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The overall goals of the Molecular Oncology & Biomarkers program are to understand the fundamental cellular and molecular processes that contribute to cancer development and progression.

Normal cells have intricate molecular mechanisms that control essential phenotypes such as differentiation, cell division and movement. The molecular pathways that control these phenotypes are disrupted in cancer cells as a result of the expression of oncogenes and loss of regulatory tumor suppressor genes. These events, which are often highly specific to individual types of cancer, disrupt specific molecular pathways that result in uncontrolled cell growth and loss of normal responses to extracellular signaling cues that result in tumor development and progression.

The research interests of the program can be divided into three broad themes:

  • Cancer Genetics
  • Epigenetics
  • Chaperone Biology

Collectively these themes address important topics of tumor cell and molecular biology including

  • The genetic basis of cancer development and progression through the roles of specific genes and pathways
  • The genetic basis of metastasis underlying the roles of metastasis suppressor genes, metastasis promoting genes, and microRNAs involved in metastasis
  • The role of transcription factors in promoting cancer progression
  • Cancer genomics in primary human tumors and mouse models of cancer using gene expression and Next Gen sequencing;
  • Application of bioinformatics tools to study complex data sets;
  • The role of oncogenes and glycoconjugates in cancer cell progression;
  • Genome-wide analysis of epigenetic changes in cancer development as a tool to identify biomarkers for prediction of progression and prognosis;
  • Analysis of heat shock chaperones and other stress proteins in cancer development and as targets for cancer therapies;
  • The role of obesity and metabolic changes in the development of cancer.

Program Members

photo of Satyanarayana Ande, PhD

Satyanarayana Ande, PhD

  • Associate Professor
photo of Ahmed Chadli, PhD

Ahmed Chadli, PhD

  • Associate Professor
photo of Zheng Dong, PhD

Zheng Dong, PhD

  • Regent's Professor
photo of Quansheng Du, PhD

Quansheng Du, PhD

  • Associate Professor
photo of Hasan Korkaya, DVM, PhD

Hasan Korkaya, DVM, PhD

  • Assistant Professor
photo of Iryna O. Lebedyeva, PhD

Iryna O. Lebedyeva, PhD

  • Assistant Professor
photo of Vivian Lui, Ph.D.

Vivian Lui, Ph.D.

  • Associate Professor
photo of Huidong Shi, PhD

Huidong Shi, PhD

  • Professor
photo of Chunhong Yan, PhD

Chunhong Yan, PhD

  • Associate Professor

Cancer Research News

Man in black coat and shirt leans against building

Moore recognized with AACR Minorities in Cancer Research award

Dr. Justin Xavier Moore has been recognized with an American Association for Cancer Research Minorities in Cancer Research award.

Colon Cancer Awareness Month ribbon in front of picture of the Georgia Cancer Center

Oncology professor answers questions regarding National Colon Cancer Awareness Month

"Colon cancer is largely preventable if patients undergo screening tests, like a surveillance colonoscopy starting at 45 years or earlier depending on family history."

photo from article Georgia Cancer Center researcher works to develop new treatment options for liver cancer

Georgia Cancer Center researcher works to develop new treatment options for liver cancer

Despite liver cancer being the third leading cause of cancer deaths worldwide, there are not many treatment options currently available for patients. Dr. Yukai He and his team want to change that.

People standing hold a big check

Paceline donates $330,069 to advance research projects at Georgia Cancer Center

This year’s fundraising total represents a 65% increase since its inaugural event held in May 2019.