
Our research program aims to identify prevention measures and effective treatments for patients with neurological disorders. Our research is divided into various subspecialties, such as stroke, dementia, neuromuscular disorders, epilepsy, and multiple sclerosis. Patients with specific neurological conditions, who meet study-specific criteria, are invited to participate in our clinical research studies.
Our clinical research activities are coordinated by a dedicated team of trained research coordinators under the leadership of Brandy Quarles. Additional staff include advanced practice providers, nurses, and therapists. Our research faculty have subspecialty training that includes research methodology, and all research is conducted under the oversight of Central and Local Institutional Review Boards. Our research funding is derived from a combination of medical industry sponsors and the National Institute of Health.
We offer a wide variety of research opportunities with our largest research projects reaching an international level and including dozens of qualified medical centers. In addition to large, multicenter clinical research, we also conduct many smaller scale investigations that involve our medical students, neurology and neurosurgery trainees. These smaller local projects introduce future physicians to research methodology as well as the essential elements of the ethical and scientific standards associated with Good Clinical Practice in human research. The findings from our local research are presented at regional and national scientific meetings.
As a medical research unit, we strive to make scientific discoveries to improve the healthcare of patients with neurological conditions.
| Publication |
|---|
​ Counseling Reproductive-Age Youth With Epilepsy: Literature Review and Expert Opinion From the Epilepsy in the Child-Bearing Ages Through Menopause ConsortiumClements, M. E., Briscoe, C., Curcio, A. M., Douglass, L. M., Kassiri, J., Liu, L. C., Mathias, S. V., Moore-Hill, D. T., Nalluri, D., Nath, A., Romeu, A. M., Syed, T., Vinarsky, V., Wiener, S., Yang, Q. Z. J. J., Betstadt, S. J., Harrison, E. I., Kulkarni, N., Puntambekar, P. & Samanta, D. & 3 others, Singla, L., Voinescu, P. E. & Kirkpatrick, L., Feb 2026, In: Pediatric Neurology. 175, p. 90-101 12 p.Research output: Contribution to journal › Review article › peer-review |
​ The Effect of Remote Ischemic Conditioning in Patients Treated with Endovascular Therapy: A RESIST Trial Post Hoc StudyBlauenfeldt, R. A., Hess, D. C., Gaist, D., Modrau, B., Valentin, J. B., Johnsen, S. P., Hjort, N., Behrndtz, A. B., Gude, M. F., Zhao, W., Jensen, J., Andersen, G. & Simonsen, C. Z., Dec 2025, In: Translational Stroke Research. 16, 6, p. 2173-2184 12 p.Research output: Contribution to journal › Article › peer-review |
​ Perioperative neurocognitive disorders: Advances in molecular mechanisms and bioactive moleculesMao, L., Wang, L., Huang, Z., Switzer, J. A., Hess, D. C. & Zhang, Q., Dec 2025, In: Ageing Research Reviews. 112, 102885.Research output: Contribution to journal › Review article › peer-review |
​ Prescribing Practices of Antiseizure Medications at US Academic Medical Centers for Pregnant People With and Without EpilepsyVoinescu, P. E., Seliger, J., Gerard, E. E., Birnbaum, A. K., Johnson, E. L., Pennell, P. B., Tsai, J. J., Nath, A., Jacobs, C. S., Decker, B. M., Mihaylova, T. G., Singla, L., Munger Clary, H. M., Cavitt, J., Gedzelman, E., Sazgar, M., Krishnaiengar, S., Zarroli, K., Smith, F. & Serafini, A. & 4 others, Hanna, J., Velez-Ruiz, N., Moore-Hill, D. & Meador, K. J., Oct 21 2025, In: Neurology. 105, 8, p. e214219Research output: Contribution to journal › Article › peer-review |
​ Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation ControlNaeini, S. E., Bhandari, B., Hill, B., Perez-Morales, N., Rogers, H. M., Khodadadi, H., Young, N., Maciel, L. M., Yu, J. C., Hess, D. C., Morgan, J. C., Salles, É. L., Wang, L. P. & Baban, B., Oct 2025, In: eNeuro. 12, 10Research output: Contribution to journal › Article › peer-review |
​ Leveraging Medical Licensure for Safer Artificial Intelligence Use in Health CareMiller, D. D., Kamath, M. V., Albers, J. & Hess, D. C., Oct 2025, In: American Journal of Medicine. 138, 10, p. 1319-1321 3 p.Research output: Contribution to journal › Editorial › peer-review |
​ Flutter Sucking: Voluntary Tongue Tremor in InfancyMorgan, L. B., Kurek, J. A., Sekul, E. A. & Morgan, J. C., Sep 2025, In: Movement Disorders Clinical Practice. 12, 9, p. 1415-1416 2 p.Research output: Contribution to journal › Article › peer-review |
​ Determinants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN TrialJin, X., Morais, A., Imai, T., Lamb, J., Nagarkatti, K., Boisserand, L., Beatty, H. E., Sansing, L. H., Khan, M. B., Dhandapani, K., Kamat, P., Hess, D. C., Patel, R. B., Kumskova, M., Chauhan, A. K., McCullough, L. D., Aronowski, J., Leira, E. C., Shi, Y. & Avery, B. D. & 3 others, Koehler, R. C., Lyden, P. D. & Ayata, C., Sep 2025, In: Stroke. 56, 9, p. 2734-2747 14 p.Research output: Contribution to journal › Article › peer-review |
​ Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trialJin, T., Niu, H., Liu, L., Yin, Y., Zhao, W., Feng, X., Xu, L., Hess, D. C., Liu, A. & Ji, X., Aug 11 2025, In: BMJ Open. 15, 8, e101350.Research output: Contribution to journal › Article › peer-review |
​ Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive RatsAlshammari, A., Pillai, B., Kamat, P., Jones, T. W., Bosomtwi, A., Khan, M. B., Hess, D. C., Li, W., Somanath, P. R., Sayed, M. A., Ergul, A. & Fagan, S. C., Jun 2025, In: Translational Stroke Research. 16, 3, p. 584-599 16 p., e0180738.Research output: Contribution to journal › Article › peer-review |
​ Correction to: Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats (Translational Stroke Research, (2025), 16, 3, (584-599), 10.1007/s12975-024-01232-1)Alshammari, A., Pillai, B., Kamat, P., Jones, T. W., Bosomtwi, A., Khan, M. B., Hess, D. C., Li, W., Somanath, P. R., Sayed, M. A., Ergul, A. & Fagan, S. C., Jun 2025, In: Translational Stroke Research. 16, 3, p. 1029 1 p.Research output: Contribution to journal › Comment/debate › peer-review |
​ Effect of Remote Ischemic Conditioning and Red Blood Cells Biomarkers on Outcomes in Patients With Acute StrokeBlauenfeldt, R. A., Maghsoodpour, A., Drasbek, K. R., Bech, J. N., Hvas, A. M., Larsen, J. B., Andersen, M. N., Nielsen, M. C., Kjølhede, M., Kjeldsen, M., Gude, M. F., Khan, M. B., Baban, B., Andersen, G. & Hess, D. C., May 20 2025, In: Journal of the American Heart Association. 14, 10, e040787.Research output: Contribution to journal › Article › peer-review |
​ NORSE secondary to anti-GAD65 antibody-positive encephalitis treated with novel adjunctive rapid titration VNS protocolLi, M., Yalcin, N., Weiss, D. L., Hill, L. A. T., Shah, M., Garcia, K. A., Vale Diaz, F. L., Rueda Carrillo, L. G., Smith, H. & Moore-Hill, D. T., Apr 2025, In: Epilepsia Open. 10, 2, p. 581-586 6 p.Research output: Contribution to journal › Article › peer-review |
​ Acute-Phase Recording of the Spreading Depolarization Continuum in Aged Nonhuman Primates during Focal Ischemic StrokeSword, J. J., Sparks, T., Debs, L. H., Major, S., Sharma, S., Jensen, M. A., Moore-Hill, D. T., Barton, K., Shah, M., Garcia, K. A., Switzer, J. A., Blake, D. T., Vale, F. L., Dreier, J. P., Hartings, J. A. & Kirov, S. A., Apr 1 2025, In: Stroke. 56, 4, p. 974-986 13 p.Research output: Contribution to journal › Article › peer-review |
​ Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical TrialPatel, R. B., Kumskova, M., Kodali, H., Budnik, I., Kuznetsov, V., Jain, A., Jha, A., Thedens, D., Dhanesha, N., Sutariya, B., Nagarkatti, K. A., Lamb, J., Kamat, P., Shi, Y., Avery, B., Imai, T., Jin, X., Chauhan, A., Boisserand, L. S. B. & Khan, M. B. & 14 others, Dhandapani, K., Sanganahalli, B. G., Sansing, L. H., Hess, D. C., Koehler, R. C., McCullough, L. D., Aronowski, J., Ayata, C., Diniz, M. A., Lyden, P. D., Planas, A. M., Chamorro, A., Chauhan, A. K. & Leira, E. C., Apr 1 2025, In: Stroke. 56, 4, p. 965-973 9 p.Research output: Contribution to journal › Article › peer-review |
​ Analysis of participant race and sex reporting and disparities in US epilepsy clinical trialsButler, M., Palacios, M. E., Carr, C., Moore-Hill, D. & Vale, F. L., Mar 2025, In: Epilepsia. 66, 3, p. 768-775 8 p.Research output: Contribution to journal › Article › peer-review |
​ Cortical acetylcholine response to deep brain stimulation of the basal forebrain in miceShanazz, K., Xie, K., Oliver, T., Bogan, J., Vale, F. L., Sword, J., Kirov, S. A., Terry, A., O’Herron, P. & Blake, D. T., Mar 2025, In: Journal of Neurophysiology. 133, 3, p. 825-838 14 p.Research output: Contribution to journal › Article › peer-review |
​ Basal forebrain activation improves working memory in senescent monkeysPennington, K. R., Debs, L., Chung, S., Bava, J., Garin, C. M., Vale, F. L., Bick, S. K., Englot, D. J., Terry, A. V., Constantinidis, C. & Blake, D. T., Mar 1 2025, In: Brain Stimulation. 18, 2, p. 185-194 10 p.Research output: Contribution to journal › Article › peer-review |
​ Pupillary changes in pentobarbital coma mimicking a neurocritical care emergencyRueda-Carrillo, L., Li, M., Garcia, K. A., Shah, M. & Yalcin, N., Feb 2025, In: Acta Neurologica Belgica. 125, 1, p. 261-264 4 p.Research output: Contribution to journal › Letter › peer-review |
​ Time of day dependent reduction in stroke infarct volume by the Reverb agonist SR9009 in miceKamat, P. K., Khan, M. B., Siddiqui, S., Hattaway, T. G., Anas, A., Rudic, R. D., Baban, B., Dhandapani, K. M. & Hess, D. C., Feb 2025, In: Experimental Neurology. 384, 115067.Research output: Contribution to journal › Article › peer-review |
​ Photobiomodulation: shining a light on depressionWang, L., Mao, L., Huang, Z., Switzer, J. A., Hess, D. C. & Zhang, Q., 2025, In: Theranostics. 15, 2, p. 362-383 22 p.Research output: Contribution to journal › Review article › peer-review |
​ ALSUntangled #76: Wahls protocolLi, X., Wicks, P., Brown, A., Shivaprasad, A., Greene, M., Crayle, J., Barnes, B., Jhooty, S., Ratner, D., Olby, N., Glass, J. D., Jackson, C., Cole, N., Armon, C., Mascias Cadavid, J., Pattee, G., Mcdermott, C. J., Chang, V., Maragakis, N. & Bertorini, T. & 2 others, Bowser, R. & Bedlack, R., 2025, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 26, 1-2, p. 181-185 5 p.Research output: Contribution to journal › Review article › peer-review |
​ Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo strokeAlptekin, A., Khan, M. B., Parvin, M., Chowdhury, H., Kashif, S., Selina, F. A., Bushra, A., Kelleher, J., Ghosh, S., Williams, D., Blumling, E., Ara, R., Bosomtwi, A., Frank, J. A., Dhandapani, K. M. & Arbab, A. S., 2025, In: Frontiers in Neurology. 16, 1543133.Research output: Contribution to journal › Article › peer-review |
​ Optimization of seizure prevention by cannabidiol (CBD)Bhandari, B., Naeini, S. E., Rezaee, S., Rogers, H. M., Khodadadi, H., Bosomtwi, A., Seyyedi, M., MacKinnon, N. J., Dhandapani, K. M., Salles, É. L., Hess, D. C., Yu, J. C., Moore-Hill, D., Vale, F. L., Wang, L. P. & Baban, B., Jan 1 2025, In: Translational Neuroscience. 16, 1, 20220362.Research output: Contribution to journal › Article › peer-review |
