The overall goals of the Molecular Oncology & Biomarkers program are to understand the fundamental cellular and molecular processes that contribute to cancer development and progression.
Normal cells have intricate molecular mechanisms that control essential phenotypes such as differentiation, cell division and movement. The molecular pathways that control these phenotypes are disrupted in cancer cells as a result of the expression of oncogenes and loss of regulatory tumor suppressor genes. These events, which are often highly specific to individual types of cancer, disrupt specific molecular pathways that result in uncontrolled cell growth and loss of normal responses to extracellular signaling cues that result in tumor development and progression.
The research interests of the program can be divided into three broad themes:
Collectively these themes address important topics of tumor cell and molecular biology including
John K. Cowell PhD, DSc, FRCPath
Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.
Learn how a researcher at the Georgia Cancer Center is working to eliminate Georgia's breast cancer disparities.
Georgia Cancer Center researcher tackles clinical trial hesitancy in the Black community in the southeast.
MCG and Georgia Cancer Center scientists have early evidence that the peptide EnnA, isolated from a fungus living symbiotically with a flowering plant known for its penchant of trapping flies, could be a powerful opponent of aggressive triple negative breast cancer.
