
Our research program aims to identify prevention measures and effective treatments for patients with neurological disorders. Our research is divided into various subspecialties, such as stroke, dementia, neuromuscular disorders, epilepsy, and multiple sclerosis. Patients with specific neurological conditions, who meet study-specific criteria, are invited to participate in our clinical research studies.
Our clinical research activities are coordinated by a dedicated team of trained research coordinators under the leadership of Brandy Quarles. Additional staff include advanced practice providers, nurses, and therapists. Our research faculty have subspecialty training that includes research methodology, and all research is conducted under the oversight of Central and Local Institutional Review Boards. Our research funding is derived from a combination of medical industry sponsors and the National Institute of Health.
We offer a wide variety of research opportunities with our largest research projects reaching an international level and including dozens of qualified medical centers. In addition to large, multicenter clinical research, we also conduct many smaller scale investigations that involve our medical students, neurology and neurosurgery trainees. These smaller local projects introduce future physicians to research methodology as well as the essential elements of the ethical and scientific standards associated with Good Clinical Practice in human research. The findings from our local research are presented at regional and national scientific meetings.
As a medical research unit, we strive to make scientific discoveries to improve the healthcare of patients with neurological conditions.
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​ Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive moleculesMao, L., Wang, L., Huang, Z., Switzer, J. A., Hess, D. C. & Zhang, Q., Dec 2025, In: Ageing Research Reviews. 112, 102885.Research output: Contribution to journal › Review article › peer-review |
​ Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation ControlNaeini, S. E., Bhandari, B., Hill, B., Perez-Morales, N., Rogers, H. M., Khodadadi, H., Young, N., Maciel, L. M., Yu, J. C., Hess, D. C., Morgan, J. C., Salles, É. L., Wang, L. P. & Baban, B., Oct 2025, In: eNeuro. 12, 10Research output: Contribution to journal › Article › peer-review |
​ Flutter Sucking: Voluntary Tongue Tremor in InfancyMorgan, L. B., Kurek, J. A., Sekul, E. A. & Morgan, J. C., Sep 2025, In: Movement Disorders Clinical Practice. 12, 9, p. 1415-1416 2 p.Research output: Contribution to journal › Article › peer-review |
​ Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive RatsAlshammari, A., Pillai, B., Kamat, P., Jones, T. W., Bosomtwi, A., Khan, M. B., Hess, D. C., Li, W., Somanath, P. R., Sayed, M. A., Ergul, A. & Fagan, S. C., Jun 2025, In: Translational Stroke Research. 16, 3, p. 584-599 16 p., e0180738.Research output: Contribution to journal › Article › peer-review |
​ Correction to: Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats (Translational Stroke Research, (2025), 16, 3, (584-599), 10.1007/s12975-024-01232-1)Alshammari, A., Pillai, B., Kamat, P., Jones, T. W., Bosomtwi, A., Khan, M. B., Hess, D. C., Li, W., Somanath, P. R., Sayed, M. A., Ergul, A. & Fagan, S. C., Jun 2025, In: Translational Stroke Research. 16, 3, p. 1029 1 p.Research output: Contribution to journal › Comment/debate › peer-review |
​ Time Dimension Influences Severity of Stroke and Heightened Immune Response in MiceKamat, P. K., Khan, M. B., Siddiqui, S., Williams, D., da Silva Lopes Salles, E., Naeini, S. E., Arbab, A. S., Rudic, D. R., Baban, B., Dhandapani, K. M. & Hess, D. C., Apr 2025, In: Translational Stroke Research. 16, 2, p. 421-437 17 p., e571.Research output: Contribution to journal › Article › peer-review |
