Rheumatology Research

The mission of the Medical College of Georgia at Augusta University’s Division of Rheumatology is to pursue research that will directly benefit patient care for rheumatic diseases and to educate future rheumatologists in this endeavor.

Current areas of research interest include:

  • Age-related and postmenopausal osteoporosis

  • Osteoporosis in Spinal Cord Injury and Disorders

  • The Interrelationship between Osteoporosis and Cardiovascular Disease

  • Health care disparities in Rheumatic Diseases

  • Cardiovascular disease in systemic lupus erythematosus 

  • Improving holistic health of patients with autoimmune disease through optimizing preventive care

 

Principal Investigator:Laura Carbone, MD
Title:
Development of a Novel Soluble Epoxide Hydrolase Inhibitor as a Strategy for Treating Neuropathic Pain in Patients with Spinal Cord Injury
Source of Funding:
Department of Defense
Funding Period:
9/30/2021-9/29/2025

Principal Investigator: Laura Carbone, MD
Title: Amino Acids and Osteoporosis in Aging
Source of Funding: Augusta University Intramural Grants Program
Funding Period: 8/1/2020-7/31/2021

 Laura Carbone, MD
  • Etingen B, Carbone LD, Guihan M, Ray C, Aslam H, Elam R, Weaver FM. Lower extremity fracture prevention and management in persons with spinal cord injuries and disorders: The patient perspective. J Spinal Cord Med. 2021 Apr 8:1-11. doi: 10.1080/10790268.2021.1907675. Epub ahead of print. PMID: 33830880. FULL TEXT

  • Guihan M, Roddick K, Cervinka T, Ray C, Sutton C, Carbone L, Weaver FM. Physical and occupational therapist rehabilitation of lower extremity fractures in veterans with spinal cord injuries and disorders. J Spinal Cord Med. 2021 Mar 11:1-9. doi: 10.1080/10790268.2021.1890680. Epub ahead of print. PMID: 33705274. FULL TEXT

  • Harvey NC, Kanis JA, Liu E, Cooper C, Lorentzon M, Bea JW, Carbone L, Cespedes Feliciano EM, Laddu DR, Schnatz PF, Shadyab AH, Stefanick ML, Wactawski-Wende J, Crandall CJ, Johansson H, McCloskey E. Predictive Value of DXA Appendicular Lean Mass for Incident Fractures, Falls, and Mortality, Independent of Prior Falls, FRAX, and BMD: Findings from the Women's Health Initiative (WHI). J Bone Miner Res. 2021 Apr;36(4):654-661. doi: 10.1002/jbmr.4239. Epub 2021 Jan 28. PMID: 33450071; PMCID: PMC7610603. FULL TEXT

  • Carbone LD, Johnson K, Larson JC, Thomas F, Wactawski-Wende J, Bollinger K, Chen Z, Watsky M. Association of vitamin D with incident glaucoma: findings from the Women's Health Initiative. J Investig Med. 2021 Jan 11:jim-2020-001645. doi: 10.1136/jim-2020-001645. Epub ahead of print. PMID: 33431603. FULL TEXT

  • Madera-Acosta A, Johnson-Wall H, Carbone LD, Meszaros A, Berman AE, White J. Cannabidiol (CBD) oil toxicity mimicking extraglandular complications of Sjögren's syndrome. Rheumatol Adv Pract. 2021 Feb 27;5(1):rkab010. doi: 10.1093/rap/rkab010. PMID: 33748661; PMCID: PMC7962723. FULL TEXT

  • Elam RE, Jackson N, Machua W, and Carbone L. Osteoporosis. Medscape Drugs & Diseases. Updated January 20, 2021. Available at: https://emedicine.medscape.com/article/330598-overview

  • Carbone LD, Ortiz Kaemena MF, Elam RE. Heart failure and osteoporosis: an association that merits further study. Pol Arch Intern Med. 2020 Nov 30;130(11):928-929. doi: 10.20452/pamw.15691. Epub 2020 Nov 30. PMID: 33252209. FULL TEXT

  • Weaver FM, Gonzalez B, Ray C, Etingen B, Schwartz A, Burns S, Le B, Aslam H, Priebe M, Carbone LD. Factors influencing providers' decisions on management of bone health in people with spinal cord injury. Spinal Cord. 2021 Jul;59(7):787-795. doi: 10.1038/s41393-020-00589-y. Epub 2020 Nov 25. PMID: 33239741. FULL TEXT

