yutao liu

Yutao Liu, M.D., PhD.

Associate Professor
Cellular Biology and Anatomy
Center for Biotechnology and Genomic Medicine
James & Jean Culver Vision Discovery Institute

Office: R&E Building CB1123
Phone: 706-721-2015
Lab: 706-721-4843
E-Mail: yutliu@augusta.edu

Laboratory Members

Research Associate/Lab Manager: Michelle Drewry, B.S.
Graduate Student: Jingwen Cai, M.S.
Graduate Student: Mariam Khaled, M.S.

Former Members

Research Associate, Arthur Zimmerman, MS; Graduate Student, Univ. of Florida
Medical Scholar, Mohammed Waqar; Medical Student, Augusta University

Education

1990-1995 MD Beijing Medical University, Beijing, China
1999-2001 MS Truman State University, Kirksville, MO
2001-2006 PhD University of Tennessee, Knoxville, TN
2006-2010 Postdoctoral Associate, Duke University Medical Center, Durham NC

Honors and Awards
  • Travel Scholarship for the 18th International Mouse Genome Conference, Seattle, WA; 2004
  • Experimental Eye Research Top Cited Article 2008-2010 for the paper entitled “The genetics of primary open-angle glaucoma: a review” by Allingham RR, Liu Y, and Rhee DJ.; 2010
  • The Thomas R. Lee Award for National Glaucoma Research, American Health Assistance Foundation, Clarksburg, MA; 2010-2013
  • “Exceptionally Good Review”, Investigative Ophthalmology & Visual Science; 2012 Dec 
  • “Exceptionally Good Review”, Investigative Ophthalmology & Visual Science; 2013 Feb 
  • Full scholarship to attend the 21st Annual Summer Training Course in Experimental Aging Research, the Barshop Institute in San Antonio, San Antonio, TX (supported by NIA funding); 2013 June
  • “Exceptionally Good Review”, Investigative Ophthalmology & Visual Science; 2013 Sept
  • “Exceptionally Good Review”, Investigative Ophthalmology & Visual Science; 2013 Dec
  • Annual Educator Award, Division of Medical Genetics, Department of Medicine, Duke University School of Medicine; 2013
News/media coverage of our research at Augusta University
  1. Our research on exosome research with Particle Matrix’s ZetaView
  2. Three glaucoma-related genes discovered from Science Daily
  3. Liu’s interview with MD Magazine at the 2016 annual ARVO meeting at Seattle, WA
  4. Our research discovery of miR-182 association with POAG and funding from BrightFocus by multiple media
    JAGWIRE, Science Daily, MedicalXpress, BioQuick News
  5. Dr. Liu’s participation of 2015 and 2016 Think Tank for The Glaucoma Foundation in New York City
Research Goals

eyeThe long term goal of our laboratory is to dissect age-related genetic diseases using systematic approaches, including human genetics/epigenetics, functional genomics, and molecular/cellular biology. Our lab has extensive research experience in the area of human genetics, bioinformatics, and functional genomics using several model systems, including human samples, in vitro cell/tissue culture and mouse models. Our research has been published in over 70 peer-reviewed articles, including Nature Genetics, PLoS Genetics, American Journal of Human Genetics, PNAS, IOVS, and Molecular Vision. Our research has been supported by a variety of different organizations, including the National Eye Institute at the National Institute of Health, several private foundations (The Glaucoma Foundation - TGF, the Glaucoma Research Foundation – GRF, the American Health Assistance Foundation – AHAF or BrightFocus, and RPB), and institutional supports.

