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The objective of the study is to assess the utility of Acceptance and Commitment Therapy, ACT, in which subjects learn new ways to manage uncomfortable experiences and feelings and to engage in positive behaviors, over Supportive Psychotherapy in which subjects talk about their experiences to date in a cohort of adult Cystic Fibrosis patients. Participants will be randomly assigned to receive six session of either ACT or supportive psychotherapy. The hypothesis is that six telehealth sessions of ACT will lead to an improvement in medication and visit compliance, as well as an overall improved sense of well-being and coping skills, particularly as compared with 6 telehealth sessions of supportive psychotherapy.