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 Shruti Sharma, PhD
 

Associate Professor
Center for Biotechnology & Genomic Medicine,
Medical College of Georgia at Augusta University
Office: 706-721-6522
    Lab: 706-721-3404
shsharma@augusta.edu
 

  

Research methods employed by the Sharma lab


Research

Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Building on my experience in vascular biology and genomic medicine, my current research focuses on understanding the role of endothelial dysfunction on vascular attributes of diabetic retinopathy. The long-term goal of my lab is to study the role of IL-6 signaling in diabetic retinopathy and uncover precise molecular mechanisms to develop novel therapeutic targets. We are currently testing a pharmacological compound, sgp130-fused chimera (sgp130Fc), to selectively inhibit the IL-6 trans-signaling pathway to prevent the inflammation and retinal vascular dysfunction associated with diabetic retinopathy. My lab is utilizing both in-vitro and rodent models of diabetic retinopathy to conduct our research.

  • Targeting of Interleukin-6 Classical and Trans-Signaling in Diabetic Retinopathy
  • Proteomics, Glycomics, and Glycoproteomic profiling in vision research
  • Discerning molecular mechanisms of Glaucomatous Optic Neuropathy 

Project 1: IL-6 Signaling MechanismProject 2: Glycoproteomics Studies

 

 

 

 

 

 

 




PROJECTS

NIH-Funded Projects

  1. 'Targeting Interleukin-6 Trans-signaling in Diabetic Retinopathy' (RO1EY026936) [Role: PI].
  2. 'Proteomic Biomarkers for Glaucomatous Optic Neuropathy' (RO1EY029728) [Role: Co-I].
  3. 'Center Core Grant for Vision Research' (P30EY031631) [Role: Co-director].

EDUCATION

PhD, Biochemistry, University of Lucknow, Lucknow, India


TEACHING

Graduate courses

  • Course Director, Translational Genomics and Proteomics (GNMD 8051)
  • Course Director, Genomic Medicine Seminar (GNMD 8060)
  • Course Director, Functional Genomics and Proteomics Using Animal Models (GNMD 8052) 

Specialty Chief Editor, Frontiers in Oxidant Physiology

Serving as Specialty Chief Editor of Frontiers in Oxidant Physiology since 2012 (impact factor: 3.367), I lead a team of 215 editors. Our goal is to publish research related to furthering the understanding of the integrative mechanisms of redox signaling in the control of complex physiological function, as this aspect is critical to our ability to understand, manage, and treat diseases associted with oxidant stress and impaired anti-oxidant defenses. As such, our interdisciplinary section includes research concerning genetic, biophysical, genomic, proteomic, cellular, molecular, biochemical, physiological, and pharmacological aspects of oxidants and redox active molecules, as well as the pathological events associated with oxidant stress.


Media Articles


Publications

More from PubMed

  1. Serum glycoproteomic alterations in patients with diabetic retinopathySharma A, Cox J, Glass J, Lee TJ, Kodeboyina SK, Zhi W, Ulrich L, Lukowski Z, Sharma S; Proteomes. (2020)
  2. Diabetes induced alterations in murine proteome are mitigated by IL-6 trans-signaling inhibition. Robinson R, Youngblood H, Iyer H, Bloom J, Lee TJ, Chang L, Lukowski Z, Zhi W, Sharma A, Sharma S; Invest Ophthalmol Vis Sci. (2020)
  3. Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy. Robinson R, Srinivasan M, Shanmugan A, Ward A, Ganapathy V, Bloom J,  Sharma A, Sharma S; Redox Biol. (2020) 
  4. Proteomic biomarkers of retinal inflammation in diabetic retinopathyYoungblood H, Robinson R, Sharma A, Sharma S; International Journal Molecular Science (2019)
  5. Unraveling the role of genetics in the pathogenesis of diabetic retinopathySharma A, Valle ML, Beveridge C, Liu Y, Sharma S; Eye (2019)
  6. Comparative STAT3-regulated gene expression profile in renal cell carcinoma subtypesRobinson RL, Sharma A, Bai S, Heneidi S, Lee TJ, Kodeboyina SK, Patel N, Sharma S; Frontiers in Oncology (2019)
  7. Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cellsValle ML, Dworshak J, Sharma A, Ibrahim AS, Al-Shabrawey M, Sharma S; Experimental Eye Research (2019)
  8. Proteomic alterations in aqueous humor from patients with primary open angle glaucomaSharma S, Bollinger KE, Kodeboyina SK, Zhi W, Patton J, Bai S, Edwards B, Ulrich L, Bogorad D, Sharma A; Investigative Ophthalmology & Visual Science (2018)
  9. IGF-binding proteins in type-1 diabetes are more severely altered in the presence of complicationsSharma A, Purohit S, Sharma S, Bai S, Zhi W, Ponny SR, Hopkins D, Steed L, Bode B, Anderson SW, She JX; Frontiers in Endocrinology (2016)
  10. Elevated serum levels of soluble TNF receptors and adhesion molecules are associated with diabetic retinopathy in patients with type-1 diabetesSharma S, Purohit S, Sharma A, Hopkins D, Steed L, Bode B, Anderson SW, Caldwell R, She JX; Mediators of Inflammation (2015)
  11. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthaseSun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman JR, Black SM; American Journal of Respiratory Cell and Molecular Biology (2014)
  12. Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injuryAggarwal S, Gross CM, Kumar S, Dimitropoulou C, Sharma S, Gorshkov BA, Sridhar S, Lu Q, Bogatcheva NV, Jezierska-Drutel AJ, Lucas R, Verin AD, Catravas JD, Black SM; American Journal of Respiratory Cell and Molecular Biology (2014)
  13. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flowOishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR; Pediatric Research (2013)
  14. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flowSharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM; Pediatric Research (2013)
  15. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flowSun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM; Antioxidants & Redox Signaling (2013)
  16. Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lambSharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM; Pulmonary Pharmacology & Therapeutics (2013)
  17. Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cellsSharma S, Sun X, Agarwal S, Rafikov R, Dasarathy S, Kumar S, Black SM; International Journal of Molecular Sciences (2012)
  18. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase ISharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM; Free Radical Biology & Medicine (2012)
  19. Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injuryAggarwal S, Dimitropoulou C, Lu Q, Black SM, Sharma S; Frontiers in Physiology (2012)
  20. PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flowSharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM; PLOS One (2012) 

GRADUATE STUDENTS

 
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 Rebekah Robinson
 
MD/PhD Student


Undergraduate: Armstrong State University, Savannah, GA
Project: IL-6/gp130 signaling in renal cell carcinoma
 
James Cox
 James Cox 
MD Student & MCG-MSP Scholar


Undergraduate: Kennesaw State University, Kennesaw, GA

Medical Scholars Program (MCG-MSP)
706-721-3404
jamcox@augusta.edu

ROTATING RESIDENTS

 
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 Jordan Herring


Department of Ophthalmology, MCG
706-721-3404  
 jherring@augusta.edu
 
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 Christopher Kuang


Department of Ophthalmology, MCG
 706-721-3404
 ckuang@augusta.edu 

LABORATORY STAFF

 
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 Justin Bloom

 


Research Assistant
706-721-3404 
 jbloom@augusta.edu
 
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 Joshua Glass

 

Research Assistant