Our current research is focused on understanding the molecular mechanisms and pathogenesis of two vision-related disorders: keratoconus (KC) and glaucoma. KC, a progressive thinning of the cornea, is the most common corneal ectasia, affecting one in every 500 to 2000 Americans. KC causes moderate to severe astigmatism, nearsightedness, swelling and cornea scarring. It is necessary for 10-20% KC patients to have cornea transplants. Our KC research is supported by a NIH R01 grant (EY023242), to identify genetic mutations in both DNA sequence and structure (i.e. copy number) in multiplex KC families using second generation DNA sequencing. We have research collaborations with investigators from California, Iowa, Illinois, Saudi Arabia, Israel, and Duke University in North Carolina. Glaucoma is the second leading cause of blindness worldwide, affecting over 60 million people. It is characterized as a progressive loss of retinal ganglion cells and visual field. Our lab has been involved in the identification of several glaucoma-associated genes, LOXL1, CDKN2B-AS1, SIX6, GALC, and chr8q22 locus. Dr. Liu is a Co-Investigator of the NEIGHBORHOOD glaucoma consortium. One of the research projects, funded by GRF currently, is to study how the exosomal miRNAs in the aqueous humor may affect glaucoma. We are characterizing how the exosomes and its content – miRNA are involved in the pathogenesis of glaucoma. This may lead to the identification of biomarkers for glaucoma. Besides the human genetics research, we are also interested in studying the ocular phenotypes in several available transgenic mouse models by characterizing their intraocular pressure, retinal ganglion cells, and cornea thickness and curveture.

Approaches

We are using a number of advanced cutting-edge technologies, including whole exome sequencing, RNA-Seq, small RNA sequencing, genome-wide DNA genotyping/gene expression, realtime PCR for DNA copy number and gene expression, droplet digital PCR, and nanoparticle tracking analysis (NTA) for exosomes. Bioinformatics is an important part of our research. We use a number of different bioinformatics tools in our daily research. We also use available mouse models to study both glaucoma and keratoconus by characterizing their ocular phenotypes.

