Cellular Biology & Anatomy Faculty - Dr. Zhang
Ming Zhang, MD, PhD
Associate Professor
Department of Cellular Biology and Anatomy
Office: R&E Building | CB2815
Research Laboratory | CB2905
Phone: 706-721-6772
Fax: 706-721-6120
mzhang@augusta.edu
Education
1992 - Tongji Medical University, PhD.; Specialty: Pediatric Infectious Diseases
1988 - Tongji Medical University, MS; Specialty: Pediatric Infectious Diseases
1985 - Hubei Medical University, MD; Specialty: Medicine
Post Doctoral Training
1996 - 2000 - Dept. of Cellular and Structural Biology, Univ. of Texas Health Science Center at San Antonio
1992 -1995 - Division of infectious diseases, Dept. of Pediatrics, Tongji Hospital, Tongji Medical University, China
Research Interests
The primary objective of our research program is to understand the pathogenesis of cytomegalovirus and herpes simplex virus ocular infections by using mouse models and organatypic retinal culture models. Our current work includes the investigation of the mechanisms of death of bystander retinal cells during ocular murine cytomegalovirus retinitis and also determine the role of cytomegalovirus in the development of age-related macular degeneration (AMD).
Ongoing Research Support
Principal Investigator: NIH, NEI, RO1, "Mechanism of death of bystander retinal cells
during MCMV infection."
Principal Investigator: Bright Focus Foundation, Macular Degeneration Research award,
"The role of cytomegalovirus in the development of neovascular age-related macular
degeneration (AMD)."
Publications
| Publication |
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Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repairLivingston, M. J., Zhang, M., Kwon, S. H., Chen, J. K., Li, H., Manicassamy, S. & Dong, Z., 2024, In: Autophagy. 20, 5, p. 1032-1053 22 p.Research output: Contribution to journal › Article › peer-review |
Transcriptome Analysis of Retinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus InfectionZhang, X., Xu, J., Marshall, B., Dong, Z., Liu, Y., Espinosa-Heidmann, D. G. & Zhang, M., Mar 2023, In: International journal of molecular sciences. 24, 5, 4322.Research output: Contribution to journal › Article › peer-review |
Zika virus induces neuronal and vascular degeneration in developing mouse retinaLi, Y., Shi, S., Xia, F., Shan, C., Ha, Y., Zou, J., Adam, A., Zhang, M., Wang, T., Liu, H., Shi, P. Y. & Zhang, W., Dec 2021, In: Acta neuropathologica communications. 9, 1, 97.Research output: Contribution to journal › Article › peer-review |
Retinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus InfectionXu, J., Liu, X., Zhang, X., Marshall, B., Dong, Z., Smith, S. B., Espinosa-Heidmann, D. G. & Zhang, M., Oct 2021, In: American Journal of Pathology. 191, 10, p. 1787-1804 18 p.Research output: Contribution to journal › Article › peer-review |
The role of caspase‐12 in retinal bystander cell death and innate immune responses against mcmv retinitisZhang, X., Xu, J., Marshall, B., Dong, Z., Smith, S. B. & Zhang, M., Aug 1 2021, In: International journal of molecular sciences. 22, 15, 8135.Research output: Contribution to journal › Article › peer-review |
P53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney diseaseMa, Z., Li, L., Livingston, M. J., Zhang, D., Mi, Q., Zhang, M., Ding, H. F., Huo, Y., Mei, C. & Dong, Z., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 5011-5026 16 p.Research output: Contribution to journal › Article › peer-review |
Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularizationXu, J., Liu, X., Zhang, X., Marshall, B., Dong, Z., Liu, Y., Espinosa-Heidmann, D. G. & Zhang, M., Jun 1 2020, In: Journal of Pathology. 251, 2, p. 200-212 13 p.Research output: Contribution to journal › Article › peer-review |
