Balakrishna Lokeshwar, PhDBal Lokeshwar

Dr. J. Harold Harrison M.D., Distinguished University Chair in Basic Sciences

Professor, Georgia Cancer Center, Augusta University

Co-Program Director, Biochemistry and Cancer Biology Graduate Program

Member, Molecular Oncology and Biomarkers Program

Research Summary

Dr. Bal Lokeswhar is a cancer researcher specializing in cancer prevention and therapy of prostate, bladder and breast cancer. Understanding and preventing the chronic inflammation in cancer progression is his primary research goal.

Contact Us

The Balakrishna Lokeshwar Lab

Health Sciences Campus

Georgia Cancer Center - M. Bert Storey Research Building

1410 Laney Walker Blvd., CN-3317, Augusta, GA 30912

(706) 723-0033

Research Interests

My research is focused on understanding the role of specific proteins that mediate benign and malignant prostate cancers, mechanism of drug-resistance and chemoprevention. The proteins belong to the G-Protein coupled receptors (GPCR) and those associated with their cellular signaling such as chemokines and cytokines and arrestins and growth factor receptors. The chemoprevention agents that I work on are natural, edible plant derived bioorganic compounds, such as curcumin and their analogs, triterpenes and polyphenols.

Selected Publications

Dr. Balakrishna Lokeshwar PubMed Publication Directory

Promotion of epithelial hyperplasia by interleukin-8-CXCR axis in human prostate. Smith DK, Hasanali SL, Wang J, Kallifatidis G, Morera DS, Jordan AR, Terris MK, Klaassen Z, Bollag R, Lokeshwar VB, Lokeshwar BL.Prostate. 2020 Sep;80(12):938-949. doi: 10.1002/pros.24026. Epub 2020 Jun 16. PMID: 32542667

Atypical chemokine receptors in tumor cell growth and metastasis. Lokeshwar BL, Kallifatidis G, Hoy JJ.Adv Cancer Res. 2020;145:1-27. doi: 10.1016/bs.acr.2019.12.002. Epub 2020 Jan 27.PMID: 32089162 Review.

β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer. Kallifatidis G, Smith DK, Morera DS, Gao J, Hennig MJ, Hoy JJ, Pearce RF, Dabke IR, Li J, Merseburger AS, Kuczyk MA, Lokeshwar VB, Lokeshwar BL.Mol Cancer Ther. 2019 Apr;18(4):801-811. doi: 10.1158/1535-7163.MCT-18-1167. Epub 2019 Feb 20.PMID: 30787175 Free PMC article.

Inhibition of androgen receptor promotes CXC-chemokine receptor 7-mediated prostate cancer cell survival. Hoy JJ, Kallifatidis G, Smith DK, Lokeshwar BL.Sci Rep. 2017 Jun 8;7(1):3058. doi: 10.1038/s41598-017-02918-3.PMID: 28596572 Free PMC article.

Research Team

photo of Dr. Kanza Mamouni

Dr. Kanza Mamouni

  • Senior Post-Doctoral Fellow

(706) 446-4976

photo of Dr. Georgios Kallifatidis

Dr. Georgios Kallifatidis

  • Lecturer, Augusta University

(706) 723-0033

photo of Bianca Marsh, B.S.

Bianca Marsh, B.S.

  • Research Associate
photo of Jeongheun (James) Kim, B.S.

Jeongheun (James) Kim, B.S.

  • Research Assistant