Guest Speaker: Minglu Gao, B.E.

Friday, May 25th, 2018

guest speaker Minglu Gao

  Seminar Title:
Molecular exploration of fungal beta-lactamases and antagonisms between two maize endophytes, Fusarium verticillioides and Sarocladium zeae

Fusarium verticillioides (Fv) is a prevalent seed-borne maize endophyte capable of causing severe kernel rot and fumonisin mycotoxin contamination. Within maize kernels, Fv is primarily confined to the pedicel, while another co-occurring seed-borne fungal endophyte, Sarocladium zeae (Sz), is generally isolated in the endosperm and embryo. In vitro competition assays have indicated Sz can inhibit the growth of Fv. The two lactam-containing antibiotics produced by Sz, named pyrrocidine A and B, are associated with this inhibition of Fv. To explore the mechanism of antagonism, RNA-seq experiments were conducted by challenging the Fv with pyrrocidine B at subinhibitory concentrations. Among the most differentially expressed genes was FVEG_11089 (up-regulated 470-fold) that codes for an ABC transporter. Deletion of FVEG_11089 caused increased sensitivity of Fv to pyrrocidine B. The expression of FVEG_11089 is independent of its adjacent and similarly-induced transcription factor. Additionally, deletion of a PB-induced zinc-binding dehydrogenase gene in Fv led to >10-fold increase in fumonisin production compared to wild type. Hence, we theorize that FVEG_11089 functions in pyrrocidine B resistance by transporting the antibiotic out of the Fv cells. Exposure to pyrrocidine B may suppress fumonisin production and affect the pathogenicity of Fv. Further exploration of the antifungal resistance mechanisms addresses the overall competitive relationships of the two maize seed endophytes colonizing the same ecological niche and how they cope with xenobiotic challenges.

  

 


 

Graduate Research Day Awards

Friday, March 23th, 2018 
Augusta University

Lynn Tran

Lynn KH Tran, recipient of the 2018 Graduate Day Research Award in Genomic Medicine.


McIndoe honored with Georgia Bio Award

February 14, 2018

McIndoe

 Dr. Richard McIndoe is one of the recipients of the 2018 Life Sciences Health Impact Awards from Georgia Bio. McIndoe and the MCG Center for Biotechnology and Genomic Medicine will receive the group's Deal of the Year Award.

Read more at Jagwire News


  

New technology enables identification of biomarkers for a wide range of diseases

February 12, 2018


She, Purohit and Sharma

'Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells.'

Read more at Jagwire News

 


 

2017

Graduate Research Day Awards Banquet

Tuesday, March 28th, 2017 
At the Kroc Center, Augusta University

It was at the Graduate Research Day Awards Banquet          

At the Graduate Research Day awards banquet, CBGM graduate students were honored for their recent successes. Robert Schleifer (left), a 5th year PhD student in the laboratory of Dr. Jin-Xiong She, was recognized for being a semi-finalist in Augusta University's inaugural 3MT competition. Paul Tran (middle left), a Graduate Year 1 M.D./Ph.D. student in Dr. She's lab, received an award for his Graduate Research Day poster as the recipient of the Award for Excellence in Research in Genomic Medicine. Also pictured are fellow graduate student Lynn Tran (middle right) and their mentor, Dr. She (right).

 

2016

 

Augusta University is researching a new drug that might help with diabetes-related blindness

Tuesday, December 27, 2016

'Dr. Shruti Sharma of the Center for Biotechnology and Genomic Medicine has a $1.5 million grant from the National Eye Institute to look at basic research into blocking inflammation among epithelial cells in light-sensing retina in the eye, Sharma is looking at a well-known agent in inflammation called interleukin-6 that can affect those cells even though they lack the receptor normally needed for such interaction, an effect called trans-signaling.'

Read more at The Augusta Chronicle.


 

Therapy could be guided 'missile' against cancer

Monday, August 1, 2016

She & Liu

'Using a double-targeted vehicle to home in on prostate cancer cells provides a highly targeted attack against interlocking mechanisms of survival to induce cell death and shrink tumors,'

Read more at The Augusta Chronicle.