
Our research program aims to identify prevention measures and effective treatments for patients with neurological disorders. Our research is divided into various subspecialties, such as stroke, dementia, neuromuscular disorders, epilepsy, and multiple sclerosis. Patients with specific neurological conditions, who meet study-specific criteria, are invited to participate in our clinical research studies.
Our clinical research activities are coordinated by a dedicated team of trained research coordinators under the leadership of Brandy Quarles. Additional staff include advanced practice providers, nurses, and therapists. Our research faculty have subspecialty training that includes research methodology, and all research is conducted under the oversight of Central and Local Institutional Review Boards. Our research funding is derived from a combination of medical industry sponsors and the National Institute of Health.
We offer a wide variety of research opportunities with our largest research projects reaching an international level and including dozens of qualified medical centers. In addition to large, multicenter clinical research, we also conduct many smaller scale investigations that involve our medical students, neurology and neurosurgery trainees. These smaller local projects introduce future physicians to research methodology as well as the essential elements of the ethical and scientific standards associated with Good Clinical Practice in human research. The findings from our local research are presented at regional and national scientific meetings.
As a medical research unit, we strive to make scientific discoveries to improve the healthcare of patients with neurological conditions.
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​ Exploring extracellular vesicle surface markers and microRNA regulation following remote ischemic conditioning in patients with stroke; a randomized-controlled pilot studyBest Jensen, R., Kjølhede, M., Just, J., Clegg, L. A., Baek, R., Kaadt, E., Elfving, B., Hess, D. C., Andersen, G., Jørgensen, M. M., Blauenfeldt, R. A. & Drasbek, K. R., Dec 2026, In: BMC Neuroscience. 27, 1, 10.Research output: Contribution to journal › Article › peer-review |
​ Neuroinflammatory and functional outcomes after TBI are sex-dependent: Lessons from estrous-phase stratified female miceRoyal, T., Ahluwalia, P., Gulhane, M., Salles, E. L., Gaur, P., Ahluwalia, M., Randhawa, T., Sunil, S., Budim, S., Akter, K., Khan, M. B., Ghosh, S., Baban, B., Hess, D. C., Vale, F. L., Dhandapani, K. M., Kolhe, R. & Vaibhav, K., May 2026, In: Neurochemistry International. 195, 106136.Research output: Contribution to journal › Article › peer-review |
​ Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusionZong, X., Huang, Z., Kong, F., Feng, Y., Zhang, Y., Zou, P., Wen Lin, H., Hess, D. C. & Zhang, Q., Mar 2026, In: Journal of Cerebral Blood Flow and Metabolism. 46, 3, p. 786-803 18 p.Research output: Contribution to journal › Article › peer-review |
​ Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networksSPAN Consortium, Mar 2026, In: Lab Animal. 55, 3, p. 74-82 9 p.Research output: Contribution to journal › Article › peer-review |
​ Angioplasty and Stenting of Persistent Primitive Trigeminal Artery Stenosis in Acute Ischemic StrokePatel, P. A., Rueda, L., Oei, M. & Giurgiutiu, D. V., Mar 2026, In: Clinical Neuroradiology. 36, 1, p. 247-250 4 p.Research output: Contribution to journal › Letter › peer-review |
