Research Interest, Education and Publications

 

photo of RAghavan Pillai Raju, PhD

RAghavan Pillai Raju, PhD

  • Professor
  • Pharmacology & Toxicology

706-443-4138

Carl Sanders Research and Education Building, CB2601
 
Office phone icon:  706-443-4138
Lab phone icon: 706-446-0019
 
 

Members of the Lab

Xiaogang Chu, PhD

  • Research Associate

Lun Cai, PhD

  • Research Assistant
 

Research Interest

Dr. Raju's laboratory is focused on the study of molecular basis of organ function changes following injury and influence of aging using a multidisciplinary approach. His research utilizes both in vivo and in vitro models. In one of the major projects in his laboratory, he investigates mitochondrial alterations and immune regulation following hemorrhagic shock. His laboratory has identified age-associated changes in mitochondrial gene expression following hemorrhagic shock and has found SIRT1 as a potential target. The sirtuin family of proteins is associated with longevity and regulates mitochondrial biogenesis factors. His continued studies demonstrate a key role for mitochondria in the outcome following hemorrhagic shock. His research led to the identification of several small molecules in improving organ function and survival following hemorrhagic shock in rodent models.  Mitochondrial dysfunction is a common denominator for both aging and injury. His laboratory uses a number of genetically modified mouse models to understand the regulation of mitochondrial function in aging and injury.  His research group is also interested in understanding how mitochondria regulate inflammation.  His long term goal is to understand the role of cellular energetics and the influence of aging in the outcome following injury. Dr. Raju has authored over 70 peer-reviewed articles, and his research is currently funded by the National Institutes of Health. 


ACADEMIC APPOINTMENTS

2000       Research Associate, Mayo Clinic, Rochester, MN

1995       Post Doc, University of Minnesota, St Paul, MN

1993       PhD, All India Institute of Medical Sciences, New Delhi

 

academic appointments

2013 - Present:    Professor, Augusta University, Augusta, GA

2007 - 2013:         Associate Professor, University of Alabama at Birmingham, Birmingham, AL

2001 - 2007:         Senior Staff Fellow, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD



Editorial Board

2014 - present    BBA - Molecular Basis of Disease

2013 - present    PLOS ONE, Academic Editor

2010 - present   Aging and Disease

2017                    Guest Editor: BBA Mol Basis of Dis

2014                    Guest Editor: Aging and Injury (Special Issue of Aging and Disease)

2006 - 2010        Journal of Immunology, Associate Editor

Frontiers in Intensive Care Medicine and Anesthesiology

 


GRANT REVIEW PANELS

Dr. Raju has served on several grant review panels including study sections of the National Institutes of Health, Department of Veterans Affairs, Department of Defense, and American Heart Association. Dr. Raju has also served on an NIH study section as a Chartered member.

 


SELECTED PUBLICATIONS

Chu X, Wen J, Raju RP. Rapid senescence-like response after acute injury.  Aging Cell. 2020 Aug 2:e13201.  Science News Story.

Chu X, Schwartz R, Diamond MP and Raju R.  A combination treatment strategy for hemorrhagic shock modulates autophagy. Frontiers in Medicine. 2019;6:281.

Chu X, Wu S and Raju R. NLRX1 regulation in acute mitochondrial injury. Frontiers in Immunology, 2019;10:2431.

Subramani K, Chu X, Warren M, Singh N and Raju R. Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock BBA Mol Basis Dis. 2019; 1865(3):688-695.

Subramani K, Raju SP, Chu X, Warren M, Pandya DC, Hoda N, Fulzele S and Raju R. Effect of plasma-derived extracellular vesicles on erythrocyte deformability in polymicrobial sepsis. International Immunopharmacology 2018; 65:244-247.

McMenamin M, Kvirkvelia N, Warren M, Jadeja R, Sharma A, Raju R and Madaio MP. Kidney targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis by restoring mitochondrial dysfunction in endothelial cells. Kidney International.2018; 94(2):280-291.

Ben H and Raju R. Mitochondria in hypoxic ischemic injury and influence of aging. Progress in Neurobiology. 2017; 157:92-116. PMC5161736.

Kumar S, Lu S, Warren M, Chu X, Haroldo, T, Caldwell, W, Diamond M, Raju R.  Mitochondrial targeting improves survival following hemorrhagic shock.  Scientific Reports 2017: 7(1):2671.

Jian B, Yang S, Chaudry IH and Raju R. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Molecular Medicine 2012 18(1):209-14.

Jian, Yang Y, Chen D, Zou L, Chatham L, Chaudry I and Raju R. Aging influences cardiac mitochondrial gene expression and cardiovascular function following trauma-hemorrhage. Mol Med 2011;17(5-6)542-9.

Raju R, Rakocevic G, Chen Z, Hoehn G, Semino-Mora C, Shi W, Olsen R, and Dalakas MC. Autoimmunity to GABARAP in Stiff-Person Syndrome. Brain 2006;129:3270-6.

Raju R, Foote J, Banga JP, Hall TR, Padoa CJ., Dalakas MC, Ortqvist E, Hampe CS.   Analysis of GAD65 Autoantibodies in Stiff Person Syndrome Patients. Journal of Immunology 2005;175: 7755.

Raju R and Dalakas MC. Gene expression profile in the muscles of patients with inflammatory myopathies: Effect of therapy with IVIg and biologic validation of disease relevant genes.  Brain 2005;128:1887-1896.

Raju R, Spack EG and David CS. Acetylcholine receptor peptide recognition in HLA DR3 transgenic mice.  In vivo responses correlate with MHC-peptide binding.  J Immunology 2001;167:1118-1124.