  • Peterkin-McCalman R, Waller JL, Le B, Oliver AM, Manning E, Elam RE, Kheda M, Nahman NS Jr, Carbone LD. Fractures in patients with rheumatoid arthritis and end-stage renal disease. Arch Osteoporos. 2020 Sep 18;15(1):146. doi: 10.1007/s11657-020-00815-3. PMID: 32948922. FULL TEXT

  • Crandall CJ, Larson J, Wright NC, Laddu D, Stefanick ML, Kaunitz AM, Watts NB, Wactawski-Wende J, Womack CR, Johnson KC, Carbone LD, Jackson RD, Ensrud KE. Serial Bone Density Measurement and Incident Fracture Risk Discrimination in Postmenopausal Women. JAMA Intern Med. 2020 Sep 1;180(9):1232-1240. doi: 10.1001/jamainternmed.2020.2986. Erratum in: JAMA Intern Med. 2020 Nov 1;180(11):1555. PMID: 32730575; PMCID: PMC7385675. FULL TEXT

  • Huang D, Weaver F, Obremskey WT, Ahn J, Peterson K, Anderson J, Veazie S, Carbone LD. Treatment of Lower Extremity Fractures in Chronic Spinal Cord Injury: A Systematic Review of the Literature. PM R. 2021 May;13(5):510-527. doi: 10.1002/pmrj.12428. Epub 2020 Aug 25. PMID: 32500657. FULL TEXT

  • Carbone L, Vasan S, Elam R, Gupta S, Tolaymat O, Crandall C, Wactawski-Wende J, Johnson KC. The Association of Methotrexate, Sulfasalazine, and Hydroxychloroquine Use With Fracture in Postmenopausal Women With Rheumatoid Arthritis: Findings From the Women's Health Initiative. JBMR Plus. 2020 Aug 18;4(10):e10393. doi: 10.1002/jbm4.10393. PMID: 33103025; PMCID: PMC7574701. FULL TEXT

  • Paudyal S, Waller JL, Oliver A, Le B, Zleik N, Nahman NS Jr, Carbone L. Rheumatoid Arthritis and Mortality in End Stage Renal Disease. J Clin Rheumatol. 2020 Mar;26(2):48-53. doi: 10.1097/RHU.0000000000000916. PMID: 32073514. FULL TEXT

  • Carbone LD, Gonzalez B, Miskevics S, Ray C, Etingen B, Guihan M, Craven BC, George V, Weaver FM. Association of Bisphosphonate Therapy With Incident of Lower Extremity Fractures in Persons With Spinal Cord Injuries or Disorders. Arch Phys Med Rehabil. 2020 Apr;101(4):633-641. doi: 10.1016/j.apmr.2019.12.010. Epub 2020 Jan 18. PMID: 31958428. FULL TEXT

  • Weaver FM, Etingen B, Guihan M, Ray C, Priebe M, Burns S, Carbone L. Spinal cord injury providers' perspectives on managing sublesional osteoporosis. J Spinal Cord Med. 2020 Jul;43(4):428-434. doi: 10.1080/10790268.2019.1704552. Epub 2019 Dec 20. PMID: 31859610; PMCID: PMC7480594. FULL TEXT

  • Essali N, Goldsmith DR, Carbone L, Miller BJ. Reply to the Letter to the Editor: Reduced neuropsychiatric events as "beneficial reactions" to drugs: Seek associations with caution. Brain Behav Immun. 2020 Feb;84:277. doi: 10.1016/j.bbi.2019.11.012. Epub 2019 Nov 18. PMID: 31751615; PMCID: PMC8211419. FULL TEXT

  • Le B, Ray C, Gonzalez B, Miskevics S, Weaver FM, Priebe M, Carbone LD. Laboratory evaluation of secondary causes of bone loss in Veterans with spinal cord injury and disorders. Osteoporos Int. 2019 Nov;30(11):2241-2248. doi: 10.1007/s00198-019-05089-1. Epub 2019 Aug 13. PMID: 31410501. FULL TEXT

  • Morse LR, Biering-Soerensen F, Carbone LD, Cervinka T, Cirnigliaro CM, Johnston TE, Liu N, Troy KL, Weaver FM, Shuhart C, Craven BC. Bone Mineral Density Testing in Spinal Cord Injury: 2019 ISCD Official Position. J Clin Densitom. 2019 Oct-Dec;22(4):554-566. doi: 10.1016/j.jocd.2019.07.012. Epub 2019 Aug 3. PMID: 31501005. FULL TEXT

