Molecular mechanisms of lung injury and repair with focus on biochemical basis of pulmonary vascular cytoskeletal and permeability regulation.
* Structure and function of cytoskeletal proteins and protein phosphatases
* Phosphorylation/dephosphorylation as mechanism of vascular cytoskeletal regulation
* Relationship between pulmonary endothelial cell (EC) contractility/cytoskeleton and barrier function in vitro and in vivo
* Crosstalk between microtubules and microfilaments in EC barrier regulation
* Cytoskeletal responses to bioactive mediators and receptor/signal coupling in EC
* HDAC-mediated epigenetic mechanisms of lung injury
Ma Q, Yang Q, Xu J, Sellers HG, Brown ZL, Liu Z, Bordan Z, Shi X, Zhao D, Cai Y, Pareek V, Zhang C, Wu G, Dong Z, Verin AD, Gan L, Du Q, Benkovic SJ, Xu S, Asara JM, Ben-Sahra I, Barman S, Su Y, Fulton DJR, Huo Y. Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. Eur Heart J. 2023 Jan 31:ehad044. doi: 10.1093/eurheartj/ehad044. Online ahead of print.PMID: 36721994
Batori RK, Chen F, Bordan Z, Haigh S, Su Y, Verin AD, Barman SA, Stepp DW, Chakraborty T, Lucas R, Fulton DJR. Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction. Front Immunol. 2022 Jul 27;13:945656. doi: 10.3389/fimmu.2022.945656. eCollection 2022.PMID: 35967431
Parinandi N, Gerasimovskaya E, Verin A. Editorial: Molecular mechanisms of lung endothelial permeability . Front Physiol. 2022 Jul 22;13:976873. doi: 10.3389/fphys.2022.976873. eCollection 2022.PMID: 35936898
