Lawrence C. Layman, MD



Education

  • MD, University of Cincinnati, Cincinnati, Ohio, 1981
  • Residency: OB/GYN: University of Louisville
  • Fellowship: Reproductive Endocrinology & Infertility: Medical College of Georgia
  • Board certified in: OB/GYN; Reproductive Endocrinology & Infertility; Clinical Genetics; and Clinical Molecular Genetics

Clinical Interests

  • Disorders of Puberty
  • Hypogonadism
  • Premature Menopause
  • Menopause
  • Recurrent Pregnancy Loss
  • Molecular Biology
  • Pediatric Gynecology
  • Infertility
  • Surgery to Preserve Reproductive Function

Research Interests

Our lab is interested to better understand processes affecting puberty, fertility, and human development. With an emphasis on translational medicine, we hope to identify genes important for the development of normal puberty, sexual differentiation, and other organs including the heart and brain. In addition we want to optimize the outcome for patients with infertility, pregnancy loss, and assisted reproductive technologies, as well as reducing the likelihood of birth defects. Most recently, we received NIH grant funding for a project to identify genes involved in uterine and vaginal development.

Current Projects

      • Identifying gene mutations in patients with absent puberty due to hypothalamic-pituitary disorders (hypogonadotropic hypogonadism and Kallmann syndrome)
      • Mouse models of infertility
      • Mapping causative genes in patients having an underdeveloped uterus and vagina
      • Study of genes involved in sex determination and differentiation

Participate in one of Dr. Layman's Research Studies

Selected Publications

 Kim YJ, Osborn DP, Lee JY, Araki M, Araki K, Mohun T, Känsäkoski J, Brandstack N, Kim HT, Miralles F, Kim CH, Brown NA, Kim HG, Martinez-Barbera JP, Ataliotis P, Raivio T, Layman LC, Kim SH. WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289. doi: 10.15252/embr.201744632. Epub 2017 Dec 20. PubMed PMID: 29263200; PubMed Central PMCID: PMC5797970.

 Williams LS, Demir Eksi D, Shen Y, Lossie AC, Chorich LP, Sullivan ME, Phillips JA 3rd, Erman M, Kim HG, Alper OM, Layman LC. Genetic analysis of Mayer-Rokitansky-Kuster-Hauser syndrome in a large cohort of families. Fertil Steril. 2017 Jul;108(1):145-151.e2. doi: 10.1016/j.fertnstert.2017.05.017. Epub 2017 Jun 7. PubMed PMID: 28600106; PubMed Central PMCID: PMC5770980.

 Ko EK, Chorich LP, Sullivan ME, Cameron RS, Layman LC. JAK/STAT signaling pathway gene expression is reduced following Nelf knockdown in GnRH neurons. Mol Cell Endocrinol. 2017 Oct 16. pii: S0303-7207(17)30546-4. doi:10.1016/j.mce.2017.10.009. [Epub ahead of print] PubMed PMID: 29050862.

 Williams LS, Kim HG, Kalscheuer VM, Tuck JM, Chorich LP, Sullivan ME, Falkenstrom A, Reindollar RH, Layman LC. A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3. Mol Cytogenet. 2016 Jul 30;9:57. doi: 10.1186/s13039-016-0264-6. eCollection 2016. PubMed PMID:27478502; PubMed Central PMCID: PMC4967518.

Quaynor SD, Bosley ME, Duckworth CG, Porter KR, Kim SH, Kim HG, Chorich LP,Sullivan ME, Choi JH, Cameron RS, Layman LC. Targeted next generation sequencing approach identifies eighteen new candidate genes in normosmic hypogonadotropic hypogonadism and Kallmann syndrome. Mol Cell Endocrinol. 2016 Aug 5;437:86-96.doi: 10.1016/j.mce.2016.08.007.  PubMed PMID: 27502037.

Quaynor SD, Ko EK, Chorich LP, Sullivan ME, Demir D, Waller JL, Kim HG, Cameron RS, Layman LC. NELF knockout is associated with impaired pubertal development and subfertility. Mol Cell Endocrinol. 2015 May 15;407:26-36. doi: 10.1016/j.mce.2015.02.015. Epub 2015 Feb 27. PubMed PMID: 25731822; PubMed Central PMCID: PMC4429764.

Quaynor SD, Stradtman EW Jr, Kim HG, Shen Y, Chorich LP, Schreihofer DA, Layman LC. Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant. N Engl J Med. 2013 Jul 11;369(2):164-71. doi: 10.1056/NEJMoa1303611. PubMed PMID: 23841731; PubMed Central PMCID: PMC3823379.

Layman LC. Clinical genetic testing for Kallmann syndrome. J Clin Endocrinol Metab. 2013 May;98(5):1860-2. doi: 10.1210/jc.2013-1624. PubMed PMID: 23650337; PubMed Central PMCID: PMC3644595.

Contact Dr. Layman

phone icon    706-721-3832; 706-721-7591

fax icon   706-721-6830; 706-721-0340 

envelope icon   lalayman@augusta.edu

map-marker icon    Medical College of Georgia 
      Department of Neuroscience        and Regenerative Medicine 
      OB/GYN 
      1120 15th Street, CA-2041 
      Augusta, GA 30912