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Research Interests

Dr. Weintraub’s research focuses on vascular biology and adipose biology with emphasis on inflammation, oxidative stress, obesity, stem cells, atherosclerosis, and abdominal aortic aneurysm. 


Projects

Mechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysm

Role of histone deacetylase 9 (HDAC9) in aging, cardiometabolic disease, and Alzheimer’s disease

Role of Duffy antigen receptor for chemokines (DARC) in ethnic susceptibility to cardiometabolic disease

Role of long non-coding RNAs in neointima hyperplasia


    

SPOTLIGHT PUBLICATIONS

https://newsroom.heart.org/news/more-than-11-million-in-research-grants-awarded-for-scientific-exploration-of-disparities-in-cardio-oncology
Heart News Published: June 28, 2021

The Medical College of Georgia at Augusta University, Boston University School of Medicine, the Medical College of Wisconsin and the University of Pennsylvania form the American Heart Association’s new focused research network devoted to addressing disparities that intersect heart disease and cancer.

Obesity-Related Disparities in the Bidirectional Risk of Cardiovascular Disease and Cancer – Our team will study obesity, a common risk factor in people with cardiovascular disease and/or cancer. Specifically, the team’s population, clinical and basic science research will investigate obesity-related disparities among Black Americans who bear a greater burden of these diseases, seeking to understand why this population develops more problems with inflammation that contributes to heart disease and cancer. The center will serve as a platform for postdoctoral training, with an emphasis on underrepresented minorities. It will also partner with Paine College in Augusta, a historically Black college, to develop an undergraduate research internship for students who desire to pursue healthcare-related careers (clinical and research).





Recent Publications

Zhang W, Zhao J, Deng L, Ishimwe N, Pauli J, Wu W, Shan S, Kempf W, Ballantyne MD, Kim D, Lyu Q, Bennett M, Rodor J, Turner AW, Lu YW, Gao P, Choi M, Warthi G, Kim HW, Barroso MM, Bryant WB, Miller CL, Weintraub NL, Maegdefessel L, Miano JM, Baker AH, Long X.  INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10. bioRxiv. 2023 Jan 9:2023.01.07.522948. doi: 10.1101/2023.01.07.522948. Preprint.PMID: 36711681 

Zou J, Wang W, Lu Y, Ayala J, Dong K, Zhou H, Wang J, Chen W, Weintraub NL, Zhou J, Li J, Su H. Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation. Cell Rep. 2023 Jan 31;42(1):112018. doi: 10.1016/j.celrep.2023.112018. Epub 2023 Jan 19.PMID: 36662623

Fang X, Chen Y, Wang J, Zhang Z, Bai Y, Denney K, Gan L, Guo M, Weintraub NL, Lei Y, Lu XY.  Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits.Mol Psychiatry. 2022 Dec 6. doi: 10.1038/s41380-022-01872-5. Online ahead of print.PMID: 36473997

Lei Y, Wang D, Bai Y, Nougaisse J, Weintraub NL, Guo M, Lu XY. Leptin enhances social motivation and reverses chronic unpredictable stress-induced social anhedonia during adolescence. Mol Psychiatry. 2022 Dec;27(12):4948-4958. doi: 10.1038/s41380-022-01778-2. Epub 2022 Sep 22.PMID: 36138127

Weintraub NL, Blomkalns AL, Ogbi M, Horimatsu T, Benson TW, Huo Y, Fulton DJ, Agarwal G, Lee R, Winkler MA, Young L, Fujise K, Guha A, Fukai T, Ushio-Fukai M, Long X, Annex BH, Kim HW. Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. Clin Sci (Lond)2022 Mar 18;136(5):309-321doi: 10.1042/CS20220031.  PubMed PMID: 35132998; PubMed Central PMCID: PMC8891815.

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News Mentions

Georgia Research Alliance