Prevention (ASAP) Lab at Georgia State University is seeking a student research assistant from Augusta Univ. who can commit 10 hours per week to a...

The Alcohol and Sexual Assault Prevention (ASAP) Lab at Georgia State University is seeking a student research assistant from Augusta Univ. who can commit 10 hours per week to a study on sexual assault and substance use prevention.
No requirements.
%Sexual Behavior & Sexual Assault% %Addiction & Substance Abuse%

Business and management projects

I am working on several research projects that are under three following research topics:

I am working on several research projects that are under three following research topics:
Students should have basic knowledge of Microsoft excel and word.
%Business, Management, Economics%

Do Compression Garments Influence VO2 during Long-Distance Running?

Do Compression Garments Influence VO2 during Long-Distance Running?

Do Compression Garments Influence VO2 during Long-Distance Running?
Students will be involved in literature review, subject recruitment, data collection, data analysis, and dissemination. Background knowledge in kinesiology, biomechanics, or human physiology is helpful but not necessary.
%Kinesiology, Physical Therapy%

Precision Medicine Discoveries in Head and Neck Cancer

We are a Precision Medicine Laboratory which focuses on discovering new precision therapies for head and neck cancer. Head and neck cancer is a very aggressive cancer affecting more than...

We are a Precision Medicine Laboratory which focuses on discovering new precision therapies for head and neck cancer. Head and neck cancer is a very aggressive cancer affecting more than 0.83 million people worldwide annually. Advanced head and neck cancer remains to be incurable, and lacks effective therapy.
Minimum of 2 semester commitment
%Cancer%

Mitochondria in Aging and Injury

Our laboratory is focused on understanding the regulation of cellular energetics in aging and injury. Multiple different projects are available for motivated undergraduate students interested in gaining hands-on experience...

Our laboratory is focused on understanding the regulation of cellular energetics in aging and injury. Multiple different projects are available for motivated undergraduate students interested in gaining hands-on experience in biomedical research. Current research programs are supported by grants from the Department of Defense and the National Institutes of Health. If you are driven, motivated and want to learn more, join our program. Opportunity for co-authorship in publications.
Some experience in laboratory experimentation that involves the use of micro pipettes.
%Aging% %Pharmacology%

Strongly correlated and collective many-particle phenomena in electronic and atomic systems

No description available.

  •   Theoretical and computational physics, Solid state, material, and atomic physics
No description available.
Calculus
%Physics%

Elucidating biological pathways of essential oils for analgesia during local thermal hyperemia

Over 40 million Americans experience chronic pain. Chronic pain creates an enormous burden on the U.S. economy through lost work and direct healthcare and medication costs totaling 600 billion...

  •   Essential Oils, Pain, Local Thermal Hyperemia, Substance P, Nitric Oxide, Neuropathy, CAM
Over 40 million Americans experience chronic pain. Chronic pain creates an enormous burden on the U.S. economy through lost work and direct healthcare and medication costs totaling 600 billion dollars annually. This burden is compounded when coupled with pain-related co-morbid conditions such as anxiety, depression, and ineffective sleep. Of Americans with chronic pain, over 6.5 million experience pain that is neuropathic in nature. Neuropathic pain has been described as prickling, tingling, burning, and electric shock-like sensations and is difficult to treat. Pharmacological approaches to neuropathic pain are minimally effective and accompanied by adverse effects such as dry mouth, weight gain, and cognitive and sexual dysfunction. Aromatherapy is a novel approach to chronic neuropathic pain. Aromatherapy is the use of essential oils (EOs), extracted from aromatic plants, to support health by eliciting physiological and psychological effects primarily through inhalation and topical-application. EOs moderate many aspects of pain signal transmission including non-competing inhibition of 5-HT, AChE, and Substance P, and antagonism of TRPA1 and TRPV1. Local thermal hyperemia (LTH) is an innovative method of testing local sensory neurons' release of substance P in response to a heat stimulus. In an earlier within-subjects study, a blend of six EOs demonstrated 13% substance P inhibition compared to placebo. The purpose of this study is to determine the effect of select EOs on substance P and nitric oxide during LTH to enhance an intervention for neuropathic pain. Study results will be used to support a NCCIH natural products for pain reduction R-21 grant application.
The student should have the following: An interest in aromatherapy or natural products/complementary modalities research, access to a laptop and internet, CITI training or be able to complete their CITI training by the end of September, attention to detail, and a willingness to work with healthy human participants in a laboratory setting. I prefer a motivated, organized, and flexible student. Additionally, a student who has two or more years remaining in their undergraduate degree program and who is willing to continue with this project during the 2022-2024 academic years is preferred. Pre-nursing or nursing major preferred, but not required.
%Pain%

