The Mei Lab

Representative Publications

2016

  • Z.H. Huang, Y. Wang, G. Hu, J-L. Zhou, L. Mei, and W-C. Xiong. YAP is a critical inducer of SOCS3, negatively regulating JAK-STAT pathway, reactive astrogliosis, and neuro-inflammation in developing mouse brain.  Cerebral Cortex. 26:2299–2310, 2015
  • Z.H. Huang, D. Sun, J.X. Hu, F.L. Tang, D.H. Lee, Y. Wang, G. Hu, X.J. Zhu, J. Zhou, L. Mei, W.C. Xiong. Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. J Neurosci. 36:5833-5849, 2016
  •  Z.H. Huang, J. Hu, J. Pan, Y. Wang, G. Hu, J. Zhou, L. Mei and W.-C. Xiong. YAP Stabilizes Smad1 and Promotes BMP2-induced Neocortical Astrocytic Differentiation. Development 143:2398-2409, 2016
  •  L. Xiong, W.F. Xia, F.L. Tang, J.X. Pan, L. Mei, W.C. Xiong. Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. EBioMedicine 9:45-60, 2016.
  •  X.D. Sun,*,** L. Li*, F. Liu, Z.H. Huang, J.C. Bean, H.F. Jiao, A. Barik, S.M. Kim, H. Wu, C. Shen, Y. Tian, T.W. Lin, R. Bates, A. Sathyamurthy, Y.J. Chen, D.M. Yin, L. Xiong, H.P. Lin, J.X. Hu, B.M. Li, T.M. Gao, W.C. Xiong, Lin Mei**. Lrp4 in astrocytes modulates glutamatergic transmission. Nature Neuroscience 19:1010-1018, 2016 (*, equal contributing; **, corresponding)
  •  Kravic, D. Huraskin, A.D. Frick, J. Jung, V. Redai, R. Palmisano, S. Marchetto, J.P. Borg, L. Mei, S. Hashemolhosseini. LAP proteins are localized at the postsynaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission. J. Neurochem. 2016 Jun 20. doi: 10.1111/jnc.13710. [Epub ahead of print]
  • Barik1,# L. Li#, A. Sathyamurthy, W.C. Xiong, and L. Mei. Schwann cells in neuromuscular junction formation and maintenance. J. Neuroscience 36:9770-9781, 2016 (Cover) (#, equal contributing)
  • Sun, T. Ikrar, M.F. Davis, N. Gong, X. Zheng, Z.D. Luo, C. Lai, L. Mei, T.C. Holmes, S.P. Gandhi, X. Xu. Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron, 192: 160-173, 2016.
    Li,* Y. Cao,* H. Wu, X. Ye, Z. Zhu, G. Xing, C. Shen, A. Barik, B. Zhang, X. Xie, W. Zhi, L. Gan, H. Su, W.C. Xiong, L. Mei. Enzymatic activity of the scaffold protein rapsyn for synapse formation. Neuron (in press). (*, equal contributing)
  • Li,* Y. Cao,* H. Wu, X. Ye, Z. Zhu, G. Xing, C. Shen, A. Barik, B. Zhang, X. Xie, W. Zhi, L. Gan, H. Su, W.C. Xiong, L. Mei. Enzymatic activity of the scaffold protein rapsyn for synapse formation. Neuron (in press). (*, equal contributing)

2015

  • D.M. Yin*, Y.J. Chen*, S. Liu, H. Jiao, C.Y. Shen, A. Sathyamurthy, T.W. Lin, W.C. Xiong, L. Mei** and C. Bergson**. Calcyon Stimulates Neuregulin 1 Maturation and Signaling. Molecular Psychiatry 20:1251-1260, 2015 (*, co-first; **, co-correspondent)

  • L.L. Bi*, X.D. Sun*, J. Zhang, Y.S. Lu, Y.H. Chen, J. Wang, M. Zhang, F. Geng, J.H. Liu, L. Mei**, and T.M. Gao**. Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors. Neuropsychopharmacology 40:974-986, 2015 (*, co-first; **, co-correspondent)

