Huabo Su

Associate Professor

Huabo Su

Associate Professor

Academic Appointment(s)

Medical College of Georgia
Department of Pharmacology and Toxicology

Medical College of Georgia
Department of Vascular Biology Center

The Graduate School

Education

  • Ph.D., Biochemistry and Molecular Bio Fudan University, 2004

  • MD, Molecular Biology Guangxi University, 2001

  • BS, Bio, General Guangxi Normal University, 1997

Awards & Honors

  • RO1, NHLB1, PI, 2019-2024 2019

  • AHA CDA (to Z.J.), Sponsor, 2019-2022 2019

  • AHA TPA, PI, 2019-2022 2019

  • AHA Postdoc Fellowship (to Z.J.), Sponsor, 2017-2019 2017

  • F31 (to L.R.), NHLBI, Sponsor, 2017-2020 2017

Courses Taught Most Recent Academic Year

  • VBIO 8010

    Methods in Cardiovascular Rese
  • BIOM 8130

    Scientific Grant Writing
  • VBIO 9020

    Vascular Biology Journal Club
  • ANAT 8050

    Graduate Histology
  • VBIO 8020

    New Frontiers in Vasc Bio
  • VBIO 9300

    Research in Vascular Bio
  • VBIO 9010

    Seminar in Vascular Bio

Scholarship

Selected Recent Publications

  • Transient inhibition of neddylation at neonatal stage evokes reversible cardiomyopathy and predisposes the heart to isoproterenol-induced heart failure., 2019
    Journal Article, Academic Journal
  • A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth., 2019
    Journal Article, Academic Journal
  • $\beta$-arrestin-biased agonism of $\beta$-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling, 2018
    Journal Article, Academic Journal
  • A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes, 2018
    Journal Article, Academic Journal
  • Neddylation mediates ventricular chamber maturation through repression of Hippo signaling, 2018
    Journal Article, Academic Journal

Research Interests

My research focuses on understanding the biological function of ubiquitin-like protein modifiers including NEDD8 and Ufm1 in cardiomyocytes, with an ultimate goal to elucidate the molecular mechanisms of heart failure and to search for novel therapeutic measures. We are particularly interested in addressing three major questions: are neddylation and ufmylation essential for cardiac function under physiological and pathological conditions? How does each modification control different cellular processes in cardiomyocyte? What proteins are targeted by NEDD8 or Ufm1 in cardiomyocytes, and how does such modification regulate the molecular function of the target? We employ in vitro molecular and cellular biology approaches, proteomics approach and the state-of-the-art in vivo mouse physiology analyses to address these questions.

Department Service

  • 2018 VBC Faculty Search Committee 2019 - Present

    Role: Committee Member
  • Research Integrity Committee 2018 - Present

    Role: Committee Member
  • Vascular Biology Center Journal Club 2015 - Present

    Role: Other

College Service

  • Judge of Graduate Research Day 2013 - Present