Yisang Yoon


Yisang Yoon


Academic Appointment(s)

Medical College of Georgia
Department of Physiology

The Graduate School


  • Ph.D., Molecular Genetics Ohio State University, 1993

  • MS, Microbiology, General Seoul National University, 1984

  • BS, Microbiology, General Seoul National University, 1982

Courses Taught Most Recent Academic Year

  • PSIO 9210

    Invest of a Problem
  • PSIO 9010

    Seminar in Physiology
  • PSIO 9300

  • PSIO 8350

    Current Trends in Physiology
  • PSIO 8315

    Teaching Practicum in Phys


Selected Recent Publications

  • Berardinelli-Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing., 2020
    Journal Article, Academic Journal
  • The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress., 2020
    Journal Article, Academic Journal
  • Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis., 2019
    Journal Article, Academic Journal
  • Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology., 2018
    Journal Article, Academic Journal
  • Mitochondrial Membrane Dynamics-Functional Positioning of OPA1., 2018
    Journal Article, Academic Journal

Research Interests

My laboratory studies mitochondria, critical cellular organelles that produce most of the cellular energy. Mitochondria are specially equipped to produce chemical energy required for cellular processes. This energy-producing process involves carefully controlled electron transport within mitochondria. However, when this process is perturbed, electrons can uncontrollably react with oxygen molecules to produce oxygen radicals that can be further converted to various highly reactive toxic chemical compounds called reactive oxygen species (ROS). Mitochondria contain elaborately organized internal structures encapsulated in dynamically changing tubular networks. This dynamic shape change is mediated by fission and fusion of membrane tubules. Our research focus is to define the molecular mechanisms of mitochondrial shape change and to understand physiological significance of mitochondrial dynamics. Our studies have found that mitochondrial shape change is a key element participating in regulation of mitochondrial electron transport and ROS production.

Department Service

  • Director Physiology Graduate Program 2019 - Present

    Role: Other
  • Graduate Education Committee 2018 - Present

    Role: Committee Chair
  • Department of Physiology Graduate Education Committee 2013 - Present

    Role: Committee Member
  • Department of Physiology Faculty Search Committee 2013 - 2017

    Role: Committee Member

University Service

  • MCG Faculty Senate Faculty Recognition Committee 2019 - Present

    Role: Committee Member

Professional Service

  • American Heart Association, MSO study section 2017 - Present

    Role: Committee Member
  • American Heart Association Fellowships Basic Science 3 - 2021

    Role: Reviewer
  • American Physiological Society “Physiological Bioenergetics: Mitochondria”, Organizing committee - 2017

    Role: Committee Member
  • Antioxidants, “Mitochondrial Shape Change in Physio-pathology” - 2017

    Role: Other
  • Diabetes UK, project Grant - 2016

    Role: Reviewer, Grant Proposal