R. Clinton Webb, PhD, FAPS

Regents' Professor

Dr. R. Clinton Webb

Phone: (706) 721-3365
Fax: (706) 721-7299
Email: cwebb@augusta.edu
Office: CA-2095
Lab: CA-2059


Education and Training

Universitaire Instelling Antwerpen: Antwerp, Belgium
Department of Medicine, (Research Associate), 1978-1979.

University of Michigan: Department of Physiology
Postdoctoral fellowship, Michigan Heart Association, 1976-1978.

University of Iowa: Iowa City, Iowa,
PhD (Anatomy), 1973-1976.

Southern Illinois University: Carbondale, Illinois
MS, 1972-1973.

Southern Illinois University: Carbondale, Illinois
BA (Physiology), 1968-1971.

University of Iowa: Iowa City, Iowa, 1967-1968.

Academic Appointments

1979 - Assistant Professor - University of Michigan

1983 - Associate Professor - University of Michigan

1987 - Professor - University of Michigan

1999 through 2018 - Department Chair - Medical College of Georgia

1999 - present - Regents' Professor - Medical College of Georgia

Research Interests

The physiology of vascular smooth muscle, with particular emphasis placed on:

  1. vascular reactivity in hypertension and diabetes
  2. penile and clitoral erection in sexual dysfunction
  3. cellular and subcellular mechanisms of contraction and relaxation of vascular smooth muscle (cell signaling, electrogenic sodium pump, subcellular calcium distribution, monovalent cation movements, nitric oxide, RhoA/Rho kinase, etc.),
  4. adrenergic neurotransmission in blood vessels
  5. intercellular communication between vascular smooth muscle cells.

Awards and honors

2019 American Physiological Society Fellow (FAPS)

2018 American Heart Association Novartis Award for Hypertension Research

2017 Distinguished Research Faculty Award from The Graduate School 

2015 Augusta University Research Institute Lifetime Achievement Award, Augusta University

2013 Irvine Page and Alva Bradley Lifetime Achievement Award, Council for High Blood Pressure Research, American Heart Association

2013 David F. Bohr Lecture, 11th International Symposium on Mechanisms of Vasodilatation

2012 AstraZeneca Award, International Society for Hypertension

2012 Carl J. Wiggers Award, Cardiovascular Section, American Physiological Society

2011 Regents’ Professor, Medical College of Georgia at Augusta University

2009 Distinguished Basic Research Award, Medical College of Georgia at Augusta University

2004 E. Eric Hypertension Research Day Lectureship, The Cardiovascular-Renal Center of the University of Tennessee Health Science Center, Memphis, Tennessee

(Go to Pub Med

Goulopoulou S, Matsumoto T, Bomfim GL, Webb RC. Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in preeclampsia. Clin Sci (Lond). 2012, 123(7):429-35. PMID: 22671429

Goulopoulou S, Hannah JL, Matsumoto T, Webb RC. Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in rat uterine artery. Am J Physiol Heart Circ Physiol. 2012302(12):H2477-88, 2012. PMCID: PMC3378266

Bomfim G, Dos Santos R, Oliveira MA, Giachini FR, Akamine E, Tostes RC, Fortes ZB, Webb RC, Carvalho MHC. Toll like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rat. Clin Sci. 2012, 122:534-543. PMID: 22233532

Matsumoto T, Szasz T, Tostes RC, Webb RC. Impaired β-adrenoceptor-induced relaxation in small mesenteric arteries from DOCA-salt hypertensive rats is due to reduced K(Ca) channel activity. Pharmacol Res. 2012, 65(5):537-45. PMCID: PMC3264768

Matsumoto T, Tostes RC, Webb RC. Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol.2011, 301(2):H409-17. PMCID: PMC3154666

Giachini FR, Lima VV, Carneiro FS, Tostes RC, Webb RC. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: Role of phosphodiesterase 1.Hypertension2011, 57:655-663. PMCID: PMC3074298

Choi H, Tostes R, Webb RC. Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin II hypertensive mice. J Am Soc Hypertension2011, 5:154-160. PMCID: PMC3085594

Allahdadi KJ, Hannan JL, Ergul A, Tostes RC, Webb RC. Internal pudendal artery from type 2 diabetic female rats demonstrate elevated endothelin-1-mediated constriction. J Sex Med. 2011, 8(9):2472-83. PMID: 21718448

Lima VV, Giachini FR, Carneiro FS, Carneiro ZN, Saleh MA, Pollock DM, Fortes ZB, Carvalho MH, Ergul A, Webb RC, Tostes RC. O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin-1.Hypertension2010, 55:180-188. PMCID: PMC2808689

Giachini FR, Sullivan JC, Lima VV, Carneiro FS, Fortes ZB, Pollock DM, Carvalho MH, Webb RC, Tostes RC. Extracellular signal-regulated kinase1/2 activation via down-regulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity.Hypertension2010, 55:172-179. PMCID: PMC2801880


Link to Dr. Webb on PubMed


Olufunke Arishe
Exchange Visitor

Fernanda Priviero, PhD
Assistant Research Scientist

2018 Webb Event2018 Webb Lab with Families

Styliani Goulopoulou, Camilla F. Wenceslau, Cameron G. McCarthy, Takayuki Matsumoto, R. Clinton Webb Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats Am J Physiol Heart Circ Physiol, published April 15, 2016. DOI: 10.1152/ajpheart.00834.2015.

Hypertension and Football: Cam McCarthy, Graduate Student in Dr. Webb's Lab is currently looking at DAMPs and its relationship to hypertension and football players. Click video to learn more.