Pulmonary, Critical Care, and Sleep Medicine Faculty

Research Interests

• Purinergic signaling in acute lung injury/ARDS
• Role of lung endothelium in sickle cell disease
• Beta-NAD mediated protection against acute chest syndrome
• Role of membrane transport system in lung inflammation

Recognition

• 2006, Graduate studies Poster Judge Committee

Training

• Biochemistry, MS, University of Mysore, India

• Biochemistry, PhD, Bangalore University, India

Teaching Areas

• Transport of oxygen and carbon dioxide in the blood
• Reverse transcription polymerase chain reaction ( RT-PCR), Electrophoretic mobility shift assay (EMSA), Chromatin immunoprecipitation (ChIP)

Completed Research Support

• Biomedical Research Grant: American Lung Association PI: Umapathy N. Siddaramappa $80,000 (07/01/2010-06/30-2012)

Beta-Nicotinamide adenine dinucleotide ( b -NAD) mediated signaling cascades protects and repairs endothelial cell barrier The goal of this Project is to characterize the ?-NAD-activated signaling cascades which protect the endothelial cell barrier dysfunction mediated by bacterial toxins and inflammatory agents.

• Pilot Study Research Program : Georgia Health Sciences University, Augusta GA

PI : Umapathy N Siddaramappa $25,000 (09/01/09-08/31/2010) Pulmonary Endothelial Cell Barrier Protection by Purinoceptors in Acute Lung Injury The goal of this project is to characterize the purinoceptor-induced endothelial cell barrier enhancement in lung microvasculature.

Ongoing Research Support

• The Role of Endothelin-1 in Sickle Cell disease - Hemoglobinopathy Translation Research Skills Development Core (HTRC). 1U01 HL117684-01, Kutlas (PI/PD) 4/1/2013-3/31/2018, NIH/H+NHLBI.

• HTRC Project - Protective effects of Bega-NAD against lund endothelial cell barrier dysfunction and platelets aggregation in sickle cell disease. Role:  HTRC Scholar (2/1/2014-1/31/2016).

Editorial board member:

• Section editor; Journal of Cardiovascular Disease Research (http://www.jcdronline.com/)

Reviewer:

• Vascular Pharmacology
• Recent Patents on Cardiovascular Drug Discovery,Journal of Cardiovascular Disease Research
• American Journal of Physiology

Invited Lectures

• Experimental Biology 2010, Anaheim, CA; Acute Lung Injury session (Apr 23-27, 2010)
• Department of Medicine- Monthly Basic Science Conference speaker (2009)
• Department of Medicine- Monthly Basic Science Conference speaker (2008)

Books and book chapters

• Umapathy NS , Zemskov EA, Jezierska A, Kolosova IA, Lucas R, Catravas JD, and Verin AD. (2010). Chapter 3: Extracellular Purines in Endothelial Cell Barrier Regulation. Pages 39-55, Springer Netherlands. Online Publication   

Patents and Inventions

• Use of Beta - Nicotinamide adenine dinucleotide (Beta-NAD).  Patent #US20120329860 A1.  Online Publication