Past Journal Club Presentations

Journal Club Presentation Archive

Explore articles previously presented and discussed during the Vascular Biology Journal Club. This archive provides a resource for trainees and faculty reviewing past topics and selecting articles for future Journal Club presentations.

Past presentations are organized by academic year. Select a year below to view presenters, featured articles, and publication information.

Past Presentations by Academic Year

2025–2026 Journal Club Presentations   |  Back to top

Date Presenter Featured Article
Aug. 15 Hunter Sellers Imidazole propionate is a driver and therapeutic target in atherosclerosis
Nature (2025)
Aug. 22 Candee Barris Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity
Circulation Research (2025)
Aug. 29 Doug Sloan Bioaccumulation of microplastics in decedent human brains
Mat Med. (2025)
Sept. 5 Josue Zambrano-Carrasco Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy
Circulation (2022)
Sept. 12 Cody Bridgewater Characterizing primary and secondary senescence in vivo
Nature Aging (2025)
Sept. 19 Chang Min Lee Tunneling nanotube–like structures regulate distant cellular interactions during heart formation
Science (2025)
Sept. 26 Emily Steinbeck Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors
Nature Cardiovascular Research (2024)
Oct. 10 Drew Speese Macrophage DNases Limit Neutrophil Extracellular Trap-Mediated Defective Efferocytosis in Atherosclerosis
Circulation Research (2025)
Oct. 17 Kelvin Orji Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling
Nature Communications (2025)
Oct. 24 Obaalologhi Wilfred CEMIP Maintains Vascular Contractility by Controlling PP1c-MLC20 Cascade in SMCs
Circulation Research (2025)
Oct. 31 Jaser Doja Genomic Editing of a Pathogenic Mutation in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice
Circulation (2025)
Nov. 14 Elizabeth Aboagye Role of the Renin-Angiotensin System in Blood Pressure Regulation in Smooth Muscle-Specific Cullin-3 Deficient Mice
Hypertension (2025)
Nov. 21 Tamasi Roy Portal hypertension contributes to ascites formation via the Piezo1−nuclear factor kappa-B−aquaporin1 pathway in liver cirrhosis
Experimental & Molecular Medicine (2025)
Dec. 5 Stephen Addo Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models
Circulation (2025)
Dec. 12 Amritha Sreekumar SM22α-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm
Circulation Research (2025)
Dec. 19 Delphine Okoye Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release
Circulation Research (2025)
Jan. 9 Doug Sloan Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction
Circulation Research (2025)
Jan. 16 Kamarajan Rajagopal, PhD
Fukai Lab		 Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis
Nature Communications (2024)
Jan. 23 Mitch Shivers Deficiency of Smooth Muscle Adar1 Exacerbates Vascular Remodeling and Pulmonary Hypertension
Circulation Research (2025)
Jan. 30 Elizabeth Aboagye Aging promotes reactivation of the Barr body at distal chromosome regions
Nature Aging (2025)
Feb. 6 Ishara M.G. Menik Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory
Nature Cardiovascular Research (2025)
Feb. 13 Tamasi Roy Identification of an IRF-ZBP1-caspase-8-NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease
Proceedings of the National Academy of Sciences (2025)
Feb. 20 Beryl Khakina Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm
Circulation Research (2025)
Feb. 27 Zach Brown Oxygen-free metabolism in the bird inner retina supported by the pecten
Nature (2026)
Mar. 6 Peter Biggs DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis
Circulation (2026)
Mar. 13 Yaksh Rathod, PhD Leptin Activates Brain–BAT–Heart Crosstalk to Promote Cardiac Protection
Circulation Research (2026)
Mar. 20 Adam Salon, PhD Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes
Science (2025)
Apr. 3 Kelvin Orji IDH2 lactylation promotes angiogenesis in murine diabetic myocardial infarction via blocking Cav1-eNOS interaction
Nature Communications (2026)
May 1 Obaalologhi Wilfred Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC-CXCL1-CXCR2 axis
Nature Cardiovascular Research (2025)
May 8 Xiaoliang Wu, PhD Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease
Cardiovascular Research (2026)
May 22 Robin Brice, PhD Distinct populations of lung capillary endothelial cells and their functional significance
Communications Biology (2026)
May 29 Shikha Yadav, PhD
Fukai Lab		 Diabetes-induced TREM2–endothelial cell signaling impairs ischemic vascular repair
Science Translational Medicine (2026)
June 5 Stephen Haigh, PhD
Fulton Lab		 Prelamin A in an LmnaL648R/L648R Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss
Arteriosclerosis, Thrombosis, and Vascular Biology (2026)

