The Transgenic and Genome Editing Core will distribute mice from the core's Shared Mouse Resource program. The program is created to help researchers share mouse models and generate novel mouse models through a cost-sharing mechanism. Genetically modified mouse models are commonly used in biomedical research. However, the generation, characterization, maintenance, and distribution of mouse models are not free but costly and time-consuming. In order to assist researchers with sharing the valuable mouse resource, the core acquires and creates novel mouse strains and maintain live colonies or cryopreserve these strains. These novel strains include research tool mice such Cre, Flp, and reporter knock-in stains, and conditional knockout mouse strains. Since the novel mouse strains are acquired or are created through a cost-sharing mechanism, individual users of these novel mouse strains will pay a small sharing fee. The sharing program operation is not subsidized by Augusta University or grants, user fees are essential to cover operating costs and to expand the repository by acquiring and creating new strains. In order to obtain the SMR mouse strain, the recipient scientist must agree and sign Uniform Biological Material Transfer Agreement.
The Core also provides services on preserving your valuable lines by cryopreservation of sperms and embryos, and resurrecting mouse lines using in vitro fertilization (IVF) or embryo transfer.
Lin Gan, PhD
Director, Genome Core