Research Interest, Education and Publications

photo of Brian Muntean, PhD

Brian Muntean, PhD

  • Assistant Professor
  • Pharmacology & Toxicology


Research & Education Building, CB 3616
Office phone icon:  706-721-1926
Lab CB 3621 phone icon:  706-721-1927


Members of the Lab

Doug Sloan

  • Research Assistant

Yini Liao

  • Research Associate

Casey Cryan

  • Graduate Student


Studies the rules and mechanisms governing information transfer between neurons, which are essential processes to provide instructions for locomotion and motor coordination.  Research utilizes CRISPR/Cas9 gene editing tools in tandem with optical imaging strategies to interrogate the molecular architecture underlying neuronal signal decoding logic.


2014-2020             Postdoc                                                                  The Scripps Research Institute                        

2014                       PhD in Medicinal Chemistry                               The University of Toledo

2009                       BS in Medicinal & Biological Chemistry            The University of Toledo



2020 - Present      Assistant Professor, Medical College of Georgia, Department of Pharmacology and Toxicology 

2020 - Present      Assistant Professor, The Graduate School



2020 - The Bow Foundation Postdoctoral Fellowship

2017 - Great Lakes GPCR Retreat Poster Award 1st Place

2016 - Ruth L. Kirschstein Postdoctoral Individual National Research Service Award


Sloan DC, Cryan CE, Muntean BS. Multiple potassium channel tetramerization domain (KCTD) family members interact with Gβγ, with effects on cAMP signaling. J Biol Chem . 2023 Mar;299(3):102924.

Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA. Members of the KCTD family are major regulators of cAMP signaling. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1).

Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA. Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Rep. 2021 Feb 2;34(5):108718.

Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. A global map of G protein signaling regulation by RGS proteins. Cell. 2020 Sep 24;S0092-8674(20)31140-5.

Muntean BS. Dorsal striatum dynamically incorporates velocity adjustments during locomotion. J Neurosci. 2020 Sep 2;40(36):6822-6824.

Muntean BS, Dao MT, Martemyanov KA. Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling. Cell Rep. 2019 Oct 22;29(4):946-960.e2.

Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA. NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. PLoS Biol. 2019 Oct 10;17(10):e3000477.

Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268.

Muntean BS, Martemyanov KA. Association with the Plasma Membrane is Sufficient for Potentiating Catalytic Activity of Regulators of G protein Signaling (RGS) Proteins of the R7 subfamily. J Biol Chem. 2016 Mar 25;291(13):7195-204.

AbouAlaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014 Feb 11;129(6):660-72.

Muntean BS, Jin X, Williams FE, Nauli SM. Primary cilium regulates CaV1.2 expression through Wnt signaling. J Cell Physiol. 2014 Dec;229(12):1926-34.


Complete List of Published Work in MyBibliography