Dental College of Georgia
Department of Oral Biology and Diagnostic Sciences
The Graduate School
I have studied fluoride toxicity to reveal the molecular mechanism of SIRT1 in dental fluorosis, a little understood disease with increasing prevalence in the United States.
Mineralized tissue biology and physiology, Molecular and Cellular Biology
In the current research project, my goal is to elucidate molecular mechanisms of how SIRT1 protects us from the toxic effects of high-level fluoride exposure. Based on my research experience in several fields, my future goal is to establish a vigorous, independent research program centered on better understanding SIRT1 function in epigenetic gene control mechanisms in oral cancer, periodontitis and tooth development.