Investigators on this PPG are listed in bold font
Nagarkoti S, Kim Y-M, Das A, Ash D, Vitriol EA, Read T-A, Sudhahar V, Hossain MS, Yadav S, Kelley Spears S, Orji N.K, Romero MJ, Lucas R, Stepp DW, de Chantemèle EB. Caldwell RB, Fulton DJR, Fukai T, Ushio-Fukai M. Endothelial Drp1 Integrates VEGF-induced Redox Signaling with Glycolysis through Cysteine Oxidation to Drive Angiogenesis. Nature Communications. 2026 May 20. PMID: 42161931.
Haigh S, Chen F, Yu Y, Bordan Z, Li X, Sridhar S, Romero MJ, Chakraborty T, Csanyi G, Joshua AT, Patel TV, Brown ZL, Shivers MA, Sellers HG, Anana F, Fukai T, Ushio-Fukai M, de Chantemele EB, Verin A, Stepp DW, Lucas R, Fulton DJR. Nox1-derived ROS Amplifies Calcium Entry and Enhances Pneumolysin-induced Lung Endothelial Barrier Dysfunction in Hyperglycemia. Antioxidant. 2026. 15(3):275. PMID: 41897422.
Ono Y, Kennard S, Wall BR, Ma J, Belin de Chantemèle EJ. Adipocyte Leptin Signaling Promotes Brown Adipose Tissue Browning Enhancing Energy Expenditure, Glycemic Control and Cardiovascular Function in Males. Diabetes. 2026. db250388. doi: 10.2337/db25-0388. Online ahead of print. PMID: 41490102.
Padgett CA, Butcher JT, Larion S, Mintz JD, Fulton DJR, Stepp DW. NADPH Oxidase 1 Mediates Endothelial Dysfunction and Hypertension in a Murine Model of Obesity. Antioxidants. 2026.15(1):60. PMID: 41596118 .
Yadav S, Ganta V, Sudhahar V, Ong Vy, Shi Y, Das A, Ash D, Nagarkoti S, Das A, McMenamin M, Kelley S, Fukai T, Ushio-Fukai M. Myeloid Drp1 Deficiency Limits Revascularization in Ischemic Muscles via Inflammatory Macrophage Polarization and Metabolic Reprograming. JCI insight.2025. 10:e177334. PMID: 39589842.
Sudhahar V, Abdelsaid K, Eaton P, Kelley S, Ushio-Fukai M, Fukai T. Exercise-Induced SOD3/H2O2 Sulfenylates PKG1α to Restore Vasodilation in Diabetes. Circ Res. 2025;137(3):449-452. PMID: 40552426.
Batori RK, Bordan Z, Padgett CA, Huo Y, Chen F, Atawia RT, Lucas R, Ushio-Fukai M, Fukai T, Belin de Chantemele EJ, Stepp DW, Fulton DJR. PFKFB3 Connects Glycolytic Metabolism with Endothelial Dysfunction in Human and Rodent Obesity. Antioxidants. 2025.14(2). PMID: 40002359.
Eaton DC, Romero MJ, Matthay MA, Hamacher J, Advani A, Wolf A, Abu Mraheil M, Chakraborty T, Stepp DW, Belin de Chantemèle EJ, Kutlar A, Kraft F, Zeitlinger M, Kranke P, Frank S, Su Y, Verin AD, Fulton DJR, Ushio-Fukai M, Fukai T, Lucas R. Endothelial ENaC as a repressor of oxidative stress and a guardian of lung capillary barrier function in bacterial and viral pneumonia. Frontiers in physiology. 2025. 16:1562626. PMID: 40260205.
Maishan M, Taenaka H, Evrard B, Matsumoto S, Ringor A, Leroux C, Lucas R, Matthay MA. The lectin-like domain of TNF reduces pneumonia-induced injury in the perfused human lung. JCI insight. 2025. 10(11). PMID: 40485585.
Fukai T, Ushio-Fukai M. Splicing factor kinase SRPK1 inhibition in monocyte: a novel therapeutic approach for peripheral arterial disease. American journal of physiology. Heart and circulatory physiology. 2025. 329(3):H1054-H1057. PMID: 40095455.
Yamamoto M, Ash D, Sudhahar V, Zaidi SAH, Rojas MA, Xu Z, Kelley Spears S, Caldwell RB, Fukai T, Ushio-Fukai M. Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury. Investigative ophthalmology & visual science. 2025. 66(12):70. PMID: 41025873.
López Moreno SF, Lenz SA, Casso-Chapa B, Paniagua-Bojorges A, Kim JH, Palaskas NL, Nead KT, Samanthapudi VSK, Mejia G, Hoang O, Lee J, Lin SH, Herrmann J, Wang G, Yusuf SW, Iliescu CA, Beinart NI, Manisty C, Ushio-Fukai M, Fukai T, Ameri P, Nurieva RI, Hildebrandt MAT, Schadler K, Koutroumpakis E, Kotla S, Le NT, Abe JI. SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk. Antioxidants. 2025.14(12). PMID: 41462587.