Exploring the Participation of NOX1 in PDAC Progression Through CA-19-9

The pancreatic cells do not proliferate, except during healing processes, like in chronic pancreatitis (CP), which is characterized by continuous healing processes in which activated pancreatic stellate cells (PaSCs), among...

  •   Pancreatic Cancer, CA-19-9, NADPH OXIDASE 1, Mice, ELISA, coefficient of determination, pancreatic stellate cells
The pancreatic cells do not proliferate, except during healing processes, like in chronic pancreatitis (CP), which is characterized by continuous healing processes in which activated pancreatic stellate cells (PaSCs), among other cells, secrete growth factors. If pancreatic cells have a mutation (e.g. K-Ras oncogene) (the first hit), the mechanisms maintaining a regulated proliferation rate during CP (the second hit) fail and cause an excess of cell division, leading to pancreatic ductal adenocarcinoma (PDAC). One of key mediators of CP are reactive oxygen species (ROS), which activate PaSCs. ROS generation can occur as a primary product of NADPH oxidase (Nox) enzymes. Previously, my lab found that Nox1 is responsible for the fibrotic tissue formation of CP (Xia D et al. Free Radic Biol Med. 2020;147:139-149). We also discovered that Nox1 in PaSCs from mice with CP facilitates the invasion of pancreatic cancer cell lines HPAC and MiaPaca-2, indicating a communication between Nox1 in PaSCs and pancreatic cancer cells. It is unknown, however, when this communication starts, and in which extent Nox1 in PaSCs from mice with CP facilitates the progression of non-invasive PanIN lesions to invasive PDAC. Carbohydrate antigen 19-9 (CA-19-9) is made by pancreatic cancer cells, amongst other cell types, including colorectal and gallbladder cancers. For that, it is not a biomarker of pancreatic cancer. However, it can be used to estimate the progression of PDAC. The aim of this proposal is to determine the extent to which Nox1 participates in PDAC progression by studying and correlating anatomo-morphometric parameters with CA-19-9 level. Rationale: Because the serum levels of CA-19-9 increase during the progression of non-invasive PanIN lesions to invasive PDAC, the student will compare the changes in the level of CA-19-9 antigen using an enzyme-linked immunosorbent assay (ELISA) kit. The student will measure the pancreas weight/body weight (PW/BW) and spleen weight/body weight (SW/BW) ratio and serum level of CA-19-9 in healthy mice, and mice with pancreatic cancer (i.e., KPC mice) expressing or not Nox1. The student then will analyze the correlation between PW/BW and SW/BW ratios and CA-19-9 level by calculating their coefficient of determination (R2).
BIOL1108, BIOL3400, CHEM1212
%Cancer%

Interrelationship between nutritional status markers with COVID 19 severity

No description available.

  •   COVID19, nutrition, nutritional markers, public health
No description available.
Working knowledge of microsoft office software, willingness to work and learn new techniques and technology and coding.
%Cancer%

Effects of endocrine disruptors on cellular and reproductive physiology

Effects of endocrine disruptors on cellular and reproductive physiology. All projects are students led and range from studying the effects of PFOA on breast cancer cells to looking at endocrine...

