Our immune system surveils and protects every organ in our bodies by repairing injuries, destroying pathogens and killing cancer cells.

The Immunology Center of Georgia (IMMCG) represents a new initiative by the Medical College of Georgia at Augusta University to leverage the ability of the immune system to combat disease. The IMMCG will accomplish this by assembling teams of biomedical researchers with strong records of scientific innovation and technological development.

The IMMCG will be co-directed by world-class immunologists Drs. Catherine ‘Lynn’ Hedrick and Klaus Ley, both of whom have made major discoveries linking immune cells to specific mechanisms of disease.

The goal of the IMMCG is to produce novel and effective treatments for conditions that heavily impact the communities of Georgia and the United States. The new center is aggressively recruiting faculty and staff to lead projects focused on cardiovascular disease, obesity and metabolic disorders, autoimmune and infectious disease, neurodegenerative disease and cancer.

 

IMMCG News

Haywire T cells attack protein in “bad” cholesterol

LJI research reveals how aggressive T cells can make heart disease even worse

T cells image

LA JOLLA, CA—Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation in the arteries.

The challenge is that the T cells involved in atherosclerosis are very rare and extremely hard to find in the bloodstream. “This is a classic needle-in-the-haystack problem,” says La Jolla Institute for Immunology (LJI) Professor Klaus Ley, M.D.

But T cells can’t hide forever. In a study published recently in Nature Cardiovascular Research, Ley and his colleagues describe a group of T cells that attack a protein called apolipoprotein B (APOB)

APOB is the main protein component of LDL, or “bad,” cholesterol. Dangerous plaques can form in the arteries as LDL levels increase in the bloodstream. These plaques can drive inflammation, block blood flow, and even break apart to trigger strokes and heart attacks...

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Immunology Center of Georgia

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Research.com's top 1000 Researchers, Dr. Ley