Lawrence C. Layman, MD


Lawrence Layman, MD

Prof & Chief, Section of Reproductive Endocrinology, Infertility, & Genetics
Department of Ob/Gyn
Developmental Neurobiology in DNRM
Neuroscience Program

MD, University of Cincinnati, Cincinnati, Ohio, 1981

Telephone: 706-721-3832, 706-721-7591
Fax: 706-721-6830, 706-721-0340
Email: llayman@augusta.edu

 

Mailing address:
Medical College of Georgia
Department of Neuroscience and Regenerative Medicine
OB/GYN
1120 15th Street, CA-2041
Augusta, GA 30912

Research Interests

Our lab is interested to better understand processes affecting puberty, fertility, and human development. With an emphasis on translational medicine, we hope to identify genes important for the development of normal puberty, sexual differentiation, and other organs including the heart and brain. In addition we want to optimize the outcome for patients with infertility, pregnancy loss, and assisted reproductive technologies, as well as reducing the likelihood of birth defects.

Current Projects include:

  • Identifying gene mutation in patients with absent puberty due to hypothalamic-pituitary disorders (hypogonadotropic hypogonadism and Kallmann syndrome)
  • Neuroendocrine regulation of reproduction
  • Mapping causative genes in patients with developmental disorders who have balanced chromosomal rearrangements
  • Study of genes involved in sex determination and differentiation
  • Improving methods of oocyte cryopreservation
  • Identifying risks for imprinting defects in patients who undergo in vitro fertilization.
Selected Publications

Layman LC, Lee EJ, Peak DB, Namnoum AB, Vu KK, van Lingen BL, Gray MR, McDonough PG, Reindollar RH, Jameson JL. Delayed puberty and hypogonadism caused by a mutation in the follicle stimulating hormone beta-subunit gene. N Engl J Med 1997;337:607-611.

Layman LC, Cohen DP, Jin M, Xie J, Li Z, Reindollar RH, Bolbolan S, Bick DP, Sherins RJ, Duck LW, Musgrove LC, Sellers JC, Neill JD. Mutations in gonadotropin-releasing hormone receptor cause hypogonadotropic hypogonadism. Nat Genet 1998;18:14-15.

Barnes RB, Namnoum A, Rosenfield RL, Layman LC. Effect of follicle stimulating hormone on ovarian androgen production in a woman with isolated follicle-stimulating hormone deficiency. N Engl J Med 2000;343:1197-1198.

Xu N, Podolsky RH, Chudgar P, Chorich LP, Liu C, McDonough PG, Warrington JA, Layman LC. Screening candidate genes for mutations in patients with hypogonadotropic hypogonadism using genome custom resequencing microarrays. Am J Obstet Gynecol 2005;192:1274-1284.

Bhagavath B, Ozata M, Ozdemir IC, Bolu E, Bick DP, Sherins RJ, Layman LC. The prevalence of GNRHR mutations in a large cohort of patients with hypogonadotropic hypogonadism. Fertil Steril 2005;84:951-7.

Bhagavath B, Podolsky RH, Ozata M, Bolu E, Bick DP, Kulharya A, Sherins RJ, Layman LC. Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism. Fertil Steril 2006; 85:706-13.

Bhagavath B, Xu N, Ozata M, Rosenfield RL, Bick DP, Sherins RJ, Layman LC. KAL1 mutations are not a common cause of idiopathic hypogonadotropic hypogonadism in humans. Mol Hum Reprod 2007;13:25-30.

Xu N, Qin Y, Reindollar RH, Tho SPT, McDonough PG, Layman LC. A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant, normosmic, isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2007;92:1155-8.

Pedersen-White JR, Chorich LP, Bick DP, Sherins RJ, Layman LC. The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Mol Human Reprod 2008;14:367-70.

Kim HG, Kurth I, Lan F, Meliciani I, Wenzel W, Eom SH, Kang GB, Rosenberger G, Tekin M, Ozata M, Bick DP, Sherins RJ, Walker SL, Morton CC, Shi Y, Gusella JF, Layman LC. Mutations in CHD7, encoding a chromatin remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Am J Hum Genet 2008;83:511-519. Featured article.