  •   Endocrine disruption, reproduction
Effects of endocrine disruptors on cellular and reproductive physiology. All projects are students led and range from studying the effects of PFOA on breast cancer cells to looking at endocrine disruption in the blue crab. A more recent project involves looking at the effects of polypropylene microparticles on human lung derived cells. Potential techniques learned include cell culture, PCR, Western blotting, ELISAs.
Completion of BIOL1108 and CHEM1212.
%Endocrinology%

Hip-Hop Pedagogy in the K-12 Social Studies Classroom

No description available.

  •   Hip-hop, education, curriculum, social studies, teachers
No description available.
A critical eye for issues of justice, equity, inclusion and diversity is required for this project.
%Education% %Pedagogy%

How do we cure high blood pressure?

https://www.augusta.edu/mcg/phy/faculty/phys_faculty_ilatovskaya.php

  •   High blood pressure, hypertension, kidney, mitochondria, oxidative stress, sex differences, transport
https://www.augusta.edu/mcg/phy/faculty/phys_faculty_ilatovskaya.php
We are looking for motivated students who can commit 2-3 semesters. You should know that we work with animals (rats) a lot, and there is a wide range of techniques that you can learn from us - prior experience in molecular biology is not needed, but encouraged.
%Chronic Illness%

Mechanism behind immune cells activation post-brain injury

Dr. Kumar Vaibhav's lab is dedicated to explore the mechanism behind immune cells activation post-brain injury. They have found that immune cells, especially macrophages, T cells and innate...

  •   Brain injury, inflammation, hemorrhages, TBI, cannabinoid, macrophages, microglia, blood flow
Dr. Kumar Vaibhav's lab is dedicated to explore the mechanism behind immune cells activation post-brain injury. They have found that immune cells, especially macrophages, T cells and innate lymphoid cells, can be polarized to pro-inflammatory states after injury, which leads to long-term chronic injury and neurological deficits. The lab further reported that modulation of cannabinoid system helps immensely to maintain the equilibrium between different polarized states of immune cells and thus, expediting the recovery from injury. However, PI emphasizes that there is a lot more to explore related to brain injury and role of cannabinoid system in homeostasis. The lab is funded through several NIH extramural awards and is actively involved in studies related to cannabinoid and non-cannabinoid system in Traumatic brain injury (TBI) and Intracerebral hemorrhages (ICH).
Willingness to learn and have interest in research bench work
%Neuroscience, Neurology, Neurosurgery%

Neurovascular communication in the brain

We are currently exploring a new model for hypertension and performing in vivo studies. These techniques have not been published yet. Relevant topics can be found in pubmed such as...

  •   Brain imaging, cerebral vessels, astrocytes, microglia, neurons, behavioral studies
We are currently exploring a new model for hypertension and performing in vivo studies. These techniques have not been published yet. Relevant topics can be found in pubmed such as https://pubmed.ncbi.nlm.nih.gov/33101063/,https://pubmed.ncbi.nlm.nih.gov/33410092/
Be able to work with animals and learn various techniques and software
%Neuroscience, Neurology, Neurosurgery%

The Actin Cytoskeleton in Motor Neuron Development and Degeneration

My lab studies the role of the actin cytoskeleton in cell motility, neural development, and in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We use live-cell and super...

  •   Actin cytoskeleton, neurodegenerative disease, microscopy, cell biology, neuroscience
My lab studies the role of the actin cytoskeleton in cell motility, neural development, and in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We use live-cell and super-resolution imaging to understand how the dynamic regulation of actin contributes to the normal function of healthy cells, and how defects in actin can cause toxicity and cell death.
Must be willing to commit at least 8 hours per week in the lab. No previous experience needed- we will teach you everything that you need to know!
%Neuroscience, Neurology, Neurosurgery% %Cell Biology%

Neural and sensory cell regeneration

Neural and sensory cell regeneration

  •   Neuroscience, degeneration, regeneration, neuroimmunology, taste, immunofluorescence, imaging
Neural and sensory cell regeneration
Basic pipetting skills and ability to make simple solutions is a plus. We are looking for motivated students and will train in needed techniques.
%Neuroscience, Neurology, Neurosurgery%

Molecular mechanisms of neuronal signal decoding logic

The goal is to better understand how neurons transduce external stimuli downstream to discrete spatiotemporal patterns of second messenger signals. Integration of signaling events enables neuronal networks to communicate with...