​ Evaluating tocilizumab in ischemic stroke: Findings from the SPAN multicenter trialChauhan, A., Lee, E. A., Patel, R. B., Kumskova, M., Leira, E. C., Chauhan, A. K., Shi, Y., Cao, S., Koehler, R. C., Dhandapani, K. M., Khan, M. B., Kamat, P. K., Arbab, A., Hess, D. C., Herman, A. L., Boisserand, L., Sansing, L. H., Morais, A., Jin, X. & Aykan, S. & 8 others, Imai, T., Ayata, C., Nagarkatti, K. A., Lamb, J., Diniz, M. A., Lyden, P. D., McCullough, L. D. & Aronowski, J., Mar 1 2026, In: Neuropharmacology. 285, 110801.Research output: Contribution to journal › Article › peer-review |
​ Exploring Sex Differences in Stroke Outcomes: A Comprehensive Analysis From the SPAN 1 TrialChauhan, A., Lee, E. A., Patel, R. B., Kumskova, M., Leira, E. C., Chauhan, A., Shi, Y., Cao, S., Koehler, R. C., Dhandapani, K. M., Khan, M. B., Kamat, P. K., Arbab, A., Hess, D. C., Herman, A. L., Boisserand, L., Sansing, L. H., Morais, A., Jin, X. & Aykan, S. & 8 others, Imai, T., Ayata, C., Nagarkatti, K. A., Lamb, J., Diniz, M. A., Lyden, P. D., Aronowski, J. & McCullough, L. D., Feb 3 2026, In: Journal of the American Heart Association. 15, 4, p. 1-14 14 p., e043220.Research output: Contribution to journal › Article › peer-review |
​ Counseling Reproductive-Age Youth With Epilepsy: Literature Review and Expert Opinion From the Epilepsy in the Child-Bearing Ages Through Menopause ConsortiumClements, M. E., Briscoe, C., Curcio, A. M., Douglass, L. M., Kassiri, J., Liu, L. C., Mathias, S. V., Moore-Hill, D. T., Nalluri, D., Nath, A., Romeu, A. M., Syed, T., Vinarsky, V., Wiener, S., Yang, Q. Z. J. J., Betstadt, S. J., Harrison, E. I., Kulkarni, N., Puntambekar, P. & Samanta, D. & 3 others, Singla, L., Voinescu, P. E. & Kirkpatrick, L., Feb 2026, In: Pediatric Neurology. 175, p. 90-101 12 p.Research output: Contribution to journal › Review article › peer-review |
​ Neuroprotective mechanism of hydrogen sulfide in okadaic acid-induced alzheimer-like pathologyKamat, P. K., Kalani, A., Debnath, N., Mushtaq, Z., Tyagi, S. C. & Tyagi, N., Feb 2026, In: GeroScience. 48, 1, p. 843-858 16 p.Research output: Contribution to journal › Article › peer-review |
​ Feasibility of a Multi-Laboratory Model of Middle Cerebral Artery Thromboembolic Stroke with Thrombolysis: TE-MCAoLin, M., Bhuiyan, M., McCurry, C., Lamb, J., Diniz, M. A., Bedirian, K., Chauhan, A. K., Jha, A., Jain, A., C. Leira, E., Patel, R., Khan, M. B., Kamat, P., Hess, D. C., Dhandapani, K., Sheng, H., Zhang, S., Yang, W., Hu, B. & Liu, C. & 8 others, Sansing, L., Caglayan, P., Guan, Q., Boisserand, L., Ayata, C., Imai, T., Lynch, K. & Lyden, P., Feb 2026, In: Translational Stroke Research. 17, 1, 20.Research output: Contribution to journal › Article › peer-review |
​ MAGEB16 AS AN EPIGENETIC TIMING REGULATOR LINKING X-CHROMOSOME BIOLOGY TO NEURODEVELOPMENTAL VULNERABILITY IN AUTISM SPECTRUM DISORDERGaspar, J. A., Dhandapani, K. M. & Hess, D. C., Jan 2 2026, In: EXCLI Journal. 25, p. 377-386 10 p.Research output: Contribution to journal › Review article › peer-review |
​ Adoptive transfer of ILC2s reveals tumor homing in glioblastoma: a proof-of-concept studyWang, L. P., Bhandari, B., Emami Naeini, S., Yu, J. C., Arbab, A. S., Young, N., Lopes Salles, É. & Baban, B., 2026, In: Frontiers in Oncology. 16, 1776061.Research output: Contribution to journal › Article › peer-review |
​ Researcher photographs in recruitment materials to increase willingness to participate in brain health researchLedford, C. J. W., Williamson, L. D., Waller, J. L., Wolf, L. E., Chase, A., Desrochers, E., Kye, B., Gunthert, Z., Hayes, H. C., Morgan, J. C. & Hess, D. C., Jan 1 2026, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 12, 1, e70215.Research output: Contribution to journal › Article › peer-review |
​ Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical InvestigationWang, L. P., Bhandari, B., Naeini, S. E., Hill, B., Rogers, H. M., Gouron, J., Perez-Morales, N., Khan, A., Meeks, W., El-Marakby, A., Young, N., Vale, F. L., Ali, S., Wallace, G., Yu, J. C., Arbab, A. S., Salles, É. L. & Baban, B., Jan 2026, In: International journal of molecular sciences. 27, 2, 757.Research output: Contribution to journal › Article › peer-review |
​ Creating Virtual Stroke Networks: Current and Future Role of Artificial Intelligence, Mobile Imaging Applications, and Telehealth in Triage and Treatment of Acute Ischemic Stroke: A Scientific Statement From the American Heart Associationon behalf of the American Heart Association Stroke Council; Council on Basic Cardiovascular Sciences; and Council on Cardiovascular and Stroke Nursing, Dec 4 2025, In: Stroke. Publish Ahead of PrintResearch output: Contribution to journal › Review article › peer-review |
​ The Stroke Preclinical Assessment Network Multi-laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAoBhuiyan, M., Lin, M., McCurry, C., Lamb, J., Diniz, M. A., Bedirian, K., Chauhan, A., Jha, A., Jain, A., Leira, E., Khan, M. B., Kamat, P. K., Hess, D. C., Sheng, H., Hu, B., Sansing, L. H., Ayata, C., Imai, T., Lynch, K. & Lyden, P., Dec 2025, In: Journal of Visualized Experiments. 2025, 226, e69522.Research output: Contribution to journal › Article › peer-review |
​ Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive moleculesMao, L., Wang, L., Huang, Z., Switzer, J. A., Hess, D. C. & Zhang, Q., Dec 2025, In: Ageing Research Reviews. 112, 102885.Research output: Contribution to journal › Review article › peer-review |
​ The Effect of Remote Ischemic Conditioning in Patients Treated with Endovascular Therapy: A RESIST Trial Post Hoc StudyBlauenfeldt, R. A., Hess, D. C., Gaist, D., Modrau, B., Valentin, J. B., Johnsen, S. P., Hjort, N., Behrndtz, A. B., Gude, M. F., Zhao, W., Jensen, J., Andersen, G. & Simonsen, C. Z., Dec 2025, In: Translational Stroke Research. 16, 6, p. 2173-2184 12 p.Research output: Contribution to journal › Article › peer-review |
​ Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment NetworkBoisserand, L. S. B., Herman, A. L., Sanganahalli, B. G., Mihailovic, J., Beatty, H. E., Johnson, C. W., Diaz, S., DeLong, J. H., Velazquez, S., Grutzendler, J., Dela Cruz, C., Zhou, J., Sheth, K. N., Matouk, C., Zhan, S., Morais, A., Imai, T., Chauhan, A., Patel, R. B. & Kumskova, M. & 19 others, Shi, Y., Avery, B. D., Lamb, J., Nagarkatti, K. A., Khan, M. B., Kamat, P. K., Dhandapani, K. M., McCullough, L. D., Aronowski, J., Hess, D., Koehler, R. C., Lyden, P., Leira, E. C., Chauhan, A. K., Ayata, C., Chen, M. H., Diniz, M. A., Hyder, F. & Sansing, L. H., Nov 18 2025, In: Stroke. 56, 11, p. 3280-3293 14 p.Research output: Contribution to journal › Article › peer-review |
​ Prescribing Practices of Antiseizure Medications at US Academic Medical Centers for Pregnant People With and Without EpilepsyVoinescu, P. E., Seliger, J., Gerard, E. E., Birnbaum, A. K., Johnson, E. L., Pennell, P. B., Tsai, J. J., Nath, A., Jacobs, C. S., Decker, B. M., Mihaylova, T. G., Singla, L., Munger Clary, H. M., Cavitt, J., Gedzelman, E., Sazgar, M., Krishnaiengar, S., Zarroli, K., Smith, F. & Serafini, A. & 4 others, Hanna, J., Velez-Ruiz, N., Moore-Hill, D. & Meador, K. J., Oct 21 2025, In: Neurology. 105, 8, p. e214219Research output: Contribution to journal › Article › peer-review |
​ Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation ControlNaeini, S. E., Bhandari, B., Hill, B., Perez-Morales, N., Rogers, H. M., Khodadadi, H., Young, N., Maciel, L. M., Yu, J. C., Hess, D. C., Morgan, J. C., Salles, É. L., Wang, L. P. & Baban, B., Oct 2025, In: eNeuro. 12, 10Research output: Contribution to journal › Article › peer-review |
