Brian Stansfield, MD
Pediatric General and Adolescent Medicine
Education and Training
Residency in Pediatrics
American Academy of Pediatrics
American Medical Association
AAP section on Perinatal Pediatrics
American Society of Hematology
American Heart Association
Southern Society for Pediatric Research
The long term research interest in our laboratory is to understand the effect of inherited mutations in p21 Ras signaling on cardiovascular development and disease. Neurofibromatosis type 1 (NF1) is the result of inactivating mutations in the NF1 tumor suppressor gene and serves as a prototypical model of accelerated p21 Ras activity. NF1 patients are at increased risk of premature and severe cardiovascular disease, including hypertension, arterial stenosis, aneurysm formation, and Moya Moya. To interrogate these pathways, we utilize mutant and lineage-restricted transgenic mice in multiple model systems to induce cardiovascular disease. We are particularly interested in identifying patient-specific therapeutic targets and biomarkers of disease.
As a clinical neonatologist, I am also interested in understanding how prematurity and/or neonatal factors contribute to cardio-metabolic disease. We are active collaborators with investigators in the Georgia Prevention Institute and lead clinical projects focused on improving utilization and outcomes in patients undergoing extracorporeal membrane oxygenation (ECMO).
Department of Defense NF140031 "Characterizing Myeloid Cell Activation in NF1 Vasculopathy" 2015-2018.
Myeloid cells are principle cellular mediators of inward and outward cardiovascular remodeling in neurofibromin-deficient mice. The goal of this project is to understand how inflammation and oxidative stress, two innate properties of activated leukocytes, contribute to cardiovascular remodeling in neurofibromin-deficient mice.
Emily Pierce (Neonatal/Perinatal Medicine Fellow, 2015 - current)
Honors and Awards
2015 Caught in the Act of Great Teaching (Augusta University)
2015 Basic Science Young Investigator Award (SSPR)
2013 NIH Loan Repayment
2012 Jack Metcoff Award for Outstanding Fellow Presentation (MWSPR)
2012 Riley Pediatric Scholar
2011 Pediatric Scientist Development Program Award
2010 Red Shoes Award for Compassionate Care, Indiana University School of Medicine
2007 William P. Kanto Resident Research Award, Medical College of Georgia
2000 American Chemical Society Undergraduate Research Award
2000 Magna Cum Laude, Georgia Southern University
Journal of Perinatology
Cellular and Molecular Life Sciences
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