  •   GPCR, cAMP, neurons, cellular signaling, microscopy
The goal is to better understand how neurons transduce external stimuli downstream to discrete spatiotemporal patterns of second messenger signals. Integration of signaling events enables neuronal networks to communicate with high fidelity where anomalies in signal decoding mechanisms can have pathological consequences. To uncover the molecular logic utilized by neurons to interrogate a diversity of signaling events, we will investigate the contributions of key elements in the molecular pathways downstream of neurotransmitter stimulation. This will be achieved through CRISPR/Cas9 gene editing in neurons expressing biosensors that report cellular activity observable through fluorescence microscopy. The project will additionally use lenti- and adeno-associated virus technology to manipulate gene expression as well as molecular cloning approaches.
Research will include mammalian cell culture, molecular cloning, and fluorescence microscopy. Experience in these areas preferred but not required.
%Cellular Biology% %Neuroscience, Neurology, Neurosurgery%

Targeting cGMP

Signaling for the treatment and prevention of intestinal disease. My laboratory aims to understand tissue renewal in the colon, and how this can be manipulated to treat ulcerative colitis and...

  •   Cancer, constipation, colitis, intestine, signaling, mouse, viagra, pharmaceutical
Signaling for the treatment and prevention of intestinal disease. My laboratory aims to understand tissue renewal in the colon, and how this can be manipulated to treat ulcerative colitis and for the prevention of colon cancer. We discovered that increasing cGMP levels with phosphodiesterase inhibitors (e.g. Viagra) can protect the colon epithelium and slow it's turnover. This is therapeutic in mouse models of colitis and colon cancer. We work with colon cancer cell lines, human and mouse intestinal organoids, andmice disease models.
Must have a passion for medical research and be an enthusiastic learner. Baskic knowledge in cell/molecular/biochm would be beneficial but not essential. Tasks depend on student effort/time in the lab. You can "hang out" to learn how the lab works, the systems/techniques we use. More effort will allow you to learn a technique or two (e.g. histology, qPCR, Western blot) to generate some data. Students who are driven can take on their own project using multiple techniques, possibly resulting in publication of results.
%Cancer% %Pharmacology%

Development of In-vivo Transparent Transgenic Zebrafish Model In Cardio-oncology Research

Development of Transgenic Zebrafish Model Organism to study the cardiomyocyte and Microglia Function in health and disease condition with special reference to the Inflammatory process (NFkB) and Apoptosis (Annexin-V...

  •   Zebrafish, cardio-oncology, experimental therapeutics, in-vivo imaging, confocal and fluorescent microscopy, microglia, cell death activity-A5, inflammatory activity-NF-kB
Development of Transgenic Zebrafish Model Organism to study the cardiomyocyte and Microglia Function in health and disease condition with special reference to the Inflammatory process (NFkB) and Apoptosis (Annexin-V) in Brain Tumor and Heart disease. EGFR/sEGFR-Breast Cancer Research, Role of soluble isoforms (extracellular domains) of EGFR Family members in targeted therapeutics and establishment of sEGFR as Biomarker in Cancer Research. In-vivo automated HTS Drug Discovery by using Zebrafish model in Diabetes beta-cell neogenesis and proliferation, Creation of acute hypoxia in the zebrafish model and its impact on Cardiovascular Biology.
The interested candidate needs to demonstrate the passion to pursue a career in biomedical research. Strong scientific background and laboratory experience. Routine and advanced Computer skills by using research software tools and webs like MAT-LAB, End-note, J-peg, FIJI, etc.
%Cell Biology% %Cancer%

miRNA-mediated mechanisms during CNS development and after spinal cord injury

My research is focused on miRNA-mediated mechanisms during CNS development and after spinal cord injury (SCI). In addition, I combine the in vivo reprogramming technology with miRNA biology to...

