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This study is made up of two parts, Dose Escaltion, and Dose Expansion. Dose escalation is to test the safety of PRT811, at different dose levels and to find outwhat effects, good and/or bad, the study drug (PRT811) has on the subject and their type of cancer. The information collected from the subjects in this study when taking different dose levels will be used to decide the highest dose of the study drug that should be used in dose expansion and for other studies which may be completed in the future.