Yao Liang Tang - Lab

Research   FACULTY PROFILE - Yao Liang Tang

My primary research goals are to identify the molecular mechanisms of stem cell mediated cardiovascular protection and regeneration. More specifically, we are interested in (1) cross talking between HIF-1α and Notch signaling in homing, survival, and differentiation of stem cells; (2) exosomes-mediated survival signaling in stem cell mediated cardio protection; (3) the regulation of small non-coding RNA (microRNA) and long non-coding RNA (LncRNA) in stem cells; (4) cardiac differentiation of human induced pluripotent stem cells; (4) role of HDAC11 in cardiovascular disease. We found that hypoxic preconditioning enhances paracrine effects of CPC transplantation and improves heart function via angiogenesis and cardiovascular lineage differentiation. I have 10-year’s interdisciplinary research experience in mouse model of myocardial ischemia/reperfusion, mouse cardiovascular physiology, mouse vascular injury model, stem cell biology, molecular biology and histology.

 

 

Lab Personnel

 

Yan Shen
Research Assistant

Chongyu (Will) Zhang, PhD