  •   Spinal cord injury (SCI) and repair, microRNAs (miRNAs), neuronal reprogramming, neurodevelopment, glial development
My research is focused on miRNA-mediated mechanisms during CNS development and after spinal cord injury (SCI). In addition, I combine the in vivo reprogramming technology with miRNA biology to induce miRNA-mediated neuronal reprogramming from endogenous reactive glial cells for SCI functional repair. Approaches include animal work, cell culture, molecular cloning, etc.
Basic knowledge on cell biology, molecular biology, and motivation for research.
%Neuroscience, Neurology, Neurosurgery% %Cell Biology%

Early signs of Alzheimer's Disease caused by dysregulation of Synaptic Neurotransmission

No description available.

  •   Alzheimer's disease, synaptic transmission, brain aging, epilepsy, electrophysiology, fluorescence microscopy
No description available.
https://www.augusta.edu/mcg/dnrm/faculty/fdeak.php
%Aging% %Neuroscience, Neurology, Neurosurgery%

Microfluidics study

Study involves microfluidics: selected sstudents will be looking at drop sizes, generation frequency, etc.

  •   Physics, experimental, fluids, microfluidics, drops, electric fields, instabilities
Study involves microfluidics: selected sstudents will be looking at drop sizes, generation frequency, etc.
Good lab skills, attention to detail, and patience are key for these experiments.
%Physics%

Mathematical modeling, analysis, and distribution of infectious diseases with multi-strains: Case study Covid-19

We present a mathematical model describing the transmission of certain diseases with multiple strains and explore the effects of vaccination and treatments on such diseases. The effects of external fluctuations...

  •   Mathematical biology; epidemiology; stochastic modeling and analysis; data analysis
We present a mathematical model describing the transmission of certain diseases with multiple strains and explore the effects of vaccination and treatments on such diseases. The effects of external fluctuations caused by factors like the rates at which testing of such disease is done, vaccination rates, variability in the number of contacts between infected and susceptible individuals, mask use per capita, social behavior, public health intervention, and so on, is also investigated. The probability distribution of the number of infections at a given point in time is also obtained.
Students must have taken calculus and/or differential equations. Taking a statistical class will also be an advantage.
%Mathematical Biology% %Epidemiology%

Mathematical modeling and forecasting of Covid-19 cases, deaths, and mutations in the United States

Area of research: Mathematical Biology

  •   Mathematical biology; epidemiology; stochastic modeling and analysis; data analysis
Area of research: Mathematical Biology
Student's skills/qualifications: Student must have taken Calculus II and/or Differential equation. Taking a statistical class will also be an advantage.
%Mathematical Biology% %Epidemiology%

Validation of a CA-19-9 ELISA kit using a mouse model of pancreatic cancer

Carbohydrate antigen (CA) 19-9 is a type of antigen released by pancreatic cancer cells. Because the serum levels of CA-19-9 increase during the progression of non-invasive...

  •   Pancreatic cancer; pancreatitis; NADPH oxidase 1; Twist1; Matrix metalloproteinase; pancreatic stellate cells; tumor microenvironment;
Carbohydrate antigen (CA) 19-9 is a type of antigen released by pancreatic cancer cells. Because the serum levels of CA-19-9 increase during the progression of non-invasive low-grade PanIN lesions to invasive PDAC, the students will compare the changes in the levels of CA-19-9 antigen between mouse models of pancreatic cancer using an enzyme-linked immunosorbent assay (ELISA) kit. However, we first need to validate the mouse CA-19-9 ELISA kit.
Determination of serum CA-19-9 level: the student will analyze the changes in the levels of CA-19-9 antigen using an enzyme-linked immunosorbent assay (ELISA) kit from MyBioSource.
%Cancer% %Cell Biology%

EV characterization and toolbox development

EV characterization and toolbox development

  •   Extracellular vesicles; exosomes; microRNA; chronic kidney injury; fibrosis; inflammation; CRISPR; RNA-sequencing
EV characterization and toolbox development
Motivation! Background on biology and data science might be needed.
%Chronic Illness% %Cell Biology%

Neurobiological mechanisms of alcohol and substance use disorders

Our lab focuses on identifying the fundamental roles of local astrocyte-neuron interaction and long-range brain circuits in alcohol/substance use disorder and its comorbidities. We are characterizing how...