  • Carbone LD, Vasan S, Prentice RL, Harshfield G, Haring B, Cauley JA, Johnson KC. The renin-angiotensin aldosterone system and osteoporosis: findings from the Women's Health Initiative. Osteoporos Int. 2019 Oct;30(10):2039-2056. doi: 10.1007/s00198-019-05041-3. Epub 2019 Jun 17. PMID: 31209511. FULL TEXT

  • Le B, Ray C, Gonzalez B, Miskevics S, Weaver FM, Priebe M, Carbone LD. Reasons for Initiation and Discontinuation of Pharmacological Therapies for Osteoporosis in Veterans with Spinal Cord Injury and Disorders. J Clin Densitom. 2021 Jan-Mar;24(1):67-77. doi: 10.1016/j.jocd.2019.06.003. Epub 2019 Jun 15. PMID: 31262561. FULL TEXT

  • Essali N, Goldsmith DR, Carbone L, Miller BJ. Psychosis as an adverse effect of monoclonal antibody immunotherapy. Brain Behav Immun. 2019 Oct;81:646-649. doi: 10.1016/j.bbi.2019.06.002. Epub 2019 Jun 3. PMID: 31170448; PMCID: PMC8210540. FULL TEXT

  • Le B, Bůžková P, Robbins JA, Fink HA, Raiford M, Isales CM, Shikany JM, Coughlin SS, Carbone LD. The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study. Calcif Tissue Int. 2019 Aug;105(2):161-172. doi: 10.1007/s00223-019-00562-9. Epub 2019 May 21. PMID: 31115639; PMCID: PMC6663558. FULL TEXT

  • Haring B, Crandall CJ, Carbone L, Liu S, Li W, Johnson KC, Wactawski-Wende J, Shadyab AH, Gass ML, Kamensky V, Cauley JA, Wassertheil-Smoller S. Lipoprotein(a) plasma levels, bone mineral density and risk of hip fracture: a post hoc analysis of the Women's Health Initiative, USA. BMJ Open. 2019 Apr 24;9(4):e027257. doi: 10.1136/bmjopen-2018-027257. PMID: 31023762; PMCID: PMC6501983. FULL TEXT

  • Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M, Lorentzon M, McGuigan F, Medina-Gomez C, Mitchell B, Newman A, Nielson C, Ohlsson C, Peacock M, Reppe S, Richards JB, Robbins J, Sigurdsson G, Spector TD, Stefansson K, Streeten E, Styrkarsdottir U, Tobias J, Trajanoska K, Uitterlinden A, Vandenput L, Wilson SG, Yerges-Armstrong L, Young M, Zillikens MC, Rivadeneira F, Kiel DP, Karasik D. Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry. J Bone Miner Res. 2019 Jul;34(7):1284-1296. doi: 10.1002/jbmr.3698. Epub 2019 Mar 19. PMID: 30888730; PMCID: PMC6650334. FULL TEXT

  • Weaver FM, Le B, Ray C, Miskevics S, Gonzalez B, Carbone LD. Predicting osteoporosis medication receipt in Veterans with a spinal cord injury: A retrospective cohort study. J Spinal Cord Med. 2019 Nov;42(6):760-767. doi: 10.1080/10790268.2019.1584259. Epub 2019 Mar 19. PMID: 30888309; PMCID: PMC6830189. FULL TEXT

  • Carbone LD, Bůžková P, Fink HA, Raiford M, Le B, Isales CM, Shikany JM, Coughlin SS, Robbins JA. Association of Dietary Niacin Intake With Incident Hip Fracture, BMD, and Body Composition: The Cardiovascular Health Study. J Bone Miner Res. 2019 Apr;34(4):643-652. doi: 10.1002/jbmr.3639. Epub 2019 Jan 19. PMID: 30659655; PMCID: PMC6663556. FULL TEXT

Alyce Oliver, MD 
  • Peterkin-McCalman R, Waller JL, Le B, Oliver AM, Manning E, Elam RE, Kheda M, Nahman NS Jr, Carbone LD. Fractures in patients with rheumatoid arthritis and end-stage renal disease. Arch Osteoporos. 2020 Sep 18;15(1):146. doi: 10.1007/s11657-020-00815-3. PMID: 32948922. FULL TEXT
  • Paudyal S, Waller JL, Oliver A, Le B, Zleik N, Nahman NS Jr, Carbone L. Rheumatoid Arthritis and Mortality in End Stage Renal Disease. J Clin Rheumatol. 2020 Mar;26(2):48-53. PMID: 32073514. FULL TEXT

