Adviye Ergul, MD, PhD


Regents' Professor, co-Director Physiology Graduate Program

Dr. Adviye Ergul

 Phone: 706-721-9103
 Fax: 706-721-7299
 Office: CA-2094
 Lab: CA-2059



learn more about Dr. Ergul's research

Education and Training

University of Georgia, Athens, GA,
Postdoctoral Associate, Department of Biochemistry and Molecular Biology, 1995-1996.

University of Miami School of Medicine, Miami, FL,
PhD - Department of Biochemistry and Molecular Biology 1995.

Ministry of Health, Haseki Hospital, Istanbul, Turkey,
Resident, Clinical Biochemistry, 1987-1990.

The University of Istanbul Cerrahpasa Medical School, Istanbul, Turkey,
MD, 1987.

Academic Appointments

1996-1998 - Assistant Research Instructor, Department of Biochemistry and Molecular Biology, University of Georgia.

1998-2000 - Assistant Research Professor, Department of Surgery, Medical University of South Carolina.

2000-2005 - Assistant Professor, Department of Clinical and Administrative Sciences, University of Georgia.

2000-present - Associate Member, Vascular Biology Center, Medical College of Georgia.

2000-present - Adjunct Assistant Professor, Department of Biochemistry & Molecular Biology, University of Georgia.

2001-present - Clinical Assistant Professor, Department of Internal Medicine, Medical College of Georgia.

2001-present - Clinical Assistant Professor, Department of Surgery, Medical College of Georgia.

2005-2006 - Associate Professor, Department of Clinical and Administrative Pharmacy, University of Georgia.

2007-2009 - Associate Professor, Department of Physiology, Medical College of Georgia.

2009-2017 - Professor, Department of Physiology, Medical College of Georgia

2017 - Regents Professor, Department of Physiology, Augusta University

Link to

  ■  Curriculum Vita

Research Interests

The overall goal of my laboratory is to better understand the regulation of vascular function and structure in diabetes in order to prevent, delay or reverse diabetes-associated complications including stroke and cognitive impairment. In collaboration with Dr. Susan Fagan, we have made the interesting observation that there is significant cerebral neovascularization in type 2 diabetic rats and when ischemia/reperfusion injury occurs, diabetic animals develop bleeding into the brain, a dreaded complication of stroke. Our efforts are focused on how diabetes alters the expression and function of key mediators that are critical for vascular integrity and function. These studies are important to identify potential mechanisms contributing to cognitive decline in diabetes as well as identifying how an ischemic injury superimposed on this existing pathology affect functional outcomes and recovery following stroke. In addition, based on the clinical evidence which suggests that acute hyperglycemic patients suffer the worst outcomes of stroke, in collaboration with Dr. Askiel Bruno from Department of Neurology, we are investigating the mechanisms that mediate greater vascular and neuronal injury in hyperglycemic stroke.

Left. Control  /  Right. Diabetes

Dr. Ergul research of brain images

Top. Representative brain images showing increased vascular remodeling and arteriogenesis in type 2 diabetic Goto-Kakizaki (GK) rats.

Bottom. When ischemia reperfusion injury is overlayed on this pathology by temporary middle cerebral artery occlusion, diabetic rats develop significant bleeding into the brain that worsens functional outcomes

Current Projects

Diabetes & Ischemic Brain Injury. This project focuses on the effects of diabetes-induced changes in the microvascular structure and function on increased risk of stroke as well as mechanisms of worsened stroke outcome in diabetes. The project also investigates how bleeding into the brain during stroke can impair the repair process and functional recovery.

Acute Hyperglycemia & Ischemic Brain Injury. This translational project focuses on the mechanisms underlying increased neurovascular injury in hyperglycemic stroke. We specifically focus on the effects of hyperglycemia on cerebrovascular function and integrity. Vascular function studies investigate the mechanisms by which hyperglycemia reduces myogenic tone in both hemispheres of the brain under normoxic and hypoxic conditions. Vascular integrity studies investigate the role of matrix metalloprotease3 (MMP3) in increased bleeding after stroke using different models of experimental stroke and hyperglycemia.

Microvascular Remodeling and Vascular Complications in Obesity and Diabetes: This project seeks to determine the physiological and molecular mechanisms of increased cerebral angiogenesis and arteriogenesis in diabetes and obesity.

