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Xiaoling Wang, MD, PhD

Professor of Medicine, Pediatrics, and Biostatistics  

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Dr. Xiaoling Wang is a genetic epidemiologist with expertise in cardiovascular disease. Her research focuses on genes responsible for blood pressure regulation as well as epigenetic regulation of complex traits such as obesity and type 2 diabetes. 

Boulder, CO, 2003
Methodology for Genetic Studies of Twins

Peking Union Medical College, Beijing, China, 2002
Genetic Epidemiology

Hebei Medical University, Shijiazhuang, China, 1997
Preventative Medicine

Member of the American Heart Association

Epigenetic basis of obesity induced cardiovascular disease and type 2 diabetes

July 1, 2011 through December 31, 2015 
Role: Principal Investigator

A genome wide methylation study on essential hypertension

August 1, 2011 through July 31, 2016
Role: Principal Investigator

Southeastern Exploratory Sickle Cell Center of Excellence

May 29, 2009 through April 29, 2014 
Role: Co-Investigator

AHA postdoctoral Fellowship

AHA SDG award

Outstanding Clinical Science Faculty Award, GHSU, Medical College of Georgia

Jamshidi Y, Gooljar SB, Snieder H, Wang X, Ge D, Swaminathan R, Spector TD, O'Dell SD. SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. Atherosclerosis. 2007;194(2):e26-33.

Snieder H, Wang X, Shiri-Sverdlov R, van Vliet-Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O'Dell SD. TUB is a candidate gene for late-onset obesity in women. Diabetologia. 2008;51(1):54-61.

Kyriakou T, Collins LJ, Spencer-Jones NJ, Malcolm C, Wang X, Snieder H, Swaminathan R, Burling KA, Hart DJ, Spector TD, O'Dell SD. Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. J Hum Genet. 2008;53(8):718-27.

Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y. Prostasin: A Possible Candidate Gene for Human Hypertension. Am J Hypertens. 2008;21(9):1028-33

Yan W, Yao H, Dai J, Cui J, Chen Y, Yang X, Harshfield GA, Wang X. Waist Circumference Cutoff Points in School-aged Chinese Han and Uygur Children. Obesity. 2008;16(7):1687-92.

Ge D, Su S, Zhu H, Dong Y, Wang X, Harshfield GA, Treiber FA, Snieder H. Stress-induced sodium excretion, a new heritable intermediate phenotype to study the genetics of salt sensitive hypertension? Hypertension. 2009;53(2):262-9.

Snieder H, Wang X, Lagou V, Penninx BW, Riese H, Hartman CA. Role of gene-stress interactions in gene-finding studies. Novartis Found Symp. 2008;293:71-82; discussion 83-6, 122-7.

Wang X, Ding X, Su S, Li Z, Riese H, Thayer JF, Treiber F, Snieder H. Genetic influences on heart rate variability at rest and during stress. Psychophysiology. 2009;46(3):458-65

Li Z, Snieder H, Harshfield G, Treiber F, Wang X. A 15-year longitudinal study on ambulatory blood pressure tracking from childhood to early adulthood. Hypertens Res. 2009;32(5):404-10

Li Z, Snieder H, Su S, Ding X, Thayer JF, Treiber FA, Wang X. A longitudinal study in youth of heart rate variability at rest and in response to stress. International Journal of Psychophysiology, 2009;73(3):212-7

Wang X, Ding X, Su S, Yan W, Harshfield G, Treiber F, Snieder H. Genetic influences on daytime and night-time blood pressure: similarities and differences. J Hypertens. 2009;27(12):2358-2364.

Wang X, Ding X, Su S, Spector TD, Mangino M, Iliadou A, Snieder H. Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interaction. Diabetologia. 2009;52(12):2578-84.

Li Z, Snieder H, Su S, Harshfield GA, Treiber FA, Wang X. A longitudinal study of blood pressure variability in African-American and European American youth. J Hypertens. 2010 Apr;28(4):715-22

Zhu H, Wang X, Gutin B, Davis CL, Keeton D, Thomas J, Stallmann-Jorgensen I, Mooken G, Bundy V, Snieder H, van der Harst P, Dong Y. Leukocyte Telomere Length in Healthy Caucasian and African-American Adolescents: Relationships with Race, Sex, Adiposity, Adipokines, and Physical Activity. J Pediatr. 2011 Feb;158(2):215-20

Wu T, Snieder H, Li L, Cao W, Zhan S, Lv J, Gao W, Wang X, Ding X, Hu Y. Genetic and environmental influences on blood pressure and body mass index in Han Chinese: a twin study. Hypertens Res. 2011 Feb;34(2):173-9

Wang X, Snieder H. Genome-wide association studies and beyond: what's next in blood pressure genetics? Hypertension. 2010 Dec;56(6):1035-7.

Wang X, Ding X, Su S, Harshfield G, Treiber F, Snieder H. Genetic influence on blood pressure measured in the office, under laboratory stress and during real life. Hypertens Res. 2011 Feb;34(2):239-44.

Wang X, Zhu H, Snieder H, Su S, Munn D, Harshfield G, Maria B, Dong Y, Treiber F, Gutin B, Shi H. Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Medicine, 2010 Dec 21;8:87

Fox ER, Young JH, Li Y, Wang X, Elliott P, van Duijn CM, Newton-Cheh C. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1;20(11):2273-84.

Wang X, Prins BP, S�ber S, Laan M, Snieder H. Beyond Genome-Wide Association Studies: New Strategies for Identifying Genetic Determinants of Hypertension. Curr Hypertens Rep. 2011 Sep 28. [Epub ahead of print]

Ehret GB, Munroe PB, Rice KM, Wang X, Levy D, Caulfield MJ, Johnson T. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-109.



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