  •   Addiction, alcohol use disorder, psychiatric disorders, motivated behaviors, neuropharmacology, electrophysiology, opto-/chemo-genetics, in vivo calcium imaging
Our lab focuses on identifying the fundamental roles of local astrocyte-neuron interaction and long-range brain circuits in alcohol/substance use disorder and its comorbidities. We are characterizing how the physiological and pathophysiological brain activities that integrate positive and negative stimuli shape behavioral outcomes during the transition from substance use to dependence. To expand our understanding of the cell type-, circuit-, context-, and age-dependent neuropharmacological basis in a variety of related pathologies, our research applies multi-layered combination of biochemical, electrophysiological, and behavioral assays with new approaches such as a real-time behavior-synchronized brain recording and computational analysis. Thus, there will be lots of opportunities of hands-on experience in neuropharmacological techniques and co-authorship in publications.
Experience of mouse handling or Matlab/Python preferred but not required.
%Psychiatry & Psychology% %Pharmacology% %Addiction & Substance Abuse%

Role of Cholinergic Systems in Memory Function

Investigates role of cholinergic systems in memory function, and how it is altered by diseases like schizophrenia and Alzheimer's Disease as well as toxins that are found in the...

  •   Neuropharmacology, neurotoxicology, learning, memory, dementia, cholinergic, aging, drug discovery
Investigates role of cholinergic systems in memory function, and how it is altered by diseases like schizophrenia and Alzheimer's Disease as well as toxins that are found in the environment such as organophosphate insecticides. He serves on NIH and DOD Study sections and is the current Secretary of the Association of Medical School Pharmacology Chairs (AMSPC).
No requirements.
%Neuroscience, Neurology, Neurosurgery% %Pharmacology% %Learning & Memory% %Aging%

Cellular mechanisms underlying the development of posttraumatic stress disorder

We employ a multidisciplinary approach toward neuroscience by using biochemical tools, in vitro whole-cell patch-clamp recordings (soma vs. dendrite), in vitro cell-attached recordings (soma vs dendrite), in...

  •   Mouse, chronic social defeat stress, social avoidance, contextual fear conditioning, hippocampus, ion channels
We employ a multidisciplinary approach toward neuroscience by using biochemical tools, in vitro whole-cell patch-clamp recordings (soma vs. dendrite), in vitro cell-attached recordings (soma vs dendrite), in vivo drug or viral mediated-gene delivery, and behavior to validate the physiological relevance of the findings.
Motivation and a good work ethic
%Neuroscience, Neurology, Neurosurgery% %Anxiety & Stress%

Predictors Of Falls In Older Males And Females With Concussion

https://www.augusta.edu/faculty/directory/view.php?id=DJEHU

  •   Older adults, falls, concussion, predictors
https://www.augusta.edu/faculty/directory/view.php?id=DJEHU
N/A
%Public Health, Health, Well-Being% %Aging%

Significance of Gene Expression: Instilling the Concept of Molecular Evolution to Foster the Understanding of Human Body and Health

In today's world it is becoming more and more important to understand the foundation of human life. Human molecular evolution is now the subject of copious amounts of research...