  • Sathyamurthy, D.M. Yin, A. Barik, C.Y. Shen, J. Bean, J.X. She, W.C. Xiong and L. Mei. ERBB3 regulation of Bergmann glia cell proliferation is required for cerebellar lamination. Development 142: 522-532, 2015.
  • Yao, P. Zheng, H. Wu, L.-M. Song, X.-F. Ying, C. Xing, Y. Li, Z.-Q. Xiao, X.-N. Zhou, T. Shen, L. Chen, Y.-H. Liu, M.-D. Lai, L. Mei, T.-M. Gao, and J.-M. Li. Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR. J. Pathology 236:65-77, 2015
  • Xiong*, J.U. Jung*, H. Wu*, W.F. Xia, J.X. Pan, C. Shen, L. Mei**, W.C. Xiong**. Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption. Proc Natl Acad Sci USA. 112:3487-92, 2015 (*, co-first; **, co-correspondent)
  • C.M. Xie, D. Wei, L. Zhao, S. Marchetto, L. Mei, J.-P. Borg, and Y. Sun. Erbin is a novel substrate of Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J. Cell Biol. 209:721-738, 2015
  • Wu*, A. Barik*, Y. Lu, C. Shen, A. Bowman, L. Li, A. Sathyamurthy, T.W. Lin, W.C. Xiong, and L. Mei. Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. eLife 4:e07266, 2015 (*, co-first)
  • F-L. Tang, J. Erion, Y. Tian, W. Liu, D-M. Yin, J. Ye, B-S. Tang, L. Mei, and W-C. Xiong.  VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of LAMP2a, a receptor for chaperone-mediated autophage that is crucial for a-synuclein degradation and prevention of pathogenesis of Parkinson’s disease. J. Neurosci. 35: 10613-10628, 2015.
  • Marino, F. Scuderi, D. Samengo, G. Saltelli, M.T. Maiuri, C. Shen, L. Mei, M. Sabatelli, G. Pani, G. Antonini, A. Evoli, E. Bartoccioni E. Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis. PLoS One 10:e0135378, 2015
  • Shi, X. Huang, B. Zhang, D. Zhu, H. Luo, Q. Lu, W.C. Xiong, Lin Mei,* and S. Luo*. The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. PLoS One. 10: e0138936, 2015
  • F-L. Tang, W. Liu, J.X. Hu, J.R. Erion, J. Ye, L. Mei, and W-C. Xiong. VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function. Cell Rep. 12:1631-1643, 2015
  • Y.-F. Guan, C.-Y. Wu, Y.-Y. Fang, Y.-N. Zeng, Z.-Y. Luo, S.-J. Lia, X.-W. Lia, X.-H. Zhu, L. Mei, and T.-M. Gao. Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission. Neuroscience 307: 151-159, 2015
  • Tian, F.L. Tang, X. Sun, L. Wen, L. Mei, B.S. Tang, W.C. Xiong. VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation. Mol. Brain. 8:70, 2015.
  • Z.-H. Huang, Y. Wang, G. Hu, J-L. Zhou, L. Mei, and W-C. Xiong. YAP is a critical inducer of SOCS3, negatively regulating JAK-STAT pathway, reactive astrogliosis, and neuro-inflammation in developing mouse brain.  Cerebral Cortex. 26:2299–2310, 2015

2014

  • B.Zhang*, C. Shen*; B. Bealmear, S. Ragheb, W.-C. Xiong, R.A. Lewis, R.P. Lisak and L. Mei. Autoantibodies to agrin in myasthenia gravis patients. PLoS One 9(3):e91816, 2014 (*, equal first author)
  • A.Barik, B. Zhang, G.S. Sohal, W.C. Xiong, L. Mei. Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. Dev. Neurobiol. 74:828-838, 2014
  • J.C. Bean, T.W. Lin, A. Sathyamurthy, D.M. Yin, W.C. Xiong, and L. Mei. Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain. J. Neurosci. 34:13549-1366, 2014. (Highlighted in This Week in the Journal, Journal of Neuroscience)
  • A.Barik*, Y. Lu*, A. Sathyamurthy, A. Bowman, C. Shen, L. Li, W.C. Xiong and L. Mei. LRP4 is critical for neuromuscular junction maintenance. J. Neurosci. (*, co-first) 34:13892-13905, 2014 (Cover Story)
  • Y.Tao*, C. Shen*, S. Luo*, W. Traoré*, S. Marchetto, M.-J. Santoni, L. Xu, B. Wu, R. Bates, X. Liu, W.C. Xiong, J.-P. Borg**, and L. Mei**. Erbin promotes homodimerization and stability of ErbB2 for breast tumor growth. Proc. Nat. Acad. Sci. USA 111: 4429-4438. (*, co-first; **, co-correspondent)
  • Y.Lu,* X.-D. Sun,* F.-Q. Hou, F. Liu, L.L. Bi, D.M. Yin, Y.J. Chen, J. Bean, H.F. Jiao, X. Liu, B.M. Li, W.C. Xiong, T.M. Gao** and L. Mei**. Maintenance of GABAergic activity by neuregulin 1/ErbB4 in amygdala for fear conditioning memory. Neuron 84:835-846, 2014 (*, co-first; **, co-correspondent)

2013

  • C.L. Wang, F.L. Tang, Y. Peng, C.Y. Shen, L. Mei, W.C. Xiong, VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1. Biol Open. 1:1248-1257, 2011. PMID: 23259059.

  • Y. Tao*, Y. Chen*, C. Shen*, Z. Luo, C.R. Bates,D. Lee, S. Marchetto, T.-M. Gao, J.-P. Borg, W.C. Xiong, Lin Mei. Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons. Nature Neurosci. 16:290-299, 2013.  (*, co-first) PMID: 23354328.

  • W.-F. Xia, F. Tang, L. Xiong, J. Jung, S. Xiong, X.-S. Li, X. Feng, L. Mei, and W.C. Xiong. Vps35-loss promotes hyper-resorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J. Cell Biol., 200:821-37, 2013.  PMID: 23509071.

  • D.M. Yin*, Y.J. Chen*, Y.S. Lu, J.C. Bean, A. Sathyamurthy, C.Y. Shen, X.H. Liu, T.W. Lin, C.A. Smith, W.C. Xiong, and L. Mei. Reversal of schizophrenia-like deficits in neuregulin 1 transgenic mice. Neuron 78:644-657, 2013. (highlighted by Preview, Neuron 78:577, 2013) PMID: 23719163.

  • W-F. Xia, J-U. Jung, S. Cui, S. Xiong, L. Xiong, X-M. Shi, L., Mei, and W-C. Xiong*. Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which is ameliorated by NAC anti-oxidant. J. Bone Min. Res. 28:2122-35. PMID: 23649480.