liu lab equipment

Publications

For a detailed list of recent publications, please refer to NCBI My Bibliography

2016

  1. Cooke Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC,  Burdon K, Aschard H, Ashley-Koch A, Brilliant M, Budenz DL, Chasman D, Choi H, Christen WG, Curhan G, De vivo I,  Fingert J, Fuchs C,  Gaasterland D, Gaasterland T, Hu F, Hunter D, Igo RP, Khajara A, Kraft P, Lee RK, Lichter PR,  Moroi SE, Qi Q, Richards JE, Realini T, Rimm E, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Ramimi R, Vollrath D, Wollstein G, Yaspan BL, Zack DJ, Zhang K, Robert N. Weinreb RN, Pericak-Vance MA, Liu Y, Aung T, MacGregor S, Howell G, Hauser MA, Pasquale LR, Haines JL, Wiggs JL. Meta-analysis of 40,495 individuals identifies TXNRD2, ATXN2 and FOXC1 as novel susceptibility loci for primary open angle glaucoma. Nat Genet. 2016. (Contributed to the genetic association and human ocular gene expression data)
  2. Kertai MD, Qi W, Li YJ, Lombard FW, Liu Y, Smith MP, Stafford-Smith M, Newman MF, Milano CA, Podgoreanu MV, Mathew JP, PEGASUS. Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers. JMCC. 2016. Feb 6.
  3. Shalaby SM, Khater MK, Perucho AM, Mohamed SA, Helwa I, Laknaur A, Lebedyeva I, Liu Y, Diamond MP, Al-Hendy A. Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells. Fertil Steril. 2016. In press.
  4. Dinkins M, Enasko J, Hernandez C, Wang G, Kong JN, Helwa I, Liu Y, Terry A, Bieberich E. Neutral sphingomyelinase-2 deficiency ameliorates Alzheimer’s disease pathology and improves cognition in the 5XFAD mouse. J. Neuroscience. 2016, 36(33):8653-67. (Contributed to the exosome characterization and measurement using ZetaView, Collaboration with Dr. Bieberich at MCG)
  5. Drewry M, Helwa I, Allingham RR, Hauser MA, Liu Y*. miRNA profile in three different normal human ocular tissues by miRNA-Seq. Invest Ophthalmol Vis Sci. 2016, 57(8): 3731-9. (Corresponding author). PMID 27415791 (This is Michelle’s first publication as a first author).
  6. Liu Y*, Bailey JC, Helwa I, Dismuke WM, Cai J, Drewry M, Brilliant MH, Budenz DL, Christen WG, Chasman DI, Fingert JH, Gaasterland D, Gaasterland T, Gordon MO, Igo RP Jr, Kang JH, Kass MA, Kraft P, Lee RK, Lichter P, Moroi SE, Realini A, Richards JE, Ritch R, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Vollrath D, Weinreb R, Medeiros F, Wollstein G, Zack DJ, Zhang K, Pericak-Vance MA, Gonzalez P, Stamer WD, Kuchtey J, Kuchtey RW, Allingham RR, Hauser MA, Pasquale LR, Haines JL, Wiggs JL. A common Variant in MIR182 is associated with primary open-angle glaucoma in the NEIGHBORHOOD consortium. Invest Ophthalmol Vis Sci. 2016, 57(10): 3974-81. (Corresponding author).
  7. Khawaja AP, Cooke Bailey JN, Kang JH, Allingham RR, Hauser MA, Brilliant M, Budenz DL, Christen WG, Fingert J, Gaasterland D, Gaasterland T, Kraft P, Lee RK, Lichter PR, Liu Y, Medeiros F, Moroi SE, Richards JE, Realini T, Ritch R, Schuman JS, Scott WK, Singh K, Sit AJ, Vollrath D, Wollstein G, Zack DJ, Zhang K, Pericak-Vance M, Weinreb RN, Haines JL, Pasquale LR, Wiggs JL. Assessing the association of mitochondrial genetic variation with primary open-angle glaucoma using gene-set analyses. Invest Ophthalmol Vis Sci. 2016, 57(11):5046-5052.
  8. Pasquale LR, Aschard H, Kang JH, Cooke Bailey JN, Lindstrom S, Chasman DI, Christen WG, Allingham RR, Ashley-Koch A, Lee RK, Moroi SE, Brilliant MH, Wollstein G, Schuman JS, Fingert J, Budenz DL, Realini T, Gaasterland T, Gaasterland D, Scott WK, Singh K, Sit AJ, Igo RP, Song YE, Hark L, Ritch R, Rhee DJ, Gulati V, Havens S, Vollrath D, Zack DJ, Medeiros F, Weinreb RN, Pericak-Vance MA, Liu Y, Kraft P, Richards JE, Rosner BA, Hauser MA, Haines JL, Wiggs JL. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a U.S.-based sample. Menopause – the Journal of the North American Menopause Society. 2016. In press.
  9. Zhang W, Zhou X, Zhang H, Yao Q, Liu Y, Dong Z. Extracellular Vesicles in Diagnosis and Therapy of Kidney Diseases. Am J Physiol Renal Physiol. 2016 Aug 31. Epub. (Collaboration with Dr. Dong at MCG)
  10. Verma SS, Cooke Bailey JN, Lucas A, Bradford Y, Linneman JG, Hauser MA, Pasquale LR, Peissig PL, Brilliant MH, McCarty CA, Haines JL, Wiggs JL, Vrabec TR, Tromp G, Ritchie MD; eMERGE Network; NEIGHBOR Consortium. Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium. PLoS Genet. 2016, 12(9):e1006186 (member of the NEIGHBOR Consortium).
  11. Hauser MA, Garrett ME, Liu Y, Dennis MF, Kimbrel NA, VA Mid-Atlantic MIRECC Workgroup, Beckman JC, Ashley-Koch AE. Further Evidence for a Role of the ADRB2 Gene in Risk for Posttraumatic Stress Disorder. J Psychiatr Res. 2016. In press.