​ NORSE secondary to anti-GAD65 antibody-positive encephalitis treated with novel adjunctive rapid titration VNS protocolLi, M., Yalcin, N., Weiss, D. L., Hill, L. A. T., Shah, M., Garcia, K. A., Vale Diaz, F. L., Rueda Carrillo, L. G., Smith, H. & Moore-Hill, D. T., Apr 2025, In: Epilepsia Open. 10, 2, p. 581-586 6 p.Research output: Contribution to journal › Article › peer-review |
​ Acute-Phase Recording of the Spreading Depolarization Continuum in Aged Nonhuman Primates during Focal Ischemic StrokeSword, J. J., Sparks, T., Debs, L. H., Major, S., Sharma, S., Jensen, M. A., Moore-Hill, D. T., Barton, K., Shah, M., Garcia, K. A., Switzer, J. A., Blake, D. T., Vale, F. L., Dreier, J. P., Hartings, J. A. & Kirov, S. A., Apr 1 2025, In: Stroke. 56, 4, p. 974-986 13 p.Research output: Contribution to journal › Article › peer-review |
​ Cortical acetylcholine response to deep brain stimulation of the basal forebrain in miceShanazz, K., Xie, K., Oliver, T., Bogan, J., Vale, F. L., Sword, J., Kirov, S. A., Terry, A., O’Herron, P. & Blake, D. T., Mar 2025, In: Journal of Neurophysiology. 133, 3, p. 825-838 14 p.Research output: Contribution to journal › Article › peer-review |
​ Basal forebrain activation improves working memory in senescent monkeysPennington, K. R., Debs, L., Chung, S., Bava, J., Garin, C. M., Vale, F. L., Bick, S. K., Englot, D. J., Terry, A. V., Constantinidis, C. & Blake, D. T., Mar 1 2025, In: Brain Stimulation. 18, 2, p. 185-194 10 p.Research output: Contribution to journal › Article › peer-review |
​ Analysis of participant race and sex reporting and disparities in US epilepsy clinical trialsButler, M., Palacios, M. E., Carr, C., Moore-Hill, D. & Vale, F. L., Mar 2025, In: Epilepsia. 66, 3, p. 768-775 8 p.Research output: Contribution to journal › Article › peer-review |
​ Pupillary changes in pentobarbital coma mimicking a neurocritical care emergencyRueda-Carrillo, L., Li, M., Garcia, K. A., Shah, M. & Yalcin, N., Feb 2025, In: Acta Neurologica Belgica. 125, 1, p. 261-264 4 p.Research output: Contribution to journal › Letter › peer-review |
​ Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literatureButler, M., Carr, C., Mehra, M., Barnett, A. M., Salley, J., Chauhan, A., Belakhlef, S., Wallace, G. C., Rutkowski, M., Vender, J. & Vale, F. L., 2025, In: Surgical Neurology International. 16, 136.Research output: Contribution to journal › Article › peer-review |
​ ALSUntangled #76: Wahls protocolLi, X., Wicks, P., Brown, A., Shivaprasad, A., Greene, M., Crayle, J., Barnes, B., Jhooty, S., Ratner, D., Olby, N., Glass, J. D., Jackson, C., Cole, N., Armon, C., Mascias Cadavid, J., Pattee, G., Mcdermott, C. J., Chang, V., Maragakis, N. & Bertorini, T. & 2 others, Bowser, R. & Bedlack, R., 2025, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 26, 1-2, p. 181-185 5 p.Research output: Contribution to journal › Review article › peer-review |
​ Angioplasty and Stenting of Persistent Primitive Trigeminal Artery Stenosis in Acute Ischemic StrokePatel, P. A., Rueda, L., Oei, M. & Giurgiutiu, D. V., 2025, (Accepted/In press) In: Clinical Neuroradiology.Research output: Contribution to journal › Letter › peer-review |
​ Optimization of seizure prevention by cannabidiol (CBD)Bhandari, B., Naeini, S. E., Rezaee, S., Rogers, H. M., Khodadadi, H., Bosomtwi, A., Seyyedi, M., Mackinnon, N. J., Dhandapani, K. M., Salles, É. L., Hess, D. C., Yu, J. C., Moore-Hill, D., Vale, F. L., Wang, L. P. & Baban, B., Jan 1 2025, In: Translational Neuroscience. 16, 1, 20220362.Research output: Contribution to journal › Article › peer-review |
​ Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective reviewWallace, G., Kundalia, R., Vallebuona, E., Cao, B., Kim, Y., Forsyth, P., Soyano, A., Smalley, I. & Pina, Y., Dec 2024, In: Breast Cancer Research. 26, 1, 55.Research output: Contribution to journal › Article › peer-review |
​ Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trialCHARM Trial investigators, Dec 2024, In: The Lancet Neurology. 23, 12, p. 1205-1213 9 p.Research output: Contribution to journal › Article › peer-review |
​ The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changesPatel, S., Khan, M. B., Kumar, S., Vyavahare, S., Mendhe, B., Lee, T. J., Cai, J., Isales, C. M., Liu, Y., Hess, D. C. & Fulzele, S., Sep 2024, In: Experimental Neurology. 379, 114867.Research output: Contribution to journal › Article › peer-review |
​ Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson’s disease studyWestenberger, A., Skrahina, V., Usnich, T., Beetz, C., Vollstedt, E. J., Laabs, B. H., Paul, J. J., Curado, F., Skobalj, S., Gaber, H., Olmedillas, M., Bogdanovic, X., Ameziane, N., Schell, N., Aasly, J. O., Afshari, M., Agarwal, P., Aldred, J., Alonso-Frech, F. & Anderson, R. & 139 others, Araújo, R., Arkadir, D., Avenali, M., Balal, M., Benizri, S., Bette, S., Bhatia, P., Bonello, M., Braga-Neto, P., Brauneis, S., Cardoso, F. E. C., Cavallieri, F., Classen, J., Cohen, L., Coletta, D., Crosiers, D., Cullufi, P., Dashtipour, K., Demirkiran, M., de Carvalho Aguiar, P., De Rosa, A., Djaldetti, R., Dogu, O., dos Santos Ghilardi, M. G., Eggers, C., Elibol, B., Ellenbogen, A., Ertan, S., Fabiani, G., Falkenburger, B. H., Farrow, S., Fay-Karmon, T., Ferencz, G. J., Fonoff, E. T., Fragoso, Y. D., Genç, G., Gorospe, A., Grandas, F., Gruber, D., Gudesblatt, M., Gurevich, T., Hagenah, J., Hanagasi, H. A., Hassin-Baer, S., Hauser, R. A., Hernández-Vara, J., Herting, B., Hinson, V. K., Hogg, E., Hu, M. T., Hummelgen, E., Hussey, K., Infante, J., Isaacson, S. H., Jauma, S., Koleva-Alazeh, N., Kuhlenbäumer, G., Kühn, A., Litvan, I., López-Manzanares, L., Luxmore, M., Manandhar, S., Marcaud, V., Markopoulou, K., Marras, C., McKenzie, M., Matarazzo, M., Merello, M., Mollenhauer, B., Morgan, J. C., Mullin, S., Musacchio, T., Myers, B., Negrotti, A., Nieves, A., Nitsan, Z., Oskooilar, N., Öztop-Çakmak, Ö., Pal, G., Pavese, N., Percesepe, A., Piccoli, T., de Souza, C. P., Prell, T., Pulera, M., Raw, J., Reetz, K., Reiner, J., Rosenberg, D., Ruiz-Lopez, M., Martinez, J. R., Sammler, E., Santos-Lobato, B. L., Saunders-Pullman, R., Schlesinger, I., Schofield, C. M., Schumacher-Schuh, A. F., Scott, B., Sesar, Á., Shafer, S. J., Sheridan, R., Silverdale, M., Sophia, R., Spitz, M., Stathis, P., Stocchi, F., Tagliati, M., Tai, Y. F., Terwecoren, A., Thonke, S., Tönges, L., Toschi, G., Tumas, V., Urban, P. P., Vacca, L., Vandenberghe, W., Valente, E. M., Valzania, F., Vela-Desojo, L., Weill, C., Weise, D., Wojcieszek, J., Wolz, M., Yahalom, G., Yalcin-Cakmakli, G., Zittel, S., Zlotnik, Y., Kandaswamy, K. K., Balck, A., Hanssen, H., Borsche, M., Lange, L. M., Csoti, I., Lohmann, K., Kasten, M., Brüggemann, N., Rolfs, A., Klein, C. & Bauer, P., Aug 1 2024, In: Brain. 147, 8, p. 2652-2667 16 p.Research output: Contribution to journal › Article › peer-review |
​ High Rate of Angiogram-Negative Subarachnoid Hemorrhage in a Rural Population: Role of Venous DrainageJones, E. D., Kaoutzani, L., Walker, S. E., Kollapaneni, S. S., Giurgiutiu, D. V. & Rahimi, S. Y., Aug 2024, In: World Neurosurgery. 188, p. e491-e496Research output: Contribution to journal › Article › peer-review |