  • C. Shen*, B. Zhang*, Y. Lu*, D. Figueiredo‎, H. Wu, B. Arnab, W.C. Xiong and L. Mei. Immunization with LRP4 induces myasthenia gravis in mice. J. Clin. Invest. 123:5190–5202, 2013. 

  • D.M. Yin, J.C. Bean, T.W. Lin, A. Sathyamurthy, W.C. Xiong, Y.J. Chen* and L. Mei*. The schizophrenia risk factor ErbB4 regulates spine formation through a non-cell-autonomous mechanism. J. Neurosci. 33:19295-19303, 2013 (*, co-correspondent)

2012

  • B. Zhang, J.S. Tzartos, M. Belimezi, S. Ragheb, B. Bealmear, R.A. Lewis, W.C. Xiong, R.P. Lisak, S.J. Tzartos, Lin Mei. Autoantibodies to LRP4 in double seronegative myasthenia gravis patients. Archive Neurol. 69:445-451, 2012

  • Y. Liu, Y. Peng, P-G. Dai, Q-S. Du, L. Mei, and W-C. Xiong. Differential regulation of myosin X movements by its cargos, DCC and neogenin. J. Cell Sci. 125:751-762, 2012

  • A. Amenta, H. Creely, M.L.T. Mercado, H. Hagiwara, B. McKechnie, B. Lechner, S. Rossi, Q. Wang, R. Owens, E. Marrero, L. Mei, W. Hoch, M. Young, D. McQuillan, R. Rotundo, and J. Fallon. Biglycan is an extracellular MuSK binding protein important for synapse stability. J. Neurosci. 32:2324-2334, 2012

  • G.H. Tan1, Y.Y. Liu1, X.L. Hu1, D.M. Yin, L. Mei* and Z.Q. Xiong*. Neuregulin1 represses limbic epileptogenesis via activation of ErbB4 signaling in parvalbumin-positive interneurons. Nature Neurosci. 15:258-266, 2012 (1, co-first; *, co-correspondent)

  • Y. Zong, B. Zhang, S. Gu, K. Lee, J. Zhou, G. Yao, D. Figueiredo, K. Perry, L. Mei* and Rongsheng Jin*. Structural basis of neuron-specific regulation of postsynaptic differentiation. Genes & Development. 26:247-258, 2012 (Cover) (*, co-correspondence).

  • H.T. Wu, Y.S. Lu, C.Y. Shen, W.C. Xiong, L. Mei. Distinct Roles of Muscle and motoneuron LRP4 in Neuromuscular Junction Formation. Neuron, 75:94-107, 2012.

  • H.T. Wu*, Yisheng Lu*, A. Barik, A. Joseph, M.M. Taketo, W.C. Xiong, L. Mei. beta-Catenin gain-of-function in muscles impairs neuromuscular junction formation. Development, 139:2392-2404.

  • B. Zhang, C. Liang, R. Bates, Y. Yin, W.C. Xiong, L. Mei. Wnt proteins regulate AChR clustering in muscle cells. Mol. Brain, 5:7 doi:10.1186/1756-6606-5-7, 2012

  • C. Liang*, Y. Tao*,**, C. Shen, Z. Tan, W.C. Xiong, L. Mei**. Erbin is required for myelination in regenerated axons after injury. J. Neurosci., 32:15169-15180, 2012 (*, co-first; **, co-correspondent). PMID: 23100438.

2011

  • A. Ting, Y. Chen, L. Wen, D.M. Yin, C. Shen, Y. Tao, X. Liu, W.C. Xiong, L. Mei. Neuregulin 1 promotes excitatory synapse development specifically in GABAergic interneurons. J. Neurosci. 31:15-25, 2011.

  • S. Cui, F. Xiong, Y. Hong, J-U. Jung, X-S. Li, J-Z. Liu, R. Yan, L. Mei, X. Feng, and W-C. Xiong. APPswe/Ab regulation of osteoclast activation and RAGE expression in an age dependent manner. J. Bone Min. Res. 26:1084-1098, 2011.

  • X.H. Liu, R. Bates, D.M. Yin, C.Y. Shen, F. Wang, S. Nan, S.A. Kirov, Y. Luo, J.-Z. Wang, W.C. Xiong, and L. Mei. Specific regulation of NRG1 isoform expression by neuronal activity. J. Neurosci. 31:8491-8501, 2011

  • F. Xiong, S. Leonov, A.C. Howard, S. Xiong, B. Zhang, L. Mei1, P. McNeil, S. Simon, and W.C. Xiong. Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin dependent manner. J. Biol. Chem. 286:35061-7, 2011.

  • C.B. Chan*, Y. Chen*, X. Liu, X. Tang, C.W. Lee, L. Mei, K. Ye. PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression. EMBO J. 30:4274-86, 2011 (*, equal contribution)

  • L. Wen*, F-L. Tang*, Y. Hong, S-W. Luo, C-L. Wang, W. He, C-Y. Shen, F. Xiong, J-U. Jung, D-H. Lee, Q-G. Zhang, D. Brann, T-W. Kim, R. Yan, L. Mei, and W-C. Xiong. Vps35 haploinsufficiency increases Alzheimer's disease neuropathology. J. Cell Biol. 195:765-779, 2011 (*, equal contribution)

2010

  • L. Wen1, Y.S. Lu1, X. Zhu1, X.M. Li, R.-S. Woo, Y.-J. Chen, D.-M. Yin, C. Lai, A. Vazdarjanova, W.C. Xiong, and L. Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Nat. Acad. Sci. USA 107:1211-1216, 2010