2015

  1. Bykhovskaya Y, Seldin MF, Liu Y, Ransom M, Li X, Rabinowitz YS. Independent origin of c.57 c>t mutation in MIR184 associated with inherited corneal and lens abnormalities. Ophthal Genet. 2015. 36(1): 95-7. (Performed genome-wide DNA genotyping using Illumina BeadChip and analyzed the SNP data).
  2. Kimbrel NA, Hauser MA, Garrett M, Ashley-Koch A, Liu Y, Dennis MF, Klein RC, Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Beckham JC. Effect of the APOE ε4 Allele and Combat Exposure on PTSD and Psychiatric Comorbidity. Depression and Anxiety. 2015; 32: 307-15.
  3. Liu Y, Garrett M, Dennis MF, Green KT, VA Mid-Atlantic MIRECC Registry Workgroup, Ashley-Koch AE, Hauser MA, Beckham JC, Kimbrel NA. An Examination of the Association between 5-HTTLPR, Combat Exposure, and PTSD Diagnosis among U. S. Veterans. PLoS One 2015 Mar 20;10(3):e0119998.
  4. Dismuke WM, Challa P, Navarro I, Stamer WD, Liu Y*. Human Aqueous Humor Exosomes. Exp Eye Res. 2015, 132:73-77. (* corresponding author)
  5. Springelkamp H, Mishra A, Hysi PG, Gharahkhani P, Höhn R, Khor CC, Cooke Bailey JN, Luo X, Ramdas WD, Vithana E, Koh V, Yazar S, Xu L, Forward H, Kearns LS, Amin N, Iglesias AI, Sim KS, van Leeuwen EM, Demirkan A, van der Lee S, Loon SC, Rivadeneira F, Nag A, Sanfilippo PG, Schillert A, de Jong PT, Oostra BA, Uitterlinden AG, Hofman A; NEIGHBORHOOD Consortium, Zhou T, Burdon KP, Spector TD, Lackner KJ, Saw SM, Vingerling JR, Teo YY, Pasquale LR, Wolfs RC, Lemij HG, Tai ES, Jonas JB, Cheng CY, Aung T, Jansonius NM, Klaver CC, Craig JE, Young TL, Haines JL, MacGregor S, Mackey DA, Pfeiffer N, Wong TY, Wiggs JL, Hewitt AW, van Duijn CM, Hammond CJ. Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology. Genet Epidemiol. 2015 Mar;39(3):207-16.
  6. Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Aravind H, Nakano S, Krumbiegel M, Harder J, Chan ASY, Burdon K, Astakhov YS, Abu-Amero KK, Zenteno JC, Nilgün Y, Zarnowski T, Pakravan M, Safieh LA, Jia L, Schlottmann PG, Williams S, Paoli D, Huang L, Lee MC, Astakhov SY, Sim KS, Foo JN, Nakano M, Ikeda Y, Ueno M, Manabe S, Hayashi K, Kazama S, Ideta R, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Inoue K, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Aihara M, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Matsuda F, Yamashiro K, Gotoh N, Miyake M, Essam A. Osman EA, Al-Obeidan SA, Owaydha O, Al-Jasim L, Al Shahwan S, Fogarty R, Leo P, Yetkin Y, Oguz C, Kanavi MR, Naderibeni A, Yazdani S, Eugeny L. Akopov EL,Toh KY, Goh Y, Meah WY, Peh SQ, Kosior-Jarecka E, Lukasik U, Uebe S, Vithana EN, Wong TY, Liu Y, Ashley Koch AE, Challa P, Rautenbach RM, Ziskind A, Carmichael T, Ramakrishnan R, Narendran K, Venkatesh R, Vijayan S, Guadarrama-Vallejo D, Perera SA, Husain R; Ho SL, Welge-Luessen UC, Mardin C, Schloetzer-Schrehardt U, Axel M. Hillmer AM, Herms S, Markus M. Nothen MM, Teo YY, Brown MA, Lischinsky I, Zhao B, Sang J, Zhang N, You Q, Vysochinskaya V, Founti P, Chatzikyriakidou A, Lambropoulos A,  Coleman AL, Wilson MR, Mori K, Rhee DJ, Kang JH, Bolchakova IM, FingertJ, Jonas JB, Xu L, Lerner F, Wang N, Yang Z, Frezzotti P, KinoshitaS, EdwardD, InataniM, Tashiro K, Reis A, Pasquale L, Janey L. Wiggs JL, Kubota T, PasuttoF, TopouzisF, DubinaM, CraigJE, YoshimuraN, SundaresanP, JohnSWN, RitchR, Hauser MA, KhorCC. A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome. Nat Genet. 2015; 47 (4): 387-92.
  7. Gordon-Shaag A, Millodot M, Shneor E, Liu Y*. The Genetic and Environmental Factors for Keratoconus. BioMed Res Intl. 2015: 795738 (* Corresponding author).
