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Research Description

Dr. Ogola laboratory’s main interest is to understand the role of sex chromosomes (XX and XY) contribution to cardiovascular disease including arterial stiffening. We are particularly interested in determining specific X-linked genes that contribute to arterial stiffening and vascular malformation and maladaptation.

Additionally, we are interested in long non-coding RNA (xist) in maintenance of X chromosome inactivation in female cells. Our aim is to establish sex differences in cardiovascular disease, understand the underlying mechanisms, and identify druggable targets.  We work hand in hand within Vascular Biology Center and externally collaborations. Our work involves transgenic rodents and tissue culture model.



Recent Publications

Visniauskas B, Kilanowski-Doroh I, Ogola BO, Mcnally AB, Horton AC, Imulinde Sugi A, Lindsey SH. Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases. J Hum Hypertens. 2022 Nov 1;doi: 10.1038/s41371-022-00771-0. [Epub ahead of print] Review. PubMed PMID: 36319856.
Ogola BO, Abshire CM, Visniauskas B, Kiley JX, Horton AC, Clark-Patterson GL, Kilanowski-Doroh I, Diaz Z, Bicego AN, McNally AB, Zimmerman MA, Groban L, Trask AJ, Miller KS, Lindsey SH. Sex differences in vascular aging and impact of GPER deletion. Am J Physiol Heart Circ Physiol2022 Aug 1;323(2):H336-H349doi: 10.1152/ajpheart.00238.2022.
Epub 2022 Jun 24. PubMed PMID: 35749718; PubMed Central PMCID: PMC9306784.
Zhang Y, Ogola BO, Iyer L, Karamyan VT, Thekkumkara T. Estrogen Metabolite 2-Methoxyestradiol Attenuates Blood Pressure in Hypertensive Rats by Downregulating Angiotensin Type 1 Receptor. Front Physiol2022;13:876777doi: 10.3389/fphys.2022.876777. eCollection 2022. PubMed PMID: 35586713; PubMed Central PMCID: PMC9108484.