Balakrishna Lokeshwar, PhD
Dr. J. Harold Harrison M.D., Distinguished University Chair in Basic Sciences
Professor, Georgia Cancer Center, Augusta University
Co-Program Director, Biochemistry and Cancer Biology Graduate Program
Member, Molecular Oncology and Biomarkers Program
Dr. Bal Lokeswhar is a cancer researcher specializing in cancer prevention and therapy of prostate, bladder and breast cancer. Understanding and preventing the chronic inflammation in cancer progression is his primary research goal.
The Balakrishna Lokeshwar Lab
Health Sciences Campus
Georgia Cancer Center - M. Bert Storey Research Building
1410 Laney Walker Blvd., CN-3317, Augusta, GA 30912
(706) 723-0033
My research is focused on understanding the role of specific proteins that mediate benign and malignant prostate cancers, mechanism of drug-resistance and chemoprevention. The proteins belong to the G-Protein coupled receptors (GPCR) and those associated with their cellular signaling such as chemokines and cytokines and arrestins and growth factor receptors. The chemoprevention agents that I work on are natural, edible plant derived bioorganic compounds, such as curcumin and their analogs, triterpenes and polyphenols.
Promotion of epithelial hyperplasia by interleukin-8-CXCR axis in human prostate. Smith DK, Hasanali SL, Wang J, Kallifatidis G, Morera DS, Jordan AR, Terris MK, Klaassen Z, Bollag R, Lokeshwar VB, Lokeshwar BL.Prostate. 2020 Sep;80(12):938-949. doi: 10.1002/pros.24026. Epub 2020 Jun 16. PMID: 32542667
Atypical chemokine receptors in tumor cell growth and metastasis. Lokeshwar BL, Kallifatidis G, Hoy JJ.Adv Cancer Res. 2020;145:1-27. doi: 10.1016/bs.acr.2019.12.002. Epub 2020 Jan 27.PMID: 32089162 Review.
β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer. Kallifatidis G, Smith DK, Morera DS, Gao J, Hennig MJ, Hoy JJ, Pearce RF, Dabke IR, Li J, Merseburger AS, Kuczyk MA, Lokeshwar VB, Lokeshwar BL.Mol Cancer Ther. 2019 Apr;18(4):801-811. doi: 10.1158/1535-7163.MCT-18-1167. Epub 2019 Feb 20.PMID: 30787175 Free PMC article.
Inhibition of androgen receptor promotes CXC-chemokine receptor 7-mediated prostate cancer cell survival. Hoy JJ, Kallifatidis G, Smith DK, Lokeshwar BL.Sci Rep. 2017 Jun 8;7(1):3058. doi: 10.1038/s41598-017-02918-3.PMID: 28596572 Free PMC article.
