David L. Mattson, PhD


Georgia Research Alliance Eminent Scholar in Hypertension, Department Chair

 PhonDr. David L. Mattsone:  (706) 721-7742
 Fax:  (706) 721-7299
 Email: dmattson@augusta.edu
 Office: CA-3123
 Lab: CA-3101

 

 


Education and Training

University of Minnesota-Duluth, Biology, BS, 1984
Medical College of Wisconsin, Physiology, PhD, 1990


Academic Appointments

1992-1997 - Assistant Professor, Medical College of Wisconsin
1997-2002 - Associate Professor, Medical College of Wisconsin
2014-2015 - Interim Senior Associate Dean of Research, Medical College of Wisconsin
2002-2019 - Professor with Tenure, Medical College of Wisconsin
2019 - Department Chair and Professor, Medical College of Georgia, Augusta University


Research Interests

 Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Additional studies are geared toward an understanding of the genetic basis of hypertension and renal disease. The work performed in my laboratory utilizes techniques taken from molecular biology, biochemistry, immunology, and integrative physiology to address the role of the kidney in the regulation of sodium and water homeostasis and arterial pressure. Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. Our experimental models include various strains of inbred and genetically manipulated rats and mice. 


Awards and Honors

1984           Summa Cum Laude, University of Minnesota Duluth
1990           Outstanding Dissertation Award, Medical College of Wisconsin
1991           Merck Sharpe & Dohme Travel Fellowship
1998           Fellow, American Heart Association Council for High Blood Pressure                                Research
2000            Established Investigator Award, American Heart Association
2006            Distinguished Lecturer in Integrative Physiology, University of                                           Saskatchewan
2008,10-16 Outstanding Medical Student Educator, Medical College of Wisconsin
2013,18       Medical College of WisconsinFaculty Service Award
2015            Medical College of Wisconsin Distinguished Service Award
2016            Medical College of Wisconsin Society of Teaching Scholars
2018            Starling Award-American Physiological Society

(Go to Pub Med)

Mattson DL. Immune mechanisms of salt-sensitive hypertension and renal end-organ damage. Nat Rev Nephrol. 2019 May;15(5):290-300.

Abais-Battad JM, Alsheikh AJ, Pan X, Fehrenbach DJ, Dasinger JH, Lund H, Roberts ML, Kriegel AJ, Cowley AW Jr, Kidambi S, Kotchen TA, Liu P, Liang M, Mattson DL. Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte Transcriptome. Hypertension. 2019 Oct;74(4):854-863.

Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Mattson DL. Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F361-F374.

Alsheikh AJ, Lund H, Dasinger JH, Abais-Battad JM, Fehrenbach DJ, Mattson DL. Renal nerves and leukocyte infiltration in the kidney during salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R182-R189.

Lerman LO, Kurtz TW, Touyz RM, Ellison DH, Chade AR, Crowley SD, Mattson DL, Mullins JJ, Osborn J, Eirin A, Reckelhoff JF, Iadecola C, Coffman TM. Animal Models of Hypertension: A Scientific Statement From the American Heart Association. Hypertension. 2019 Jun;73(6):e87-e120.

Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension. (Abais-Battad JM, Lund H, Fehrenbach DJ, Dasinger JH, Alsheikh AJ, Mattson DL.) Hypertension. 2019 Feb;73(2):440-448.

Influence of dietary protein on Dahl salt-sensitive hypertension: a potential role for gut microbiota. (Abais-Battad JM, Mattson DL.) Am J Physiol Regul Integr Comp Physiol. 2018 Nov 01;315(5):R907-R914.

Heat stress nephropathy and hyperuricemia. (Mattson DL.) Am J Physiol Renal Physiol. 2018 Oct 01;315(4):F757-F758.

Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions. (Li Y, Pan X, Roberts ML, Liu P, Kotchen TA, Cowley AW Jr, Mattson DL, Liu Y, Liang M, Kidambi S.) Epigenomics. 2018 06;10(6):797-811.

Genetics: An integrated genetic analysis of disease. (Mattson DL.) Nat Rev Nephrol. 2018 May;14(5):287-288.

The complement system in hypertension and renal damage in the Dahl SS rat.(Regal JF, Laule CF, McCutcheon L, Root KM, Lund H, Hashmat S, Mattson DL.) Physiol Rep. 2018 Mar;6(6):e13655.