​ Leveraging Medical Licensure for Safer Artificial Intelligence Use in Health CareMiller, D. D., Kamath, M. V., Albers, J. & Hess, D. C., Oct 2025, In: American Journal of Medicine. 138, 10, p. 1319-1321 3 p.Research output: Contribution to journal › Editorial › peer-review |
​ Flutter Sucking: Voluntary Tongue Tremor in InfancyMorgan, L. B., Kurek, J. A., Sekul, E. A. & Morgan, J. C., Sep 2025, In: Movement Disorders Clinical Practice. 12, 9, p. 1415-1416 2 p.Research output: Contribution to journal › Article › peer-review |
​ Determinants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN TrialJin, X., Morais, A., Imai, T., Lamb, J., Nagarkatti, K., Boisserand, L., Beatty, H. E., Sansing, L. H., Khan, M. B., Dhandapani, K., Kamat, P., Hess, D. C., Patel, R. B., Kumskova, M., Chauhan, A. K., McCullough, L. D., Aronowski, J., Leira, E. C., Shi, Y. & Avery, B. D. & 3 others, Koehler, R. C., Lyden, P. D. & Ayata, C., Sep 2025, In: Stroke. 56, 9, p. 2734-2747 14 p.Research output: Contribution to journal › Article › peer-review |
​ Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trialJin, T., Niu, H., Liu, L., Yin, Y., Zhao, W., Feng, X., Xu, L., Hess, D. C., Liu, A. & Ji, X., Aug 11 2025, In: BMJ Open. 15, 8, e101350.Research output: Contribution to journal › Article › peer-review |
​ Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: illustrative caseLedford, W. L., Carr, C. J., Alfaro, M. G., Conger, C., Sharma, S., Henson, J. W. & Nguyen, K. D., Jul 2025, In: Journal of Neurosurgery: Case Lessons. 10, 1, CASE2566.Research output: Contribution to journal › Article › peer-review |
​ Effect of Remote Ischemic Conditioning and Red Blood Cells Biomarkers on Outcomes in Patients With Acute StrokeBlauenfeldt, R. A., Waller, J. L., Drasbek, K. R., Bech, J. N., Hvas, A. M., Larsen, J. B., Andersen, M. N., Nielsen, M. C., Kjølhede, M., Kjeldsen, M., Gude, M. F., Khan, M. B., Baban, B., Andersen, G. & Hess, D. C., May 20 2025, In: Journal of the American Heart Association. 14, 10, e040787.Research output: Contribution to journal › Article › peer-review |
​ Acute-Phase Recording of the Spreading Depolarization Continuum in Aged Nonhuman Primates during Focal Ischemic StrokeSword, J. J., Sparks, T., Debs, L. H., Major, S., Sharma, S. J., Jensen, M. A., Moore-Hill, D. T., Barton, K., Shah, M., Garcia, K. A., Switzer, J. A., Blake, D. T., Vale, F. L., Dreier, J. P., Hartings, J. A. & Kirov, S. A., Apr 1 2025, In: Stroke. 56, 4, p. 974-986 13 p.Research output: Contribution to journal › Article › peer-review |
​ Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical TrialPatel, R. B., Kumskova, M., Kodali, H., Budnik, I., Kuznetsov, V., Jain, A., Jha, A., Thedens, D., Dhanesha, N., Sutariya, B., Nagarkatti, K. A., Lamb, J., Kamat, P., Shi, Y., Avery, B., Imai, T., Jin, X., Chauhan, A., Boisserand, L. S. B. & Khan, M. B. & 14 others, Dhandapani, K., Sanganahalli, B. G., Sansing, L. H., Hess, D. C., Koehler, R. C., McCullough, L. D., Aronowski, J., Ayata, C., Diniz, M. A., Lyden, P. D., Planas, A. M., Chamorro, A., Chauhan, A. K. & Leira, E. C., Apr 1 2025, In: Stroke. 56, 4, p. 965-973 9 p.Research output: Contribution to journal › Article › peer-review |
​ Basal forebrain activation improves working memory in senescent monkeysPennington, K. R., Debs, L., Chung, S., Bava, J., Garin, C. M., Vale, F. L., Bick, S. K., Englot, D. J., Terry, A. V., Constantinidis, C. & Blake, D. T., Mar 1 2025, In: Brain Stimulation. 18, 2, p. 185-194 10 p.Research output: Contribution to journal › Article › peer-review |