  8. Ashley-Koch AE, Garrett ME, Gibson J, Liu Y, Dennis MF, Kimbrel NA, VA MIRECC Workgroup, Beckham JC, Hauser MA. Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans. J Affect Disord. 2015.184:225-234.
  9. Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, Mani B, Chen LJ, Kee C, Garway-Heath DF, Sripriya S, Fuse N, Abu-Amero KK, Huang C, Namburi P, Burdon K, Perera SA, Gharahkhani P, Lin Y, Ueno M, Ozaki M, Mizoguchi T, Krishnadas SR, Osman EA, Lee MC, Chan AS, Tajudin LS, Do T, Goncalves A, Reynier P, Zhang H, Bourne R, Goh D, Broadway D, Husain R, Negi AK, Su DH, Ho CL, Blanco AA, Leung CK, Wong TT, Yakub A, Liu Y, Nongpiur ME, Han JC, Hon DN, Shantha B, Zhao B, Sang J, Zhang N, Sato R, Yoshii K, Panda-Jonas S, Ashley Koch AE, Herndon LW, Moroi SE, Challa P, Foo JN, Bei JX, Zeng YX, Simmons CP, Bich Chau TN, Sharmila PF, Chew M, Lim B, Tam PO, Chua E, Ng XY, Yong VH, Chong YF, Meah WY, Vijayan S, Seongsoo S, Xu W, Teo YY, Cooke Bailey JN, Kang JH, Haines JL, Cheng CY, Saw SM, Tai ES; ICAARE-Glaucoma consortium; NEIGHBORHOOD consortium, Richards JE, Ritch R, Gaasterland DE, Pasquale LR, Liu J, Jonas JB, Milea D, George R, Al-Obeidan SA, Mori K, MacGregor S, Hewitt AW, Girkin CA, Zhang M, Sundaresan P, Vijaya L, Mackey DA, Wong TY, Craig JE, Sun X, Kinoshita S, Wiggs JL, Khor CC, Yang Z, Pang CP, Wang N, Hauser MA, Tashiro K, Aung T, Vithana EN. A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet. 2015; 24 (13): 3880-92.
  10. Wang Y, Zhang L, Li Y, Chen L, Wang X, Guo W, Zhang X, Qin G, He S, Zimmerman A, Liu Y, Kim I, Weintraub NL, Tang Y. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int J Cardiol. 2015; 192: 61-9. (contributed to exosome size/concentration/zeta potential measurement and data interpretation).
  11. Abu-Amero KK, Helwa I, Al-Muammar A, Strickland S, Hauser MA, Allingham RR, Liu Y*. Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population. J Negat Results Biomed. 2015; 14:10. (* Corresponding author)
  12. Kimbrel NA, Garrett ME, Dennis MF, Liu Y, Patanam I, VA Mid-Atlantic MIRECC Workgroup, Ashley-Koch AE, Hauser MA, Beckham JC. Effect of Genetic Variation in the Nicotinic Receptor Genes on Risk for Posttraumatic Stress Disorder. Psychiatry Res. 2015; 229(1-2):326-31.
  13. Abu-Amero KK, Helwa I, Al-Muammar A, Strickland S, Hauser MA, Allingham RR, Liu Y*. Screening of the miR-184 for mutations in a keratoconus cohort from Saudi Arabia. BioMed Res Intl. 2015: 604508 (* Corresponding author).
  14. Hauser MA*, Aboobakar IF*, Liu Y*, Miura S, Whigham BT, Challa P, Wheeler J, Williams A, Santiago-Turla C, Qin X, Rautenbach RM, Ziskind A, Ramsay M, Uebe S, Song L, Safi A, Vithana EN, Mizoguchi T, Nakano S, Kubota T, Hayashi K, Manabe SI, Kazama S, Mori Y, Miyata K, Yoshimura N, Reis A, Crawford GE, Pasutto F, Carmichael TR, Williams SE, Ozaki M, Aung T, Khor CC, Stamer WD, Ashley-Koch AE, Allingham RR Genetic Variants and Cellular Stressors Associated with Exfoliation Syndrome Modulate antisense Promoter Activity within the LOXL1 Locus. Hum Mol Genet. 2015; 24(22): 6552-63. (* Co-first author with equal contribution).
  15. Cai J, Perkumas KM, Qin X, Hauser MA, Stamer WD, Liu Y*. Expression profiling of human Schlemm’s cananl endothelial cells from eyes with and without glaucoma. Invest Ophthalmol Vis Sci. 2015; 56: 6747-6753.  (Corresponding author). This is Jingwen’s first publication after joining the lab in 2014 December!