Hong Shi, MD
  • Shi H, Kim HW, Weintraub NL. Macrophage immunometabolism in perivascular adipose tissue. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):731-733. doi: 10.1161/atvbaha.120.315779. Epub 2021 Jan 27. PMID: 33746500; PMCID: PMC7978142. FULL TEXT

  • Kim HW, Shi H, Winkler MA, Lee R, Weintraub NL. Perivascular Adipose Tissue and Vascular Perturbation/Atherosclerosis. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2569-2576. doi: 10.1161/ATVBAHA.120.312470. Epub 2020 Sep 3. PMID: 32878476; PMCID: PMC7577939. FULL TEXT

  • Shi H, Gudjonsson JE, Kahlenberg JM. Treatment of cutaneous lupus erythematosus: current approaches and future strategies. Curr Opin Rheumatol. 2020 May;32(3):208-214. doi: 10.1097/BOR.0000000000000704. PMID: 32141953; PMCID: PMC7357847. FULL TEXT

  • Leo C, Wang Y, Mold A, Quintana J, Shi H, Abdullah M, Alaie D, Petrillo R. Noncirrhotic hyperammonemia: A factor behind dementia to alter mental status. Clin Case Rep. 2019 Sep 27;7(11):2118-2122. doi: 10.1002/ccr3.2436. PMID: 31788262; PMCID: PMC6878079. FULL TEXT

Rachel Elam, MD
  • Etingen B, Carbone LD, Guihan M, Ray C, Aslam H, Elam R, Weaver FM. Lower extremity fracture prevention and management in persons with spinal cord injuries and disorders: The patient perspective. J Spinal Cord Med. 2021 Apr 8:1-11. doi: 10.1080/10790268.2021.1907675. Epub ahead of print. PMID: 33830880. FULL TEXT

  • Carbone LD, Ortiz Kaemena MF, Elam RE. Heart failure and osteoporosis: an association that merits further study. Pol Arch Intern Med. 2020 Nov 30;130(11):928-929. doi: 10.20452/pamw.15691. Epub 2020 Nov 30. PMID: 33252209. FULL TEXT

  • Carbone L, Vasan S, Elam R, Gupta S, Tolaymat O, Crandall C, Wactawski-Wende J, Johnson KC. The Association of Methotrexate, Sulfasalazine, and Hydroxychloroquine Use With Fracture in Postmenopausal Women With Rheumatoid Arthritis: Findings From the Women's Health Initiative. JBMR Plus. 2020 Aug 18;4(10):e10393. doi: 10.1002/jbm4.10393. PMID: 33103025; PMCID: PMC7574701. FULL TEXT

  • Peterkin-McCalman R, Waller JL, Le B, Oliver AM, Manning E, Elam RE, Kheda M, Nahman NS Jr, Carbone LD. Fractures in patients with rheumatoid arthritis and end-stage renal disease. Arch Osteoporos. 2020 Sep 18;15(1):146. doi: 10.1007/s11657-020-00815-3. PMID: 32948922. FULL TEXT

  • Padala SA, Medepalli VM, Mohammed A, Vakiti A, Elam R, Gupta SJ. Management of Immunosuppression During Severe COVID-19 Infection in a Patient With Pulmonary and Cardiac Sarcoidosis. J Clin Rheumatol. 2020 Sep;26(6):229-232. doi: 10.1097/RHU.0000000000001557. PMID: 32694353; PMCID: PMC7437431. FULL TEXT

  • Elam RE, Jackson N, Machua W, and Carbone L. Osteoporosis. Medscape Drugs & Diseases. Updated January 20, 2021. Available at: https://emedicine.medscape.com/article/330598-overview

 * Only publications in the past two years have been listed. 

Irina Madera Acosta, MD
  • Madera-Acosta A, Johnson-Wall H, Carbone LD, Meszaros A, Berman AE, White J. Cannabidiol (CBD) oil toxicity mimicking extraglandular complications of Sjögren's syndrome. Rheumatol Adv Pract. 2021 Feb 27;5(1):rkab010. doi: 10.1093/rap/rkab010. PMID: 33748661; PMCID: PMC7962723. FULL TEXT
Adam Meszaros, MD
  • Madera-Acosta A, Johnson-Wall H, Carbone LD, Meszaros A, Berman AE, White J. Cannabidiol (CBD) oil toxicity mimicking extraglandular complications of Sjögren's syndrome. Rheumatol Adv Pract. 2021 Feb 27;5(1):rkab010. doi: 10.1093/rap/rkab010. PMID: 33748661; PMCID: PMC7962723. FULL TEXT

 * Only publications in the past two years have been listed.