  • Y.E. Yu1, L. Wen1, J. Silva, Z. Li, K. Head, K. Sossey-Alaoui, A. Pao, L. Mei, and J.K. Cowell. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum. Mol. Genet. 19:1702-1711, 2010

  • D.H. Lee, L.J. Zhou, Z. Zhou, J.X. Xie, J.U. Jung, Y. Liu, C.X. Xi, L. Mei, W.C. Xiong. Neogenin inhibits HJV secretion and regulates BMP induced hepcidin expression and iron homeostasis. Blood 115:3136-3145, 2010

  • J. Pang, S. Zhang, P. Yang, B. Hawkins-Lee, J. Zhong, Y. Zhang, B. Ochoa, J.A. Agundez, M.A. Voelckel, W. Gu, W.C. Xiong, L. Mei, J.X. She, C.Y. Wang. Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome. Am. J. Hum. Genet. 86:957-962, 2010

  • Z. Zhou, J-X. Xie, D-H. Lee, L. Mei, and W-C. Xiong. Neogenin regulation of endochondral bone formation by regulating BMP receptor association with lipid raft and enhancing BMP signaling. Dev. Cell 19:90-102, 2010

  • X.-H. Zhu,1 H.-C. Yan,1 J. Zhang, H.-D. Qu, X.-S. Qiu, L. Chen, S.-J. Li, X. Cao, J.C. Bean, L.-H. Chen, X.-H. Qin, J.-H. Liu, X.-C. Bai, L. Mei, and T.-M. Gao. Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats. J. Neurosci., 30:12653-12663, 2010.

2009

  • Y. Tao, P. Dai, Y. Liu, S. Marchetto, W.C. Xiong, J.-P. Borg, L. Mei. Erbin regulates NRG1 signaling and myelination. Proc. Nat. Acad. Sci. USA 106:9477-9482, 2009 (highlighted at Faculty of 1000, 2009)

  • P.-C. Chen, L.-N. Qin, X.-M. Li, B. Walters, J. Wilson, L. Mei, and S. Wilson. The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. J. Neurosci. 29:10909-10919, 2009

  • S.-W. Luo#, C. Zhang#, B. Zhang, C.-H. Kim, Y.-Z. Qiu, Q.-S. Du, L. Mei, and W.C. Xiong. Regulation of heterochromatin remodeling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J. 28:2568-2582, 2009

  • C-X. Xi, F. Xiong, Z. Zhou, L. Mei, and W-C. Xiong. PYK2 interacts with MyD88 and regulates LPS-induced NF-kB activation in macrophages. J. Leuk. Biol. 87:415-423, 2009

2008

  • Q. Wang, B. Zhang, Y.E. Wang, W.C. Xiong, L. Mei. The Ig1/2 Domain of MuSK Binds to Muscle Surface and Is Involved in Acetylcholine Receptor Clustering. Neurosignals. 16:246-253, 2008.

  • G.M. Pitcher, S. Beggs, R.-S. Woo, Lin Mei and M.W. Salter. ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. NeuroReport 19:139-143, 2008

  • D. Zhu, Z. Yang, Z. Luo, S. Luo, W.C. Xiong, Lin Mei. MuSK endocytosis in AChR clustering in response to agrin. J. Neurosci. 28:1688-1696, 2008

  • X.M. Li*, X.-P. Dong*, S.W. Luo, B. Zhang, D.H. Lee, A.K.L. Ting, H. Neiswender, C.H. Kim, E. Carpenter-Hyland, T.M. Gao, W.C. Xiong, L. Mei. Retrograde regulation of motoneuron differentiation by muscle ?-catenin. Nature Neurosci. 11:262-268, 2008 (highlighted in Nature Neurosci. 2008 and in Science Signal. 1:ec81, 2008)

  • X.R. Ren, Y. Hong, Z. Feng, H.M. Yang, L. Mei, W.C. Xiong. Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. Neurosignals. 16:235-245, 2008.

  • C.-H. Kim, H.Neiswender, E.J. Baik, W.C. Xiong, and Lin Mei. beta-Catenin interacts with MyoD and regulates its transcription activity. Mol. Cell Biol. 28:2941-2951, 2008

  • Z. Zhou, J.Y. Han, C.X. Ci, J.X. Xie, X. Feng, C.Y. Wang, Lin Mei, W.C. Xiong. HMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE. J. Bone Miner Res. 23:1084-1096, 2008

  • J. Arikkath, I. Israely, Y. Tao, Lin Mei, X. Liu, L.F. Reichardt. Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J. Neurosci. 28:7047-7056, 2008

  • S. Luo, B. Zhang, X.-p. Dong, Y. Tao, A. Ting, Z. Zhou, J. Meixiong, J. Luo, F.C.A. Chiu, W.C. Xiong, L. Mei. HSP90? Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance. Neuron 60:97-110, 2008

  • D.V. Krivosheya, L. Tapia, A. Ting, R. Hines, K. Huang, J.N. Levinson, Y. Kang, A.M. Craig, Lin Mei, S. Bamji, A. El-Husseini. ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. J. Biol. Chem. 283:32944-32956, 2008 

  • B. Zhang, S. Luo, Q. Wang, T. Suzuki, W.C. Xiong, Lin Mei. LRP4 serves as a co-receptor of agrin. Neuron 60:285-297, 2008 (highlighted in Nature 455:1153, 2008; Nature Rev. Neurosci. 9:886, 2008; Neuron, 60:526, 2008)

