Dr. Harshfield is a psychologist and physiologist whose research involves the identification of factors related to impaired functioning of the renal body-fluid system and blood pressure in African-Americans and obese individuals and the relationship to target organ damage to the heart, kidney, and vasculature. The factors involved include the activity of the sympathetic nervous system, the renin-angiotensin-aldosterone system, the endothelial system, natriuretic peptides, and adipose-derived substances, including leptin and angiotensinogen as well as genetic polymorphisms related to impaired sodium handling.
Education & Training
NIH, Cornell Medical Center, NY 1980
Miami University, Oxford, Ohio, 1978
Miami University, Oxford, Ohio, 1977
Wittenberg University, Springfield, Ohio 1974
Contributed to the development of the field of automatic, noninvasive ambulatory blood
first in adults and then in youth.
Discovered the blunted nocturnal decline in blood pressure that characterizes African-American adults and adolescents:
A pioneer of the concept of stress-induced sodium retention in humans:
Honors & Awards
1978 Behavior Genetics Association Dobzhanzky Award, outstanding research paper
1981 - 86 Research Career Development Award
1987 - 88 Senior Investigator-American Heart Association, Greater Los Angeles Affiliate
2003 Medical College of Georgia Distinguished Faculty Award for Clinical Faculty Research
2008 Medical College of Georgia School of Medicine Award, Outstanding Research Faculty Member
2009 Medical College of Georgia Research Institute, Distinguished Research Award for Clinical Research
2012 GHSU Research Institute, Mahesh Distinguished Research Award
Harshfield GA, Pickering TG, Laragh JH. A validation study of the Del Mar Avionics Ambulatory Blood Pressure System. Ambulatory Electrocardiol. 1979;1:7-12.
Pickering TG, Harshfield GA, Kleinert HD, Blank S, Laragh JH. Blood pressure during normal daily activities, sleep, and exercise. Comparison of values in normal and hypertensive subjects. Jama. 1982;247(7):992-6
Devereux RB, Pickering TG, Harshfield GA, Kleinert HD, Denby L, Clark L, et al. Left ventricular hypertrophy in patients with hypertension: Importance of blood pressure response to regularly recurring stress. Circulation. 1983;68:470-6.
Harshfield GA, Pickering TG, Blank S, Lindahl C, Stroud L, Laragh JH. Ambulatory blood pressure monitoring: Recorders, applications, and analysis. In: Weber M, Drayer J, editors. Ambulatory blood pressure monitoring. Darmstadt: Steinhopff-Verlag; 1984. p. 1-7.
Harshfield GA, Hwang C, Blank SG, Pickering TG. Research techniques for ambulatory blood pressure monitoring. In: Schneiderman N, Kaufman P, Weis SM, editors. Research Methods in Cardiovascular Behavioral Medicine. BY, NY: Plenum Press; 1989. p. 293-309.
Harshfield GA, Hwang C, Edmunson J, Grim CE. Daily blood pressure patterns in blacks. CVD EPIDEM Newsletter. 1987;41:137.
Harshfield GA, Pulliam DA, Alpert BS, Stapleton FB, Willey ES, Somes GW. Ambulatory blood pressure patterns in children and adolescents: influence of renin-sodium profiles. Pediatrics. 1991;87(1):94-100.
Harshfield GA. Factors associated with differences in the diurnal variation of blood pressure in humans. In: Schmidt TF, Engel BT, Blumchen G, editors. Temporal variations of the cardiovascular system. Berlin: Springer-Verlag; 1992. p. 272-82.
Harshfield GA, Pulliam DA, Somes GW, Alpert BS. Ambulatory blood pressure patterns in youth. Am J Hypertens. 1993;6(11 Pt 1):968-73.
Harshfield GA, Alpert BS, Pulliam DA, Somes GW, Wilson DK. Ambulatory blood pressure recordings in children and adolescents. Pediatrics. 1994;94(2 Pt 1):180-4.
Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, et al. Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. Hypertension. 2008;52(3):433-51.
Wang X, Poole JC, Treiber FA, Harshfield GA, Hanevold CD, Snieder H. Ethnic and gender differences in ambulatory blood pressure trajectories: results from a 15-year longitudinal study in youth and young adults. Circulation. 2006;114(25):2780-7.
Li Z, Snieder H, Su S, Harshfield GA, Treiber FA, Wang X. A longitudinal study of blood pressure variability in African-American and European American youth. J Hypertens. 2010;28(4):715-22.
Harshfield GA, Wilson M, Hanevold C, Kapuku G, Mackey L, Gillis D, et al. Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths. Am J Hypertens. 2002;15(10):903-6.
Wilson ME, Harshfield GA, Ortiz L, Hanevold C, Kapuka G, Mackey L, et al. Relationship of body composition to stress-induced pressure natriuresis in youth. Am J Hypertens. 2004;17(11 Pt 1):1023-8.
