Carl Sanders Research and Education Building, CB2601
Members of the Laboratory
Xiaogang Chu, PhD
Lun Cai, PhD
Dr. Raju's laboratory is focused on the study of molecular basis of organ function
changes following injury and influence of aging using a multidisciplinary approach.
His research utilizes both in vivo and in vitro models. In one of the major projects
in his laboratory, he investigates mitochondrial alterations and immune regulation
following hemorrhagic shock. His laboratory has identified age-associated changes
in mitochondrial gene expression following hemorrhagic shock and has found SIRT1 as
a potential target. The sirtuin family of proteins is associated with longevity and
regulates mitochondrial biogenesis factors. His continued studies demonstrate a key
role for mitochondria in the outcome following hemorrhagic shock. His research led
to the identification of several small molecules in improving organ function and survival
following hemorrhagic shock in rodent models. Mitochondrial dysfunction is a common
denominator for both aging and injury. His laboratory uses a number of genetically
modified mouse models to understand the regulation of mitochondrial function in aging
and injury. His research group is also interested in understanding how mitochondria
regulate inflammation. His long term goal is to understand the role of cellular energetics
and the influence of aging in the outcome following injury. Dr. Raju has authored
over 70 peer-reviewed articles, and his research is currently funded by the National
Institutes of Health.
Education and post doctoral training
1993 - PhD, All India Institute of Medical Sciences, New Delhi
1995 - Post Doc, University of Minnesota, St Paul, MN
2000 - Research Associate, Mayo Clinic, Rochester, MN
2001-2007: Senior Staff Fellow, National Institute of Neurological Disorders and
Stroke, National Institutes of Health, Bethesda, MD
2007-2013: Associate Professor, University of Alabama at Birmingham, Birmingham,
2013-Present: Professor, Augusta University, Augusta, GA
Journal of Immunology, Associate Editor (2006-2010)
Aging and Disease (2010-present)
PLOS ONE, Academic Editor (2013-present)
Guest Editor: Aging and Injury (Special Issue of Aging and Disease, April 2014)
BBA - Molecular Basis of Disease (2014- present)
Guest Editor: BBA Mol Basis of Dis (2017)
Frontiers in Intensive Care Medicine and Anesthesiology
GRANT REVIEW PANELS
Dr. Raju has served on several grant review panels including study sections of the
National Institutes of Health, Department of Veterans Affairs, Department of Defense,
and American Heart Association. Dr. Raju has also served on an NIH study section as
a Chartered member.
Chu X, Wen J, Raju RP. Rapid senescence-like response after acute injury. Aging Cell. 2020 Aug 2:e13201. Science News Story.
Chu X, Schwartz R, Diamond MP and Raju R. A combination treatment strategy for hemorrhagic shock modulates autophagy. Frontiers in Medicine. 2019;6:281.
Chu X, Wu S and Raju R. NLRX1 regulation in acute mitochondrial injury. Frontiers in Immunology, 2019;10:2431.
Subramani K, Chu X, Warren M, Singh N and Raju R. Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin
in hemorrhagic shock BBA Mol Basis Dis. 2019; 1865(3):688-695.
Subramani K, Raju SP, Chu X, Warren M, Pandya DC, Hoda N, Fulzele S and Raju R. Effect of plasma-derived extracellular vesicles on erythrocyte deformability in polymicrobial
sepsis. International Immunopharmacology2018; 65:244-247.
McMenamin M, Kvirkvelia N, Warren M, Jadeja R, Sharma A, Raju R and Madaio MP. Kidney targeted inhibition of protein kinase C-α ameliorates nephrotoxic
nephritis by restoring mitochondrial dysfunction in endothelial cells. Kidney International.2018; 94(2):280-291.
Ben H and Raju R. Mitochondria in hypoxic ischemic injury and influence of aging. Progress in Neurobiology. 2017; 157:92-116. PMC5161736.
Kumar S, Lu S, Warren M, Chu X, Haroldo, T, Caldwell, W, Diamond M, Raju R. Mitochondrial targeting improves survival following hemorrhagic shock. Scientific Reports 2017: 7(1):2671.
Jian B, Yang S, Chaudry IH and Raju R. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating
Sirt1. Molecular Medicine 2012 18(1):209-14.
Jian, Yang Y, Chen D, Zou L, Chatham L, Chaudry I and Raju R. Aging influences cardiac mitochondrial gene expression and cardiovascular function
following trauma-hemorrhage. Mol Med2011;17(5-6)542-9.
Raju R, Rakocevic G, Chen Z, Hoehn G, Semino-Mora C, Shi W, Olsen R, and Dalakas MC. Autoimmunity to GABARAP in Stiff-Person Syndrome. Brain 2006;129:3270-6.
Raju R, Foote J, Banga JP, Hall TR, Padoa CJ., Dalakas MC, Ortqvist E, Hampe CS. Analysis
of GAD65 Autoantibodies in Stiff Person Syndrome Patients. Journal of Immunology 2005;175: 7755.
Raju R and Dalakas MC. Gene expression profile in the muscles of patients with inflammatory
myopathies: Effect of therapy with IVIg and biologic validation of disease relevant
genes. Brain 2005;128:1887-1896.
Raju R,Spack EG and David CS. Acetylcholine receptor peptide recognition in HLA DR3 transgenic
mice. In vivo responses correlate with MHC-peptide binding. J Immunology 2001;167:1118-1124.