2014

  1. Ozel AB, Moroi SE, Reed DR, Nika M, Schmidt C, Akbari S, Scott K, Rozsa F, Pawar H, Musch DC, Lichter PR, Gaasterland D, Branham K, Gilbert J, Garnai S, Chen W, Othman M, Heckenlively J, Swaroop A, Abecasis G, Friedman DS, Zack D, Ashley-Koch A, Ulmer M, Kang JH, NEIGHBOR Consortium, Liu Y, Yaspan B, Haines J, Allingham RR, Hauser MA, Pasquale L, Wiggs JL, Richards JE, Li JZ. Genome wide Association Study and Meta-Analysis of Intraocular Pressure. Human Genet. 2014. 133(1):41-57.
  2. Loomis SJ, Pasquale LR, Kang JH, Weinreb RN, Yaspan BL, Bailey JC, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, R. Rand Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Jonathan L. Haines JL, Wiggs JL. Association of CAV1CAV/2 genomic variants with primary open angle glaucoma overall and by gender and pattern of visual field loss. Ophthalmology. 2014. 121(2): 508-16.
  3. Guffanti G, Koch AA, Roberts AL, Garrett M, Solovieff N, Ratanatharathorn A, De Vivo I, Dennis M, Ranu H, Smoller JW, Liu Y, Purcell SM, Veterans Affairs Mid-Atlantic Mental Illness research, Education, and Clinical Center Workgroup, Beckham J, Hauser MA, Koenen KC. No Association between RORA polymorphisms and PTSD two independent samples. Molecular Psychiatry. 2014 Oct; 19(10): 1056-1057.
  4. Kang JH, Loomis SJ, Yaspan BL, Bailey JC, Weinreb RN, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Gaasterland D, Gaasterland T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Forman JP, Buys ES, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL, Pasquale LR. Vascular Tone Pathway Polymorphisms in Relation to Primary Open Angle Glaucoma. Eye. 2014. 28(6): 662-71.
  5. Carnes MU, Liu YP, Allingham R, Whigham BT, Havens S, Garrett ME, Qiao C, NEIGHBORHOOD Consortium Investigators, Katsanis N, Wiggs JL, Pasquale LR, Ashley-Koch A, Oh EC, Hauser MA. Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma. PLoS Genet. 2014. 10(5): e1004372.
  6. Sun W, Sheng Y, Weng Y, Xu CX, Williams SE, Liu YT, Hauser MA, Allingham RR, Jin MJ, Chen GD. Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis. Int J Ophthalmol. 2014. 7(3): 550-6.
  7. Bailey JN, Yaspan BL, Pasquale LR, Hauser MA, Kang JH, Loomis SJ, Brilliant M, Budenz DL, Christen WG, Fingert J, Gaasterland D, Gaasterland T, Kraft P, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Richards JE, Realini T, Schuman JS, Scott WK, Singh K, Sit AJ, Vollrath D, Wollstein G, Zack DJ, Zhang K, Pericak-Vance MA, Allingham RR, Weinreb RN, Haines JL, Wiggs JL. Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. Hum Genet. 2014, 133(10): 1319-30.
