Amy Abdulovic-Cui

CLASSES TAUGHT
  • BIOL 1101: Fundamentals of Biology
  • BIOL 1107: Principles of Biology I
  • BIOL 3200: Genetics
  • BIOL 4950: Developmental Biology
  • BIOL 4950: Molecular Genomics
EDUCATIONAL/CAREER BACKGROUND
  • B.S. in Biochemistry - Grove City College, Grove City, PA
  • PhD. in Biological and Biomedical Sciences - Emory University, Atlanta, GA
  • Postdoctoral Fellow at National Institute of Environmental Health Sciences - Durham, NC
FUN FACT(S)

Many people ask about the origin of my last name. Abdulovic (my maiden name) is Slovak as my grandfather grew up in the former country of Yugoslavia. Cui (my married name) is Filipino as my husband was born in the Philippines. How to say my name: Abdul (like Paula Abdul) + o + vic + Qee (sounds like bee).

I grew up in Pittsburgh PA and I am a huge football fan and of course my favorite team is the 6-time Super Bowl Champion Pittsburgh Steelers. 

It would take a person typing 60 words per minute, eight hours a day, around 50 years to type the human genome.

RESEARCH INTERESTS

My primary research focuses on all aspects of DNA fidelity. I am interested in how different agents damage DNA and then how that damage is converted into mutations with the genome. Recently, I have focused my research the mechanism of DNA replication looking specifically at how the different DNA polymerases and cellular concentrations of nucleotides affect genome stability. Currently my research focuses on genome stability of highly repetitive DNA sequences or microsatellites. Mutations in microsatellites are associated in many human cancers including Nonpolyposis Colorectal Cancer. In my research I utilize the budding yeast Saccharomyces cerevisiae as a model genetic system to examine the mutagenic potential of microsatellites.

I am also interested in using DNA sequence analysis to investigate the genetic diversity of a given population. I am currently working with Dr. Reichmuth to investigate the genetic health of multiple crab species along the coast of South Carolina and Georgia.

CURRENT UNDERGRADUATE RESEARCH PROJECTS AND STUDENTS

Atique Alam and Natasha Hashmi: Microsatellite instability with imbalanced dNTP pools
Montel Hughes: Investigating the genetic diversity of different crab species in the Satilla River
Amanda Arvidsson:  Toxicity of sodium fluoride to Saccharomyces cerevisiae
Andy Mai & Sarah Ozturk: Role of Hob1 in non-homologous end-joining in fission yeast 

FORMER UNDERGRADUATE RESEARCH PROJECTS AND STUDENTS

Austin Coleman, April Hammack and Sierra Mannix:  Investigating the genetic diversity of different crab species along the Georgia and South Carolina coast lines
Amy Jackson and Amanda Jackson: DNA polymerase fidelity across repetitive DNA
Quang Le: Determining the genetic requirements for microsatellite repeats
Vivian Nguyen: Microsatellite instability with imbalanced dNTP pools

PUBLICATIONS

1. Lujan SA, Williams JS, Pursell ZF, Abdulovic-Cui AL, Clark AB, Nick McElhinny SA, and Kunkel TA. “Mismatch repair balances leading and lagging strand DNA replication fidelity.” Plos Genetics, 2012 Oct 8 (10)

2. Abdulovic, AL, Hile, SE, Kunkel, TA, and Eckert, KA "The in vitro fidelity of yeast DNA Polymerase asu and polymerase asu holoenzymes during dinucleotide microsatellite DNA synthesis" DNA Repair 2011 May; 10(5): 497-505.

3. Abdulovic, AL, Kumar, D, Jorgen, V, Nisson AK, Kunkel, TA, and Chabes, A. "Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools." Nucleic Acids Research, 2011 March; 39(4): 1360-1371.

4. Abdulovic, AL, Minesinger, BK, Jinks-Robertson S., The effect of sequence context on spontaneous Polasu-dependent mutagenesis in Saccharomyces cerevisiae. Nucleic Acids Research, 2008 Apr;36(6):2082-2093.

5. Abdulovic AL, Minesinger, BK, Jinks-Robertson S., Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Polasu. DNA Repair 2007 Sept; 6(9): 1307-1318.

6. Kim, N, Abdulovic, AL, Gealy, R., Lippert, MJ, Jinks-Robertson, S. Transcriptional-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication DNA Repair 2007 Sept; 6(9): 1285-1296.

7. Abdulovic AL, Kim N, Jinks-Robertson S., Mutagenesis and the three R's in yeast. DNA Repair (Amst). 2006 Apr 8;5(4):409-421. 

8. Abdulovic AL, Jinks-Robertson S., The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesis. Genetics. 2006 Mar;172(3):1487-1498. 

9. Minesinger BK, Abdulovic AL, Ou TM, Jinks-Robertson S., The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae. DNA Repair (Amst). 2006 Feb 3;5(2):226-234. 

PRESENTATIONS

1. Arvidsson, A.R. and Abdulovic-Cui, A.L. “Examination of Sodium Fluoride’s effect on yeast cell growth and genomic stability.” Georgia Academy of Sciences, Augusta, GA

2.  Alam, A.I., Hashmi, N.A., and Abdulovic-Cui, A.L. “Effect of a RNR1 mutation on DNA microsatellite stability in yeast.” Georgia Academy of Sciences, Augusta, GA

3. Coleman, A., Mannix, S.D., Hammak, A.E., Reichmuth, J.M. and Abdulovic-Cui, A.L. “Successfully sequencing swimming crab mitochondrial DNA: Diversity of blue crabs and speckled crabs” Coastal Estuarine Research Federation Conference, San Diego, CA

4. Mannix, S.D., Hammak, A.E., Coleman, A.L., Reichmuth, J.M. and Abdulovic-Cui, A.L. “Population genetics of three crab species along the southeastern Atlantic coast.” Phi Kappa Phi Fine Arts and Science Conference, Augusta, GA. , Georgia Academy of Science Conference, Valdosta, GA, and Southeastern Estuarine Research Society Meeting Charleston, SC

5. Jackson, A., Jackson, A., and Abdulovic-Cui, A.L. “Investigating the fidelity of Pol? and Pol? across microsatellite sequences in vivo..” Phi Kappa Phi Fine Arts and Science Conference, Augusta, GA.

6. Le, Q., Nguyen, V., and Abdulovic-Cui, A.L. “Investigating the Mutagenic Potential of Microsatellite Sequences in Saccharomyces cerevisiae.” - Southeast Regional Yeast Meeting, Birmingham, AL. and Phi Kappa Phi Fine Arts and Science Conference, Augusta, GA.

7. Hammak, A., Mannix, S., Reichmuth, J. and Abdulovic-Cui, A.L. “Discussion of the genetic diversity of crab species along the coasts of South Carolina and Georgia” Science in the Park 2007-2011. Fort Pulaski, GA


INVITED TALKS

March 2014 - Augusta University Cancer Center Biochemistry & Molecular Biology Seminar series “Investigating DNA replication fidelity in Saccharomyces cerevisiae

October 2013 - Georgia College & State University Graduate Seminar series “Investigating the fidelity of DNA replication across microsatellite sequences in yeast”