Education:
1986-1990            B.S., Biochemistry, Nankai University, Tianjin, P.R. China
1994-1999            Ph.D., Molecular Neuroscience, Wayne State University, Michigan

Postdoctoral Training:
1999-2001            Rutgers University

Research Interests:
Spinal cord injury (SCI) and repair, microRNAs (miRNAs), neuronal reprogramming, neurodevelopment, glial development, neural stem/progenitor cells, cell transplantation.

My research is focused on miRNA-mediated mechanisms during CNS development and after SCI. In addition, I combine the in vivo reprogramming technology with miRNA biology to induce miRNA-mediated neuronal reprogramming from endogenous reactive glial cells for SCI functional repair. MiRNAs are small and chemically modifiable, which makes them ideal candidates for therapy as synthetic drug. In fact, some miRNAs are already in clinical trials. My long-term research interest is to understand mechanisms of CNS development and injury, and their therapeutic potentials to treat SCI with a focus on miRNAs.

hedong li research

Current projects:

  • MicroRNA function during neuronal reprogramming in treating spinal cord injury (NIH, R01, PI).
  • Manipulating NeuroD1 expression by microRNAs to optimize neuronal conversion for spinal cord injury repair (NIH, R21, PI).
  • In vivo reprogramming reactive astrocytes into functional neurons by microRNA-124 in the injured spinal cord (NIH, R21, PI).
  • MicroRNA-mediated non-cell-autonomous regulation of cortical GABAergic interneuron development (pending).

Lab members:
We are currently recruiting postdoctoral fellows, research assistants, and graduate students. We also welcome motivated undergraduate students to join our laboratory.

Selected publications:

Dr. Hedong Li’s NCBI Bibliography link