Xin-Yun Lu, MD, PhD

Education:

1993-1998 Ph.D. in Pharmacology, Washington State University, WA
1987-1990 M.Sc. in Biochemistry, Zhanjiang Medical College, China
1982-1987 M.D., Binzhou Medical College, China

Training:

1998-2001 Postdoctoral Fellowship, Mental Health Research Institute, Univ. of Michigan, Medical School, Ann Arbor, MI.

Research Interests

Chronic stress, neurodegeneration, depression, synaptic plasticity, behavior

Research in our lab is focused on understanding molecular, cellular and epigenetic mechanisms underlying the pathogenesis of neurodegenerative and neuropsychiatric disorders. Our on-going projects include 1) cellular mechanisms underlying chronic stress-accelerated brain aging and neurodegeneration; 2) histone modifications during aging and in Alzheimer’s disease (AD); 3) adipokine modulation of synaptic plasticity and cognitive behaviors; 4) role of inflammaging progression in neurodegeneration; and 5) hippocampal and hypothalamic neurons in stress response and adaptation.

Dr. Lu lab image

molecular books

Lab Members

Xin-Yun Lu, MD, PhD - Professor
Yun Lei, PhD – Assistant Professor
Jacob Garza, PhD – Senior Research Scientist
Yuting Chen, PhD – Postdoctoral Fellow
Maryam Malek, PhD - Postdoctoral Fellow
Elina K C, PhD - Postdoctoral Fellow
Florika Patel - Research Associate
Yu Bai – Research Associate
Ning Wu – Research Assistant
Shu Chen – Research Assistant

Jayvon Nougiasse - MD/PhD Student
Amin Karimi Moghaddam - PhD Student
Sankeerth Kanumuri - PhD Student
Nithya Rajanala - MD Student

Rebecca McDonald - Honors Program, Neuroscience Undergraduate Student
Aditi Yellu, BS/MD - Professional Scholars Program
Cole Dorminey - Honors Program, Undergraduate Student

Open Positions in the Lab

We are currently welcoming postdoctoral fellows, graduate students and undergraduate students to join our laboratory.

Postdoctoral Fellows

We seek postdoctoral fellows interested in studying Alzheimer’s disease, depression and PTSD. The ideal candidates will hold a PhD in neuroscience, physiology, molecular/cell biology, metabolic biology or neuropharmacology. Expertise in electrophysiology, transgenic mouse models, epigenetics, imaging, and in vitro and in vivo adipose biology is desirable. Candidates are expected to have good communication skills and have a strong drive for building a successful research career.

Graduate Students

We welcome graduate students and are interested in potential rotation students. Prospective students can apply to our lab through the Graduate Program in Neuroscience as well as through the MD/PhD Program.

Undergraduate Students

We accept motivated undergraduate students who are interested in biomedical research.