Harshfield GA, Wilson ME, Hanevold C, Kapuku GK, Mackey L, Gillis D, et al. Impaired stress-induced pressure natriuresis increases cardiovascularload in African American youths. Am J Hypertens. 2002;15(10 Pt 1):903-6.
Savoca MR, Mackey L, Evans C, Wilson MA, Ludwig DA, Harshfield GA. The association of ambulatory blood pressure and dietary caffeine in adolescents. Am J Hypertens 2005; 18:116-20.
Lu Y, Zhu H, Wang X, Snieder H, Huang Y, Harshfield GA, Treiber FA, Dong Y. Effects of Dopamine Receptor Type 1 and Gs Protein alpha Subunit Gene Polymorphisms on Blood Pressure at Rest and in Response to Stress. Am J Hypertens. 2006;19:832-6.
Kapuku GK, Harshfield GA, Davis HC, Treiber FA. Early markers of cardiovascular disease. Vascul Pharmacol 2006;45(5):277-80.
Wang X, Poole JC, Treiber FA, Harshfield GA, Hanevold CD, Snieder H. Ethnic and gender differences in ambulatory blood pressure trajectories: results from a 15-year longitudinal study in youth and young adults. Circulation 2006;114(25):2780-7.
Ge D, Zhu H, Huang Y, Treiber FA, Harshfield GA, et al. Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects. Hypertension 2007;49(1):107-12.
Savoca MR, Domel Baxter S, Ludwig DA, Evans CD, Mackey ML, Wilson ME, Hanevold C, Harshfield GA. A 4-day sodium-controlled diet reduces variability of overnight sodium excretion in free-living normotensive adolescents. J Am Diet Assoc. 2007;107:490-4.
Harshfield GA, Hanevold C, Kapuku GK, Dong Y, Castles ME, Ludwig DA. The association of race and sex to the pressure natriuresis response to stress. Ethnicity & Disease 2007;17:498-302.
Zhu H, Yan W, Ge D, Treiber FA, Harshfield GA, et al. Relationships of Cardiovascular Phenotypes With Healthy Weight, at Risk of Overweight, and Overweight in US Youths. Pediatrics 2008;121(1):115-22.
Kapuku GK, Ge D, Vemulapalli S, Harshfield GA, Treiber FA, Snieder H. Change of Genetic Determinants of Left Ventricular Structure in Adolescence: Longitudinal Evidence From the Georgia Cardiovascular Twin Study. Am J Hypertens. Apr 24 2008.
Barnes VA, Pendergrast RA, Harshfield GA, Treiber FA. Impact of breathing awareness meditation on ambulatory blood pressure and sodium handling in prehypertensive African American adolescents. Ethnicity & disease. Winter 2008;18(1):1-5.
Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, Mahoney L, McCrindle B, Mietus-Snyder M, Steinberger J, Daniels S. Ambulatory Blood Pressure Monitoring in Children and Adolescents: Recommendations for Standard Assessment. A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure Research. Hypertension. Aug 4 2008.
Zhu H, Yan W, Tan Y, Li K, Kapuku G, Treiber FA, Su S, Harshfield GA, Snieder H, Dong Y. Adhesion molecule polymorphisms and pulse wave velocity in American youth. Twin Res Hum Genet. Oct 2008;11(5):517-523.
Zhu H, Chao J, Guo D, Li K, Huang Y, Hawkins K, Wright N, Stallmann-Jorgenson I, Yan W, Harshfield GA, Dong Y. Urinary Prostasin: A Possible Biomarker For Renal Pressure Natriuresis In Black Adolescents. Pediatric Research. Dec 24 2009.
Savoca MR, Quandt SA, Evans CD, Flint TL, Bradfield AG, Morton TB, Harshfield GA, Ludwig DA. Views of hypertension among young African Americans who vary in their risk of developing hypertension. Ethnic and Dis., 19, 28-34.
Ge D, Su S, Zhu H, Dong Y, Wang X, Harshfield GA, Treiber FA, Snieder H. Stress-induced sodium excretion: a new intermediate phenotype to study the early genetic etiology of hypertension? Hypertension. Feb 2009;53(2):262-269.
Wang X, Zhu H, Snieder H, Su S, Munn D, Harshfield G, Maria BL, Dong Y, Treiber F, Gutin B, Shi H. (2010). "Obesity related methylation changes in DNA of peripheral blood leukocytes." BMC Med 8: 87.
Wang X, Ding X, Su S, Harshfield G, Treiber F, Snieder H. (2011). "Genetic influence on blood pressure measured in the office, under laboratory stress and during real life." Hypertens Res 34(2): 239-244.
1120 15th Street, Augusta, GA 30912