2024–2025 Journal Club Presentations   |  Back to top

Date Presenter Featured Article
Aug. 16 Suhib Alhusban Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
Nat Commun (2023)
Aug. 23 Hunter Sellers ROS-induced ribosome impairment underlies ZAKa-mediated metabolic decline in obesity and aging
Science (2023)
Aug. 30 Chang Min Lee Mitochondrial transfer mediates endothelial cell engraftment through mitophagy
Nature (2024)
Sept. 6 Chongyu (Will) Zhang Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition
Nat Cardiovasc Res (2023)
Sept. 13 Candee Barris Xist ribonucleoproteins promote female sex-biased autoimmunity
Cell (2024)
Sept. 20 WonMo Ahn Lp-PLA2 (Lipoprotein-Associated Phospholipase A2) Deficiency Lowers Cholesterol Levels and Protects Against Atherosclerosis in Rabbits
Arterioscler Thromb Vasc Biol (2023)
Oct. 11 Ann Cormier SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
Nat Commun (2024)
Oct. 18 Stephen Addo NF1 deficiency drives metabolic reprogramming in ER+ breast cancer
Mol Metab (2024)
Oct. 25 Amritha Sreekumar Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice
Nat Commun (2024)
Nov. 1 David Kim lncRNA VELRP Modulates Pulmonary Arterial Smooth Muscle Cell Proliferation and Promotes Vascular Remodeling in Pulmonary Hypertension
ATVB (2024)
Nov. 8 Drew Speese Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity
Nat Commun (2024)
Nov. 22 Khalia Cummings Macrophage-to-endothelial cell crosstalk by the Cholesterol Metabolite 27HC Promotes Atherosclerosis in Male Mice
Nat Commun (2023)
Dec. 6 Beryl Khakina Endothelial-to-Mesenchymal Transition Contributes to Accelerated Atherosclerosis in Hutchinson-Gilford Progeria Syndrome
Circulation (2024)
Dec. 13 Peter Biggs Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth
Nat Commun (2024)
Dec. 20 Ishara Menik Social Bonds Retain Oxytocin-Mediated Brain-Liver Axis to Retard Atherosclerosis
Circ Res (2024)
Jan. 17 Delphine Okoye FSH Is Responsible for Androgen Deprivation Therapy–Associated Atherosclerosis in Mice by Exaggerating Endothelial Inflammation and Monocyte Adhesion
Arterioscler Thromb Vasc Biol
Jan. 24 Zach Brown Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
Nature (2024)
Jan. 31 Amritha Sreekumar Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice
Nat Commun (2024)
Feb. 7 Jaser Doja Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm
Nat Cardiovasc Res (2025)
Feb. 14 Barun Chatterjee, PhD Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
Nat Commun (2022)
Feb. 21 Stephen Addo Disruption of PCSK9 Suppresses Inflammation and Attenuates Abdominal Aortic Aneurysm Formation
Arterioscler Thromb Vasc Biol (2025)
Feb. 28 Mitch Shivers Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Nat Metab (2025)
Mar. 7 Cody Bridgewater Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
Nature (2025)
Mar. 21 Josue Zambrano-Carrasco Spatially organized cellular communities form the developing human heart
Nature (2024)
Mar. 28 Khalia Cummings Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice
Nat Commun (2024)
Apr. 4 Yilang Li, PhD Overexpression of Wild-Type TMEM43 Improves Cardiac Function in Arrhythmogenic Right Ventricular Cardiomyopathy Type 5
Circ Res
Apr. 18 Siva Kuppuswamy, PhD DCBLD1 Modulates Angiogenesis by Regulation of the VEGFR-2 Endocytosis in Endothelial Cells
Arterioscler Thromb Vasc Biol (2025)
May 9 Md. Selim Hossain, PhD Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model
Nat Metab (2025)
May 16 Chongyu (Will) Zhang, PhD Mechanistic basis of lineage restriction
bioRxiv (2024)
May 23 Md. Sadikul Islam, PhD Reducing Granules Without Splicing Restoration Alleviates RBM20 Cardiomyopathy
Circulation Research
May 30 Adeel Zaidi, PhD Hypoglycemia promotes inner blood-retinal barrier breakdown and retinal vascular leakage in diabetic mice
Sci Transl Med