​ Parkinson’s disease variant detection and disclosure: PD GENEration, a North American studyon behalf of the Parkinson’s Foundation & and Parkinson Study Group PD GENEration investigators, Aug 1 2024, In: Brain. 147, 8, p. 2668-2679 12 p.Research output: Contribution to journal › Article › peer-review |
​ A Mixed-Method Pilot Project: The Evaluation of Telehealth Training in a College of NursingHamilton, W., Walters, C. & Howington, Z., Jul 1 2024, In: Nursing Education Perspectives. 45, 4, p. 254-255 2 p.Research output: Contribution to journal › Article › peer-review |
​ Case Presentation of Autoimmune Septin-5 Cerebellar AtaxiaNijim, W., Morgan, J., Montalvo, M., McKeon, A. & McLeod, C., Jun 2024, In: Movement Disorders Clinical Practice. 11, 6, p. 734-737 4 p.Research output: Contribution to journal › Article › peer-review |
​ Carotid artery dissection and non-aneurysmal subarachnoid hemorrhage following carotid endarterectomyKaoutzani, L., Garcia, K. A. & Rahimi, S. Y., May 1 2024, In: Journal of Surgical Case Reports. 2024, 5, rjae331.Research output: Contribution to journal › Article › peer-review |
​ Artery of Percheron StrokeSaltz, G., Bruno, A. & Nichols, F., Apr 2024, In: Annals of Neurology. 95, 4, p. 800-801 2 p.Research output: Contribution to journal › Article › peer-review |
​ Effect of Remote Ischemic Conditioning in Ischemic Stroke Subtypes: A Post Hoc Subgroup Analysis from the RESIST TrialBlauenfeldt, R. A., Mortensen, J. K., Hjort, N., Valentin, J. B., Homburg, A. M., Modrau, B., Sandal, B. F., Gude, M. F., Berhndtz, A. B., Johnsen, S. P., Hess, D. C., Simonsen, C. Z. & Andersen, G., Apr 1 2024, In: Stroke. 55, 4, p. 874-879 6 p.Research output: Contribution to journal › Article › peer-review |
​ Evaluation of bidirectional gut-brain axis and anorectal function in Parkinson's disease with constipationYan, Y., Tennekoon, K., Eubanks, A., Herekar, A., Shimoga, D., Ayyala, D. N., McLeod, C., Kurek, J. A., Morgan, J. C., Rao, S. S. C. & Sharma, A., Mar 2024, In: Neurogastroenterology and Motility. 36, 3, e14728.Research output: Contribution to journal › Article › peer-review |
​ Stroke and Obstructive Sleep Apnea: What Patients Need to KnowKutty, R. G., Giurgiutiu, D. V., Kwon, Y. & Healy, W. J., Mar 2024, In: ATS Scholar. 5, 1, p. 218-219 2 p.Research output: Contribution to journal › Article › peer-review |
​ Allogeneic Stem Cell Therapy for Acute Ischemic Stroke: The Phase 2/3 TREASURE Randomized Clinical TrialHoukin, K., Osanai, T., Uchiyama, S., Minematsu, K., Taguchi, A., Maruichi, K., Niiya, Y., Asaoka, K., Kuga, Y., Takizawa, K., Haraguchi, K., Yoshimura, S., Kimura, K., Tokunaga, K., Aoyama, A., Ikawa, F., Inenaga, C., Abe, T., Tominaga, A. & Takahashi, S. & 8 others, Kudo, K., Fujimura, M., Sugiyama, T., Ito, M., Kawabori, M., Hess, D. C., Savitz, S. I. & Hirano, T., Feb 12 2024, In: JAMA Neurology. 81, 2, p. 154-162 9 p.Research output: Contribution to journal › Article › peer-review |
​ An Aerosol Jet Printed Microcoil for Cochlear Micromagnetic StimulationGanesh, S., Sarreal, R. R. S., Blake, D., Tridandapani, S. & Bhatti, P. T., 2024, 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 - Proceedings. Institute of Electrical and Electronics Engineers Inc., (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution |
​ Cardiovascular and cerebrovascular changes during pregnancyShah, M. & Lee, K., Dec 8 2023, Neurological Disorders in Pregnancy: A Comprehensive Clinical Guide. Springer International Publishing, p. 117-129 13 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter |
​ Rheo-Erythrocrine Dysfunction as a Biomarker for Remote Ischemic Conditioning Treatment in Acute Ischemic Stroke: A Pilot Randomized Controlled TrialKjølhede, M., Andersen, G., Valentin, J. B., Nielsen, M. C., Andersen, M. N., Khan, M. B., Bech, J. N., Hess, D. C. & Blauenfeldt, R. A., Nov 21 2023, In: Journal of the American Heart Association. 12, 22, e031466.Research output: Contribution to journal › Letter › peer-review |
​ Rethinking NBM DBS: Intermittent stimulation improves sustained attention in Parkinson's diseaseSasikumar, S., Cohn, M., Youm, A., Duncan, K., Boogers, A., Strafella, A. P., Blake, D. T. & Fasano, A., Nov 1 2023, In: Brain Stimulation. 16, 6, p. 1643-1645 3 p.Research output: Contribution to journal › Letter › peer-review |
​ Remote Ischemic Conditioning for Acute Stroke: The RESIST Randomized Clinical TrialBlauenfeldt, R. A., Hjort, N., Valentin, J. B., Homburg, A. M., Modrau, B., Sandal, B. F., Gude, M. F., Hougaard, K. D., Damgaard, D., Poulsen, M., Diedrichsen, T., Schmitz, M. L., Von Weitzel-Mudersbach, P., Christensen, A. A., Figlewski, K., Grove, E. L., Hreiðarsdóttir, M. K., Lassesen, H. M., Wittrock, D. & Mikkelsen, S. & 19 others, Væggemose, U., Juelsgaard, P., Kirkegaard, H., Rostgaard-Knudsen, M., Degn, N., Vestergaard, S. B., Damsbo, A. G., Iversen, A. B., Mortensen, J. K., Petersson, J., Christensen, T., Behrndtz, A. B., Bøtker, H. E., Gaist, D., Fisher, M., Hess, D. C., Johnsen, S. P., Simonsen, C. Z. & Andersen, G., Oct 3 2023, In: JAMA. 330, 13, p. 1236-1246 11 p.Research output: Contribution to journal › Article › peer-review |
​ Concurrent Cardio-Cerebral Infarctions in COVID-19: A Systematic Review of Published Case Reports/SeriesDesai, R., Mondal, A., Prasad, A., Vyas, A., Jain, A., Rupareliya, C., Shah, M., Paul, T., Kumar, G. & Sachdeva, R., Oct 2023, In: Current Problems in Cardiology. 48, 10, 101814.Research output: Contribution to journal › Review article › peer-review |
​ A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic strokeLyden, P. D., Diniz, M. A., Bosetti, F., Lamb, J., Nagarkatti, K. A., Rogatko, A., Kim, S., Cabeen, R. P., Koenig, J. I., Akhter, K., Arbab, A. S., Avery, B. D., Beatty, H. E., Bibic, A., Cao, S., Boisserand, L. S. B., Chamorro, A., Chauhan, A., Diaz-Perez, S. & Dhandapani, K. & 29 others, Dhanesha, N., Goh, A., Herman, A. L., Hyder, F., Imai, T., Johnson, C. W., Khan, M. B., Kamat, P., Karuppagounder, S. S., Kumskova, M., Mihailovic, J. M., Mandeville, J. B., Morais, A., Patel, R. B., Sanganahalli, B. G., Smith, C., Shi, Y., Sutariya, B., Thedens, D., Qin, T., Velazquez, S. E., Aronowski, J., Ayata, C., Chauhan, A. K., Leira, E. C., Hess, D. C., Koehler, R. C., McCullough, L. D. & Sansing, L. H., Sep 20 2023, In: Science Translational Medicine. 15, 714, eadg8656.Research output: Contribution to journal › Article › peer-review |
​ Safety and Tolerability of Direct Ischemic Postconditioning Following Thrombectomy for Acute Ischemic StrokeWu, L., Wei, M., Zhang, B., Zhang, B., Chen, J., Wang, S., Luo, L., Liu, S., Li, S., Ren, C., Hess, D. C., Song, H., Zhao, W. & Ji, X., Sep 1 2023, In: Stroke. 54, 9, p. 2442-2445 4 p.Research output: Contribution to journal › Article › peer-review |
​ Remote Ischemic Conditioning: Challenges and OpportunitiesZhao, W., Hausenloy, D. J., Hess, D. C., Yellon, D. M. & Ji, X., Aug 1 2023, In: Stroke. 54, 8, p. 2204-2207 4 p.Research output: Contribution to journal › Review article › peer-review |
​ Pre-stroke Adherence to Hypertension Medications in a Bi-racial United States Stroke BeltBruno, A., Muppa, J. & Cabahug, I. N. K., Jul 2023, In: High Blood Pressure and Cardiovascular Prevention. 30, 4, p. 333-336 4 p.Research output: Contribution to journal › Article › peer-review |

