Dongwen Lyu
Assistant Professor
Dongwen Lyu
Assistant Professor
Academic Appointment(s)
Medical College of Georgia
Department of Cellular Biology and Anatomy
Administration
Department of The Graduate School
- DLYU@augusta.edu
- (706) 721-8268
- 1410 Laney-Walker Blvd, CN-3130, Augusta, GA 30912
- Personal Website
Education
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Ph.D., Genetics, General Capital Normal University, 2014
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MS, Genetics, General Capital Normal University, 2011
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BS, Biotechnology Minzu University, 2008
Courses Taught Most Recent Academic Year
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MOIM 9210
Invest of a Problem
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MOIM 8030
Biological Signaling
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BIOM 8230
Biology of Proteins in Disease
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MOIM 9040
MOIM Journal Club
Teaching Interests
I am dedicated to teaching molecular biology and drug discovery with an emphasis on translational innovation.
Scholarship
Selected Recent Publications
- Development of polyHis-targeting PROTAC degraders, 2026
Journal Article, Academic Journal - Single-Assay characterization of Ternary Complex assembly and activity in targeted protein degradation, 2025
Journal Article, Academic Journal - Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader, 2025
Journal Article, Academic Journal - Discovery of BCL-xL and BCL-w dual degrader: exploration of a new linker tethering position of ABT-263, 2025
Journal Article, Academic Journal - An unbiased proteomic platform for activity-based arginylation profiling. , 2025
Journal Article, Academic Journal
Research Interests
My research focuses on targeted protein degradation and chemical biology approaches to modulate disease-associated proteins in cancer and aging. We develop innovative small-molecule degraders—including PROTACs, molecular glues, and next-generation platforms—and dissect mechanisms regulating protein folding, arginylation, alternative splicing, and protein quality control.
Department Service
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GCC Research Faculty Recruitment Committee 2025 - Present
Role: Committee Member
College Service
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11/15/25 IGP Review 2025 - 2026
Role: Committee Member
Professional Service
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NIH Director's Pioneer 2025 - Present
Role: Committee Member
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NIH Study Section 2025 - Present
Role: Committee Member
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NIH Study Section 2025 - Present
Role: Committee Member
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Angew. Chem. Int. Ed 2024 - Present
Role: Reviewer
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Drug Discovery Today 2024 - Present
Role: Reviewer