  • G. C. Dobbins, S.-w. Luo, Z. Yang, W.C. Xiong, Lin Mei. alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering. Mol. Brain 1:18, 2008

2007

  • X.-J. Zhu, C.-Z. Wang, P.-G. Dai, Y. Xie, N.-N. Song, Y. Liu, Lin Mei, Y.-Q. Ding, and W.-C. Xiong. Myosin X regulates netrin receptors and functions in axonal path-finding. Nature Cell Biology 9:184-192, 2007

  • I. Calin-Jageman, K. Yu, R.A. Hall, Lin Mei, and A. Lee. Erbin enhances voltage-dependent facilitation of Cav1.3 Ca2+ channels through relief of an autoinhibitory domain in the Cav1.3 alpha1 subunit. J. Neurosci. 27:1374-1385, 2007

  • Y. Liu, Y. Tao, R.-S. Woo, W.C. Xiong, and Lin Mei. Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons. Biochem. Biophys. Res. Comm. 354:505-510, 2007

  • B. Zhang1, S.-w. Luo1, X.-P. Dong1, X. Zhang, C. Liu, Z. Luo, W.C. Xiong, L. Mei. b-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J. Neurosci. 27:3968-3973, 2007 (high-lighted in “This Week in The Journal,” J. Neurosci. and Nature Rev. Neurosci., 8:324, 2007). 

  • Bo Li, R.S. Woo, Lin Mei, Roberto Malinow. The neuregulin1 receptor ErbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54:583-597, 2007 (high-lighted in Neuron 54:495-497, 2007; Nature 448:263, 2007 and Nature Rev. Neurosci., 8:492, 2007).

  • R.-S. Woo*, X.M. Li*, Y. Tao, E. Carpenter-Hyland, Y.Z. Huang, J. Weber, H. Neiswender, X..-p. Dong, J. Wu, M. Gassmann, C. Lai, W.-C. Xiong, T.-M. Gao, L. Mei. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 54:599-610, 2007 (high-lighted in Neuron 54:495-497, 2007; Nature 448:263, 2007 and Nature Rev. Neurosci., 8:492, 2007).

  • F. Dai, C. Chang, X. Lin, P. Dai, Lin Mei, and X.-H. Feng. Erbin inhibits TGF? signaling through a novel Smad-interacting domain. Mol. Cell. Biol. ;27:6183-6194, 2007.

  • F. Chen, L. Qian, Z.-H. Yang, Y. Huang, S.T. Ngo, N.-J. Ruan, J. Wang, C. Schneider, P.G. Noakes, Y.-Q. Ding, Lin Mei, Z.-G. Luo. Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron 55: 247-260, 2007

  • C. Brooks, Q. Wei, L. Feng, G. Dong, Y. Tao, L. Mei, Z.-J. Xie, D. C Chan, Z. Dong. Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with Mitofusins. Proc. Natl. Acad. Sci., USA 104:11649-11654, 2007 

  • A.L. Gheyara, A. Vallejo-Illarramendi, K. Zang, Lin Mei, R. St-Arnaud, S. Dedhar, and L.F. Reichardt. Deletion of Integrin Linked Kinase (Ilk) from Skeletal Muscles of Mice Resembles Muscular Dystrophy due to a7b1 Integrin Deficiency. Am. J. Phathol. 171:1966-1977, 2007

2006

  • Y. Xie, Y. Hong, X.Y. Ma, X.R. Ren, S. Ackerman, L. Mei, and W.C. Xiong. DCC-dependent PLC signaling in netrin-1-induced neurite elongation. J. Biol. Chem. 281: 2605-2611, 2006

  • Z. Zhou, D. Immel, C-X. Xi, A. Bierhaus, X. Feng, L. Mei, P. Nawroth, D. M. Stern, and W-C. Xiong. Regulation of Osteoclast Function and Bone Mass by RAGE. J. Exp. Med. 203:1067-1080, 2006D. Zhu, W.-C. Xiong, and Lin Mei. Lipid Rafts Serve as a Signaling Platform for Nicotinic Acetylcholine Receptor Clustering. J. Neurosci. 26: 4841-4851, 2006

  • X. P. Dong, X.-M. Li, T.-M. Gao, G.-S. Feng, W.C. Xiong, L. Mei. SHP2 is dispensable for neuromuscular junction formation and maintenance. NeuroSignals, 15:53-62, 2006

  • P. Dai, W.C. Xiong, and Lin Mei. Erbin inhibits RAF activation by disrupting the SUR-8-RAS-RAF complex. J. Biol. Chem. 281:927-933, 2006

2005

  • X.L. Yang, Y.Z. Huang, W.C. Xiong, and Lin Mei. Neuregulin-induced Expression of the Acetylcholine Receptor Requires Endocytosis of ErbB Receptors. Mol. Cell. Neurosci. 28:335-346, 2005

  • C.-H. Kim, W.C. Xiong, L. Mei. Inhibition of MuSK expression by CREB interacting with a CRE-like element and MyoD. Mol. Cell. Biol. 25:5329-5338, 2005

  • Y. Xie, Y.-Q. Ding, Y. Hong, Z. Feng, S. Navarre, C.-X. Xi, X.-J. Zhu, C.-L. Wang, S. L. Ackerman, D. Kozlowski, Lin Mei, and W.-C. Xiong. Phosphatidylinositol Transfer Protein alpha in Netrin-1-Induced PLC Signaling and Neurite Outgrowth. Nature Cell Biol. 7:1124 � 1132, 2005