Glycolysis inhibitors suppress renal interstitial fibrosis via divergent effects on fibroblasts and tubular cellsWei, Q., Su, J., Dong, G., Zhang, M., Huo, Y. & Dong, Z., 2019, In: American Journal of Physiology - Renal Physiology. 316, 6, p. F1162-F1172Research output: Contribution to journal › Article › peer-review |
Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates smad2/3Ma, Z., Wei, Q., Zhang, M., Chen, J. & Dong, Z., Dec 12 2018, In: American Journal of Physiology - Renal Physiology. 315, 6, p. F1822-F1832Research output: Contribution to journal › Article › peer-review |
Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infectionsXu, J., Liu, X., Mo, J., Marshall, B., Perry, L., Dong, Z. & Zhang, M., May 18 2018, In: Molecular Vision. 24, p. 379-394 16 p.Research output: Contribution to journal › Article › peer-review |
Depletion of the receptor-interacting protein kinase 3 (RIP3) decreases photoreceptor cell death during the early stages of ocular murine cytomegalovirus infectionXu, J., Mo, J., Liu, X., Marshall, B., Atherton, S. S., Dong, Z., Smith, S. & Zhang, M., May 2018, In: Investigative Ophthalmology and Visual Science. 59, 6, p. 2445-2458 14 p.Research output: Contribution to journal › Article › peer-review |
Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potentialYang, D., Livingston, M. J., Liu, Z., Dong, G., Zhang, M., Chen, J. K. & Dong, Z., Feb 1 2018, In: Cellular and Molecular Life Sciences. 75, 4, p. 669-688 20 p.Research output: Contribution to journal › Review article › peer-review |
Exosome production and its regulation of EGFR during wound healing in renal tubular cellsZhou, X., Zhang, W., Yao, Q., Zhang, H., Dong, G., Zhang, M., Liu, Y., Chen, J. & Dong, Z., 2017, In: American Journal of Physiology - Renal Physiology. 312, 6, p. F963-F970Research output: Contribution to journal › Article › peer-review |
Cytomegalovirus Blocks Autophagy During Infection of the Retinal Pigment Epithelial Cells: Functional Relationship Between Autophagy and ApoptosisZhang, M., Atherton, S. S. & Mo, J., Jan 1 2016, Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Volume 9: Human Diseases and Autophagosome. Elsevier, p. 267-279 13 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitisMo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.Research output: Contribution to journal › Article › peer-review |
Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cellsMo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In: Molecular Vision. 20, p. 1161-1173 13 p.Research output: Contribution to journal › Article › peer-review |
Decrease of murine cytomegalovirus-induced retinitis by intravenous delivery of immediate early protein-3-specific siRNAMarshall, B., Mo, J., Covar, J., Atherton, S. S. & Zhang, M., Jun 6 2014, In: Investigative Ophthalmology and Visual Science. 55, 7, p. 4151-4157 7 p.Research output: Contribution to journal › Article › peer-review |
Virus spread and immune response following anterior chamber inoculation of HSV-1 Lacking the Beclin-binding domain (BBD)Zhang, M., Covar, J., Zhang, N. Y., Chen, W., Marshall, B., Mo, J. & Atherton, S. S., 2013, In: Journal of Neuroimmunology. 260, 1-2, p. 82-91 10 p.Research output: Contribution to journal › Article › peer-review |
Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epitheliumGnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 2011, In: Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.Research output: Contribution to journal › Article › peer-review |
Lack of TNF-α promotes caspase-3-independent apoptosis during murine cytomegalovirus retinitisZhang, M., Covar, J., Marshall, B., Dong, Z. & Atherton, S. S., Mar 2011, In: Investigative Ophthalmology and Visual Science. 52, 3, p. 1800-1808 9 p.Research output: Contribution to journal › Article › peer-review |
Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infectionGnana-Prakasam, J. P., Zhang, M., Martin, P. M., Atherton, S. S., Smith, S. B. & Ganapathy, V., May 1 2009, In: Biochemical Journal. 419, 3, p. 533-543 11 p.Research output: Contribution to journal › Article › peer-review |
Murine cytomegalovirus infection and apoptosis in organotypic retinal culturesZhang, M., Marshall, B. & Atherton, S. S., Jan 2008, In: Investigative Ophthalmology and Visual Science. 49, 1, p. 295-303 9 p.Research output: Contribution to journal › Article › peer-review |
Tumor necrosis factor-α-induced apoptosis in murine cytomegalovirus retinitisZhou, J., Zhang, M. & Atherton, S. S., Apr 2007, In: Investigative Ophthalmology and Visual Science. 48, 4, p. 1691-1700 10 p.Research output: Contribution to journal › Article › peer-review |
Lack of iNOS facilitates MCMV spread in the retinaZhang, M., Zhou, J., Marshall, B., Xin, H. & Atherton, S. S., Jan 2007, In: Investigative Ophthalmology and Visual Science. 48, 1, p. 285-292 8 p.Research output: Contribution to journal › Article › peer-review |
Tumor necrosis factor alpha and macrophages in the brain of herpes simplex virus type 1-infected BALB/c miceFields, M., Zheng, M., Zhang, M. & Atherton, S. S., Dec 2006, In: Journal of NeuroVirology. 12, 6, p. 443-455 13 p.Research output: Contribution to journal › Article › peer-review |
A comprehensive system for consistent numbering of HCV sequences, proteins and epitopesKuiken, C., Combet, C., Bukh, J., Shin-I, T., Deleage, G., Mizokami, M., Richardson, R., Sablon, E., Yusim, K., Pawlotsky, J. M., Simmonds, P., Korber, B., Abfalterer, W., Calef, C., Foley, B., Funkhouser, R., Gaschen, B., Lang, D., Leitner, T. & Szinger, J. & 1 others, , Nov 2006, In: Hepatology. 44, 5, p. 1355-1361 7 p.Research output: Contribution to journal › Review article › peer-review |
Infection of retinal neurons during murine cytomegalovirus retinitisZhang, M., Xin, H., Roon, P. & Atherton, S. S., Jun 2005, In: Investigative Ophthalmology and Visual Science. 46, 6, p. 2047-2055 9 p.Research output: Contribution to journal › Article › peer-review |
Ocular reactivation of MCMV after immunosuppression of latently infected BALB/c miceZhang, M., Xin, H., Duan, Y. & Atherton, S. S., Jan 2005, In: Investigative Ophthalmology and Visual Science. 46, 1, p. 252-258 7 p.Research output: Contribution to journal › Article › peer-review |
Apoptosis in the retina during MCMV retinitis in immunosuppressed BALB/c miceZhang, M. & Atherton, S. S., Aug 2002, In: Journal of Clinical Virology. 25, SUPPL. 2, p. 137-147 11 p.Research output: Contribution to journal › Article › peer-review |
Murine Cytomegalovirus infection causes apoptosis of uninfected retinal cellsBigger, J. E., Tanigawa, M., Zhang, M. & Atherton, S. S., 2000, In: Investigative Ophthalmology and Visual Science. 41, 8, p. 2248-2254 7 p.Research output: Contribution to journal › Article › peer-review |
Identification of highly elevated levels of melatonin in bone marrow: Its origin and significanceTan, D. X., Manchester, L. C., Reiter, R. J., Qi, W. B., Zhang, M., Weintraub, S. T., Cabrera, J., Sainz, R. M. & Mayo, J. C., Oct 18 1999, In: Biochimica et Biophysica Acta - General Subjects. 1472, 1-2, p. 206-214 9 p.Research output: Contribution to journal › Article › peer-review |
Hepatitis C virus infection in different groups of children in Wuhan areaFeng, F., Yong-sui, D. & Ming, Z., Dec 1993, In: Journal of Tongji Medical University. 13, 4, p. 239-243 5 p.Research output: Contribution to journal › Article › peer-review |