Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach (10-07-020)

Why is this study being done?: Researchers have found a link between COPD and heart disease; however, a link is all they have found. This project is an attempt to understand what contributes to heart disease in patients with lung disease.

Who is eligible to participate?:
Must be at least 18 years of age. Healthy men and women. Patients with COPD.

What is involved?: All participants will provide blood samples and have non-invasive arterial health measurements. The study is comprised of 4 protocols, each having 1 to 2 visits. Participants can choose 1 or more protocols.

Who can I contact for additional information?: Submit a research interest form or contact Dr. Ryan Harris or Nichole Seigler @ 706-721-5998.


Cardiovascular Health Risk Database (11-07-009)

Why is this study being done?: The purpose of this study is to establish a database to determine the relationship between physical characteristics and overall cardiovascular health.


Who is eligible to participate?:
Healthy men, women, and children.

What is involved?: 1 experimental day.

Who can I contact for additional information?: Submit a research interest form or contact Dr. Ryan Harris or Nichole Seigler @ 706-721-5998.


Influence of Cystic Fibrosis on Vascular Endothelial Function at Rest and During Exercise (09-12-115)

Why is this study being done?: This project is an attempt to understand why heart disease develops in patients already diagnosed with lung disease.

What is involved?: Non-invasive measures of arterial health and multiple blood samples will be taken at Rest and during cycling exercise. A total of 2 study visits will be required; a preliminary day and 1 experimental day. There is also the option to participate in an additional experimental day.

Who can I contact for additional information?: Submit a research interest form or contact Dr. Ryan Harris or Nichole Seigler @ 706-721-5998.


Diabetes and Vascular Function: The Influence of Estrogen (10-10-079)

Why is this study being done?: To examine the role of estrogen on arterial health in premenopausal women with diabetes.

Who is eligible to participate?: Premenopausal women and men with diabetes at least 18 years of age.

What is involved?: Non-invasive measures of arterial health and a small blood sample will be taken. 2 study visits lasting approximately 60 minutes each.

Who can I contact for additional information?: Submit a research interest form or contact Dr. Ryan Harris or Nichole Seigler @ 706-721-5998.



Responders and Non-Responders to Acute Physiological Stress (RNAPS) (09-12-115)

Why is this study being done?: In order to determine who responds to acute physiological stress.

Who is eligible to participate?: Healthy adults ages 18-65.

What is involved?: Volunteers will participate in a single bout of exercise and/or eat a single high-fat meal. Non-invasive measures of their arterial health will be taken and they will have blood drawn multiple times. The study consists of a preliminary day and 2 protocols. You may participate in both protocols, but are not required to do so.

Who can I contact for additional information?: Submit a research interest form or contact Dr. Ryan Harris or Nichole Seigler @ 706-721-5998.



Epigenetics of Obesity (EpiGO)

Why is this study being done?: To identify the differences between overweight and lean individuals that reflect environmental impact.


Who is eligible to participate?:
Healthy adolescents aged from 14-20 years old with body mass index ?30 kg/m2 or <25 kg/m2

What is involved?: Study participants will visit the Georgia Prevention Center for three hours with a parent or guardian. Several health measurements will be taken during the visit, and a small amount of blood will be drawn. Participants will be paid and receive free health information.

Who can I contact for additional information?: Submit a research interest form or contact Gwen Bulluck or Kashala Carter at 706-721-7647.



Angiotensin (1-7) and Hypertension: Influence of Sex and Race (ANG-SR)

Why is this study being done?: This project is an attempt to understand how sex and race effect Angiotensin (1-7), a blood pressure biomarker, in adults who have high blood pressure but have not yet started medications.

Who is eligible to participate?: Adults who are between the ages of 18-50 years old and have no current or prior (past 6 months) use of antihypertensive mediations.

What is involved?: Blood pressure measurements, height, weight, hip and waist measurements, filling out questionnaires about lifestyle, health and family information, ultrasound of artery stiffness, blood draws, low level x-ray body and limb scans to measure body composition and bone health will be performed.

Who can I contact for additional information?: Submit a research interest form or contact Dr. Ryan Harris or Nichole Seigler @ 706-721-5998.



Cardiovascular and Immune Dysfunction Associated with Prediabetes/Diabetes (DRF) (Pro 00000737)

Why is this study being done?: Type 2 diabetes associated with obesity and chronic inflammation is a major public health problem, which causes morbidity and death due to vascular complications. Before people develop type 2 diabetes, they almost always have "pre-diabetes" (blood glucose levels that are higher than normal, but not high enough to be diagnosed as diabetes). Mechanisms responsible for this pathology are not understood. Thus, there is great need to define the mechanisms and metabolic processes that cause vascular injury and develop new therapies for prevention or reversal. Our objective is to generate evidence of novel biomarkers and targets for interrupting disease progression.

Who is eligible to participate?: Healthy individuals age 13-45 who don't take medications or vitamin/herbal supplements are eligible to participate. Eligibility will be decided based on preliminary telephonic screening.

What is involved?: Following procedures are involved after subject provides consent:

  1. Anthropometric measurements such as height, weight, hip and waist circumference

  2. Seating and 24 hour ambulatory blood pressure

  3. Urine and blood collection.

  4. Pulse wave velocity measurement

  5. Flow mediated dilation test

  6. Carotid intima-media thickness measurement


Who can I contact for additional information?:
Dr. Jigar Bhagatwala or Dr. Samip Parikh - Phone number: 706-721-1764.

Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (IRB# 611523)

Why is this study being done? To determine if taking two capsules daily of vitamin K supplement for eight weeks (two months) can improve markers in blood associated with diabetes risk. Vitamin K is a fat-soluble vitamin found mostly in leafy green vegetables (e.g., spinach, broccoli, kale, and collards) and in soybean oil and canola oil. Vitamin K is necessary for normal blood clotting and may be needed for other activities such as normal glucose metabolism. Understanding the role of vitamin K in glucose metabolism may help develop preventive strategies and early interventions to reduce obesity-related disorders such as type 2 diabetes.

Who is eligible to participate? Overweight but otherwise healthy children between ages 8 and 17 years old.

What is involved? If you decide to have your child take part in the study, your child must:

  • take vitamin K supplements each day for 2 months
  • not take any other vitamin, mineral, or herbal supplements during the study
  • give blood samples and other health measurements at study entry and 2 months later

Who can I contact for additional information? Dr. Norman Pollock @ 706-721-5424 or npollock@augusta.edu

 

Role of Cardiometabolic Risk Factors in Childhood Bone Development (IRB# 616274)

Why is this study being done? To clarify the relationship of adiposity with bone development during adolescence, and to explicate the mechanisms that regulate the effect of excess adiposity on bone. Peak bone strength is a major determinant of bone health and fracture risk in later life and so there is a clear need for studies covering pediatric populations to identify key factors that regulate bone development and the relative changes in the relationship between fat and bone during growth. 

Who is eligible to participate? Healthy children between ages 9 to 15 years old.

What is involved? If you decide to have your child take part in the study, your child must:

  • give blood samples and other health measurements at baseline testing visit and again 1 and 2 years later.
  • not use medication or receive treatment likely to interfere with study evaluation

Who can I contact for additional information? Dr. Norman Pollock @ 706-721-5424 or npollock@augusta.edu

 

Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (IRB# 620511)

Why is this study being done? To determine if taking two capsules daily of vitamin K supplement for eight weeks (two months) can improve markers in blood associated with diabetes risk. Vitamin K is a fat-soluble vitamin found mostly in leafy green vegetables (e.g., spinach, broccoli, kale, and collards) and in soybean oil and canola oil. Vitamin K is necessary for normal blood clotting and may be needed for other activities such as normal glucose metabolism. Understanding the role of vitamin K in glucose metabolism may help develop preventive strategies and early interventions to reduce obesity-related disorders such as type 2 diabetes.

Who is eligible to participate? Overweight but otherwise healthy adults between ages 18 and 65 years old.

What is involved? If you decide to take part in the study, you must:

  • take vitamin K supplements each day for 2 months
  • not take any other vitamin, mineral, or herbal supplements during the study
  • give blood samples and other health measurements at study entry and 2 months later

Who can I contact for additional information? Dr. Norman Pollock @ 706-721-5424 or npollock@augusta.edu

 

Avapro - Salt Study (IRB# 611881)

Why is this study being done? To look at how a medication called Avapro (irbesartan) affects hormones and blood pressure following stress.

Who is eligible to participate? Obese and diagnosed with non-treated high blood pressure (by Augusta University Hypertension Clinic Physician) African American adults between ages 18 and 50 years old.

What is involved? If you decide to take part in the study, you must:

  • Visit the Georgia Prevention Institute or Children's Research Unit in the Children's Hospital of Georgia over a period of five weeks
  • Eat a sodium-controlled diet (food provided) for three days before testing day
  • not take any prescription medications during the study
  • Take a low dose blood pressure medication during one of the testing weeks

Who can I contact for additional information? Kim Norland, Deborah Stewart, or Pam Putnam at 706-721-1755

 

Phentolamine - Salt Study (IRB# 611851)

Why is this study being done? To look at how the medication Phentolamine affects hormones and blood pressure following mental stress.

Who is eligible to participate? Healthy (no diagnosis of high blood pressure) African American adults between ages 18 and 50 years old.

What is involved? If you decide to take part in the study, you must:

  • Visit the Georgia Prevention Institute over a period of five weeks
  • Eat a sodium-controlled diet (food provided) for three days before testing day
  • not take any prescription medications during the study
  • Take a low dose of an alpha-adrenergic receptor blocker medication during one of the testing weeks

Who can I contact for additional information? Kim Norland, Deborah Stewart, or Pam Putnam at 706-721-1755

 

MMF - Salt Study (IRB# 611878)

Why is this study being done? To look at how a medication called mycophenolate mofetil (MMF), which is an immunosuppressant, effects sodium excretion and blood pressure following a mental stressor.

Who is eligible to participate? Healthy (no diagnosis of high blood pressure) African American adults between ages 18 and 50 years old.

What is involved? If you decide to take part in the study, you must:

  • Visit the Georgia Prevention Institute or Children's Research Unit in the Children's Hospital of Georgia twice over a period of three weeks
  • Eat a sodium-controlled diet (food provided) for three days before testing day
  • not take any prescription medications during the study
  • Take a low dose of an immunosuppressant medication during one of the testing weeks

Who can I contact for additional information? Kim Norland, Deborah Stewart, or Pam Putnam at 706-721-1755