​ Cortical acetylcholine response to deep brain stimulation of the basal forebrain in miceShanazz, K., Xie, K., Oliver, T., Bogan, J., Vale, F. L., Sword, J. J., Kirov, S. A., Terry, A., O’Herron, P. & Blake, D. T., Mar 2025, In: Journal of Neurophysiology. 133, 3, p. 825-838 14 p.Research output: Contribution to journal › Article › peer-review |
​ Sleep Disturbances in Chronic PainYoung, K., Fabbro, E. D., Giurgiutiu, D. V. & Healy, W. J., Mar 2025, In: ATS Scholar. 6, 1, p. 109-110 2 p.Research output: Contribution to journal › Comment/debate › peer-review |
​ Pupillary changes in pentobarbital coma mimicking a neurocritical care emergencyRueda-Carrillo, L., Li, M., Garcia, K. A., Shah, M. & Yalcin, N., Feb 2025, In: Acta Neurologica Belgica. 125, 1, p. 261-264 4 p.Research output: Contribution to journal › Letter › peer-review |
​ ALSUntangled #76: Wahls protocolLi, X., Wicks, P., Brown, A., Shivaprasad, A., Greene, M., Crayle, J., Barnes, B., Jhooty, S., Ratner, D., Olby, N., Glass, J. D., Jackson, C., Cole, N., Armon, C., Mascias Cadavid, J., Pattee, G., Mcdermott, C. J., Chang, V., Maragakis, N. & Bertorini, T. & 2 others, Bowser, R. & Bedlack, R., 2025, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 26, 1-2, p. 181-185 5 p.Research output: Contribution to journal › Review article › peer-review |
​ Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literatureButler, M., Carr, C., Mehra, M., Barnett, A. M., Salley, J., Chauhan, A., Belakhlef, S., Wallace, G. C., Rutkowski, M., Vender, J. & Vale, F. L., 2025, In: Surgical Neurology International. 16, 136.Research output: Contribution to journal › Article › peer-review |
​ ALSUntangled #80: ISRIB (Integrated stress response InhiBitor)Mascias Cadavid, J., Mena Bravo, A., Barkhaus, P., Barnes, B., Benatar, M., Breevoort, S., Brown, A., Carter, G. T., Crayle, J., Foucher, J., Heiman-Patterson, T., Hobson, E., Jackson, C., Jhooty, S., Mallon, E., Mcdermott, C., Pattee, G., Pierce, K., Pioro, E. & Ratner, D. & 4 others, Rivner, M., Tito, E., Wicks, P. & Bedlack, R., 2025, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 26, 7-8, p. 821-824 4 p.Research output: Contribution to journal › Article › peer-review |
​ A Case Report of Bartonella henselae-Related New-Onset Refractory Status Epilepticus / Febrile Infection–Related Epilepsy Syndrome Complicated With Stimulus-Induced Rhythmic, Periodic, or Ictal DischargesLi, M., Rueda Carrillo, L. G., Park, Y., Strickland, S., Andrews, A. & Aquino-Cabrera, M., 2025, (Accepted/In press) In: Journal of Child Neurology. 08830738251381702.Research output: Contribution to journal › Article › peer-review |
​ Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo strokeAlptekin, A., Khan, M. B., Parvin, M., Chowdhury, H., Kashif, S., Selina, F. A., Bushra, A., Kelleher, J., Ghosh, S., Williams, D., Blumling, E., Ara, R., Bosomtwi, A., Frank, J. A., Dhandapani, K. M. & Arbab, A. S., 2025, In: Frontiers in Neurology. 16, 1543133.Research output: Contribution to journal › Article › peer-review |
​ Optimization of seizure prevention by cannabidiol (CBD)Bhandari, B., Naeini, S. E., Rezaee, S., Rogers, H. M., Khodadadi, H., Bosomtwi, A., Seyyedi, M., Mackinnon, N. J., Dhandapani, K. M., Salles, É. L., Hess, D. C., Yu, J. C., Moore-Hill, D., Vale, F. L., Wang, L. P. & Baban, B., Jan 1 2025, In: Translational Neuroscience. 16, 1, 20220362.Research output: Contribution to journal › Article › peer-review |
​ Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective reviewWallace, G., Kundalia, R., Vallebuona, E., Cao, B., Kim, Y., Forsyth, P., Soyano, A., Smalley, I. & Pina, Y., Dec 2024, In: Breast Cancer Research. 26, 1, 55.Research output: Contribution to journal › Article › peer-review |