​ A Case Report of Bartonella henselae-Related New-Onset Refractory Status Epilepticus / Febrile Infection–Related Epilepsy Syndrome Complicated With Stimulus-Induced Rhythmic, Periodic, or Ictal DischargesLi, M., Rueda Carrillo, L. G., Park, Y., Strickland, S., Andrews, A. & Aquino-Cabrera, M., 2025, (Accepted/In press) In: Journal of Child Neurology. 08830738251381702.Research output: Contribution to journal › Article › peer-review |
​ Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusionZong, X., Huang, Z., Kong, F., Feng, Y., Zhang, Y., Zou, P., Wen Lin, H., Hess, D. C. & Zhang, Q., 2025, (Accepted/In press) In: Journal of Cerebral Blood Flow and Metabolism. 0271678X251382874.Research output: Contribution to journal › Article › peer-review |
​ Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literatureButler, M., Carr, C., Mehra, M., Barnett, A. M., Salley, J., Chauhan, A., Belakhlef, S., Wallace, G. C., Rutkowski, M., Vender, J. & Vale, F. L., 2025, In: Surgical Neurology International. 16, 136.Research output: Contribution to journal › Article › peer-review |
​ ALSUntangled #80: ISRIB (Integrated stress response InhiBitor)Mascias Cadavid, J., Mena Bravo, A., Barkhaus, P., Barnes, B., Benatar, M., Breevoort, S., Brown, A., Carter, G. T., Crayle, J., Foucher, J., Heiman-Patterson, T., Hobson, E., Jackson, C., Jhooty, S., Mallon, E., Mcdermott, C., Pattee, G., Pierce, K., Pioro, E. & Ratner, D. & 4 others, Rivner, M. H., Tito, E., Wicks, P. & Bedlack, R., 2025, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 26, 7-8, p. 821-824 4 p.Research output: Contribution to journal › Article › peer-review |
​ Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trialCHARM Trial investigators, Dec 2024, In: The Lancet Neurology. 23, 12, p. 1205-1213 9 p.Research output: Contribution to journal › Article › peer-review |
​ Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and strokeHuang, Z., Xu, P., Hess, D. C. & Zhang, Q., Dec 2024, In: Translational Neurodegeneration. 13, 1, 61.Research output: Contribution to journal › Review article › peer-review |
​ Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective reviewWallace, G., Kundalia, R., Vallebuona, E., Cao, B., Kim, Y., Forsyth, P., Soyano, A., Smalley, I. & Pina, Y., Dec 2024, In: Breast Cancer Research. 26, 1, 55.Research output: Contribution to journal › Article › peer-review |
​ Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s DiseaseKhodadadi, H., Salles, É. L., Naeini, S. E., Bhandari, B., Rogers, H. M., Gouron, J., Meeks, W., Terry, A. V., Pillai, A., Yu, J. C., Morgan, J. C., Vaibhav, K., Hess, D. C., Dhandapani, K. M., Wang, L. P. & Baban, B., Nov 2024, In: International journal of molecular sciences. 25, 21, 11764.Research output: Contribution to journal › Article › peer-review |
​ The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changesPatel, S., Khan, M. B., Kumar, S., Vyavahare, S., Mendhe, B., Lee, T. J., Cai, J., Isales, C. M., Liu, Y., Hess, D. C. & Fulzele, S., Sep 2024, In: Experimental Neurology. 379, 114867.Research output: Contribution to journal › Article › peer-review |
​ Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) TrialMorais, A., Imai, T., Jin, X., Locascio, J. J., Boisserand, L., Herman, A. L., Chauhan, A., Lamb, J., Nagarkatti, K., Diniz, M. A., Kumskova, M., Dhanesha, N., Kamat, P. K., Khan, M. B., Dhandapani, K. M., Patel, R. B., Sutariya, B., Shi, Y., van Leyen, K. & Kimberly, W. T. & 8 others, Hess, D. C., Aronowski, J., Leira, E. C., Koehler, R. C., Chauhan, A. K., Sansing, L. H., Lyden, P. D. & Ayata, C., Aug 16 2024, In: Circulation research. 135, 5, p. 575-592 18 p.Research output: Contribution to journal › Article › peer-review |
​ High Rate of Angiogram-Negative Subarachnoid Hemorrhage in a Rural Population: Role of Venous DrainageJones, E. D., Kaoutzani, L., Walker, S. E., Kollapaneni, S. S., Giurgiutiu, D. V. & Rahimi, S. Y., Aug 2024, In: World Neurosurgery. 188, p. e491-e496Research output: Contribution to journal › Article › peer-review |
​ Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson’s disease studyWestenberger, A., Skrahina, V., Usnich, T., Beetz, C., Vollstedt, E. J., Laabs, B. H., Paul, J. J., Curado, F., Skobalj, S., Gaber, H., Olmedillas, M., Bogdanovic, X., Ameziane, N., Schell, N., Aasly, J. O., Afshari, M., Agarwal, P., Aldred, J., Alonso-Frech, F. & Anderson, R. & 139 others, Araújo, R., Arkadir, D., Avenali, M., Balal, M., Benizri, S., Bette, S., Bhatia, P., Bonello, M., Braga-Neto, P., Brauneis, S., Cardoso, F. E. C., Cavallieri, F., Classen, J., Cohen, L., Coletta, D., Crosiers, D., Cullufi, P., Dashtipour, K., Demirkiran, M., de Carvalho Aguiar, P., De Rosa, A., Djaldetti, R., Dogu, O., dos Santos Ghilardi, M. G., Eggers, C., Elibol, B., Ellenbogen, A., Ertan, S., Fabiani, G., Falkenburger, B. H., Farrow, S., Fay-Karmon, T., Ferencz, G. J., Fonoff, E. T., Fragoso, Y. D., Genç, G., Gorospe, A., Grandas, F., Gruber, D., Gudesblatt, M., Gurevich, T., Hagenah, J., Hanagasi, H. A., Hassin-Baer, S., Hauser, R. A., Hernández-Vara, J., Herting, B., Hinson, V. K., Hogg, E., Hu, M. T., Hummelgen, E., Hussey, K., Infante, J., Isaacson, S. H., Jauma, S., Koleva-Alazeh, N., Kuhlenbäumer, G., Kühn, A., Litvan, I., López-Manzanares, L., Luxmore, M., Manandhar, S., Marcaud, V., Markopoulou, K., Marras, C., McKenzie, M., Matarazzo, M., Merello, M., Mollenhauer, B., Morgan, J. C., Mullin, S., Musacchio, T., Myers, B., Negrotti, A., Nieves, A., Nitsan, Z., Oskooilar, N., Öztop-Çakmak, Ö., Pal, G., Pavese, N., Percesepe, A., Piccoli, T., de Souza, C. P., Prell, T., Pulera, M., Raw, J., Reetz, K., Reiner, J., Rosenberg, D., Ruiz-Lopez, M., Martinez, J. R., Sammler, E., Santos-Lobato, B. L., Saunders-Pullman, R., Schlesinger, I., Schofield, C. M., Schumacher-Schuh, A. F., Scott, B., Sesar, Á., Shafer, S. J., Sheridan, R., Silverdale, M., Sophia, R., Spitz, M., Stathis, P., Stocchi, F., Tagliati, M., Tai, Y. F., Terwecoren, A., Thonke, S., Tönges, L., Toschi, G., Tumas, V., Urban, P. P., Vacca, L., Vandenberghe, W., Valente, E. M., Valzania, F., Vela-Desojo, L., Weill, C., Weise, D., Wojcieszek, J., Wolz, M., Yahalom, G., Yalcin-Cakmakli, G., Zittel, S., Zlotnik, Y., Kandaswamy, K. K., Balck, A., Hanssen, H., Borsche, M., Lange, L. M., Csoti, I., Lohmann, K., Kasten, M., Brüggemann, N., Rolfs, A., Klein, C. & Bauer, P., Aug 1 2024, In: Brain. 147, 8, p. 2652-2667 16 p.Research output: Contribution to journal › Article › peer-review |
​ Parkinson’s disease variant detection and disclosure: PD GENEration, a North American studyon behalf of the Parkinson’s Foundation & and Parkinson Study Group PD GENEration investigators, Aug 1 2024, In: Brain. 147, 8, p. 2668-2679 12 p.Research output: Contribution to journal › Article › peer-review |
​ A Mixed-Method Pilot Project: The Evaluation of Telehealth Training in a College of NursingHamilton, W., Walters, C. & Howington, Z., Jul 1 2024, In: Nursing Education Perspectives. 45, 4, p. 254-255 2 p.Research output: Contribution to journal › Article › peer-review |
​ Case Presentation of Autoimmune Septin-5 Cerebellar AtaxiaNijim, W., Morgan, J., Montalvo, M., McKeon, A. & McLeod, C., Jun 2024, In: Movement Disorders Clinical Practice. 11, 6, p. 734-737 4 p.Research output: Contribution to journal › Article › peer-review |
​ Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastomaWang, L. P., Chagas, P. S., Salles, É. L., Naeini, S. E., Gouron, J., Rogers, H. M., Khodadadi, H., Bhandari, B., Alptekin, A., Qin, X., Vaibhav, K., Costigliola, V., Hess, D. C., Dhandapani, K. M., Arbab, A. S., Rutkowski, M., Yu, J. C. & Baban, B., Jun 2024, In: Medical Oncology. 41, 6, 140.Research output: Contribution to journal › Article › peer-review |
