Yisang Yoon

Scholarship

Selected Recent Publications

• Non-conventional mitochondrial permeability transition: Its regulation by mitochondrial dynamics., 2022
  Journal Article, Academic Journal
• Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouse., 2022
  Journal Article, Academic Journal
• Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation., 2021
  Journal Article, Academic Journal
• Comparison Between an Intraocular Lens With Extended Depth of Focus (Tecnis Symfony ZXR00) and a New Monofocal Intraocular Lens With Enhanced Intermediate Vision (Tecnis Eyhance ICB00)., 2021
  Journal Article, Academic Journal
• Berardinelli-Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing., 2020
  Journal Article, Academic Journal

Research Interests

My laboratory studies mitochondria, critical cellular organelles that produce most of the cellular energy. Mitochondria are specially equipped to produce chemical energy required for cellular processes. This energy-producing process involves carefully controlled electron transport within mitochondria. However, when this process is perturbed, electrons can uncontrollably react with oxygen molecules to produce oxygen radicals that can be further converted to various highly reactive toxic chemical compounds called reactive oxygen species (ROS). Mitochondria contain elaborately organized internal structures encapsulated in dynamically changing tubular networks. This dynamic shape change is mediated by fission and fusion of membrane tubules. Our research focus is to define the molecular mechanisms of mitochondrial shape change and to understand physiological significance of mitochondrial dynamics. Our studies have found that mitochondrial shape change is a key element participating in regulation of mitochondrial electron transport and ROS production.