PhD, University of Illinois, Urbana/Champaign, 1967
1120 15TH Street, CA-1006
Augusta, GA 30912
Dr. Yu's current research includes the study of complex glycoconjugates, particularly glycosphingolipids, play crucial roles in determining cellular properties, such as intercellular interactions, recognition and adhesion. He and his staff are developing an understanding of the role of stage-specific glycoconjugates in governing cell events via several signaling pathways. His current projects are focused in the following areas:
Yu, R. K., Usuki, S., and Ariga, T. Ganglioside molecular mimicry and its pathological roles in Guillain-Barr syndrome and related diseases. Infect. & Immun. 74: 6517-6527, 2006.
Yu, R.K. and Yanagisawa, M. Glycosignaling in neural stem cells: Involvement of glycoconjugates in signal transduction modulating the neural stem cell fate. J. Neurochem. 103, 39-46, 2007.
Yanagisawa, M. and Yu, R.K. The expression and functions of glycoconjugates in neural stem cells. Glycobiol. 17: 57R-74R, 2007 (ranked among the top 5 of the most frequently read articles in Glycobiology).
Ngamukote, S., Yanagisawa, M., Ariga, T., Ando, S., and Yu, R.K. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. J. Neurochem. 103: 2327-2341, 2007.
Usuki, S., Nakatani, Y.; Taguchi, K. Fujita, T., Tanabe, S., Utsunomi, I. Gu, Y.-H.,Cawthraw, S., Newell, D., Pajaniappan, M., Thompson, S., Ariga, T.. and Yu, R. K. Topology and patch-clamp analysis of the sodium channel in relationship to the anti-lipid A antibody in campylobacteriosis. J. Neurosci. Res. 86: 3359-74, 2008.
Ariga, T., McDonald, M. P., and Yu, R. K. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease A review. J. Lipid Res. 49: 1157-1175, 2008.
Kaida, K., Ariga, T., and Yu, R. K. Antiganglioside antibodies and their pathophysiological
effects on Guillain-Barr Syndrome and related disorders A review. Glycobiology, 19: 676
692, 2009. doi:10.1093/glycob/cwp027, [PMID: 19240270].
Dasgupta, S., Silva, J., Wang, G., and Yu, R. K. Sulfoglucuronosyl paragloboside (SGPG)
ligand for T cell adhesion. Regulation of SGPG expression via NFkB signaling. J. Neurosci.
Res.87: 3591-9, 2009 [PMID: 19533738].
Nakatani, Y., Yanagisawa, M., Suzuki, Y., and Yu, R. K. Characterization of GD3 ganglioside
a novel biomarker for neural stem cells. Glycobiology, 20: 78-86, 2010 [PMID: 19776077].
Usuki, S., Taguchi, K., Gu, Y.-H., Thompson, S. A. and Yu, R. K. Development of a
therapy for lipo-oligosaccharide-induced experimental neuritis: Use of peptide glycomimics. J.
Neurochem. (in press).