David Stepp

Charbonnier Chair for Physiology

David Stepp

Charbonnier Chair for Physiology

Professor

Academic Appointment(s)

Medical College of Georgia
Department of Physiology

The Graduate School

Other Duties

Co-Director, AU Medical Associates

Co-Director

  • (706) 721-1949
  • CB 3211B

Education

  • Ph.D., Physiology, General University of Pennsylvania, 1993

  • BS, Biology/Biological Sciences, G University of South Carolina -, 1988

Awards & Honors

  • Exemplary Teaching Award Medical College of Georgia, Augusta University, 2018

  • Exemplary Teaching Award, School of Medicine 2011

  • Virendra Mahesh Distinguished Research Award 2010

Courses Taught Most Recent Academic Year

  • VBIO 9210

    Investigation of a Prob
  • VBIO 9300

    Research in Vascular Bio
  • BIOM 8033

    Integrated Systems Biol
  • VBIO 8010

    Methods in Cardiovascular Rese
  • MEDI 5163

    Mod 4 Gastrointest & Nutrition
  • MEDI 5159

    Mod 5: Genitourinary
  • VBIO 8020

    New Frontiers in Vasc Bio
  • BIOM 8012

    Scientific Communications
  • VBIO 9010

    Seminar in Vascular Bio
  • BIOM 8040

    Intro to Faculty Research
  • BIOM 8130

    Scientific Grant Writing

Scholarship

Selected Recent Publications

  • Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis., 2019
    Journal Article, Academic Journal
  • Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding., 2018
    Journal Article, Academic Journal
  • Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins., 2018
    Journal Article, Academic Journal
  • Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension., 2018
    Journal Article, Academic Journal
  • A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome., 2018
    Journal Article, Academic Journal

Research Interests

Work in our lab is devoted to unraveling links between obesity and cardiometabolic dysfunction. While weight loss is ideal, the overwhelming majority of the obese population – either due to chronic entrainment of metabolism or behavior, increased age or accumulation of injuries – retain or regain excess weight. A critical need therefore is to break the links between obesity and its cardiovascular outcomes. The CORE HYPOTHESIS of our laboratory is that resolution of endocrine and metabolic abnormalities in obesity is the path to preventing cardiovascular disease in overweight patients. Currently, the central theme of these studies is that the balance of nitric oxide (NO) derived from eNOS and the loss of its bioavailability from NADPH Oxidase (NOX)-generated super-oxide is a key determinant of cardiometabolic health. Changes in glycemic status, either absolute levels or pattern of hyperglycemia, appear to be a primary determinant of states in which super-oxide excess reduces NO below a threshold needed for full cardiovascular function. Thus, the glucose-NOS/NOX axis in the primary focus of studies in our lab.

Professional Service

  • Atherosclerosis, Thrombosis and Vascular Biology 2010 - Present

    Role: Editorial Review Board Member
  • Basic Research in Cardiology 2010 - Present

    Role: Editorial Review Board Member
  • Frontiers in Oxidant Physiology 2010 - Present

    Role: Editorial Review Board Member
  • Circulation Research 2009 - Present

    Role: Editorial Review Board Member
  • American Journal of Physiology (Regulatory) 2007 - Present

    Role: Editorial Review Board Member