Dept. of Population Health Science
Dept. of Neuroscience & Regenerative Medicine
2013 – 2016 Ph.D. in Biostatistics, University of Michigan, Ann Arbor, MI
2011 – 2013 M.S. in Biostatistics, University of Michigan, Ann Arbor, MI
2005 – 2009 B.S. in Biological Science, Peking University, China
2010 – 2011 Research Trainee, Dept. of Neuroscience, Johns Hopkins University School
of Medicine, MD
Statistical Methodologies: Monte Carlo Methods and Simulations, Resampling Methods,
Mixed-effects Models, Generalized Linear Models, Statistical Computing and Numerical
Application areas: Genomics, Bioinformatics, Neuroscience
My research includes two directions: 1). Methodological research in biostatistics
and bioinformatics; and 2). Collaborative research in biomedical science. My research
interests are developing statistical methodologies and computational techniques for
the mining and analysis of large-scale genomic data, focusing on the improvement of
the computational efficiency of resampling-based testing methods in genomic data analysis
and the application of multilevel models for the study of complex genomic data. I
have a broad range of interests in applying statistical methodologies and bioinformatics
tools to scientific questions in biomedical science and public health, particularly
neurological and psychiatric disorders.
- Yang Shi, Mengqiao Wang, Weiping Shi, Ji-Hyun Lee, Huining Kang, Hui Jiang (2019). Accurate
and efficient estimation of small p-values with the cross-entropy method: applications
in genomic data analysis. Bioinformatics, 35 (14): 2441-2448.
- Yang Shi and Ji-Hyun Lee (2018). Sample size calculations for group randomized trials with
unequal group sizes through Monte Carlo simulations. Statistical Methods in Medical Research, 27 (9): 2569-2580
- Dali Ding, Weiping Shi, Yang Shi (2018). Numerical simulation of embryo transfer: how the viscosity of transferred
medium affects the transport of embryos. Theoretical Biology and Medical Modelling, 15 (1): 20.
- Yang Shi, Arul M Chinnaiyan, Hui Jiang (2015). rSeqNP: A non-parametric approach for detecting
differential expression and splicing from RNA-Seq data. Bioinformatics, 31 (13): 2222-2224.
- Kang Wang, Yang Shi, Zhu-Yue Li, Ye-Lei Xiao, Jie Li, Xiang Zhang, Hong-Yuan Li (2019). Metastatic Pattern
Discriminates Survival Benefit of Primary Surgery for De Novo Stage IV Breast Cancer:
A Real-World Observational Study. European Journal of Surgical Oncology, 45(8):1364-1372.
- Irene Orlow, Yang Shi, Peter A Kanetsky, Nancy Thomas, Li Luo, Sergio Corrales-Guerrero, Anne E Cust, Lidia
Sacchetto, Roberto Zanetti, Stefano Rosso, Bruce K Armstrong, Terence Dwyer, Alison
Venn, Richard P Gallagher, Stephen B Gruber, Loraine D Marrett, Hoda Anton-Culver,
Klaus Busam, Colin B Begg, Marianne Berwick (2018). The interaction between vitamin
D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma
survival. Pigment Cell & Melanoma Research, 31 (2): 287-296.
- Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon, James Brewer, Steven
Edland, Jerzy Wegiel, Benjamin Tycko, Alena Savonenko, Roger H Reeves, Juan C Troncoso,
Chris J McBain, Douglas Galasko, Paul F Worley (2017). NPTX2 and Cognitive Dysfunction
in Alzheimer’s disease. eLife, 6: e23798.
- Jack Cuzick, Orrin Myers, Ji-Hyun Lee, Yang Shi, Julia C Gage, William C Hunt, Michael Robertson, Cosette M Wheeler (2017). Outcomes
in women with cytology showing atypical squamous cells of undetermined significance
with vs without human papillomavirus testing. JAMA Oncology, 3 (10): 1327-1334.