Brian Muntean, PhD
Research Interest, Education and Publications
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Research & Education Building, CB 3616 Members of the Lab |
RESEARCH INTEREST
Studies the rules and mechanisms governing information transfer between neurons, which are essential processes to provide instructions for locomotion and motor coordination. Research utilizes CRISPR/Cas9 gene editing tools in tandem with optical imaging strategies to interrogate the molecular architecture underlying neuronal signal decoding logic.
EDUCATION & POST-DOCTORAL TRAINING
2014-2020 Postdoc The Scripps Research Institute
2014 PhD in Medicinal Chemistry The University of Toledo
2009 BS in Medicinal & Biological Chemistry The University of Toledo
ACADEMIC APPOINTMENTS
2020 - Present Assistant Professor, Medical College of Georgia, Department of Pharmacology and Toxicology
2020 - Present Assistant Professor, The Graduate School
HONORS
2020 - The Bow Foundation Postdoctoral Fellowship
2017 - Great Lakes GPCR Retreat Poster Award 1st Place
2016 - Ruth L. Kirschstein Postdoctoral Individual National Research Service Award
SELECTED PUBLICATIONS
Sloan DC, Cryan CE, Muntean BS. Multiple potassium channel tetramerization domain (KCTD) family members interact with Gβγ, with effects on cAMP signaling. J Biol Chem . 2023 Mar;299(3):102924.
Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA. Members of the KCTD family are major regulators of cAMP signaling. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1).
Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA. Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Rep. 2021 Feb 2;34(5):108718.
Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. A global map of G protein signaling regulation by RGS proteins. Cell. 2020 Sep 24;S0092-8674(20)31140-5.
Muntean BS. Dorsal striatum dynamically incorporates velocity adjustments during locomotion. J Neurosci. 2020 Sep 2;40(36):6822-6824.
Muntean BS, Dao MT, Martemyanov KA. Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling. Cell Rep. 2019 Oct 22;29(4):946-960.e2.
Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA. NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. PLoS Biol. 2019 Oct 10;17(10):e3000477.
Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268.
Muntean BS, Martemyanov KA. Association with the Plasma Membrane is Sufficient for Potentiating Catalytic Activity of Regulators of G protein Signaling (RGS) Proteins of the R7 subfamily. J Biol Chem. 2016 Mar 25;291(13):7195-204.
AbouAlaiwi WA, Muntean BS, Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014 Feb 11;129(6):660-72.
Muntean BS, Jin X, Williams FE, Nauli SM. Primary cilium regulates CaV1.2 expression through Wnt signaling. J Cell Physiol. 2014 Dec;229(12):1926-34.