Huabo Su

Associate Professor

Huabo Su

Associate Professor

Academic Appointment(s)

Medical College of Georgia
Department of Pharmacology and Toxicology

Medical College of Georgia
Department of Vascular Biology Center

The Graduate School

Education

  • Ph.D., Biochemistry and Molecular Biology Fudan University, 2004

  • MD, Molecular Biology Guangxi University, 2001

  • BS, Bio, General Guangxi Normal University, 1997

Awards & Honors

  • APS-CV section fellow American Physiology Society Cardiovascular Section, 2022

  • RO1, NHLB1, PI, 2019-2024 2019

  • AHA CDA (to Z.J.), Sponsor, 2019-2022 2019

  • AHA TPA, PI, 2019-2022 2019

  • AHA Postdoc Fellowship (to Z.J.), Sponsor, 2017-2019 2017

Courses Taught Most Recent Academic Year

  • VBIO 9210

    Investigation of a Prob
  • BIOM 8060

    Intro to Research II
  • VBIO 9020

    Vascular Biology Journal Club
  • BIOM 8040

    Intro to Faculty Research
  • BIOM 8050

    Intro to Research I
  • VBIO 8010

    Methods in Cardiovascular Rese
  • BIOM 8130

    Scientific Grant Writing

Scholarship

Selected Recent Publications

  • Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis, 2022
    Journal Article, Academic Journal
  • BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism., 2022
    Journal Article, Academic Journal
  • Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability, 2021
    Journal Article, Academic Journal
  • Editorial: Post-translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease, 2021
    Journal Article, Academic Journal
  • Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation, 2021
    Journal Article, Academic Journal

Research Interests

My research focuses on understanding the biological function of ubiquitin-like protein modifiers including NEDD8 and Ufm1 in cardiomyocytes, with an ultimate goal to elucidate the molecular mechanisms of heart failure and to search for novel therapeutic measures. We are particularly interested in addressing three major questions: are neddylation and ufmylation essential for cardiac function under physiological and pathological conditions? How does each modification control different cellular processes in cardiomyocyte? What proteins are targeted by NEDD8 or Ufm1 in cardiomyocytes, and how does such modification regulate the molecular function of the target? We employ in vitro molecular and cellular biology approaches, proteomics approach and the state-of-the-art in vivo mouse physiology analyses to address these questions.

Department Service

  • 2018 VBC Faculty Search Committee 2019 - Present

    Role: Committee Member
  • Research Integrity Committee 2018 - Present

    Role: Committee Member
  • Vascular Biology Center Journal Club 2015 - Present

    Role: Other

College Service

  • Animal Resarch Advisory Committee 2022 - Present

    Role: Committee Member
  • Judge of Graduate Research Day 2013 - Present

Professional Service

  • AHA, Transformative Project Award, Cardiac Biology BSc Committee 2022 - Present

    Role: Reviewer, Ad Hoc Reviewer
  • Moderator, ACRE-CAAC Joint Seminar Series 2022, Feb 23, 2022, Virtual 2022 - Present

    Role: Conference-Related
  • Research Grants Council, Hong Kong, China 2022 - Present

    Role: Reviewer, Ad Hoc Reviewer
  • NIH, NIH Directors Early Independence Awards ZRG1 PSE-H 70 (DP5 mechanism) 2021 - Present

    Role: Reviewer, Ad Hoc Reviewer
  • NIH, Special Emphasis panel ZRG1 CVRS-Q (02) 2021 - Present

    Role: Reviewer, Ad Hoc Reviewer