Muthusamy Thangaraju

Associate Professor

Muthusamy Thangaraju

Associate Professor

Academic Appointment(s)

Medical College of Georgia
Department of Biochemistry and Molecular Biology

The Graduate School


Dr. Muthusamy Thangaraju is a breast cancer researcher. I started my research career as a breast cancer researcher in 1991 as a graduate student at the University of Madras, India followed by post-doctoral fellowships at McGill University, Montreal, Canada (where I studied the role of protein tyrosine phosphatases, SHP1 and SHP2, in regulation of apoptotic signaling in breast cancer); Mayo Clinic, Rochester, MN ( where I expanded my research to investigate the role of BRCA1 and BRCA2 in regulation of apoptotic signaling in breast cancer); and at the National Cancer Institute (NCI), Frederick, MD (where I explored the functional implication of CCAAT/Enhancer Binding Protein delta (CEBPD) in mammary gland development and its relevance to mammary tumor growth and progression).


  • Ph.D., Biochemistry University of Madras, 1996

  • MS, Chemistry, General Rajah Serfoji Govts Art Colleg, 1989

Awards & Honors

  • Outstanding Young Scientist Award Augusta University, 2010

  • Spring Research Festivel Best Poster Award National Cancer Institute (NCI), 2002

  • NCI Research Fellowship National Cancer Institute, 2001

  • Travel grant UICC, 1998

  • Post-Doctoral Fellowship Royal Victoria Hospital Research Institute, McGill University, Montreal, Canada, 1998

Courses Taught Most Recent Academic Year

  • MEDS 3000

    Biological Chemistry
  • BCMB 8201

    Cur Topics & Tech in MB
  • BIOM 8215

    Fundamentals of Oncology I
  • BCMB 9300

  • BCMB 9010

    Seminar in BMB
  • BIOM 8021

    Biochem & Gene Regulation
  • BCMB 8340

    Elements of Scientific Pres
  • MEDI 5088

    Medical Scholars Program

Teaching Interests

Biochemistry and Molecular Biology, Signal Transduction, Epigenetics and Cancer Stem Cells


Selected Recent Publications

  • Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model., 2019
    Journal Article, Academic Journal
  • Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study., 2019
    Journal Article, Academic Journal
  • Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice., 2019
    Journal Article, Academic Journal
  • α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling., 2018
    Journal Article, Academic Journal
  • Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon., 2018
    Journal Article, Academic Journal

Research Interests

Role of epigenetics in regulation of mammary stem and progenitor cells (MaSC) and breast cancer stem cells (BCSCs). My research is focus on the isolation and characterization of MaSC and BCSCs and explore the role of DNA methylation, histone deacetylation and histone methylation in these cells. We are also interested in developing small molecules to target BCSCs by utilizing state of the art gene-targeting strategies and spontaneous mouse mammary tumor models.

Department Service

  • Department Space Committee 2015 - Present

    Role: Attendee, Meeting
  • Faculty recruitment committee 2015 - Present

    Role: Attendee, Meeting
  • Medical Student Interview Committee 2015 - Present

    Role: Attendee, Meeting
  • Students Promotion and Academic Committee 2015 - Present

    Role: Attendee, Meeting
  • Tumor Tissue Bank 2013 - Present

    Role: Attendee, Meeting

College Service

  • Student Promotion committee 2016 - 2019

    Role: Committee Member

University Service

  • MD admission committee 2016 - 2019

    Role: Task Force Member