2004

  • Y. Ren, S. Meng, L. Mei, Z.J. Zhao, R. Jove, and J. Wu. Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J. Biol. Chem. 279:8497-8505, 2004

  • S. Wang, J. Skorczewski, X. Feng, Lin Mei, J.E. Murphy-Ullrich. Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. J Biol. Chem. 279:34311-34322, 2004

  • X.-R. Ren, G.-l. Ming, Y. Xie, Y. Hong, D.-m. Sun, Z. Zhao, Z. Feng, Q. Wang, S. Shim, Z. Chen, H.-j. Song, L. Mei, and W.-c. Xiong. Focal Adhesion Kinase in Netrin-1 Signaling. Nature Neurosci. 7:1204-1212, 2004

  • J. Bao, H. Lin, Y. Ouyang, D. Lei, A. Osman, T.-W. Kim, L. Mei, P. Dai, K.K Ohlemiller, R.T. Ambron. Activity-Dependent Transcription Regulation of PSD-95 by Neuregulin-1 and Eos. Nature Neurosci. 7:1250-1258, 2004

  • S. Suzuki, T. Numakawa, K. Shimazu, H. Koshimizu, T. Hara, H. Hatanaka, L. Mei, B. Lu, M. Kojima. BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol. 2004 Dec 20;167:1205-1215.

2003

  • Y.Z. Huang, M. Zang, W.C. Xiong, Z. Luo, Lin Mei. Erbin suppresses the MAP kinase pathway. J. Biol. Chem. 278:1108-1114, 2003 (featured in Science STKE, pe 37, 2003).

  • L. Ma, Y.Z. Huang, G.M. Pitcher, J.G. Valtschanoff, Y.H. Ma, L.Y. Feng, B. Lu, W.C. Xiong, M.W. Salter, R.J. Weinberg, and L. Mei. Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. J. Neurosci. 23:3164-3175, 2003. (highlighted in “This Week in The Journal”, J. Neurosci. 23(8):i, 2003) Q. Wang1, Y. Xie1, Q.-S. Du1, X.-J. Wu, X. Feng, L. Mei, J. McDonald, and W.C. Xiong. Regulation of the formation of osteoclastic actin rings by PYK2 interacting with gelsolin. J. Cell Biol. 160:565-575, 2003 (1, equal contributing first authors)

  • W.C. Xiong and L. Mei. Roles of fak family kinases in nervous system. Front Biosci. 8:S676-682, 2003

  • C.-H. Kim, Wen C. Xiong, Lin Mei. Regulation of MuSK expression by a novel signaling pathway. J. Biol. Chem. 278:38522-38527, 2003

  • T.M. Lanigan, A. Liu, Y.Z. Huang, L. Mei, B. Margolis, K.-L. Guan. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J. 17:2048-2060, 2003

  • Z.G. Luo, H.-S. Je, Q. Wang, F. Yang, G. Clem Dobbins, Z.-H. Yang, W.C. Xiong, B. Lu, L. Mei: Implication of geranylgenanyltransferase I in synaptogenesis. Neuron 40:703-717, 2003 (highlighted in “Faculty of 1000”, 2003)

2002

  • H.-J. Lee, K.-M. Jung, Y.Z. Huang, L.B. Bennett, J.S. Lee, L. Mei, and T.-W. Kim. Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J. Biol. Chem. 277: 6318-6323, 2002.

  • Z.G. Luo1, Q. Wang1, J.Z. Zhou, J. Wang, Z. Luo, M. Liu, X. He, A. Wynshaw-Boris, W.C. Xiong, B. Lu, Lin Mei. Regulation of AChR Clustering by Disheveled Interacting with MuSK and PAK1. Neuron 35:489-505, 2002. (1, equal contributing first authors) (highlighted in Curr. Opinion Neurobiol. 12:463-470, 2002)

  • N.S. Hamblet, N. Lijam, P. Ruiz-Lozano, J. Wang, Y. Yang, Z. Luo, L. Mei, K.R. Chien, D.J. Sussman, and A. Wynshaw-Boris: Disheveled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129:5827-5838, 2002

  • S.O., Kim, K. Loesch, X. Wang, J. Jiang, L. Mei, J.M. Cunnick, J. Wu, S.J. Frank. A role for Grb2-associated binder-1 in growth hormone signaling. Endocrinology, 143:4856-4867, 2002

2001

  • X.R. Ren, Q.S. Du, Y.Z. Huang, S.Z. Ao, L. Mei, W.C. Xiong. PSGAP, a novel PH and SH3 domain containing rhoGAP protein, interacts with PYK2 and FAK. J. Cell Biol. 152: 971-984, 2001

  • Y.Z. Huang, Q. Wang, W.C. Xiong, L. Mei. Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. J. Biol. Chem. 276:19318-19326, 2001

  • J.M. Cunnick, L. Mei, C.A. Doupnik, and J. Wu. Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. J. Biol. Chem. 276:24380-24387, 2001. 