  8. Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor CC , Loomis SJ, Cooke Bailey JN, Gibson J, Thorleifsson G , Janssen SF, Luo X, Ramdas W, Vithana E, Nongpiur ME, Montgomery GW, Xu L, Mountain JE, Gharahkhani P, Lu Y, Amin N, Karssen L, Sim K, van Leeuwen E, Iglesias AI, Verhoeven V, Hauser MA, Loon S, Despriet D, Nag A, Venturini C, Sanfilippo PG, Schillert A, Kang JH, Landers J, Jonasson F, Cree AJ, van Koolwijk LME, Rivadeneira F Souzeau E, Jonsson V, Menon G, Blue Mountains Eye Study – GWAS group, Weinreb RN, deJong PTVM, Oostra BA, Uitterlinden AG, Hofman A, Ennis S, Thorsteinsdottir U, Burdon KP, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Spector YD, Mirshahi A, Saw S-M, Vingerling JR, Teo Y-Y, Haines JL, Wolfs RCW, Lemij HG, Tai E-S, Jansonius NM, Jonas JB, Cheng C-Y , Aung T, Viswanathan AC, Klaver CCW, Craig JE, Macgregor S , Mackey DA, Lotery AJ, Stefansson K, Bergen AAB, Young TL, Wiggs JL, Pfeiffer N, Wong T-Y, Pasquale LR, Hewitt AW, van Duijn CM, Hammond CJ. Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nat Commun. 2014, 5: 4883.
  9. Gharahkhani P, Burdon KP, Fogarty R, Sharma S, Hewitt AW, Martin S, Law MH, Cremin K, Cooke Bailey JN, Loomis SJ, Pasquale LRHaines JL, Hauser MA, Viswanathan AC, McGuffin P, Topouzis F, Foster PJ, Graham SL, Casson RJ, Chehade M, White AJ, Zhou T, Souzeau E, Landers J, Fitzgerald JT, Klebe S, Ruddle JB, Goldberg I, Healey PR, Wellcome Trust Case Control Consortium, NEIGHBORHOOD consortium, Mills RA, Wang JJ, Montgomery GW, Martin NJ, Radford-Smith G, Whiteman DC, Brown MA, Wiggs JL, Mackey DA, Mitchell P, Macgregor S, Craig JE. Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. Nat Genet. 2014, 46(10): 1120-5.
  10. Hysi PG, Cheng C-Y, Springelkamp H, Macgregor S, Cooke Bailey JN, Wojciechowski R, Vitart V, N Abhishek , Hewitt AW, Höhn R, Venturini C, Mirshahi A, Ramdas WD, Thorleifsson G, Vithana E, Khor CC, Stefansson AB, Liao J, Haines JL, Amin N, Wang YX, Wild PS, Ozel AB, Li JZ, Fleck BW, Zeller T, Staffieri SE, Teo Y-Y, Cuellar-Partida G, Luo X, Allingham RR, Richards JE, Senft A, Karssen LC, Zheng Y, Bellenguez C, Xu L, Iglesias AI, Wilson JF, Kang JH, van Leeuwen EM, Jonsson V, Thorsteinsdottir U, Despriet DDG, Ennis S, Moroi SE, Martin NG, Jansonius NM, Yazar S, Tai E, Amouyel P, Kirwan J, van Koolwijk LME, Hauser MA, Jonasson F, Leo P, Loomis SJ, Fogarty R, Rivadeneira F, Kearns L, Lackner KJ, de Jong PTVM, Simpson CL, Pennell CE, Oostra BA, Uitterlinden AG, Saw S-M, Lotery AJ, Bailey-Wilson JE, Hofman A, Vingerling JR, Maubaret C, Pfeiffer N, Wolfs RCW, Lemij HG, Young TL, Pasquale LR, Delcourt C, Spector TD, Klaver CCW, Small KS, Burdon KP, Stefansson K, Wong T-Y, BMES GWAS Group, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium1, Viswanathan A, Mackey DA Craig JE, Wiggs JL, van Duijn CM, Hammond CJ, Aung T. Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet. 2014, 46(10): 1126-30.
  11. Liu Y*, Garrett ME, Yaspan BL, Cooke Bailey JN, Loomis SJ, Brilliant M, Budenz DL, Christen WG, Fingert JH, Gaasterland D, Gaasterland T, Kang JH, Lee RK, Lichter PR, Moroi SE, Realini T, Richards JE, Schuman JS, Scott WK, Singh K, Sit AJ, Vollrath D, Weinreb RN, Wollstein G, Zack DJ, Zhang K, Pericak-Vance M, Haines JL, Pasquale LR, Wiggs JL, Allingham RR, Ashley-Koch AE, Hauser MA. DNA Copy Number Variants of Known Glaucoma Genes in Relation to Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2014. 55(12): 8251-8 (*Corresponding author).