Ranya El Sayed

Assistant Professor

Ranya El Sayed

Assistant Professor

Academic Appointment(s)

Dental College of Georgia
Department of Periodontics

Administration

Medical College of Georgia
Department of Cellular Biology and Anatomy

Bio

Dr. Ranya Elsayed is an assistant professor at the Periodontics Department. Dr. Elsayed graduated from the dental school at Ain Shams University, Cairo, Egypt. She earned her PhD in Oral Biology and Maxillofacial Pathology, Dental College of Georgia along with an MBA at the Hull College of Business, Augusta University. After completing her postdoctoral training at Molecular Immunology and microbiology lab at the Periodontics Department, she joined the Periodontics Department in October 2021 as an assistant professor.

  • (706) 446-7156
  • CB2604

Education

  • MBA, Business Administration and Ma Augusta University, 2020

  • Ph.D., Oral Biology and Oral and Maxi Augusta University, 2019

Awards & Honors

  • 2022 American Association of Immunologists AAI Early Career Faculty Travel Grant American association of Immunologists, 2022

  • International Association for Dental Research IADR Microbiology and Immunology Travel grant award International Association for Dental Research IADR , 2021

  • Plenary poster award American Society for Bone and Mineral Research ASBMR 2021 Annual Meeting American Society for Bone and Mineral Research ASBMR, 2021

  • Distinction honor award for PhD thesis, The Graduate School, Augusta University, 2019

  • First place in Poster and oral presentation Dental College of Georgia Research and Table clinic Day DCG,Augusta University, 2019

Courses Taught Most Recent Academic Year

  • PERI 5211

    Fundamentals of Periodontology
  • BMHS 5401

    Hematopoietic System

Scholarship

Selected Recent Publications

  • Exogenous and Endogenous Dendritic Cell-Derived Exosomes: Lessons Learned for Immunotherapy and Disease Pathogenesis., 2021
    Journal Article, Academic Journal
  • Matrix-Bound Zolzoledronate Enhances the Biofilm Colonization of Hydroxyapatite: Effects on Osteonecrosis., 2021
    Journal Article, Academic Journal
  • Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells., 2021
    Journal Article, Academic Journal
  • Proteomic Characterization, Biodistribution, and Functional Studies of Immune-Therapeutic Exosomes: Implications for Inflammatory Lung Diseases., 2021
    Journal Article, Academic Journal
  • Enterococcus faecalis shifts macrophage polarization toward M1-like phenotype with an altered cytokine profile., 2021
    Journal Article, Academic Journal

Research Interests

Periodontitis (PD) is a chronic disease of aging or inflammaging that affects 70.1% of Americans 65 years and older. PD has been linked to increased risk of other age-related diseases with more serious mortality and morbidity profiles such as Alzheimer’s disease. Increased accumulation of senescent cells with a characteristic senescence-associated secretory phenotype (SASP) occurs with advanced age, contributing to inflammaging and the pathophysiology of age-related diseases. Our laboratory has recently identified a novel pathogenic mechanism for initiation and amplification of immune senescence and alveolar bone loss in PD via microbially-induced dendritic cell SASP exosomes. My research will focus on dissecting out the role and molecular mechanisms of age-related and microbially-induced SASP exosomes in periodontal disease. Exosomes can travel to distant sites and have been shown to cross the blood-brain barrier. Thus, my lab is interested to study the role of microbially-induced SASP exosomes associated with PD in the development of systemic diseases such as Alzheimer’s. We anticipate an important outcome of these studies to be the identification of novel diagnostic biomarkers and senolytic therapies for periodontitis and other age-related diseases to warrant a healthy aging to our population.

College Service

  • Research and Table Clinic Day 2022 - Present

    Role: Other

University Service

  • Flowcytometry core advisory board 2022 - Present

    Role: Committee Member

Professional Service

  • Frontiers in Microbiology peer-reviewed journal 2022 - Present

    Role: Editorial Review Board Member
  • Frontiers in Cellular and infection Microbiology 2022 - Present

    Role: Editor, Associate Editor
  • International journal of nanomedicine 2022 - Present

    Role: Reviewer
  • Frontiers in Cellular and infection Microbiology 2021 - Present

    Role: Reviewer
  • Scientific Reports-Nature 2021 - Present

    Role: Reviewer