Recent Publications

Veerapaneni P, Goo B, Ahmadieh S, Shi H, Kim DS, Ogbi M, Cave S, Chouhaita R, Cyriac N, Fulton DJ, Verin AD, Chen W, Lei Y, Lu XY, Kim HW, Weintraub NL (2024). Transgenic overexpression of HDAC9 promotes adipocyte hypertrophy, insulin resistance and hepatic steatosis in aging mice. Biomolecules. 2024 Apr 18;14(4):494. doi: 10.3390/biom14040494.
Gharpure M, Vyavahare S, Ahluwalia P, Gupta SK, Lee TJ, Lohakare J, Kolhe R; Lei Y, Deak F, Lu XY, Isales CM, Fulzele S (2024). Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology. Neurobiology of Disease. 2024 Feb:191:106404.doi:10.1016/j.nbd.2024.106404.
Ahmadieh S, Goo B, Zarzour A, Kim D, Shi H, Veerapaneni P, Chouhaita R, Yiew NKH, Gonzalez CD, Chakravartty A, Pennoyer J, Hassan N, Benson TW, Ogbi M, Fulton DJ, Lee R, Rice RD, Hilton LR, Lei Y, Lu XY, Chen W, Kim HW, Weintraub NL (2024). Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat fed mice. Obesity. 2024 Jan;32(1):107-119. doi: 10.1002/oby.23924.
Shi X, Ding K, Rosario R, Ajith A, Su Y, Shaw S, Lawrence MM, Lu XY, Horuzsko A, Isales CM (2024). Effects of Systemic PPARγ Inhibition on Bone and Immune Cells in Aged Female Mice. J Gerontol A Biol Sci Med Sci. 2024 Feb 1;79(2):glad247. doi: 10.1093/gerona/glad247
Kumro J, Tripathi A, Lei Y, Sword J, Callahan P, Terry A, Lu XY, Kirov S, Pillai A, Blake DT (2023). Chronic basal forebrain activation improves spatial memory, boosts neurotrophin receptor expression, and lowers BACE1 and Aβ42 levels in the cerebral cortex in mice. Cereb Cortex. 2023 Jun 8;33(12):7627-7641. doi: 10.1093/cercor/bhad066.
Xiang G, Liu X, Wang J, Lu S, Yu M, Zhang Y, Sun B, Huang B, Lu XY, Li X, Zhang D (2023). Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons. Transl Psychiatry. 2023 Jun 15;13(1):206. doi: 10.1038/s41398-023-02496-1.
Fang X, Chen Y, Wang J, Zhang Z, Bai Y, Denney K, Gan L, Guo M, Weintraub NL, Lei Y, Lu XY (2023). Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits. Molecular Psychiatry 28(3):1365–1382. Published: 06 December 2022. doi: 10.1038/s41380-022-01872-5.
Stranahan AM, Guo DH, Yamamoto M, Hernandez CM, Khodadadi H, Baban B, Zhi W, Lei Y, Lu XY, Ding K, Isales CM. (2023) Sex differences in adipose tissue distribution determine susceptibility to neuroinflammation in mice with dietary obesity. Diabetes 72(2):245-260. Published: 11 November 2022. doi: 10.2337/db22-0192.
Saggu S, Chen Y, Wang H, Cottingham C, Zhang S, Augelli-Szafran C, Jiao K, Lu XY and Wang Q (2023). Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation. Molecular Psychiatry 28(2): 588–600 2022. Published: 10 November 2022. doi: 10.1038/s41380-022-01851-w.
Lei Y, Wang D, Bai Y, Nougaisse J, Weintraub NL, Guo M, Lu XY (2022). Leptin enhances social motivation and reverses chronic unpredictable stress-induced social anhedonia during adolescence. Molecular Psychiatry 27(12):4948-4958. Published: 22 September 2022. doi: 10.1038/s41380-022-01778-2.
Kim J, Lei Y, Lu XY, and Kim CS (202). Glucocorticoid-glucocorticoid receptor-HCN1 channels reduce neuronal excitability in dorsal hippocampal CA1 neurons. Molecular Psychiatry 27(10):4035-4049. Published: 5 July 2022. doi: 10.1038/s41380-022-01682-9. Online ahead of print.
Miller B, McEvoy JP, McCall WV, Lu XY (2022). Lower adiponectin levels as a predictor of depressive symptoms in African-American males with schizophrenia. Schizophrenia Research. 2022 Nov 18;250:134-136.
Chin E, Ma Q, Ruan H, Chin C, Somasundaram A, Zhang C, Liu C, Lewis M, White MA, Smith T, Battersby M, Yao WD, Lu XY, Arap W, Licinio J, Wong ML (2022). The epigenetic reader PHF21B modulates social memory and synaptic plasticity-related genes in mice. JCI Insight. 2022 Jul 22;7(14): e158081. doi: 10.1172/jci.insight. 158081
Goo B, Ahmadieh S, Zarzour A, Yiew NKH, Kim D, Shi H, Greenway J, Cave S, JNguyen J, Arbindi S, Wendolowski M, Veerapaneni P, Ogbi M, Chen W, Lei Y, Lu XY, Kim HW, Weintraub NL. Sex-dependent role of adipose tissue HDAC9 in diet-induced obesity and metabolic dysfunction. Cells, 2022 Aug 30;11(17):2698. doi: 10.3390/cells11172698.
Fang X, Jiang S, Wang J, Bai Y, Kim CS, Blake DT, Weintraub NL, Lei Y, Lu XY (2022). Chronic unpredictable stress induces depression-related behaviors via suppressing AgRP neuron activity. Molecular Psychiatry. 26(6): 2299-2315. doi: 10.1038/s41380-020-01004-x. Epub 2021 Jan 11. Selected as a "SPOTLIGHT" article by Trends in Neurosciences.
Kim NS, Wen Z, Liu J, Zhou Y, Guo Z, Xu C, Lin YT, Yoon KJ, Park J, Cho M, Kim M, Wang X, Yu H, Salamuru S, Christian KM, Hsu KS, Xia M, Li W, Ross CA, Margolis RL, Lu XY^#, Song H^#, Ming GL^# (2021). Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation. Nature Communications. 2021 Mar 3;12(1):1398. doi: 10.1038/s41467-021-21713-3. ^#co-corresponding authors
Wong ML, Arcos-Burgos M, Liu S, Licinio AW, Yu C, Chin EWM, Yao WD, Lu XY, Bornstein SR, Licinio J (2021) Rare Functional Variants Associated with Antidepressant Remission in Mexican-Americans: Short title: Antidepressant remission and pharmacogenetics in Mexican-Americans. Journal of Affective Disorders. 279:491-500. doi: 10.1016/j.jad.2020.10.027. Epub 2020 Oct 17.
Li C, Meng F, Lei Y, Liu J, Liu J, Zhang J, Liu F, Liu C, Guo M, Lu XY (2020). Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade.Molecular Psychiatry. 26(8):3701-3722. doi: 10.1038/s41380-020-00922-0. Epub 2020 Oct 26
Li C, Meng F, Garza JC, Liu J, Lei Y, Kirov S, Guo M, Lu XY (2021). Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular Psychiatry. 26(8):4205-4220. doi: 10.1038/s41380-020-0649-0. Epub 2020 Jan 24
Lei Y, Wang J, Wang D, Li C, Liu B, Fang X, You J, Guo M, Lu XY (2020). SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex. Molecular Psychiatry. 25:1094-1111. doi: 10.1038/s41380-019-0352-1. Epub 2019 Jan 31
Yiew NKH, Greenway C, Zarzour A, Ahmadieh S, Goo B, Kim D, Benson TW, Ogbi M, Tang YL, Chen W, Stepp D, Patel V, Hilton R, Lu XY, Hui DY, Kim HW, Weintraub NL (2019). Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E. Journal of Biological Chemistry. 294(21):8577-8591.
Sun F, Lei Y, You J, Li C, Sun L, Garza J, Zhang D, Guo M, Scherer P, Lodge D, Lu XY (2019). Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1. Molecular Psychiatry, 24(1):126-144.

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Xin-Yun Lu, MD, PhD - Lab

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