  •   Molecular Evolution, Gene Expression, Color Deficiency, Pedagogy
In today's world it is becoming more and more important to understand the foundation of human life. Human molecular evolution is now the subject of copious amounts of research about how our species has evolved. Differences in gene and protein expression can be subtle yet extremely impactful. Advancements in genomics clearly reveal how differences in gene expression impact human health and physiology. As technology continues to improve, it becomes possible to gain a more accurate picture of what each gene contributes to the human body. Principles of Human Anatomy & Physiology I & II are required courses for students who like to pursue their career in the health related field (e.g. Pre-Med, Physician Assistant, Nursing, Physical Therapy, Nuclear Imaging, etc). Traditionally it has been observed that majority of the students taking these courses struggle due to the complexity of the human body. Primary purpose of my pedagogical research is to develop and provide students with active learning modules and/or resources for their better understanding of the concepts associated with anatomy and physiology.
Students with Majors in Biology/Cell and Molecular Biology in their junior year
%Genetics% %Pedagogy% %Evolution%

Perspectives of Participating in CrossFit from BIPOC and Marginalized Identities

CrossFit has become a phenomenon of exercise modality in the past decade. It has also been a controversial mode of exercise since it gained popularity in the early 2000s and...

  •   CrossFit, inclusion, diversity, equity, exercise, wellbeing, belonging
CrossFit has become a phenomenon of exercise modality in the past decade. It has also been a controversial mode of exercise since it gained popularity in the early 2000s and has seen itself in the light of critics on more than one occasion. The CrossFit philosophy is comprised of what researchers consider embracing individuality, buying into the CrossFit culture, and a singular commonality. This project will focus on the last of the three: the singular commonality. Researchers have deemed this term to reflect a willingness to adopt the CrossFit lifestyle in order to improve themselves (Belger, 2012; Dawson, 2017; Herz, 2014; Murphy 2012). One could argue that within this community, by being surrounded by like-minded individuals, a sense of inclusion, belonging, and connectedness to CrossFit is established. However, over recent years, CrossFit has found itself in the spotlight for instances that call into question the inclusive nature it preaches. This project is meant to explore the sense of belonging BIPOC and marginalized identities have within their CrossFit space. This project is a mixed method study examining a sense of belonging through quantitative measures (Sense of Belonging Instrument, Hagerty & Patusky, 1995) and exploring the emotions behind the numbers, giving life to the narratives of those who remain committed to CrossFit through interviews. This project will become a significant hub of data that will allow for further exploration of the acceptance of these gym members within the CrossFit community and how the CrossFit community can expand its support for marginalized communities.
Students will need to complete CITI Human Subject Based Training, Group 2 Non-FDA Regulated Research and Group 6 Social Behavior Research
%Public Health, Health, Well-Being% %Diversity, Equity, & Inclusion%

Characterization of the enzymatic homologation pathway

Natural products (NPs), secondary metabolites biosynthesized by microorganisms and plants, are a very important source of drugs and drug leads. Infectious diseases, atuoimmune diseases, and other ailments have been treated...

  •   Natural product, enzyme, drug discovery, protein engineering, gene engineering, homologation
Natural products (NPs), secondary metabolites biosynthesized by microorganisms and plants, are a very important source of drugs and drug leads. Infectious diseases, atuoimmune diseases, and other ailments have been treated by these molecules throughout human history. In ancient times, crude drugs that are dried and/or ground organism matters were used to treat these diseases. The clinical use of NPs was greatly intensified by the discovery and isolation of the first pure antibiotic penicillin in 1928. NP drugs generally have high selectivity (less adverse effects) thanks to their complex chemical structures. In the past 40 years, more than 60% of U.S. Food and Drug Administration (FDA) approved small molecule drugs have been NP related. However, a new threat has been appearing in recent years. According to the World Health Organization, infections by antibiotic-resistant pathogens are increasing globally and are anticipated as one of the greatest threats to human health in the future. Therefore, new drug candidates for use in clinics are in high demand. This project aims to characterize a biochemical process called homologation of amino acids. Homologation is a reaction that adds one carbon on the amino acid side chain, which results in production of an uncommon amino acid that has one-carbon longer side chain. Homologated amino acids are produced by the enzymatic pathway that involves five enzymes, and the resulting compounds are used to produce biologically active NPs with higher selectivity and/or stability. By understanding the pathway and engineering it to apply to production of other NPs, it will be possible to produce new NPs with enhanced bioactivity, bioavailability, and biostability.
Students will need to complete Initial Biosafety and Bloodborne Pathogen Training, NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecule, and Initial Chemical Safety Training,
%Pharmacology% %Genetics%

