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Ruth Caldwell

Professor

Ruth Caldwell

Professor

Academic Appointment(s)

Medical College of Georgia
Department of Cellular Biology and Anatomy

Medical College of Georgia
Department of Vascular Biology Center

Medical College of Georgia
Department of Culver Vision Discovery Inst

Emeritus Faculty

Bio

I am a founding member of the Vascular Biology Center and the Vision Discovery Institute and VA Career Scientist. I have published over 140 peer reviewed articles and serve on numerous national review panels. My research is supported by grants from the NIH, VA and AHA. Our current focus is on the potential the urea cycle enzyme arginase as therapeutic target for diabetic retinopathy and other forms of ischemic retinopathy.

Education

  • Ph.D., Biopsychology. University of Memphis The, 1979

  • MS, Biopsychology University of Memphis The, 1976

  • BA, Mathematics, General Agnes Scott College, 1964

Awards & Honors

  • Keith Green Lectureship Vision Discovery Institute, 2021

  • VA Career Scientist 2015

  • Fellow of the AHA 2014

  • Excellence in Research Award 2012

  • Excellence in Research Award 2009

Courses Taught Most Recent Academic Year

  • OPTH 5002

    Ophthalmology Rsch Elect

Teaching Interests

Vascular Biology, Retinal Cell Biology

Scholarship

Selected Recent Publications

  • ARGINASE: A MULTIFACETED ENZYME IMPORTANT IN HEALTH AND DISEASE, 2018
    Manuscript
  • Adipose Tissue Constituents and the Adipokine Resistin Impair Vascular Endothelial Function in Obesity via Elevated Arginase Activity, 2017
    Conference Proceeding
  • Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway (vol 8, e71868, 2013), 2017
    Other
  • Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis, 2017
    Journal Article, Academic Journal
  • Netrin-1 is a novel regulator of vascular endothelial function in diabetes, 2017
    Journal Article, Academic Journal

Research Interests

The current focus of our group’s research is on the potential of the superoxide generating enzyme NADPH oxidase and the urea cycle enzyme arginase as therapeutic targets for diabetic retinopathy and other forms of ischemic retinopathy.

Department Service

  • VBC Search Committee 2016 - 2017

    Role: Committee Member

Professional Service

  • AHA/Vascular biology review group/reviewer 2013 - Present

    Role: Reviewer

  • VA IACUC 2010 - Present

    Role: Chairperson

  • NIH Grant Review 2017 - 2018

    Role: Committee Member

  • NIH National Eye Institute/Study Section/Ad hoc Review group member 2012 - 2016

    Role: Reviewer