  • Q.S. Du, X.R. Ren, Q. Wang, L. Mei, and W.C. Xiong. Inhibition of PYK2-induced cytoskeletal reorganization, PYK2 autophosphorylation, and focal adhesion targeting by FAK. J. Cell Sci. 114: 2977-2987, 2001

  • K. Wong1, X.R. Ren1, Y.Z. Huang, Yi Xie, Guofa Liu, H. Saito, Hao Tang, Leng Wen, S. Brady-Kalnay, L. Mei, J.Y. Wu, W.C. Xiong2, and Y. Rao2. Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway. Cell 107:209-221, 2001 (1, equal contributing first authors; 2, equal corresponding authors)

  • A. Liu, M.S. Prenger, D.D. Norton, L. Mei, J.W. Kusiak, and G. Bai. NGF uses Ras/Erk and PI3K cascades to upregulate the NR1 promoter. J. Biol. Chem. 276: 45372-45379, 2001

2000

  • Y.Z. Huang, S.S. Won, D.W. Ali, Q. Wang, M. Tanowitz, Q.S. Du, W.C. Xiong, K.A. Pelkey, M.W. Salter, and Lin Mei. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26:443-455, 2000

  • J.M. Cunnick, J. Dorsey, T. Munoz-Antonia, Lin Mei, and J. Wu: Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor. J. Biol. Chem. 275:13842-13848, 2000

  • Y.X. Tao, Yang Z. Huang, L. Mei and R.A. Johns. Expression of PSD-95/SAP90 is critical for N-Methyl-D-Aspartate receptor-mediated thermal hyper-algesia in the spinal cord. Neuroscience 98:201-206, 2000

1999

  • J. Si and Lin Mei: ERK MAP kinase activation is required for ARIA-induced increase in all five AChR subunit mRNAs as well as synapse-specific expression of the AChR e-transgene. Mol. Brain Res. 67:18-27, 1999.

  • L. Feng, C.-Y. Wang, H. Jiang, C. Oho, Lin Mei, and B. Lu: Differential signaling of GDNF and BDNF in cultured ventral mesencephalic neurons. Neuroscience 93:265-273, 1999 

  • J. Si, Q. Wang, and Lin Mei: Essential roles of c-JUN and c-JUN NH2-terminal kinase (JNK) in neuregulin increased expression of acetylcholine receptor epsilon-subunit. J. Neurosci. 19:8498-8508, 1999

  • S. Won, J. Si, M. Colledge, K.S. Ravichandran, S.C. Froehner, Lin Mei: Neuregulin-increased expression of AChR epsilon-subunit gene requires ErbB3 interaction with Shc. J. Neurochem. 73:2358-2368, 1999

  • M. Tanowitz, J. Si, G.S. Feng, and Lin Mei: Regulation by neuregulin-mediated AChR synthesis by protein tyrosine phosphatase SHP2. J. Neurosci. 19:9426-9435, 1999

1998

  • C.Y. Wang, J. Ni, H. Jiang, T.A. Hsu, M. Dugich-Djordjevic, L. Feng, M. Zhang, Lin Mei#, R. Gentz#, and B. Lu#: Cloning and characterization of GDNF receptor beta: a novel receptor for members of GDNF family of neurotrophic factors. Neurosci. 83:7-14, 1998. #share senior authorship.

  • J.M. Cunnick, J.F. Doresey, Lin Mei, and J. Wu: Reversible regulation of SHP-1 tyrosine phosphatase activity by oxidation. Biochem. Mol. Biol. Internat. 45:887-894, 1998.

1997

  • J. Si, D.S. Miller and L. Mei. Identification of an element required for acetylcholine receptor-inducing activity (ARIA)-induced expression of the acetylcholine receptor e subunit gene. J. Biol. Chem. 272:10367-10371, 1997.

1996

  • M.B. Tanowitz, H. Sun, and Lin Mei: Surgical denervation increases the protein tyrosine phosphatase activity in skeletal muscles. Brain Res. 712:299-306, 1996.

  • Lin Mei, A.M. Kachinsky, J. Seidan, R. Kuncl, J.B. Miller, and R.L. Huganir: Differential expression of PTP1D, a protein tyrosine phosphatase, in skeletal muscle fibers. Exp. Cell Res. 224:379-390, 1996.

  • J. Si, Z. Luo, and Lin Mei: Induction of acetylcholine receptor gene by ARIA requires activation of MAP kinase. J. Biol. Chem. 271:19752-19759, 1996.

Reviews, Previews, news and views:

  • Lin Mei and J. Si: Tyrosine phosphorylation and synapse formation at the neuromuscular junction. Life Sci. 57:1459-1466, 1995

  • J. Si, M. Tanowitz, S. Won and Lin Mei: Regulation by ARIA/Neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction. Life Sci. 62:1497-1502, 1998.

  • Y.Z. Huang and Lin Mei: Neuregulin/Erbin signal transduction pathway in the development of nervous system. Progress Physiol. Sci. 32:197-203, 2001

  • Y. Z. Huang, Q. Wang, S. Won, Z.G. Luo; W.C. Xiong, Lin Mei: Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Int. J. Dev. Neurosci. 726:1-13, 2002

  • L. Mei and W.C. Xiong: Two birds with one stone: a novel motif for AChR assembly quality control. Trends Neurosci. 26:178-81, 2003

  • Z. Luo, Q. Wang, G. C. Dobbins, S. Levy, W.C. Xiong, Lin Mei. Signaling complexes for postsynaptic differentiation. J. Neurocytol. 32:697-708, 2003

  • X.L. Yang, W.C. Xiong, L. Mei. Lipid rafts in neuregulin signaling at synapses. Life Sci. 75:2495-2504, 2004

  • W.C. Xiong and Lin Mei: An Unconventional Role of Neurotransmission in Synapse Formation. Neuron 46:521-523, 2005.

