Sex hormones interaction with sex chromosomes in Arterial Stiffening: The goal of this project is to understand the role of sex hormones (estradiol and testosterone) interaction with sex chromosomes complement (XX and XY) in vascular biology. The project utilizes four core genotype mouse model that has a mutated Y chromosome (Y-) and translocated Sry (sex determining) gene to an autosome yielding female mice with (XX or XY-) and male mice with (XXsry or XY-Sry). This project elucidates the role of sex chromosomes, sex hormones, and their interaction in arterial stiffening.
Anil Sakamuri, PhD
