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Current Projects

“Circadian origins of vascular disease in obesity”
Studies will determine how the disruption in circadian rhythm impairs the cardiovascular function in obesity.

“Circadian Clock Control of Endothelial Identity in Atherosclerosis”
Our overarching hypothesis is that circadian rhythmicity is important to maintain endothelial homeostasis via Sox17 expression and that perturbation of rhythms corrupts endothelial function and encourages the development of atherosclerosis.





Spotlight Publications

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.
Fulton D., Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC.  Nature. 1999 Jun 10;399(6736):597-601.

  FULL ARTICLE   

Glucose wears down circadian clocks in obesity, may drive cardiovascular risk

https://www.wjbf.com/top-stories/jennie-mcg-researchers-identify-link-between-high-glucose-and-function-of-circadian-clocks-in-cells/
https://jagwire.augusta.edu/glucose-wears-down-circadian-clocks-in-obesity-may-drive-cardiovascular-risk/


    

Recent Publications

Larion S, Padgett CA, Butcher JT, Mintz JD, Fulton DJ, Stepp DW. The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm. Am J Physiol Gastrointest Liver Physiol2022 Oct 1;323(4):G387-G400doi: 10.1152/ajpgi.00130.2022. Epub 2022 Aug 23. PubMed PMID: 35997288; PubMed Central PMCID: PMC9602907.

He, X., Dong, K., Shen, J., Hu, G., Mintz, J. D., Atawia, R. T., Zhao, J., Chen, X., Caldwell, R. W., Xiang, M., Stepp, D. W., Fulton, D. J. & Zhou, J. The Long Noncoding RNA Cardiac Mesoderm Enhancer-Associated Noncoding RNA (Carmn) Is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility. Jul 2023, In: Gastroenterology. 165, 1p.71-87 17 p.

Hu, L., Yu, Y., Shen, Y., Huang, H., Lin, D., Wang, K., Yu, Y., Li, K., Cao, Y., Wang, Q., Sun, X., Qiu, Z., Wei, D., Shen, B., Chen, J., Fulton, D., Ji, Y., Wang, J. & Chen, F., Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages. May 2023In: Redox Biology. 61, 102638.

Ma, Q., Yang, Q., Xu, J., Sellers, H. G., Brown, Z. L., Liu, Z., Bordan, Z., Shi, X., Zhao, D., Cai, Y., Pareek, V., Zhang, C., Wu, G.Dong, Z.Verin, A. D.Gan, L.Du, Q., Benkovic, S. J., Xu, S., Asara, J. M., Ben-Sahra, I., Barman, S., Su, Y., Fulton, DJR. & Huo, Y., Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. Apr 7 2023In: European Heart Journal. 4414p. 1265-1279 15 p.

Batori RK, Chen F, Bordan Z, Haigh S, Su Y, Verin AD, Barman SA, Stepp DW, Chakraborty T, Lucas R, Fulton DJR. Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction. Front Immunol2022;13:945656doi: 10.3389/fimmu.2022.945656. eCollection 2022. PubMed PMID: 35967431; PubMed Central PMCID: PMC9363592.

 

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