Robert K. Yu, PhD, Med ScD


Robert K. Yu, PhD, Med Sc D

Professor
Department of Neuroscience and Regenerative Medicine
Department of Neurology

PhD, University of Illinois, Urbana/Champaign, 1967

Telephone: 706-721-0699
Fax: 706-721-8727
Email: ryu@augusta.edu

Mailing Address:
Augusta University 
DNRM
1120 15TH Street, CA-1006
Augusta, GA 30912

Research Interests

Dr. Yu's current research includes the study of complex glycoconjugates, particularly glycosphingolipids, play crucial roles in determining cellular properties, such as intercellular interactions, recognition and adhesion. He and his staff are developing an understanding of the role of stage-specific glycoconjugates in governing cell events via several signaling pathways. His current projects are focused in the following areas:

  • Developmental neurobiology the role of glycoconjugates in cellular proliferation and differentiation as well as the metabolic basis and regulatory mechanisms for changes in their expression in normal brain development;
  • Stem cell biology role of glycoconjugates in neural stem cell differentiation and proliferation as well as use of stem cells in transplantation therapy;
  • Mechanisms of neurodegenerative disorders the basic mechanisms underlying a variety of neurodegenerative disorders, including neuroplasia, multiple sclerosis, autoimmune demyelinating neuropathies, mucopolysaccharidoses, sensorineural hearing loss, Parkinson's disease and Alzheimer's disease
  • Neurooncology basic mechanisms of tumorigenesis and development of vaccine-based tumor suppression strategies.
Selected Publications

Yu, R. K., Usuki, S., and Ariga, T. Ganglioside molecular mimicry and its pathological roles in Guillain-Barr syndrome and related diseases. Infect. & Immun. 74: 6517-6527, 2006.

Yu, R.K. and Yanagisawa, M. Glycosignaling in neural stem cells: Involvement of glycoconjugates in signal transduction modulating the neural stem cell fate. J. Neurochem. 103, 39-46, 2007.

Yanagisawa, M. and Yu, R.K. The expression and functions of glycoconjugates in neural stem cells. Glycobiol. 17: 57R-74R, 2007 (ranked among the top 5 of the most frequently read articles in Glycobiology).

Ngamukote, S., Yanagisawa, M., Ariga, T., Ando, S., and Yu, R.K. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. J. Neurochem. 103: 2327-2341, 2007.

Usuki, S., Nakatani, Y.; Taguchi, K. Fujita, T., Tanabe, S., Utsunomi, I. Gu, Y.-H.,Cawthraw, S., Newell, D., Pajaniappan, M., Thompson, S., Ariga, T.. and Yu, R. K. Topology and patch-clamp analysis of the sodium channel in relationship to the anti-lipid A antibody in campylobacteriosis. J. Neurosci. Res. 86: 3359-74, 2008.

Ariga, T., McDonald, M. P., and Yu, R. K. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease A review. J. Lipid Res. 49: 1157-1175, 2008.

Kaida, K., Ariga, T., and Yu, R. K. Antiganglioside antibodies and their pathophysiological
effects on Guillain-Barr Syndrome and related disorders A review. Glycobiology, 19: 676
692, 2009. doi:10.1093/glycob/cwp027, [PMID: 19240270].

Dasgupta, S., Silva, J., Wang, G., and Yu, R. K. Sulfoglucuronosyl paragloboside (SGPG) is a
ligand for T cell adhesion. Regulation of SGPG expression via NFkB signaling. J. Neurosci.
Res.87: 3591-9, 2009 [PMID: 19533738].

Nakatani, Y., Yanagisawa, M., Suzuki, Y., and Yu, R. K. Characterization of GD3 ganglioside as
a novel biomarker for neural stem cells. Glycobiology, 20: 78-86, 2010 [PMID: 19776077].

Usuki, S., Taguchi, K., Gu, Y.-H., Thompson, S. A. and Yu, R. K. Development of a novel
therapy for lipo-oligosaccharide-induced experimental neuritis: Use of peptide glycomimics. J.
Neurochem. (in press).