2023–2024 Journal Club Presentations   |  Back to top

Date Presenter Featured Article
Aug. 18 Beryl Khakina Angiotensin II–Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats
Hypertension (2023)
Aug. 25 Hunter Sellers Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression
Nature Methods (2023)
Sept. 1 Candee Barris Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
Nature Communications (2022)
Sept. 8 Zach Brown SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension
Circulation (2023)
Sept. 15 Jaser Doja Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
JCI Insight (2023)
Sept. 22 Md. Selim Hossain Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway
PNAS (2023)
Sept. 29 Steve Haigh Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes
Science (2023)
Oct. 6 Suhib Alhusban ATF4 Protects the Heart from Failure by Antagonizing Oxidative Stress
Circulation Research (2022)
Oct. 13 Cody Rosewater Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice
Nature Communications (2023)
Oct. 20 Ishara M.G. Menik Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia
Circulation Research (2023)
Oct. 27 WonMo Ahn Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice
Nature Communications (2023)
Nov. 3 Josue Zambrano-Carrasco Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1
Circulation Research (2023)
Dec. 1 David Kim BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility
Nucleic Acids Research (2023)
Dec. 8 Mitch Shivers ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension
Science Translational Medicine (2020)
Dec. 15 Chang Min Lee Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target
PNAS (2023)
Jan. 5 Zsuzsanna Bordan Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension
Circulation Research (2023)
Jan. 12 Sonia Batan Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy
Nature Communications (2023)
Jan. 19 Amr Salem Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation
Immunity (2023)
Jan. 26 Nestor Ishimwe Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration
Circulation (2023)
Feb. 2 Andrew Speese Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells
Genome Medicine (2023)
Feb. 9 Taylor Kress CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6
Circulation Research (2024)
Feb. 16 Yoichi Ono Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
Nature Communications (2022)
Feb. 23 Sheela Nagarkoti Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation
Cell Reports (2023)
Mar. 1 Maryam Rezaei-Gazik Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart
Nucleic Acids Research (2023)
Mar. 15 Rahul Patil MicroRNA-1 protects the endothelium in acute lung injury
JCI Insight (2023)
Mar. 22 Mai Yamamoto Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization
Journal of Neuroinflammation (2023)
Mar. 29 Ishara M.G. Menik Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells
Arteriosclerosis, Thrombosis, and Vascular Biology (2024)
Apr. 5 Chang Min Lee HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells
Circulation (2023)
Apr. 19 Qimei Han Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence
Circulation Research (2023)
Apr. 26 Mohamed Nofal Hyperglycolysis in endothelial cells drives endothelial injury and microvascular alterations in peritoneal dialysis
Clinical and Translational Medicine (2023)
May 10 Beryl Khakina LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic Stroke
Circulation Research (2024)

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