Awards and accomplishments

2018 Veterans Administration Senior Research Career Scientist Award

2013 Augusta University Student Government Association Faculty Leader Award

2013-2018 Veterans Administration Research Career Scientist Award

2015 Phi Kappa Phi Honor Society

2015 The Graduate School at Augusta University, the Distinguished Research Award

2014 Augusta University Faculty Senate Outstanding Faculty Award for Graduate Studies

2014 Augusta University Research Institute Virendra Mahesh Distinguished Research Award

2012 GHSU Distinguished Research Professor American Heart Association Council on High Blood Pressure Research Leadership Committee

Dr. Ergul with students

Dr. Ergul with students (VA)

2017 AHA Conference Dr. Ergul Lab PostersDr. Ergul with lab personnel at 2017 AHA Stroke Conference
Top: Drs. Yasir Abdul, Weiguo Li
Bottom: Graduate students John Paul Valenzuela, Becca Ward


*Representative Publications*

(Go to Pub Med)

Elgebaly MM, Ogbi S Li W, Prakash R, Johnson MH, Mezzetti EM, Bruno A, Fagan SC and Ergul A. Neurovascular outcomes in acute hyperglycemia and diabetes: A comparative analysis in experimental stroke. Trans. Stroke Res., 2:391-398, 2011. PMID: 21909340

Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A,Johnson MA, Alhusban A, Soliman S, Fagan SC. Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. PLoS ONE, 6(9):e24551, 2011. PMID: 21912702

Ergul A, Kelly-Cobbs A, Abdalla M, and Fagan SC. Cerebrovascular complications of diabetes. Endocr Metab Immune Disord Drug Targets, 12(2):148-158, 2012. PMID: 22236022

Prakash R, Shenoy S, El-Remessy A, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC and Ergul A. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes, 61(6):1533-1542, 2012. PMID: 22403298

Coucha M, Li W, and Ergul A. Endothelin receptor A antagonism improves large artery vasorelaxation after ischemic stroke. Life Sciences, 91(13-14):676-680, 2012. PMID: 22365958

Switzer JD, Sikora A, Ergul A, Waller JL, Hess DC, Fagan SC. Minocycline prevents IL-6 increase after acute ischemic stroke. Transl Stroke Res, 3(3):363-368, 2012. PMID:23105953

Ergul A, Alhusban A, and Fagan SC. Angiogenesis: A Harmonized Target for Recovery after Stroke. Stroke, 43(8):2270-2274, 2012. PMID: 22618382

Kelly-Cobbs AI, Prakash R, Knight RA, Li W, Ogbi S, Jonhson M and Ergul A. Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: Role of peroxynitrite in hypoxia-mediated loss of myogenic tone. J Pharmacol Exp Ther, 342(2):407-15, 2012. PMID: 22570365

Hoda N, Hill W, Ergul A, Fagan SC, and Hess D. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue plasminogen activator in murine model of embolic stroke. Stroke, 43(10):2794-9, 2012. PMID:22910893

Fagan, S.C., Lapchak, P.A., Liebeskind, D.S, Ishrat, T., and Ergul, A. Recommendations for preclinical research in hemorrhagic transformation. Transl Stroke Res.;4(3):322-327, 2013. PMID:23730351.

 Dr. Ergul's FACULTY ProfileLink to Dr. Ergul on PubMed


Yasir Abdul, PhD
Post-doctoral Fellow

Heba Ahmed
Research Assistant

Guangkuo (Glenn) Dong
Senior Research Assistant

LaDonya Jackon
Graduate Student

Sarah Jamil
Research Assistant

Weiguo Li, MD, PhD
Assistant Research Scientist

Rebecca Ward
Graduate Student

2017 AHA Dr. Ergul's MenteesPictured left to right, top row to bottom: Dr. Weiguo Li, Dr. Yasir Abdul, Dr. Sherif Hafez, John Paul Valenzuela, Dr. Mohammed Abdelsaid, Dr. Adviye Ergul, Rebecca Ward, (2017)

Dr. Ergul's Lab 2016Pictured left to right, top row to bottom: Guangkuo (Glenn) Dong, Dr. Weiguo Li, Dr. Adviye Ergul, Rebecca Ward, Dr. Yasir Abdul,  John Paul Valenzuela (2016)

Dr. Ergul's Lab (2015)Pictured left to right, top row to bottom: Dr. Weiguo Li, Trevor Hardigan, Dr. Mohammed Abdelsaid, John Paul Valenzuela, Guangkuo (Glenn) Dong, Dr. Sherif Hafez, Dr. Yasir Abdul, Rebecca Ward, Dr. Adviye Ergul (2015)

Dr. Ergul's Lab

Pictured left to right, top row to bottom: Sherif Hafez, Dr. Mohammed Abdelsaid, Dr. Weiguo Li, Dr. Roshini Prakash, Maha Coucha, Dr. Adviye Ergul, Handong Ma, Zhi Qu

Recent Lab Personnel Achievements

LaDonya Jackson received the Minority Travel Fellowship Award to attend the 2018 APS Conference: Cardiovascular, Renal and Metabolic Diseases: Sex-Specific Implications for Physiology.

Dr. Rebecca Ward successfully defended.

Dr. Yasir Abdul was awarded second place in the post-doctoral category for his poster at the 2017 STaR Conference.

Rebecca Ward received the Young Investigator Travel Award for an oral abstract presentation.

Dr. Weiguo Li received funding for a DiaComp Pilot & Feasibility Project.