  • G. Clement Dobbins, Bin Zhang, Wen C. Xiong, and Lin Mei. The role of the cytoskeleton in neuromuscular junction formation. J. Mol. Neurosci. 30:115-118, 2006.

  • Q. Wang, B. Zhang, W.C. Xiong, and L. Mei. MuSK signalings at the neuromuscular junction. J. Mol. Neurosci. 30:223-226, 2006

  • Lin Mei and Wen C. Xiong. Signal integration by focal adhesion kinase at point contacts in growth cones. Cell Science Reviews 3:47-53, 2007

  • W.C. Xiong and Lin Mei. Neuregulin-1 in schizophrenia. Future Neurology 2:477-480, 2007.

  • L. Mei and W.C. Xiong. Neuregulin-1 signaling in neural development, synaptic plasticity and schizophrenia. Nature Rev. Neurosci. 9:437-452, 2008

  • B. Zhang, W.C. Xiong, L. Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev. Cell 16:325-327, 2009

  • Wen C. Xiong and L. Mei. FAK interaction with MBD2: a link from cell adhesion to nuclear chromatin remodeling. Cell Adhesion & Migration. 4:77-80, 2009

  • H. Wu, Wen C. Xiong, L. Mei. To build a synapse: Signaling pathways in neuromuscular junction assembly. Development 137:1017-1033, 2010

  • Y. Lu1, D.M. Yin1, W.-C. Xiong, and L. Mei. Modeling schizophrenia in neuregulin 1 and ErbB4 mutant mice. In: Animal Models of Schizophrenia. Ed: P. O'Donnell, Humana Press, 2011.

  • D.M. Yin, Y. Chen, A. Sathyamurthy, W.C. Xiong, and L. Mei. Synaptic dysfunction in schizophrenia. Adv. Exp. Med. Biol. 970: 493-516, 2012. PMID: 22351070.

  • A. Barik, W.C. Xiong, L. Mei. MuSK: A kinase critical for the formation and maintenance of the neuromuscular junction. In: Protein Kinase Technologies, Ed: Hideyuki Mukai, Springer, 2012.

  • Y. Peng, W.C. Xiong, and L. Mei. Culture of Dissociated Hippocampal Neuron. In: Neural Development: Methods and Protocols, Ed: R. Zhou and L. Mei. Humana Press, New York. 2013.

  • C. Wang and L. Mei. Immunofluorescence Staining with Frozen Mouse or Chick Embryonic Tissue Sections. In: Neural Development: Methods and Protocols, Ed: R. Zhou and L. Mei. Humana Press, New York. 2013.

  • H. Wu and L. Mei. Morphological Analysis of Neuromuscular Junctions by Immunofluorescent Staining of Whole-Mount Mouse Diaphragms. In: Neural Development: Methods and Protocols, Ed: R. Zhou and L. Mei. Humana Press, New York. 2013.

  • D.M. Yin, W.C. Xiong, L. Mei. Adolescent dopamine slows spine maturation. Nature Neuroscience, 16:1514-1516, 2013.

  • C. Shen, W.C. Xiong, L. Mei. Caspase-3, shears for synapse pruning. Dev. Cell 28:604-606, 2014.
  • L. Mei and K.-A. Nave, Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron, 83:27-49, 2014.
  • R.P. Lisak, B. Zhang, C. Shen, L. Mei. Neuromuscular junction as Achilles' heel: Yet another autoantibody? Neurology. 84:214-215, 2015. 
  • N. Muthusamy, Y.J. Chen, D.M. Yin, L. Mei, C. Bergson.  C. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. J. Neurochem. 132:20-31, 2015. 
  • C. Shen, W.C. Xiong and L. Mei. LRP4 in neuromuscular junction and bone development and diseases. Bone, 80:101-108, 2015.
  • E.Fei, W.C. Xiong and L. Mei. Ephrin-B3 recruits PSD -95 to synapses. Nature Neuroscience 18:1535-1537, 2015
  • R.P. Lisak, B. Zhang, C. Shen, L. Mei. Neuromuscular junction as Achilles' heel: Yet another autoantibody? Neurology. 84:214-215, 2015.

  • Fei, W.C. Xiong, and L. Mei. Ephrin-B3 recruits PSD -95 to synapses. Nature Neuroscience 18:1535-1537, 2015

Books:

  • Neural Development: Methods and Protocols, Editors: Renping Zhou and Lin Mei. Humana Press, New York. 2013

Patent Applications:

 1. L. Mei, W.C. Xiong, R.S. Woo, and X.M. Li. Compositions and methods for treating neurological disorders. US Patent Application #: 20100136004; Publication Date: 06/03/2010.

2. W.C. Xiong, J.H. Lee, L. Mei. Netrin-1 compositions and methods of use thereof. US Patent Application #: 20100260774; Publication Date: 10/14/2010.

3. L. Mei, Y. Tao, W.C. Xiong. Methods and compositions for modulating ErbB2 activity. US Patent Application #: 20100291077; Publication Date: 11/18/2010.

4. L. Mei, W.C. Xiong, B. Zhang, C.Y. Shen. International Patent Application #: PCT/US2010/053483; Filing Date: 10/21/2010. International Publication Number: WO 2011/050134 A2; Publication Date: 04/28, 2011.

5. L. Mei, W.C. Xiong, Y. Tao, C.Y. Shen, S.W. Luo. Erbin peptides. U.S.S.N. 61/768,333