Simulated Predator Exposure Affects Neuroinflammation and Plasticity-Related Gene Expression

https://www.augusta.edu/faculty/directory/view.php?id=AVAZDARJANOVA

  •   Predator, immediate-early gene expression, Arc, neuroinflammation, PTSD, rats, hippocampus, prefrontal cortex
https://www.augusta.edu/faculty/directory/view.php?id=AVAZDARJANOVA
Students will need to complete the Board of Regents Basic Training Right to Know, Board of Regents Hazardous Waste Awareness Training, Board of Regents Bloodborne Pathogens Training, and Initial Biosafety and Bloodborne Pathogen Training
%Genetics%

Development of potential antiviral drug candidates for SARS-CoV-2

https://www.augusta.edu/scimath/chemistryandphysics/siva-panda.php

  •   Drug Development, Synthesis, Antiviral, Computational Studies
https://www.augusta.edu/scimath/chemistryandphysics/siva-panda.php
Organic Chemistry
%%

Feasibility of Telehealth for Medical-Dental Integration

To test the feasibility of implementing a novel telehealth technology aimed at improving medical-dental integration. Specific Aim: Measure the implementation outcomes of telehealth technology in terms of acceptability, appropriateness...

  •   Oral health, tele-health, tele-dentistry, medical-dental integration, nursing-dental integration, primary care, Medical Smartphone Applications
To test the feasibility of implementing a novel telehealth technology aimed at improving medical-dental integration. Specific Aim: Measure the implementation outcomes of telehealth technology in terms of acceptability, appropriateness, and feasibility for both the patient and the primary care office. Research Interventions: Use of iphone app with photo taking technology and cheek retractors as an oral health assessment/screening tool that facilitates the assessment and referral time between primary care providers and contact dentists. Study Endpoints: Primary a. Feasibility survey measurements from patient: acceptability, appropriateness, and feasibility b. Feasibility assessment by focus group for patients c. Oral health quality of life survey using the Oral Health Impact Profile-14 (OHIP-14) collected via the Oh I Can data aggregator d. Oral digital images with clinical interpretation.
Students will need to complete CITI Human Subject Based Training, Group 6 Social Behavioral Research
%Dentistry & Oral Biology% %Telehealth% %Primary Care%

"I can be a scientist too." Development of scientific inquiry and views of the nature of science in authentic research experiences

The goal of the project is to understand better how science and education researchers can better serve students and teachers in the classroom through inquiry activities and curricula while being...

  •   Science education; scientific inquiry; how students/teachers view science; biology education, inclusion, virtual learning environments; research experiences
The goal of the project is to understand better how science and education researchers can better serve students and teachers in the classroom through inquiry activities and curricula while being inclusive and culturally responsive. This project will look at how undergraduate students, 6-8th grade students, and their teachers view scientific inquiry and the nature of science. Research participants will complete the Inclusive Biologist Exploring Active Research with Students (iBEARS) program in Spring 2023, culminating in the design and implementation of an experimental research project. iBEARS is a novel course in higher education that utilizes undergraduate students to support scientific inquiry (the process of science) by developing scientific inquiry practices for K-12 students through virtual mentorship. The undergraduate students virtually mentor K-12 science students via Zoom conferencing over a 16-week college semester to support the inquiry science practices of K-12 students in the classroom by developing an experimental research project, culminating in creating a research poster. Qualitative and quantitative methodology will be used, as researchers will analyze Likert scale surveys, watch and analyze classroom observations, and analyze reflections and interviews/focus groups.
Students will need to complete CITI Human Subject Based Training, Group 6 Social Behavioral Research
%Education% %Research Methods%

What will you discover?

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