Jimok Kim, PhD

Assistant Professor
Department of Neuroscience & Regenerative Medicine
Department of Neurology

PhD, University of Maryland, Baltimore, Maryland, 2004

Phone: 706-721-1371
Fax: 706-434-7414
Email: jimkim@augusta.edu

Mailing Address:
Department of Neuroscience and Regenerative Medicine
Medical College of Georgia
1120 15th Street Room CA-3004
Augusta, GA 30912

Research Interests

The overarching goal of our research is to understand the molecular and cellular mechanisms of cognitive dysfunction, with a focus on synaptic pathology. We are particularly interested in determining the role of cannabinoids, including marijuana constituents, in regulating synaptic transmission, neuronal activity and cognitive behavior in rodent models. Current research involves the physiological function of endogenous cannabinoids in the brain, cellular and behavioral effects of cannabis-like drugs, and cannabinoid-related pathology of psychiatric disorders. We also aim to develop therapeutic use of cannabinoid substances in such disorders. Our laboratory takes multidisciplinary approaches including electrophysiology, imaging, biochemistry, molecular biology and behavioral assays, using tissue cultures, brain slices and live animals.

Selected Publications

1.    Du H, Kwon I-K, Kim J (2013) Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. The Journal of Neuroscience 33(38): 15022-15031

2.    Kim J*, Tsien RW, Alger BE (2012) An improved test for detecting multiplicative homeostatic synaptic scaling. PLoS ONE 7(5): e37364 (*corresponding author)

3.    Waddell J, Kim J, Alger BE, McCarthy MM (2011) The depolarizing action of GABA in cultured hippocampal neurons is not due to the absence of ketone bodies. PLoS ONE 6(8): e23020

4.    Alger BE, Kim J (2011) Supply and demand for endocannabinoids. Trends in Neuroscience 34: 304-315

5.    Kim J, Alger BE (2010) Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nature Neuroscience 13(5): 592-600

6.    Kim J, Tsien RW (2008) Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron 58: 925-937

7.    Edwards DA*, Kim J*, Alger BE (2006) Multiple mechanisms of endocannabinoid response initiation in hippocampus. Journal of Neurophysiology 95(1): 67-75 (*equal contribution)

8.    Kim J, Alger BE (2004) Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Nature Neuroscience 7(7): 697-698

9.    Kim J, Isokawa M, Ledent C, Alger BE (2002) Activation of muscarinic acetylcholine receptors enhances the release of endocannabinoids in the hippocampus. The Journal of Neuroscience 22(23): 10182-10191

10.  Kim J, Alger BE (2001) Random response fluctuation leads to spurious paired-pulse facilitation. The Journal of Neuroscience 21(24): 9608-9618