Dr. Ogola laboratory’s main interest is to understand the role of sex chromosomes (XX and XY) contribution to cardiovascular disease including arterial stiffening. We are particularly interested in determining specific X-linked genes that contribute to arterial stiffening and vascular malformation and maladaptation.
Additionally, we are interested in long non-coding RNA (xist) in maintenance of X chromosome inactivation in female cells. Our aim is to establish sex differences in cardiovascular disease, understand the underlying mechanisms, and identify druggable targets. We work hand in hand within Vascular Biology Center and externally collaborations. Our work involves transgenic rodents and tissue culture model.