Kress TC, Barris CT, Kennard, S, Belin de Chantemele, EJ. Novel Experimental Approach to investigate immune control of vascular function: Co-Culture of Murine Aortas with T Lymphocytes or Macrophages. Bio Protoc. 2025. 15(17):e5440. PMID: 40948901.
Barris CT, Kress TC, Antonova G, Jordan CR, Newman A, Faulkner JL, Saeed MI, Kennard S, Belin de Chantemèle EJ. Female Sex Hormones Do Not Drive the Sex-Specific Mechanisms of Obesity-Related Hypertension. Am J Physiol Heart Circ Physiol. 2025. 329(6):H1526-H1535. PMID: 41187991.
Sudhahar V, Xiao Z, Das A, Ash D, Yadav S, Matier CD, Pezacki AT, Chatterjee B, Antipova OA, Vogt S, McMenamin M, Kelley S, Csanyi G, Lee J, Jo H, Chang CJ, Rao J, Kaplan JH, Ushio-Fukai M, Fukai T. Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis. 2025. bioRxiv. PMID: 39975331.
Hossain MS, Das A, Rafiq AM, Deák F, Bagi Z, Outlaw R, Sudhahar V, Yamamoto M, Kaplan JH, Ushio-Fukai M, Fukai T. Altered copper transport in oxidative stress-dependent brain endothelial barrier dysfunction associated with Alzheimer's disease. Vascular pharmacology. 2024.157:107433. PMID: 39317307.
Investigators on this PPG are listed in bold font
Nagarkoti S, Das A, Ash D, Kelley S, Lucas R, Stepp D, de Chantemele EB, Fulton DJR, Fukai T, Ushio- Fukai M. Excess Glycolysis-Driven ROS Limit VEGFR2 Activation and Reparative Angiogenesis in Type1 Diabetes via Cysteine Oxidation of VEGFR2. SfRBM Washington DC, 2025.
Ash D, Youn S-W, Varadarajan S, Das A, Kelley S, Lucas R, Stepp D, Fulton DJR, de Chantemele EB, Hill BG, Kaplan JH, Ushio-Fukai M, Fukai T. The P-type ATPase transporter ATP7A as a Critical Regulator of Copper Metabolism, Metabolic Reprogramming, and EndMT in Atherosclerosis. SfRBM Washington DC, 2025.
Salon A, Kennard S, Wall B, Stepp DW, Lucas R, Fukai T, Ushio-Fukai M, Fulton DJR, de Chantemele EB. Sex Hormone-dependent Mechanisms of Endothelial Dysfunction and Inflammation in Type1 diabetes. SfRBM Washington DC, 2025.
Salon A, Nagarkoti S, Kelley S, Lucas R, Stepp DW, Fulton DJR, Fukai T, Ushio-Fukai M, de Chantemele EB. Reducing Endothelial Glycolysis Impairs Vascular Function and Drives Sex-Specific Metabolic Changes. SfRBM Washington DC, 2025.
Sudhahar V, Xiao Z, Das A, Ash D, Yadav S, Kelley S, Lee J, Jo H, Chang CJ, Rao J, Kaplan JH, Ushio- Fukai M, Fukai T Mechanistic Insight into Disturbed Flow–Induced Mitochondrial Copper Overload and Cuproptosis in Atherosclerosis. AHA Scientific Meeting. New Orleans. 2025.
Yadav S, Kelley S, Fukai T, Ushio-Fukai M. Macrophage Cu Transporter CTR1 deficiency Impairs Post- Ischemic Revascularization by Promoting cGAS-STNG Pathway and Pro-Inflammatory Macrophage Phenotypes. AHA Scientific Meeting. New Orleans. 2025.
Das A, Chatterjee B, Kaplan JH, Fukai T, Ushio-Fukai M. Novel Role of Copper Transporter CTR1 in VEGF- C-induced VEGFR3 Signaling and Lymphangiogenesis. AHA Scientific Meeting. New Orleans. 2025.
Hossain MS, Das A, Bennet A, Rafiq AM, Miller J, Vaibhav K, Deák F, Kang S, Kelly S, Sudhahar V, Ushio- Fukai M, Fukai T. Cu Transport Proteins as Novel Therapeutic Targets for Cu-dependent Brain Endothelial Barrier Dysfunction and Cuproptosis linked to Alzheimer’s Disease Society for Redox Biology and Medicine (SfRBM). Washington DC, 2025.
Salon A, Kennard S, Wall B, Belin de Chantemèle EJ. Type 1 Diabetes Alters Endothelium- Dependent Relaxation and Endothelial Cell Bioenergetics More Severally in Young Female than aged-match Male mice. American Physiological Society Summit, Baltimore, ML, April 2025.
Saloň A, Kennard S, Wall B, Stepp DW, Lucas R, Fukai T, Ushio-Fukai M, Fulton DJR, Belin de Chantemèle EJ. Type 1 Diabetes Impairs Endothelial Function and Promotes Systemic Inflammation via Sex Hormone-Dependent Mechanisms in Mice. Vascular Biology 2025, NAVBO, Cape Cod, MS, October 2025.