MD, University of Puerto Rico, San Juan, Puerto Rico, 1982
1120 15th Street, CA-1018
Augusta, GA 30912
Our laboratory has a longstanding interest in defining nutrient effects on bone mass as well as overall energy balance. We have coined the term “entero-osseous axis” to explain the highly interrelated connections between nutrient-stimulated gut hormone release and bone formation. Initially, we focused on defining the indirect effects of nutrients, i.e. mechanisms by which nutrients stimulate the release of hormones that modulate bone cell functions, demonstrating the importance of overall nutrient intake, gut-, adipocyte-, and skeletal muscle-derived hormonal signals on bone mass. More recently we have focused on direct nutrient effects on bone cell function. Little is known about direct nutrient effects on osteoprogenitor/bone marrow stromal cells (BMSCs), the key targets for anabolic bone formation. Thus, currently we are working on the effects of aging on nutrition-dependent signaling pathways in BMSCs.
Bollag RJ, Zhong Q, Phillips P, Min L, Crawford KB, Zhong L, Cameron R, Mulloy A, Rasmussen H, Ding KH, Isales CM. Osteoblast-derived Cells Express Functional Glucose-dependent Insulinotropic Peptide Receptors, Endocrinology, 2000; 141:1228-1235.
Bollag RJ, Zhong Q, Ding KH, Phillips P, Zhong L, Qin F, Cranford J, Mulloy, AL, Cameron R, Isales CM. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. Mol Cell Endo. 2001, 177: 35-41.
Hamrick M, Pennington C, Newton D, Xie D, Isales CM. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine, Bone, 2004 34:376-383.
Zhong Q, Sridhar S, Ruan L, Ding KH, Xie D, Insogna K, Kang B, Xu J, Bollag RJ and Isales CM, Multiple Melanocortin Receptors Are Expressed in Bone Cells; Bone, 2005 36:820-831.
Xie D, Cheng H, Hamrick M, Zhong Q, Ding KH, Correa D, Williams S, Mulloy A, Bollag W, Bollag RJ, Runner RR, McPherson JC, Insogna K and Isales CM, Glucose-dependent Insulinotropic Polypeptide Receptor Knockout Mice Have Altered Bone Turnover; Bone, 2005 37:759-769.
Hamrick MW, Ding KH, Pennington C, Chao YJ, Wu YD, Howard B, Immel D, Borlongan C, McNeil PL, Bollag WB, Curl WW, Yu J, Isales CM. Age-Related Loss of Muscle Mass and Bone Strength in Mice is Associated with a Decline in Physical Activity and Serum Leptin, Bone, 39: 845-853, 2006
Zhong Q, Itokawa T, Sridhar S, Xie D, Ding KH, Bollag WB, Bollag RJ, Hamrick M, Insogna K and Isales CM. Effects of Glucose-dependent Insulinotropic peptide on Osteoclast Function, Am J. Physiol, Endo, 292:543-548, 2007.
Xie D, Zhong Q, Ding KH, Cheng H, Williams S, Correa D, Bollag WB, Bollag RJ, Insogna I, Troiano N, Coady C, Hamrick M, Isales CM. Glucose-dependent Insulinotropic Peptide-Overexpressing Transgenic Mice Have Increased Bone Mass, Bone, 40:1352?1360, 2007.
Shi X, Hamrick MW, Isales CM. Energy Balance, Myostatin and GILZ: Factors Regulating Adipocyte Differentiation in Belly and Bone. PPAR Research, doi:10.1155/2007/92501, 2007
Ding KH, Shi XM, Zhong Q, Kang B, Xie D, Bollag WB, Bollag RJ, Hill W, Washington W, Mi QS, Insogna K, Chutkan N, Hamrick M, Isales CM. Impact of Glucose-Dependent Insulinotropic Peptide on Age-Induced Bone Loss. J Bone Miner Res; 23:536�543, 2008